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Forced vital capacity (FVC)
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chr10:123,438,113-124,889,817
Best TWAS P=2.3e-09 · Best GWAS P=2.76e-24 conditioned to 1.64e-15
123.4M
123.6M
123.8M
124M
124.2M
124.4M
124.6M
124.8M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Skin Sun Exposed Lower leg
PLEKHA1
0.16
0.02
lasso
5
0.01
4.0e-02
-6.7
-6.0
2.3e-09
0.30
0.44
0.07
TRUE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
ARMS2
0.23
0.20
lasso
2
0.21
7.0e-09
-4.9
-5.2
1.5e-07
0.55
0.92
0.02
TRUE
2
METSIM
Adipose
PLEKHA1
0.05
0.03
lasso
4
0.04
3.6e-07
3.5
-5.5
3.0e-08
0.32
0.95
0.00
FALSE