[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr16:68,901,284-71,093,625

Best TWAS P=1.51e-13 · Best GWAS P=4.18e-19 conditioned to 0.619

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COG4	0.19	0.23	enet	28	0.27	4.3e-33	-4.6	6.2	6.0e-10	0.32	0.78	0.22	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NOB1	0.04	0.05	enet	12	0.04	7.2e-06	-5.7	6.2	6.3e-10	0.61	0.86	0.12	FALSE
3	GTEx	Adipose Subcutaneous	NFAT5	0.09	0.02	enet	19	0.05	8.2e-05	-2.6	-5.8	6.1e-09	-0.53	0.08	0.65	TRUE
4	GTEx	Brain Nucleus accumbens basal ganglia	PDXDC2P	0.26	0.17	lasso	5	0.13	2.2e-04	5.7	5.5	4.7e-08	0.44	0.34	0.05	FALSE
5	GTEx	Cells Transformed fibroblasts	COG4	0.23	0.18	lasso	5	0.20	1.3e-14	-4.7	6.0	2.6e-09	0.26	0.77	0.23	FALSE
6	GTEx	Esophagus Mucosa	COG4	0.14	0.06	lasso	4	0.08	7.8e-06	-4.6	5.9	3.7e-09	0.26	0.33	0.63	FALSE
7	GTEx	Skin Sun Exposed Lower leg	COG4	0.08	0.03	enet	13	0.04	3.8e-04	5.4	5.4	8.8e-08	0.22	0.01	0.96	FALSE
8	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	-4.3	-6.3	2.2e-10	-0.54	0.65	0.05	FALSE
9	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	-6.6	7.4	1.5e-13	0.77	0.09	0.71	TRUE
10	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	-4.4	6.7	1.9e-11	0.69	0.12	0.57	FALSE
11	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-5.0	6.2	7.1e-10	0.76	0.10	0.88	FALSE
12	METSIM	Adipose	WWP2	0.08	0.04	enet	19	0.07	2.7e-10	6.6	6.3	2.6e-10	0.74	0.43	0.57	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	NFAT5	0.02	0.01	enet	5	0.01	6.6e-04	-2.7	-6.2	5.4e-10	-0.64	0.02	0.54	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CLEC18A	0.10	0.06	lasso	2	0.04	6.3e-03	5.5	5.5	3.4e-08	0.53	0.04	0.20	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PDXDC2	0.20	0.02	blup	26	0.07	1.8e-04	5.7	6.4	1.2e-10	0.46	0.01	0.88	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	CLEC18A	0.14	0.18	lasso	5	0.15	4.5e-09	5.5	5.7	1.0e-08	0.56	0.41	0.59	FALSE
17	The Cancer Genome Atlas	Glioblastoma Multiforme	PDXDC2	0.10	0.12	lasso	3	0.10	4.7e-04	5.5	5.5	3.3e-08	0.53	0.02	0.66	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COG4	0.10	0.07	enet	7	0.08	1.9e-09	-4.6	6.0	1.7e-09	0.24	0.52	0.47	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PDXDC2	0.14	0.05	enet	6	0.05	3.2e-06	5.7	5.7	1.4e-08	0.42	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLEC18C	0.06	0.05	lasso	1	0.04	3.8e-05	5.7	5.7	1.1e-08	0.44	0.52	0.29	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDXDC2	0.03	0.04	enet	4	0.04	4.0e-05	5.7	5.7	1.3e-08	0.45	0.01	0.98	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	COG4	0.08	0.08	lasso	3	0.09	1.0e-10	-3.9	5.5	3.5e-08	0.25	0.68	0.31	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	COG4	0.03	0.00	blup	30	0.01	9.7e-03	-4.5	5.6	2.3e-08	0.23	0.08	0.18	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CLEC18A	0.06	0.10	lasso	1	0.09	6.9e-11	5.5	5.5	3.8e-08	0.53	0.86	0.14	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDXDC2	0.09	0.01	blup	26	0.06	4.7e-05	5.7	5.6	2.8e-08	0.47	0.01	0.91	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	COG4	0.11	0.04	lasso	3	0.06	2.3e-03	-4.7	5.8	7.0e-09	0.25	0.21	0.41	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PDXDC2	0.26	0.19	lasso	3	0.23	1.3e-09	5.7	5.2	1.7e-07	0.43	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	5.7	6.1	1.4e-09	0.63	0.01	0.39	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLEC18A	0.12	0.11	lasso	2	0.11	3.4e-07	5.5	5.5	3.4e-08	0.56	0.60	0.38	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	PDXDC2	0.05	0.01	blup	26	0.03	9.5e-03	5.7	6.7	2.4e-11	0.55	0.01	0.74	FALSE
31	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CLEC18A	0.17	0.09	enet	8	0.11	8.5e-04	5.7	6.6	4.8e-11	0.63	0.01	0.81	FALSE
32	The Cancer Genome Atlas	Skin Cutaneous Melanoma	COG4	0.26	-0.01	blup	30	0.02	1.1e-01	-3.6	5.6	1.6e-08	0.25	0.02	0.28	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLEC18A	0.20	0.09	lasso	5	0.08	8.8e-04	6.6	6.6	3.2e-11	0.70	0.00	0.92	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	PDXDC2	0.12	0.16	blup	26	0.15	1.1e-14	5.7	5.3	1.2e-07	0.45	0.01	0.99	FALSE