Best TWAS P=2.3e-09 · Best GWAS P=2.76e-24 conditioned to 1.64e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -6.7 | -6.0 | 2.3e-09 | 0.30 | 0.44 | 0.07 | TRUE |
| 2 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 3.5 | -5.5 | 3.0e-08 | 0.32 | 0.95 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | -4.9 | -5.2 | 1.5e-07 | 0.55 | 0.92 | 0.02 | TRUE |