TWAS hub - NFAT5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0890	0.0370	0.00074	0.021	NA	0.048	NA	0.023	0.00760	NA	8.2e-05	NA	0.00490
2	NTR	Blood	0.0295	0.0147	0.01100	0.005	0.005	0.007	0.005	0.005	0.00640	0.0090	1.3e-03	0.0064	0.00840
3	TCGA	Breast Invasive Carcinoma	0.0243	0.0138	0.00440	0.013	0.011	0.014	NA	0.013	0.00074	0.0018	6.6e-04	NA	0.00092

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age when periods started (menarche)	16.2	38.9	59.1	-7.7	-1.1	-7.5
Forced vital capacity (FVC), Best measure	10.2	37.5	63.9	-6.8	-1.4	-8.0
Arm fat percentage (left)	10.2	40.8	102.0	4.4	-1.1	10.1
Arm fat percentage (right)	9.6	37.9	94.5	4.3	-1.0	9.7
Forced vital capacity (FVC)	9.4	36.1	59.4	-7.0	-0.6	-7.7
Diabetes (self-reported)	9.2	14.2	22.4	4.0	-1.9	4.7
BMI	9.1	52.7	121.0	6.1	-0.3	11.0
Type 2 Diabetes (T2D) (2018)	8.9	16.6	30.3	4.0	-1.8	5.5
Diabetes diagnosed by doctor	8.4	13.9	25.0	3.7	-1.6	5.0
Body fat percentage	7.4	29.3	75.3	3.4	-1.1	8.7
Body mass index (BMI)	7.3	31.2	75.3	4.2	-0.8	8.7
Forced expiratory volume in 1-second (FEV1)	7.2	24.1	38.5	-5.8	0.0	-6.2
Forced expiratory volume in 1-second (FEV1), Best measure	7.2	22.8	40.5	-5.3	-0.3	-6.4
Trunk fat percentage	7.0	28.0	72.6	3.2	-1.0	8.5
Lung FVC	6.8	34.8	59.6	-6.6	-0.9	-7.7
Waist circumference	6.8	24.8	56.6	4.2	-0.4	7.5
Supplements: Fish oil (including cod liver oil)	6.8	8.8	20.6	-4.5	-1.2	-2.1
Relative age voice broke	6.7	10.2	19.3	-3.1	1.3	-4.4
Long-standing illness, disability or infirmity	6.4	9.8	22.5	2.6	0.2	4.7
Medication: Metformin	6.3	8.8	12.4	3.5	-1.8	3.3
Gout (self-reported)	6.3	8.6	21.4	2.0	-0.6	4.6
Leg fat percentage (right)	6.2	22.6	54.5	3.4	-1.4	7.4
Sitting height	6.1	43.1	85.6	-6.6	0.3	-9.2
Arm fat mass (right)	6.0	24.6	62.7	3.1	-1.1	7.9
Arm fat mass (left)	6.0	24.6	62.7	3.2	-1.1	7.9
Supplements: Vitamin C	5.9	7.0	15.3	-1.7	1.7	-3.9
Leg fat percentage (left)	5.8	20.9	51.7	3.2	-0.9	7.2
Hand grip strength (left)	5.6	14.8	28.9	-3.7	1.3	-5.4
Mineral and other dietary supplements	5.6	7.5	17.9	4.2	0.9	2.0
Number of self-reported non-cancer illnesses	5.5	9.5	20.5	2.8	-0.3	4.5
Whole body fat mass	5.1	21.5	56.2	2.6	-1.2	7.5
Leg fat mass (right)	5.1	19.6	49.7	2.8	-1.2	7.0
Medication for cholesterol, blood pressure or diabetes	4.9	8.1	13.7	-3.2	-0.0	-3.7
Trunk fat mass	4.8	20.5	53.6	2.5	-1.2	7.3
Serious illness, injury or assault to yourself	4.7	5.6	16.3	0.8	-0.0	4.0
Alcohol intake versus 10 years previously	4.7	7.0	10.3	3.2	-1.1	3.1
Medication: Allopurinol	4.7	6.2	14.2	2.1	-0.4	3.8
Leg fat mass (left)	4.5	17.6	45.4	2.6	-0.9	6.7
Risk taking	4.3	6.3	7.0	2.6	2.6	2.3
Back pain experienced in last month	4.2	6.1	11.6	-3.4	0.4	-2.5
Vascular/heart problems diagnosed by doctor	4.2	11.4	18.6	-4.3	0.4	-3.9
Nervous feelings	4.1	7.7	8.3	-2.8	2.6	-2.9
Medication: Simvastatin	4.1	6.1	10.8	2.7	0.5	3.3
Medication for hormone replacement therapy	4.0	4.4	8.5	-2.9	0.2	-2.2
Pack years adult smoking proportion	4.0	6.1	11.4	2.4	-1.0	3.4
Worry (Nagel 2018)	3.9	8.2	12.0	-3.4	0.8	-3.5
Peak expiratory flow (PEF)	3.9	9.1	15.1	-3.5	0.0	-3.9
Alcohol intake frequency.	3.9	9.1	20.8	1.9	-1.7	4.6
Medication: Lisinopril	3.9	5.0	8.2	2.9	-1.4	2.2
Cholesterol lowering medication	3.9	5.7	10.5	2.6	-0.3	3.2
Pack years of smoking	3.9	5.8	10.0	2.6	-0.7	3.2
Cardiovascular Disease	3.8	12.6	23.7	3.6	-1.1	4.9
Eye problems/disorders: Diabetes related eye disease	3.8	4.1	5.3	1.5	-2.2	2.3
High blood pressure	3.8	10.7	17.2	4.1	-0.4	3.8
Hypertension (Self-reported)	3.8	10.7	17.7	4.2	-0.5	3.8
Hand grip strength (right)	3.7	10.0	19.8	-3.1	-0.5	-4.5
Systolic blood pressure, automated reading	3.6	10.4	19.1	3.5	-0.3	4.4
Standing height	3.5	34.3	64.3	-6.2	-0.4	-8.0
Diabetes (mother)	3.4	4.3	7.6	2.3	-0.5	2.8
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	6.1	-2.5	-1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	8.5	-0.6	-1.7	2.9
Triglycerides	3.3	5.4	13.3	1.6	0.5	3.6
Fluid intelligence score	3.3	6.9	15.1	1.5	-1.8	3.9
Pulse rate, automated reading	3.3	10.7	26.4	2.4	-0.1	5.1
Verbal and Numeric Reasoning (VNR)	3.2	7.7	16.2	1.2	-2.4	4.0
Hip circumference	3.2	14.0	38.2	1.4	-1.3	6.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.8	18.5	-1.1	0.9	-4.3
Financial situation satisfaction	3.2	4.0	4.8	-2.2	-2.0	-1.9
Medication: Blood pressure	3.1	5.4	8.7	2.7	-0.2	3.0
Hearing difficulty/problems: Yes	2.9	4.4	11.1	1.3	-0.4	3.3
Pulse wave reflection index	2.9	3.6	6.5	-1.4	2.5	-1.6
Eye problems/disorders: None of the above	2.9	3.3	5.4	-1.0	1.9	-2.3
Supplements: Zinc	2.8	3.1	6.0	-1.1	1.4	-2.4
Taking other prescription medications	2.8	4.2	9.7	1.7	0.5	3.1
Osteoarthritis (self-reported)	2.8	3.6	5.1	2.2	1.5	1.9
Medication: Blood pressure	2.8	5.4	11.6	3.4	0.9	1.9
High cholesterol (Self-reported)	2.8	4.9	10.8	1.9	-0.4	3.3
Type 2 Diabetes (T2D) (2012)	2.7	3.1	4.9	2.0	-0.6	2.2
Height	2.7	52.5	112.4	-6.7	-0.3	-10.6
Chronotype (morning person)	2.7	6.3	14.7	-2.0	-0.6	-3.8
Myopia	2.7	3.8	6.5	1.5	2.6	-1.7
Breastfed as a baby	2.6	3.2	5.1	-2.3	-0.3	-2.1
Medication: Aspirin	2.6	3.5	5.5	1.7	-1.5	2.3
Medication: Bendroflumethiazide	2.6	3.9	5.9	2.4	0.0	2.4
Alcohol drinker status: Previous	2.6	3.0	7.4	1.1	0.4	2.7
Average weekly spirits intake	2.5	3.1	4.9	1.1	-1.7	2.2
Birth weight	2.5	5.5	11.4	-1.4	1.7	-3.4
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	9.1	-2.5	0.1	-3.0
Wears glasses or contact lenses	2.5	2.9	5.0	2.2	-1.3	1.4
Unable to work because of sickness or disability	2.5	3.2	9.4	-0.3	0.3	3.1
Supplements: Calcium	2.5	2.8	6.2	-1.1	0.9	-2.5
Vitamin and mineral supplements	2.4	3.3	6.6	1.7	-0.4	2.6
Past tobacco smoking	2.4	4.5	7.8	-1.5	-2.8	-1.8
Worrier / anxious feelings	2.4	4.5	7.8	-2.3	-0.6	-2.8
Illnesses of siblings: Diabetes	2.4	3.0	8.5	0.6	-0.2	2.9
Blood Red Count	2.3	22.6	37.9	4.8	-2.6	6.2
Waist Hip Ratio (WHR)	2.3	10.2	20.6	4.5	2.0	2.4
Number of treatments/medications taken	2.3	4.2	6.8	2.4	0.1	2.6
Relative age of first facial hair	2.3	4.8	8.9	-2.2	0.7	-3.0
Impedance of leg (left)	2.3	11.3	22.0	-3.5	-0.1	-4.7
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	7.7	-1.0	-1.5	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	7.3	0.9	2.7	-0.3
Ever smoked	2.3	4.0	10.1	0.7	3.2	1.2
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	6.7	1.2	0.6	2.6
Neuroticism score	2.2	4.6	9.9	-3.1	-0.4	-2.0
Medication: Cholesterol lowering	2.2	3.4	8.9	1.1	0.1	3.0
Suffer from ‘nerves’	2.2	3.5	5.2	-2.3	-0.5	-2.2
Medication: Aspirin	2.2	2.8	4.2	1.2	-1.6	2.0
Average weekly fortified wine intake	2.1	2.4	3.7	-1.9	-0.3	-1.8
Number of incorrect matches in round	2.1	3.5	5.6	2.4	2.2	-0.2
Financial difficulties in last 2 years	2.1	2.8	5.3	-0.5	-2.3	1.7
Illnesses of siblings	2.1	2.9	7.3	-1.1	0.3	-2.7
Falls in the last year	2.1	2.8	5.0	0.3	1.8	2.2
Noisy workplace	2.1	2.6	7.0	-0.8	0.5	-2.6
Comparative body size at age 10	2.1	5.8	10.2	2.7	-0.0	3.2
Shortness of breath walking on level ground	2.1	2.5	5.1	1.4	0.5	2.3
Smoking status: Previous	2.1	3.1	5.4	1.6	2.3	1.1
Average weekly champagne plus white wine intake	2.1	2.9	4.4	-1.0	1.8	-2.1
Neuroticism (Nagel 2018)	2.0	4.6	8.5	-2.9	0.2	-2.3
Systolic Blood Pressure	2.0	9.9	16.5	3.4	-1.3	4.1
Medication: Atenolol	2.0	2.5	3.9	1.8	-0.3	2.0
Knee pain experienced in last month	2.0	3.1	7.5	0.5	1.2	2.7
Mother’s age at death	2.0	2.5	4.1	-0.2	1.8	-2.0
Mean Putamen Volume	1.9	2.2	5.8	0.8	2.4	0.3
HbA1C	1.9	2.1	4.1	2.0	0.7	1.3
Neuroticism	1.9	4.6	8.1	-2.8	-0.2	-2.4
Chronic bronchitis/emphysema (father)	1.9	2.2	5.6	0.6	-0.8	2.4
Number of children fathered	1.9	2.1	5.1	-2.3	-0.7	-0.8
Chest pain or discomfort	1.9	2.8	7.2	-1.0	-0.5	2.7
Eye problems/disorders: Cataract	1.9	2.2	4.3	1.5	0.0	2.1
Medication: Atorvastatin	1.9	2.4	5.2	1.4	0.1	2.3
Major Depression (MDD)	1.8	2.1	3.5	1.3	1.1	1.9
Fasting Glucose	1.8	2.2	6.3	0.3	-0.4	2.5
Diabetes (father)	1.8	2.2	4.6	1.4	-0.3	2.1
Impedance of leg (right)	1.8	8.9	17.0	-3.1	-0.6	-4.1
Maternal smoking around birth	1.8	2.5	5.9	1.2	-0.6	2.4
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	4.5	-2.1	-0.6	-1.5
Father’s age at death	1.8	2.5	7.0	-0.1	0.6	-2.6
Age at last live birth	1.8	2.6	5.0	-0.1	2.2	-1.6
Medication: Levothyroxine sodium	1.7	2.8	6.5	1.2	0.8	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	7.7	-2.8	-0.1	-0.7
Happiness	1.7	2.1	6.0	-0.5	-0.4	-2.4
Exposure to tobacco smoke outside home	1.7	2.3	3.5	-1.3	-1.3	-1.9
Miserableness	1.7	3.0	5.7	-2.4	-1.7	-0.5
Coronary Artery Disease (CAD)	1.6	1.9	5.0	-0.8	-2.2	-0.3
Sensitivity / hurt feelings	1.6	2.7	4.4	-2.1	1.2	-1.6
Alcohol usually taken with meals	1.6	2.6	5.0	-0.4	1.6	-2.2
Had other major operations	1.6	1.9	3.7	1.2	1.9	0.8
Weight	1.6	8.0	21.6	1.2	-1.0	4.7
Hair/balding pattern: Pattern 3	1.6	2.4	5.6	0.8	1.1	2.4
Exposure to tobacco smoke at home	1.6	1.8	4.3	2.1	0.1	1.0
Loud music exposure frequency	1.6	1.8	5.0	-0.3	-2.2	-0.6
Medication: Paracetamol	1.6	2.7	3.9	2.0	1.3	1.6
Mean time to correctly identify matches	1.6	3.1	7.6	1.3	2.8	-0.2
Medication: Paracetamol	1.6	2.5	3.2	1.8	1.0	1.8
Alzheimer’s Disease (in father)	1.5	1.6	2.3	-0.6	1.5	-1.4
Reaction Time	1.5	2.8	7.8	0.6	2.8	-0.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.5	-0.8	1.9	-1.3
Qualifications: CSEs or equivalent	1.5	1.9	2.9	-1.3	1.1	-1.7
Osteoporosis (self-reported)	1.5	1.9	3.9	1.2	2.0	-0.6
Body Mass Index (BMI) (2010)	1.4	1.9	5.1	0.6	0.6	2.3
Townsend deprivation index at recruitment	1.4	2.0	4.0	2.0	-0.6	1.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.3	-0.1	0.9	-2.1
Mood swings	1.4	2.5	3.7	-1.9	-0.9	-1.7
Medication: Gliclazide	1.4	1.6	3.4	0.4	-1.1	1.8
HDL Cholesterol	1.3	2.2	4.4	-1.3	0.8	-2.1
Blood Eosinophil Count	1.3	9.9	21.6	1.9	-2.1	4.7
Smoking Status	1.3	3.1	7.6	1.1	2.8	0.7
Fed-up feelings	1.3	2.3	3.1	-1.6	-1.1	-1.8
Hearing difficulty/problems with background noise	1.3	2.0	2.8	1.2	1.4	1.7
Had menopause	1.3	1.6	3.5	1.0	1.9	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	3.3	0.5	1.5	1.8
Age at first live birth	1.3	2.2	3.1	-1.2	1.5	-1.8
Migraine (self-reported)	1.3	1.6	2.7	1.6	1.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.0	0.2	-2.0	0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.7	-1.1	-1.0	1.7
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.2	1.4	-1.7	2.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.8	-2.2	0.2	-0.6
Ever had hysterectomy (womb removed)	1.2	1.3	3.6	0.6	-0.0	1.9
Prospective memory result	1.2	1.5	2.9	-0.8	1.0	-1.7
Length of working week for main job	1.2	1.4	3.8	-0.1	-0.6	1.9
Tense / ‘highly strung’	1.2	2.0	4.6	-2.1	0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	1.7	1.1	0.4
Medication: Ibuprofen	1.2	1.4	2.4	-1.5	-0.8	1.1
Leg pain on walking	1.2	1.5	2.2	-1.4	-1.5	0.7
Ever had bowel cancer screening	1.2	1.4	3.1	0.1	1.1	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	3.0	-1.7	-0.8	-0.9
Prostate Cancer	1.1	1.6	3.3	-0.2	-1.2	1.8
Severe depression (siblings)	1.1	1.3	3.1	-0.2	0.8	1.8
Time employed in main current job	1.1	1.3	1.9	1.4	0.3	-1.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	6.2	0.1	0.4	2.5
Worry too long after embarrassment	1.1	1.8	2.6	-1.6	-0.5	-1.6
Pulse wave peak to peak time	1.1	1.2	3.4	-0.0	-1.8	-0.6
Neck or shoulder pain in last month	1.1	1.5	2.5	-1.6	-0.9	1.1
Heart disease (mother)	1.1	1.3	1.8	-1.2	0.8	-1.3
Illnesses of father: Heart disease	1.1	1.5	3.1	0.5	1.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.9	-1.7	0.2	-0.8
Pain experienced in last month	1.1	1.8	4.4	2.1	-1.1	-0.2
Age at First Birth	1.0	1.5	2.2	1.5	-1.5	-0.4
Ulcerative Colitis	1.0	1.4	2.2	-1.5	-1.2	0.7
Hypothyroidism (self reported)	1.0	2.4	6.5	0.3	0.8	2.5
Current tobacco smoking	1.0	1.7	3.9	0.5	0.9	2.0
Pulse rate	1.0	1.7	4.0	1.0	-0.1	2.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.9	-1.4	-0.8	1.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.7	-1.9	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.9	-1.3	0.3	-1.4
Alcohol drinker status: Never	1.0	1.2	1.8	1.0	-1.0	1.3
Depressed Affect (Nagel 2018)	0.9	1.8	3.6	-1.9	-1.1	-0.9
Depression (Nagel 2018)	0.9	1.4	3.6	-1.9	-0.5	-0.4
Lung FEV1/FVC ratio	0.9	4.3	7.6	2.8	1.8	1.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	-1.9	0.1	-1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	1.0	-0.1	1.5
Heart attack	0.9	1.1	1.8	1.3	0.6	1.1
Hair/balding pattern: Pattern 4	0.9	2.3	4.7	2.2	1.4	0.3
Medication: Amlodipine	0.9	1.3	3.6	0.5	0.3	1.9
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.0	-1.0	-1.4	-0.7
High blood pressure (siblings)	0.9	1.3	3.6	0.5	0.3	1.9
Medication for pain relief, constipation, heartburn	0.9	1.5	2.3	-1.4	0.4	-1.5
Illnesses of father: None of the above (group 1)	0.9	1.1	1.9	-1.4	-0.2	-1.1
Smoking status: Current	0.9	1.4	2.8	0.5	1.1	1.7
Ever depressed for a whole week	0.9	1.1	2.0	1.4	0.8	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	2.1	0.5	1.4	-1.1
Ulcerative Colitis (UC)	0.8	1.4	2.2	-1.4	-1.5	0.3
Breast Cancer	0.8	2.0	4.9	0.6	0.8	-2.2
Ovarian Cancer	0.8	1.1	2.9	0.4	-1.7	-0.3
Angina	0.8	1.1	3.2	-0.2	-0.3	1.8
Hair/balding pattern: Pattern 2	0.8	1.0	1.5	-1.1	-1.2	-0.5
Mouth/teeth dental problems	0.8	1.2	3.4	1.8	0.1	0.5
Number of live births	0.8	1.1	2.3	1.5	-0.3	0.9
Medication: Lansoprazole	0.8	0.9	1.2	0.6	-1.1	1.1
Pulse wave Arterial Stiffness index	0.8	1.0	2.7	-0.2	1.6	0.3
Blood clot in the leg (DVT)	0.8	1.0	1.9	1.0	0.5	1.4
Headache pain in last month	0.8	1.4	2.3	0.5	1.3	1.5
Medication: Omeprazole	0.8	1.0	1.5	0.9	-1.2	0.7
Guilty feelings	0.8	1.2	1.7	-1.3	-0.7	-1.2
Commuting to job workplace: Cycle	0.8	0.9	1.9	0.6	0.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.5	1.2	-1.2	0.3
Bipolar Disorder (2011)	0.7	0.6	1.4	-1.2	0.7	-0.3
Lupus	0.7	1.0	1.9	-0.9	-1.4	0.7
Allergy or Eczema	0.7	1.9	3.7	-1.4	0.3	-1.9
Medication: Co-codamol	0.7	0.8	1.1	-0.7	-0.8	1.1
Multivitamins +/- minerals	0.7	0.8	1.4	-1.0	-0.3	-1.2
Depression (self-reported)	0.7	0.8	2.1	-0.6	0.1	1.5
Angina (self-reported)	0.7	0.9	2.2	-0.4	-0.4	1.5
Family relationship satisfaction	0.7	0.9	2.6	1.6	0.2	0.2
Breast cancer (self-reported)	0.7	0.8	1.6	0.8	-1.2	0.6
Average weekly beer plus cider intake	0.7	1.0	2.2	-1.5	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.6	1.3	0.4	0.9
Impedance of whole body	0.7	3.8	6.7	-2.6	-0.2	-2.1
Blood White Count	0.6	4.5	13.0	0.6	0.3	3.6
Stomach or abdominal pain in last month	0.6	0.8	1.1	0.5	1.1	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	-1.1	-0.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	-0.9	0.0	1.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-0.9	0.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.4	-0.0	1.6	-0.0
Medication: Seretide 50 evohaler	0.6	0.7	1.4	0.8	0.1	1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	1.4	-0.1	-0.5
Illnesses of father: High blood pressure	0.6	0.7	1.6	0.7	-0.4	1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	0.7	0.2	1.2
Heel T-Score	0.5	3.6	5.4	-1.4	-1.8	-2.3
Respiratory disease	0.5	1.0	2.6	-1.6	-0.5	-0.4
Medication: Ramipril	0.5	0.7	1.3	0.8	-1.1	-0.0
Trunk fat-free mass	0.5	3.0	5.4	-1.8	-0.6	-2.3
Illnesses of mother	0.5	0.7	1.3	-0.8	-0.1	-1.1
Trunk predicted mass	0.5	2.9	5.2	-1.8	-0.6	-2.3
Wheeze or whistling in the chest in last year	0.5	0.9	1.2	-0.8	-0.9	1.1
Had major operations	0.5	0.6	1.6	-0.3	-1.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.3	-1.0	-0.2	-1.1
Number of operations (self-reported)	0.5	0.8	1.5	1.2	0.2	0.9
Irritability	0.5	0.9	2.2	-0.7	1.5	0.0
Age started oral contraceptive pill	0.5	0.6	1.5	-0.6	0.0	-1.2
Heart disease (siblings)	0.5	0.6	1.1	1.0	0.4	0.7
Crohns Disease (2017)	0.4	0.8	1.6	1.3	0.6	0.8
Crohns Disease (2012)	0.4	0.6	0.8	0.9	0.7	0.7
Blood Platelet Count	0.4	4.8	7.2	-0.7	2.7	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	-1.1	0.5	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.6	0.8	-0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.2	-0.1	-1.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.9	-0.4	0.7
Allergy	0.4	0.9	2.3	1.5	0.3	0.5
Pain all over the body in last month	0.4	0.4	0.7	-0.4	0.7	0.8
Birth weight of first child	0.4	0.6	1.5	0.6	0.1	1.2
Number of full brothers	0.4	0.5	1.1	0.4	-0.4	1.1
Health satisfaction	0.4	0.5	1.0	-0.5	1.0	-0.5
Overall health rating	0.4	0.8	2.3	-0.0	-0.4	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	0.2	1.2	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	0.4	-0.9	0.7
Friendships satisfaction	0.4	0.5	0.9	0.6	0.9	-0.5
Qualifications: nursing, teaching	0.4	0.7	1.1	0.9	-1.0	0.4
Medication for cholesterol	0.4	0.6	1.9	-1.4	-0.1	-0.1
Ever taken oral contraceptive pill	0.4	0.5	1.0	-0.4	-0.6	1.0
Hearing aid user	0.4	0.5	0.8	-0.1	0.8	0.9
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.4	0.9	-0.8
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	1.1	0.1	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	0.3	1.5	-0.3
Schizophrenia (2018)	0.3	0.7	1.9	0.5	1.4	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	1.0	-0.2
LDL Cholesterol	0.3	0.4	1.0	-1.0	0.5	-0.0
Rheumatoid Arthritis	0.3	0.4	1.0	-1.0	0.5	0.1
Tanning	0.3	3.4	7.0	1.2	2.6	-1.3
Leg fat-free mass (left)	0.3	1.8	5.1	0.1	-0.6	2.2
Supplements: Glucosamine	0.3	0.4	0.6	-0.8	0.4	-0.7
High blood pressure (mother)	0.3	0.4	0.5	0.6	0.5	0.7
Leg predicted mass (left)	0.3	1.8	4.8	0.1	-0.6	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.8	-0.6	-1.3	0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	1.0	0.3	0.6
Loneliness, isolation	0.3	0.4	1.2	0.0	0.1	1.1
Commuting to job workplace: Public transport	0.3	0.4	0.5	-0.7	0.4	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.7	-0.2	-0.8
Bipolar Disorder (2018)	0.2	0.4	1.0	-0.2	1.0	-0.3
Irritable Bowel Disease (IBD)	0.2	0.6	0.8	-0.9	-0.6	0.7
Impedance of arm (right)	0.2	1.1	2.8	-1.7	-0.5	-0.3
Asthma	0.2	0.5	1.2	-1.1	-0.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.5	-0.1	0.6
Emphysema/chronic bronchitis	0.2	0.3	0.3	-0.4	-0.6	-0.5
Leg fat-free mass (right)	0.2	0.8	2.5	-0.2	-0.2	1.6
Average weekly red wine intake	0.2	0.4	0.9	-0.4	-0.1	-0.9
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.5	0.6	0.0
Asthma (self-reported)	0.2	0.5	1.4	-1.2	-0.1	-0.3
Leg predicted mass (right)	0.2	0.9	2.6	-0.2	-0.2	1.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.4	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.3	-0.6	0.2
Neuroticism (2016)	0.1	0.2	0.3	-0.5	-0.6	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	0.1	0.6
Schizophrenia (2014)	0.1	0.3	0.7	0.4	0.8	0.2
Hair Pigment	0.1	1.9	2.6	-1.6	-1.0	-1.5
Qualifications: None of the above	0.1	0.2	0.4	0.6	0.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	-0.8	-0.3	0.0
Lung cancer (father)	0.1	0.1	0.1	-0.2	0.3	0.3
Impedance of arm (left)	0.1	0.7	1.7	-1.3	-0.5	0.3
Glaucoma (self-reported)	0.1	0.2	0.2	0.4	-0.5	0.4
Arm fat-free mass (right)	0.1	0.7	1.1	-1.0	-0.3	-0.9
Qualifications: College or University degree	0.1	0.3	0.4	0.7	0.3	0.5
Arm predicted mass (right)	0.1	0.5	0.8	-0.9	-0.1	-0.9
Comparative height size at age 10	0.1	0.6	0.8	-0.9	0.6	0.7
Number of full sisters	0.1	0.1	0.1	0.3	0.4	-0.1
Whole body fat-free mass	0.1	0.5	1.0	-1.0	-0.5	-0.5
Whole body water mass	0.1	0.5	1.0	-1.0	-0.4	-0.6
Basal metabolic rate	0.1	0.5	0.7	-0.6	-0.7	0.8
Arm fat-free mass (left)	0.1	0.7	1.2	-1.1	-0.3	-0.8
Diastolic blood pressure, automated reading	0.1	0.5	0.7	0.7	0.8	0.4
Arm predicted mass (left)	0.1	0.5	0.9	-1.0	-0.2	-0.6

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