[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr15:82,250,003-85,883,064

Best TWAS P=3.24e-17 · Best GWAS P=6.96e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Artery Tibial	AC103965.1	0.27	0.26	enet	31	0.30	1.8e-23	5.35	-8.4	3.2e-17	0.56	1.00	0.00	TRUE
45	GTEx	Esophagus Gastroesophageal Junction	RP11-382A20.2	0.13	0.03	enet	20	0.07	1.1e-03	3.51	6.5	9.4e-11	-0.12	0.11	0.14	TRUE
69	GTEx	Testis	BTBD1	0.06	0.01	enet	8	0.04	1.1e-02	4.24	-6.3	3.4e-10	0.00	0.12	0.28	TRUE
96	The Cancer Genome Atlas	Soft Tissue Sarcoma	GOLGA6L5	0.09	0.08	enet	4	0.09	5.2e-06	-4.08	-6.2	6.5e-10	0.45	0.06	0.39	TRUE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOLGA6L5	0.04	0.04	enet	5	0.05	4.6e-11	-3.72	-6.1	1.1e-09	0.44	0.14	0.84	TRUE
23	GTEx	Brain Cortex	BTBD1	0.33	0.13	lasso	5	0.22	7.9e-07	4.88	-6.0	2.3e-09	0.08	0.17	0.20	TRUE
36	GTEx	Cells EBV-transformed lymphocytes	RP11-152F13.7	0.46	0.12	lasso	9	0.16	7.4e-06	-3.76	-5.6	2.7e-08	0.10	0.14	0.45	TRUE
97	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WHAMM	0.14	0.17	enet	5	0.13	2.5e-04	-5.56	-5.5	3.2e-08	0.00	0.02	0.54	TRUE
95	The Cancer Genome Atlas	Rectum Adenocarcinoma	WHAMM	0.25	0.06	blup	55	0.09	4.2e-03	-5.33	5.5	3.8e-08	-0.12	0.01	0.77	TRUE
44	GTEx	Esophagus Gastroesophageal Junction	CSPG4P11	0.18	0.06	lasso	2	0.06	3.5e-03	5.56	-5.5	4.5e-08	0.43	0.23	0.04	TRUE
9	GTEx	Adipose Visceral Omentum	RP11-152F13.7	0.14	0.01	enet	12	0.07	1.9e-04	-2.08	-5.5	4.9e-08	0.06	0.10	0.37	TRUE
4	GTEx	Adipose Subcutaneous	WHAMM	0.46	0.45	lasso	3	0.47	2.7e-42	-4.96	5.4	5.5e-08	-0.12	0.42	0.58	TRUE
31	GTEx	Breast Mammary Tissue	AC103965.1	0.13	0.11	lasso	1	0.13	2.9e-07	5.35	-5.3	8.9e-08	0.40	0.89	0.05	TRUE
22	GTEx	Brain Cerebellum	GOLGA6L5	0.18	0.13	lasso	3	0.07	3.2e-03	-5.34	-5.2	2.4e-07	0.29	0.34	0.06	TRUE
84	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WHAMM	0.10	0.11	enet	4	0.11	5.1e-07	-5.33	5.1	2.9e-07	-0.15	0.07	0.93	TRUE
21	GTEx	Brain Cerebellum	AC103965.1	0.13	0.02	enet	21	0.01	2.1e-01	5.47	-7.9	2.1e-15	0.67	0.04	0.72	FALSE
65	GTEx	Small Intestine Terminal Ileum	RP11-182J1.14	0.26	0.01	enet	27	0.12	1.3e-03	-11.48	7.8	6.1e-15	-0.61	0.02	0.62	FALSE
62	GTEx	Prostate	RP11-182J1.16	0.24	0.06	enet	27	0.08	6.2e-03	0.67	-7.8	9.0e-15	0.48	0.09	0.10	FALSE
26	GTEx	Brain Cortex	RP11-182J1.14	0.24	0.03	enet	14	0.16	3.2e-05	5.72	7.5	6.3e-14	-0.46	0.07	0.22	FALSE
57	GTEx	Nerve Tibial	AC103965.1	0.20	0.22	enet	17	0.27	5.1e-19	5.35	-7.5	7.8e-14	0.58	1.00	0.00	FALSE
32	GTEx	Breast Mammary Tissue (Male)	AC103965.1	0.24	0.14	lasso	4	0.11	1.4e-03	5.25	-7.0	2.5e-12	0.53	0.12	0.29	FALSE
18	GTEx	Artery Tibial	CSPG4P11	0.16	0.24	lasso	4	0.23	3.0e-18	5.35	-6.8	7.7e-12	0.54	1.00	0.00	FALSE
16	GTEx	Artery Tibial	SCAND2P	0.12	0.05	enet	16	0.08	8.7e-07	-4.62	-6.8	1.0e-11	0.39	0.26	0.62	FALSE
64	GTEx	Skin Sun Exposed Lower leg	AC103965.1	0.33	0.17	enet	24	0.23	4.8e-19	5.35	-6.7	1.9e-11	0.45	1.00	0.00	FALSE
38	GTEx	Cells Transformed fibroblasts	AC103965.1	0.15	0.09	lasso	7	0.11	1.3e-08	5.46	-6.7	2.0e-11	0.49	0.98	0.01	FALSE
47	GTEx	Esophagus Mucosa	AC103965.1	0.20	0.19	enet	47	0.16	8.4e-11	5.35	-6.5	6.9e-11	0.38	1.00	0.00	FALSE
37	GTEx	Cells Transformed fibroblasts	SCAND2P	0.29	0.20	enet	39	0.21	6.5e-16	-4.62	-6.5	8.2e-11	0.32	0.69	0.31	FALSE
41	GTEx	Colon Transverse	RP11-182J1.14	0.23	0.19	enet	27	0.18	3.9e-09	5.47	6.5	8.2e-11	-0.46	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZSCAN2	0.11	0.00	blup	46	0.03	1.2e-04	3.57	6.5	8.4e-11	-0.25	0.01	0.49	FALSE
61	GTEx	Pituitary	AC103965.1	0.30	0.16	enet	10	0.24	8.4e-07	5.11	-6.5	8.9e-11	0.45	0.40	0.21	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GOLGA6L5	0.04	0.01	blup	7	0.03	4.9e-04	5.54	-6.3	3.0e-10	0.44	0.00	0.97	FALSE
63	GTEx	Prostate	RP11-182J1.14	0.25	0.09	enet	25	0.09	2.9e-03	5.58	6.3	3.2e-10	-0.35	0.19	0.08	FALSE
60	GTEx	Pancreas	RP11-182J1.16	0.08	-0.01	enet	11	-0.01	7.9e-01	-3.50	-6.2	4.9e-10	0.46	0.05	0.16	FALSE
59	GTEx	Pancreas	AC103965.1	0.29	0.23	lasso	9	0.18	2.8e-08	5.47	-6.2	5.2e-10	0.44	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WHAMM	0.14	0.05	enet	11	0.08	1.0e-04	-5.33	6.2	6.5e-10	-0.15	0.01	0.98	FALSE
29	GTEx	Brain Nucleus accumbens basal ganglia	AC103965.1	0.29	0.23	enet	21	0.27	6.9e-08	5.72	-6.1	9.2e-10	0.48	0.86	0.08	FALSE
24	GTEx	Brain Cortex	GOLGA6L4	0.42	0.21	lasso	7	0.28	2.8e-08	-4.11	-6.1	9.3e-10	0.36	0.63	0.06	FALSE
25	GTEx	Brain Cortex	AC103965.1	0.17	0.19	lasso	3	0.16	4.3e-05	5.25	-6.1	1.1e-09	0.46	0.21	0.45	FALSE
51	GTEx	Esophagus Muscularis	AC103965.1	0.18	0.14	enet	16	0.14	7.6e-09	5.56	-6.1	1.2e-09	0.46	1.00	0.00	FALSE
46	GTEx	Esophagus Mucosa	UBE2Q2P1	0.38	0.26	enet	37	0.28	3.7e-19	5.35	6.0	1.4e-09	-0.38	1.00	0.00	FALSE
39	GTEx	Colon Sigmoid	RN7SL417P	0.17	0.06	lasso	4	0.12	6.1e-05	5.72	6.0	1.6e-09	-0.46	0.28	0.09	FALSE
5	GTEx	Adipose Subcutaneous	AC103965.1	0.24	0.14	lasso	6	0.15	2.6e-12	5.46	-6.0	1.7e-09	0.44	1.00	0.00	FALSE
56	GTEx	Nerve Tibial	SCAND2P	0.23	0.11	enet	18	0.13	2.6e-09	-4.36	-6.0	1.9e-09	0.36	0.92	0.08	FALSE
49	GTEx	Esophagus Mucosa	CSPG4P11	0.21	0.01	enet	28	0.08	3.7e-06	-3.50	-6.0	2.5e-09	0.46	0.86	0.04	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADAMTSL3	0.10	0.04	lasso	4	0.04	8.7e-06	-8.39	-6.0	2.6e-09	0.24	0.24	0.02	FALSE
40	GTEx	Colon Sigmoid	RP11-182J1.14	0.31	0.29	lasso	9	0.30	2.7e-11	5.72	6.0	2.6e-09	-0.46	1.00	0.00	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	GOLGA6L5	0.06	0.09	blup	7	0.09	1.5e-10	-4.08	-6.0	2.7e-09	0.40	0.05	0.94	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	SCAND2P	0.21	0.11	lasso	3	0.12	3.4e-05	-4.62	-5.9	3.2e-09	0.39	0.17	0.29	FALSE
10	GTEx	Adipose Visceral Omentum	RP11-182J1.14	0.17	0.05	enet	18	0.08	6.9e-05	5.54	5.9	3.8e-09	-0.40	0.75	0.02	FALSE
6	GTEx	Adipose Subcutaneous	RP11-182J1.14	0.11	0.11	lasso	9	0.12	8.1e-10	5.35	5.8	4.8e-09	-0.46	1.00	0.00	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	GOLGA6L4	0.21	0.04	lasso	5	0.09	2.3e-03	-9.18	-5.8	4.8e-09	0.25	0.06	0.06	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GOLGA6L5	0.06	0.06	blup	7	0.06	1.5e-04	-5.34	-5.8	7.5e-09	0.40	0.00	0.91	FALSE
33	GTEx	Breast Mammary Tissue (Male)	RN7SL417P	0.20	0.12	lasso	3	0.10	3.1e-03	5.58	5.8	8.2e-09	-0.46	0.06	0.12	FALSE
7	GTEx	Adipose Subcutaneous	CSPG4P11	0.19	0.17	lasso	5	0.20	7.9e-16	5.46	-5.7	9.7e-09	0.42	1.00	0.00	FALSE
48	GTEx	Esophagus Mucosa	RP11-182J1.16	0.20	0.05	lasso	5	0.10	1.8e-07	5.72	-5.7	9.7e-09	0.42	0.90	0.00	FALSE
53	GTEx	Heart Atrial Appendage	RP11-182J1.14	0.06	0.05	lasso	3	0.05	3.6e-03	5.72	5.7	1.0e-08	-0.44	0.18	0.24	FALSE
34	GTEx	Breast Mammary Tissue (Male)	RP11-182J1.14	0.04	-0.01	enet	1	-0.01	5.9e-01	5.72	5.7	1.1e-08	-0.43	0.03	0.08	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBE2Q2P1	0.03	0.03	lasso	3	0.02	9.2e-04	5.47	5.7	1.1e-08	-0.43	0.00	0.91	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	GOLGA6L5	0.07	0.01	enet	5	0.06	5.2e-05	-4.08	-5.7	1.2e-08	0.40	0.00	0.95	FALSE
20	GTEx	Brain Cerebellar Hemisphere	CSPG4P11	0.30	0.21	lasso	3	0.16	7.6e-05	5.56	5.7	1.5e-08	-0.44	0.39	0.08	FALSE
93	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GOLGA6L5	0.10	0.04	enet	2	0.10	9.9e-05	-4.08	-5.7	1.5e-08	0.41	0.00	0.81	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	GOLGA6L5	0.05	0.04	blup	7	0.05	5.1e-07	-4.08	-5.7	1.6e-08	0.42	0.11	0.60	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOLGA6L5	0.11	0.03	blup	7	0.09	5.5e-10	-4.08	-5.7	1.6e-08	0.43	0.33	0.62	FALSE
11	GTEx	Adrenal Gland	AC103965.1	0.09	0.00	enet	5	-0.01	7.7e-01	5.72	-5.6	1.9e-08	0.43	0.09	0.08	FALSE
35	GTEx	Breast Mammary Tissue (Male)	CSPG4P11	0.05	0.02	lasso	6	0.03	7.1e-02	5.16	-5.6	1.9e-08	0.44	0.03	0.09	FALSE
75	The Cancer Genome Atlas	Colon Adenocarcinoma	GOLGA6L5	0.04	0.04	blup	7	0.03	8.2e-03	-4.08	-5.5	3.5e-08	0.38	0.01	0.60	FALSE
43	GTEx	Esophagus Gastroesophageal Junction	AC103965.1	0.13	0.14	lasso	4	0.15	3.2e-06	5.72	-5.5	3.7e-08	0.42	0.48	0.06	FALSE
19	GTEx	Brain Cerebellar Hemisphere	UBE2Q2P1	0.18	0.08	enet	18	0.12	4.2e-04	5.58	5.5	3.9e-08	-0.45	0.18	0.18	FALSE
86	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NMB	0.06	0.04	enet	9	0.02	2.7e-02	4.65	-5.5	4.0e-08	0.30	0.01	0.64	FALSE
67	GTEx	Spleen	GOLGA6L5	0.46	0.34	lasso	9	0.40	2.0e-11	-3.70	-5.5	4.1e-08	0.44	0.71	0.18	FALSE
72	GTEx	Thyroid	AC103965.1	0.30	0.25	lasso	7	0.25	1.8e-19	5.46	-5.5	4.1e-08	0.42	1.00	0.00	FALSE
12	GTEx	Artery Aorta	AC103965.1	0.10	0.12	lasso	3	0.10	3.9e-06	5.54	-5.5	4.2e-08	0.40	0.95	0.02	FALSE
54	GTEx	Lung	AC103965.1	0.20	0.14	lasso	4	0.16	1.8e-12	5.35	-5.5	4.6e-08	0.40	1.00	0.00	FALSE
14	GTEx	Artery Aorta	CSPG4P11	0.11	0.10	lasso	4	0.08	3.1e-05	5.46	-5.5	4.7e-08	0.40	0.93	0.01	FALSE
8	GTEx	Adipose Visceral Omentum	AC103965.1	0.12	0.13	lasso	5	0.10	1.0e-05	5.46	-5.5	4.8e-08	0.40	0.97	0.01	FALSE
50	GTEx	Esophagus Muscularis	SCAND2P	0.11	0.05	lasso	3	0.10	1.9e-06	-4.62	-5.4	6.0e-08	0.32	0.44	0.40	FALSE
79	The Cancer Genome Atlas	Glioblastoma Multiforme	GOLGA6L5	0.20	0.05	blup	7	0.07	4.7e-03	-5.34	-5.4	6.8e-08	0.35	0.00	0.57	FALSE
52	GTEx	Esophagus Muscularis	CSPG4P11	0.12	0.16	lasso	5	0.18	4.0e-11	5.46	-5.4	7.1e-08	0.38	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC388152	0.12	0.08	lasso	3	0.08	1.9e-03	5.37	-5.4	7.7e-08	0.40	0.00	0.66	FALSE
92	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC388152	0.08	0.11	lasso	3	0.11	2.4e-05	5.37	-5.4	7.8e-08	0.40	0.00	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	BTBD1	0.07	0.01	bslmm	356	0.04	1.7e-05	-4.20	-5.4	8.0e-08	-0.03	0.54	0.28	FALSE
55	GTEx	Muscle Skeletal	SCAND2P	0.05	0.00	lasso	4	0.00	1.3e-01	-4.36	-5.4	8.4e-08	0.35	0.13	0.14	FALSE
58	GTEx	Ovary	RP11-182J1.14	0.19	0.04	enet	17	0.17	7.3e-05	-0.39	5.3	8.7e-08	-0.12	0.05	0.07	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC388152	0.04	0.05	enet	2	0.05	4.2e-04	5.35	-5.3	8.8e-08	0.41	0.00	0.88	FALSE
71	GTEx	Testis	RP11-182J1.14	0.10	0.19	lasso	1	0.17	6.7e-08	5.35	5.3	8.9e-08	-0.40	0.94	0.00	FALSE
77	The Cancer Genome Atlas	Esophageal Carcinoma	LOC388152	0.10	0.08	enet	2	0.08	1.8e-03	5.34	-5.3	8.9e-08	0.41	0.00	0.73	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC388152	0.02	0.03	lasso	1	0.02	1.2e-03	5.34	-5.3	9.1e-08	0.40	0.00	0.92	FALSE
68	GTEx	Stomach	AC103965.1	0.14	0.11	lasso	3	0.10	1.1e-05	5.25	-5.3	1.0e-07	0.40	0.84	0.01	FALSE
73	METSIM	Adipose	WHAMM	0.35	0.30	lasso	2	0.30	4.0e-46	-5.33	5.3	1.0e-07	-0.14	0.10	0.90	FALSE
76	The Cancer Genome Atlas	Esophageal Carcinoma	GOLGA6L5	0.12	0.07	blup	7	0.12	1.0e-04	-5.34	-5.3	1.0e-07	0.35	0.01	0.80	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	GOLGA6L5	0.15	0.16	lasso	3	0.19	1.8e-18	-4.08	-5.3	1.1e-07	0.38	0.56	0.37	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LOC388152	0.14	0.14	enet	20	0.18	6.7e-22	5.54	-5.3	1.3e-07	0.43	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Glioblastoma Multiforme	BTBD1	0.20	0.06	lasso	2	0.13	9.1e-05	5.57	-5.3	1.3e-07	0.07	0.00	0.96	FALSE
15	GTEx	Artery Coronary	CSPG4P11	0.18	0.02	enet	14	0.11	2.0e-04	4.67	-5.2	2.0e-07	0.36	0.08	0.09	FALSE
66	GTEx	Spleen	GOLGA6L4	0.55	0.20	enet	19	0.40	2.6e-11	-3.71	-5.2	2.0e-07	0.40	0.89	0.01	FALSE
70	GTEx	Testis	AC103965.1	0.07	0.07	lasso	2	0.06	1.6e-03	5.35	-5.2	2.1e-07	0.39	0.52	0.04	FALSE
30	GTEx	Brain Putamen basal ganglia	AC103965.1	0.26	0.19	lasso	7	0.22	4.5e-06	5.72	-5.2	2.7e-07	0.39	0.69	0.10	FALSE
27	GTEx	Brain Hypothalamus	AC103965.1	0.21	0.24	lasso	6	0.21	1.4e-05	5.72	-5.1	2.9e-07	0.42	0.32	0.18	FALSE
13	GTEx	Artery Aorta	RP11-182J1.16	0.11	0.12	lasso	3	0.11	1.6e-06	5.46	-5.1	3.0e-07	0.39	0.94	0.00	FALSE