Best TWAS P=5.39e-20 · Best GWAS P=7.88e-23 conditioned to 0.000113
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | LHFPL2 | 0.38 | 0.02 | lasso | 9 | 0.04 | 4.0e-02 | 2.1 | -7.1 | 1.7e-12 | 0.52 | 0.04 | 0.47 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -9.7 | -9.2 | 5.4e-20 | 0.86 | 0.02 | 0.86 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 4.3 | -5.2 | 2.3e-07 | 0.53 | 0.04 | 0.55 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -9.5 | -6.4 | 1.5e-10 | 0.58 | 0.02 | 0.82 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 4.4 | -8.3 | 1.3e-16 | 0.80 | 0.02 | 0.92 | FALSE |