Best TWAS P=3.11e-10 · Best GWAS P=2.27e-07 conditioned to 0.935
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WBP1L | 0.05 | 0.00 | enet | 8 | 0.00 | 5.3e-01 | -5.2 | 5.2 | 2.2e-07 | -0.87 | 0.05 | 0.61 | FALSE |
2 | GTEx | Adrenal Gland | TMEM180 | 0.19 | 0.15 | enet | 12 | 0.09 | 3.5e-04 | -4.8 | -6.3 | 3.1e-10 | 0.82 | 0.06 | 0.91 | TRUE |
3 | GTEx | Artery Coronary | TMEM180 | 0.14 | 0.05 | enet | 13 | 0.04 | 2.4e-02 | -4.9 | -5.7 | 1.0e-08 | 0.84 | 0.06 | 0.76 | FALSE |
4 | GTEx | Esophagus Muscularis | SUFU | 0.07 | 0.04 | enet | 18 | 0.03 | 5.2e-03 | -4.8 | -6.0 | 2.6e-09 | 0.78 | 0.06 | 0.89 | FALSE |
5 | GTEx | Esophagus Muscularis | TMEM180 | 0.23 | 0.22 | enet | 19 | 0.19 | 1.6e-11 | -4.8 | -5.1 | 3.0e-07 | 0.93 | 0.05 | 0.94 | FALSE |
6 | GTEx | Heart Atrial Appendage | TMEM180 | 0.42 | 0.21 | enet | 35 | 0.27 | 2.1e-12 | -4.9 | -5.9 | 3.0e-09 | 0.67 | 0.07 | 0.93 | FALSE |
7 | GTEx | Heart Left Ventricle | TMEM180 | 0.19 | 0.17 | enet | 14 | 0.17 | 3.7e-09 | -4.9 | -5.2 | 1.8e-07 | 0.90 | 0.05 | 0.95 | FALSE |
8 | GTEx | Uterus | TMEM180 | 0.22 | 0.00 | enet | 23 | 0.00 | 2.6e-01 | -4.9 | -5.6 | 1.7e-08 | 0.64 | 0.04 | 0.43 | FALSE |
9 | NTR | Blood | ACTR1A | 0.03 | 0.03 | enet | 19 | 0.03 | 1.4e-09 | -4.8 | 5.3 | 9.6e-08 | -0.84 | 0.09 | 0.91 | FALSE |