Best TWAS P=2.18e-10 · Best GWAS P=3.41e-10 conditioned to 0.193
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | 5.9 | -6.3 | 2.2e-10 | 0.90 | 0.01 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | -6.3 | -6.2 | 5.4e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | -4.5 | -6.1 | 8.2e-10 | 0.77 | 0.13 | 0.41 | FALSE |
| 3 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | -4.7 | -6.0 | 2.1e-09 | 0.85 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | -3.3 | -5.4 | 5.2e-08 | 0.64 | 0.12 | 0.72 | FALSE |
| 4 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | -4.5 | 5.3 | 1.1e-07 | -0.73 | 0.88 | 0.11 | FALSE |