TWAS
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Usage
Models
Genes
Traits
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Traits
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Forced vital capacity (FVC)
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chr5:77,052,232-78,753,539
Best TWAS P=5.39e-20 · Best GWAS P=7.88e-23 conditioned to 0.000113
77M
77.2M
77.4M
77.6M
77.8M
78M
78.2M
78.4M
78.6M
78.8M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
AP3B1
0.02
0.00
blup
126
0.01
1.8e-02
-9.7
-9.2
5.4e-20
0.86
0.02
0.86
TRUE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
AP3B1
0.05
0.02
blup
126
0.03
5.0e-04
4.4
-8.3
1.3e-16
0.80
0.02
0.92
FALSE
1
GTEx
Pituitary
LHFPL2
0.38
0.02
lasso
9
0.04
4.0e-02
2.1
-7.1
1.7e-12
0.52
0.04
0.47
FALSE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
AP3B1
0.08
0.01
enet
20
0.02
9.7e-04
-9.5
-6.4
1.5e-10
0.58
0.02
0.82
FALSE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
AP3B1
0.16
0.06
enet
18
0.09
2.2e-05
4.3
-5.2
2.3e-07
0.53
0.04
0.55
FALSE