Best TWAS P=1.79e-11 · Best GWAS P=5.99e-12 conditioned to 0.0437
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | -6.5 | -6.5 | 6.0e-11 | 0.94 | 0.01 | 0.94 | FALSE |
| 2 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | -6.5 | 6.0 | 1.4e-09 | -0.76 | 0.02 | 0.98 | FALSE |
| 3 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | -6.9 | -6.7 | 1.8e-11 | 0.88 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | -6.5 | 6.3 | 3.2e-10 | -0.90 | 0.00 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | -6.5 | 6.3 | 2.4e-10 | -0.93 | 0.00 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMA4 | 0.08 | 0.02 | blup | 40 | 0.03 | 1.1e-02 | 4.9 | 5.3 | 9.6e-08 | -0.54 | 0.04 | 0.22 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | 4.5 | 5.8 | 4.8e-09 | -0.64 | 0.18 | 0.53 | FALSE |