Hub : Genes

CLEC18C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Head and Neck Squamous Cell Carcinoma 0.0515 0.0310 1.6e-03 0.016 0.006 0.014 NA 0.003 5.7e-03 6.0e-02 8.8e-03 NA 1.4e-01
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0551 0.0319 2.2e-04 0.048 0.034 0.033 NA 0.038 4.3e-06 9.5e-05 1.3e-04 NA 3.8e-05
3 TCGA Lung Adenocarcinoma 0.0613 0.0281 2.7e-04 0.020 0.022 0.023 NA 0.024 1.9e-03 1.1e-03 9.2e-04 NA 6.6e-04
4 TCGA Prostate Adenocarcinoma 0.2284 0.0680 2.9e-14 0.128 0.135 0.114 NA 0.128 2.5e-13 5.2e-14 6.3e-12 NA 2.6e-13
5 TCGA Thyroid Carcinoma 0.0550 0.0280 3.6e-03 0.037 0.027 0.035 NA 0.037 1.6e-04 1.0e-03 2.2e-04 NA 1.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 2.2 -0.4 -1.5 -0.1 1.0 0.9
Bipolar Disorder or Schizophrenia 0.1 0.3 0.5 0.1 -0.6 -0.6 -0.3 -0.7
Depressed Affect (Nagel 2018) 0.6 1.2 3.5 -1.9 1.1 -0.8 -0.4 -0.6
Depression (Nagel 2018) 0.5 0.7 2.0 -1.4 1.0 -0.3 -0.7 -0.3
Intelligence (Savage-Jansen 2018) 0.9 2.8 8.4 -0.8 -0.3 -2.9 -0.7 -2.1
Neuroticism (Nagel 2018) 0.3 0.7 1.9 -1.4 1.1 -0.2 -0.3 -0.5
Schizophrenia (2018) 0.5 1.0 2.8 0.1 0.5 -0.7 -1.3 -1.7
Schizophrenia vs Biploar Disorder 0.7 0.9 1.9 0.0 0.6 -0.5 -1.3 -1.4
Worry (Nagel 2018) 1.0 2.0 5.0 -1.8 2.2 0.6 -1.2 -0.4
Alzheimer’s Disease (in mother) 0.2 0.2 0.8 -0.9 0.0 0.2 0.2 0.2
Alzheimer’s Disease (in father) 7.8 8.5 12.0 -3.5 3.4 -1.0 -3.5 -2.4
Alzheimer’s Disease (including proxy) 3.8 5.6 11.7 -3.4 2.7 -0.3 -2.4 -1.8
Crohns Disease (2017) 1.6 3.5 8.4 1.0 -1.9 0.9 2.9 1.8
Irritable Bowel Disease (IBD) 0.6 1.5 3.6 0.3 -1.9 -0.9 1.8 0.2
Ulcerative Colitis (UC) 0.7 1.3 3.7 -1.1 -0.7 -1.9 -0.1 -1.1
Major Depression (MDD) 1.4 1.7 5.2 0.0 -2.3 -0.2 1.6 0.9
Reaction Time 4.6 8.7 12.3 3.5 -3.3 2.3 2.7 2.8
Verbal and Numeric Reasoning (VNR) 2.0 4.7 9.5 -1.6 0.7 -3.1 -2.0 -2.7
Breast Cancer 0.8 1.8 3.7 -0.8 1.9 0.7 -1.7 -1.1
Ovarian Cancer 0.1 0.1 0.3 0.5 -0.0 -0.2 -0.1 -0.1
Prostate Cancer 0.2 0.2 0.4 -0.1 -0.5 0.5 -0.5 0.6
Age at First Birth 0.6 0.8 2.0 -1.1 1.4 -0.5 -0.4 -0.6
Bipolar Disorder (2011) 0.4 0.4 0.9 0.0 1.0 0.9 -0.1 0.6
Body Mass Index (BMI) (2010) 2.2 3.0 9.0 1.4 -1.4 0.7 3.0 1.3
Coronary Artery Disease (CAD) 1.2 1.4 2.5 1.1 -0.8 1.3 0.9 1.6
Crohns Disease (2012) 0.5 0.8 3.5 0.0 -1.9 -0.6 0.6 0.2
Mean Putamen Volume 0.8 1.0 2.1 0.8 -1.0 0.3 1.4 0.9
Fasting Glucose 1.1 1.3 2.7 1.1 -1.5 -1.6 0.1 -0.8
HbA1C 0.2 0.2 0.7 0.4 0.1 0.1 0.8 -0.1
HDL Cholesterol 0.5 0.9 1.9 -1.4 1.2 -0.4 -0.6 -0.7
LDL Cholesterol 0.1 0.2 0.6 0.1 -0.6 0.2 0.2 0.8
Lupus 0.3 0.4 1.2 0.1 -0.4 -0.4 -1.1 -0.6
Neuroticism (2016) 0.2 0.2 0.8 0.0 -0.1 -0.2 -0.9 -0.6
Primary Biliary Cirrhosis 1.4 2.0 4.3 -0.3 -0.9 -2.1 -1.1 -2.0
Rheumatoid Arthritis 1.4 2.0 3.8 0.2 -0.4 1.6 1.8 2.0
Schizophrenia (2014) 0.3 0.6 1.6 0.6 -0.2 -0.5 -0.9 -1.3
Triglycerides 0.7 1.2 4.2 0.3 -2.0 -0.7 0.5 1.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.1 -0.3 -0.5 -0.1
Ulcerative Colitis 2.1 3.0 7.0 -1.3 -1.6 -2.7 -1.1 -1.5
Blood Eosinophil Count 1.2 9.1 24.4 1.6 -4.9 -3.9 1.3 -1.4
Blood Platelet Count 0.5 5.4 9.7 -1.6 -0.3 -3.1 -2.5 -2.9
Blood Red Count 0.4 3.7 10.0 3.2 -2.5 -0.9 1.1 -0.1
Blood White Count 0.9 6.5 14.9 1.6 -3.9 -3.6 0.6 -1.5
Heel T-Score 0.9 7.4 18.1 1.9 1.9 4.2 1.7 2.9
BMI 5.6 32.3 65.3 5.6 -7.0 -0.6 8.1 3.9
Height 1.3 25.0 85.7 -3.1 9.3 4.6 -2.8 -0.2
Waist Hip Ratio (WHR) 0.4 1.8 3.2 -0.4 0.1 -1.6 -1.7 -1.8
Systolic Blood Pressure 1.8 9.1 21.3 0.3 -0.3 4.1 2.7 4.6
Smoking Status 5.9 14.0 34.7 -1.0 -2.2 -5.9 -1.8 -5.1
Allergy or Eczema 0.3 0.7 1.7 -1.3 1.1 0.0 -0.7 -0.2
Cardiovascular Disease 3.0 10.0 19.7 2.2 -1.4 2.8 4.4 4.0
Hypothyroidism (self reported) 0.6 1.3 2.9 1.4 -1.7 -1.2 0.6 -0.2
Respiratory disease 0.9 2.0 5.2 0.2 -1.8 -2.3 0.2 -1.1
Type 2 Diabetes (T2D) (2018) 2.3 4.3 7.3 2.7 -2.4 -0.3 2.6 1.5
Lung FEV1/FVC ratio 0.7 3.5 7.6 -2.7 2.4 1.5 0.2 1.4
Lung FVC 3.2 16.2 35.2 -2.0 4.1 5.9 1.8 4.6
Neuroticism 0.9 2.1 4.4 -2.0 2.1 0.6 -1.4 -0.2
Chronotype (morning person) 0.5 1.2 2.6 -1.6 1.3 0.7 -0.8 0.7
Hair Pigment 0.3 7.2 12.2 -2.6 1.4 -3.1 -2.4 -3.5
Tanning 0.2 2.7 7.9 2.8 -1.5 0.9 1.1 1.0
Hand grip strength (left) 2.2 5.7 14.0 -1.4 3.7 3.2 0.2 1.5
Number of treatments/medications taken 1.0 1.8 5.5 0.0 -0.6 0.6 2.3 1.6
Average weekly spirits intake 0.8 1.0 2.9 0.5 -1.7 -1.0 0.7 -0.3
Sensitivity / hurt feelings 0.2 0.4 1.1 -1.0 0.7 0.5 -0.1 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.5 -0.6 1.2 -0.3 -0.6 -0.5
Hearing difficulty/problems: Yes 1.0 1.5 2.9 1.7 -0.7 1.4 0.9 1.2
Relative age of first facial hair 2.5 5.2 9.3 -1.6 0.9 -2.3 -2.9 -3.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.3 -1.1 -0.2 -0.9 -1.1 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 -0.4 0.6 0.8 -0.7 0.1
Ever had hysterectomy (womb removed) 0.8 0.9 2.1 0.3 -0.6 0.9 1.4 1.1
Systolic blood pressure, automated reading 3.8 11.0 21.9 1.0 -1.6 3.7 4.0 4.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.8 -0.1 -0.0 -0.9 0.7 -0.1
Angina 2.1 2.8 5.5 2.3 -2.3 -1.4 0.9 -0.6
Medication for hormone replacement therapy 3.8 4.3 8.7 -3.0 2.1 -0.6 -2.6 -1.2
Vitamin and mineral supplements 0.5 0.7 1.9 1.0 -1.4 -0.7 0.1 0.1
Supplements: Zinc 0.4 0.4 0.9 -1.0 0.6 -0.3 -0.7 -0.4
Medication: Co-codamol 1.0 1.2 3.2 -0.5 -1.1 -1.8 -0.4 -1.1
Medication: Metformin 1.9 2.7 6.3 2.5 -1.8 0.2 1.6 1.2
Diabetes (father) 0.5 0.7 2.1 1.1 -1.4 0.1 -0.1 0.3
Diabetes (mother) 1.3 1.7 4.3 0.1 -0.6 0.9 1.7 2.1
Severe depression (siblings) 0.2 0.3 1.1 -1.1 0.2 -0.2 0.2 0.3
Pack years adult smoking proportion 4.5 6.9 11.2 3.0 -3.3 0.4 3.1 2.2
Impedance of leg (right) 2.1 10.2 18.2 -4.0 4.3 -0.2 -3.5 -2.1
Leg fat-free mass (left) 0.6 3.3 9.0 1.9 -1.2 0.4 3.0 1.6
Trunk fat percentage 2.0 7.9 16.1 2.5 -3.6 -1.4 4.0 1.6
Hand grip strength (right) 3.4 9.3 24.5 -2.5 4.9 3.6 -0.7 1.4
Townsend deprivation index at recruitment 1.3 1.8 5.2 1.7 -2.3 -0.2 0.9 0.4
Current tobacco smoking 2.5 4.1 10.7 0.0 -1.5 -3.3 -0.7 -2.6
Average weekly fortified wine intake 2.0 2.3 3.4 -1.4 0.1 -1.9 -1.8 -1.6
Maternal smoking around birth 4.2 6.1 15.4 2.6 -3.9 -1.7 2.3 0.1
Fed-up feelings 0.5 0.9 1.9 -1.4 1.2 0.4 0.7 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 2.6 -1.6 1.0 -0.8 -0.5 -0.7
Relative age voice broke 1.5 2.3 5.0 -1.8 2.2 0.4 -1.6 -0.7
Taking other prescription medications 0.5 0.7 1.7 0.1 -1.1 -0.3 1.3 0.8
Age when periods started (menarche) 4.9 11.7 29.1 -3.9 5.4 2.6 -2.7 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.8 -0.5 1.3 1.2 -0.0 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 3.8 1.9 -0.0 1.7 0.7 1.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.4 0.2 1.1 -0.9 -1.0 -1.8
Qualifications: CSEs or equivalent 0.8 1.1 3.3 -1.5 1.8 0.2 -0.1 0.2
Serious illness, injury or assault to yourself 3.0 3.7 10.4 1.6 -2.0 -0.6 3.2 0.9
High blood pressure 3.5 9.9 17.8 1.6 -1.3 3.3 4.2 4.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.7 -1.9 1.9 -0.2 -1.3 -0.7
Multivitamins +/- minerals 1.5 1.9 5.4 -0.9 2.3 1.5 0.4 0.8
Stomach or abdominal pain in last month 1.1 1.4 2.7 -1.3 1.6 -0.3 -1.1 -1.0
Supplements: Glucosamine 0.7 0.9 2.6 -1.0 0.5 -0.3 1.6 0.6
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 6.0 -2.5 1.4 0.5 -1.5 0.2
Medication: Atenolol 2.1 2.6 4.2 2.0 -2.0 0.3 2.0 0.8
Medication: Levothyroxine sodium 1.1 1.8 3.9 2.0 -1.4 0.8 1.0 1.2
Sitting height 1.3 9.2 23.1 0.2 4.0 4.8 1.2 2.4
Chronic bronchitis/emphysema (father) 1.9 2.2 3.9 2.0 -1.5 0.4 1.9 1.2
High blood pressure (mother) 0.5 0.7 1.5 0.0 -0.6 1.2 0.7 1.2
Body mass index (BMI) 4.2 17.8 36.1 3.9 -5.4 -0.8 6.0 2.8
Impedance of leg (left) 2.5 12.2 22.8 -4.2 4.8 -0.1 -3.9 -2.3
Leg predicted mass (left) 0.7 3.5 9.4 2.0 -1.2 0.4 3.1 1.6
Trunk fat mass 1.8 7.7 18.7 2.5 -3.0 -0.8 4.3 1.9
Waist circumference 2.7 9.8 20.2 2.8 -4.0 -1.1 4.5 1.9
Number of incorrect matches in round 1.8 3.0 5.3 1.5 -0.9 2.1 2.3 1.4
Past tobacco smoking 4.5 8.3 22.0 0.8 1.5 4.7 1.0 4.0
Alcohol usually taken with meals 0.3 0.4 1.1 0.6 0.7 1.0 0.2 0.4
Nervous feelings 0.5 0.9 2.4 -0.6 1.0 0.1 -1.5 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 6.6 -1.1 2.6 0.6 -1.0 -0.6
Hearing difficulty/problems with background noise 0.8 1.4 2.2 0.9 -0.2 1.5 1.4 1.3
Hair/balding pattern: Pattern 2 1.5 2.0 2.3 -1.5 1.2 -1.5 -1.3 -1.5
Had menopause 0.8 1.0 3.3 0.7 -0.1 1.8 0.3 1.0
Had other major operations 0.2 0.2 0.5 -0.6 0.1 0.7 -0.3 0.3
Forced vital capacity (FVC) 2.9 11.2 31.4 -3.5 5.6 3.1 -1.0 1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.3 5.9 2.1 -0.2 2.4 1.6 2.0
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 1.4 -1.2 -0.1 0.2 -0.3
Qualifications: None of the above 0.3 0.6 1.5 -0.2 -0.9 0.3 1.2 0.7
Financial difficulties in last 2 years 0.3 0.4 0.6 0.5 -0.7 0.3 0.6 0.8
Mouth/teeth dental problems 1.8 2.8 5.6 2.4 -2.1 1.0 0.9 1.4
Heart attack 1.2 1.5 4.6 0.6 -2.1 -1.4 -0.1 -0.8
Allergy 0.7 1.7 3.1 1.8 -1.2 1.4 0.7 1.1
Pain all over the body in last month 1.3 1.4 2.7 0.0 1.6 1.4 1.0 1.1
Diabetes (self-reported) 2.2 3.3 5.7 2.0 -2.4 -0.4 2.2 1.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.6 -1.6 1.6 -0.2 -1.0 -0.6
Medication: Ramipril 0.3 0.3 1.0 -1.0 0.6 -0.4 -0.4 -0.1
Medication: Simvastatin 2.0 3.0 4.2 2.1 -1.2 1.1 2.1 1.9
Fluid intelligence score 1.0 2.1 6.8 -0.5 -0.7 -2.6 -0.7 -1.6
Illnesses of siblings 3.1 4.4 6.4 -1.8 1.9 -1.7 -2.3 -2.5
Neuroticism score 1.3 2.6 5.8 -2.4 2.2 0.1 -1.5 -0.6
Weight 1.2 5.9 17.1 2.1 -2.0 -0.1 4.1 1.9
Impedance of arm (right) 1.8 8.6 16.2 -3.2 1.7 -2.5 -4.0 -2.7
Arm fat percentage (right) 3.8 15.0 32.4 3.2 -5.7 -2.6 4.8 1.6
Trunk fat-free mass 0.4 2.2 4.8 0.5 1.3 1.6 2.2 1.3
Hip circumference 2.4 10.5 25.9 2.6 -3.7 -0.7 5.1 2.4
Time employed in main current job 0.9 1.1 1.6 0.9 -0.6 -1.3 1.0 -1.2
Alcohol intake versus 10 years previously 4.5 6.8 10.9 2.0 -1.1 2.6 3.3 3.3
Father’s age at death 2.0 2.7 6.7 -2.0 2.6 0.3 -1.6 -0.4
Worrier / anxious feelings 2.6 4.9 11.7 -2.1 3.4 1.3 -2.5 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.3 -1.1 0.6 0.2 0.6 0.7
Falls in the last year 3.1 4.2 8.7 0.7 -2.9 -2.0 2.8 -0.2
Hair/balding pattern: Pattern 3 1.4 2.1 7.0 0.5 -2.6 -1.8 0.4 -0.3
Number of live births 1.3 1.9 4.2 -0.6 1.7 2.1 -0.3 1.4
Forced expiratory volume in 1-second (FEV1) 3.5 11.9 32.6 -3.6 5.7 3.3 -0.7 1.7
Pulse rate 2.2 3.7 7.7 1.6 -2.8 -1.7 2.3 0.0
Happiness 0.2 0.3 0.8 -0.4 0.6 0.9 -0.3 0.1
Noisy workplace 1.5 1.9 3.2 0.6 -1.0 1.8 1.4 1.8
Qualifications: A levels/AS levels or equivalent 1.3 3.0 4.2 -1.6 1.0 -2.1 -1.9 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.7 0.3 -0.5 -1.3 0.2 -0.5
Mouth/teeth dental problems: Dentures 0.6 1.0 2.3 -0.1 -1.5 0.5 1.0 1.2
Asthma 0.9 1.9 4.8 -0.5 -1.4 -2.2 -0.7 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.2 -0.2 0.2 -0.3 1.8 0.7
Medication: Cholesterol lowering 2.0 3.1 7.8 1.3 -1.8 0.2 2.8 1.6
Depression (self-reported) 0.9 1.1 3.0 -1.7 1.4 0.4 -0.0 0.4
Medication: Lansoprazole 0.1 0.1 0.3 0.1 -0.0 0.2 -0.5 0.2
Prospective memory result 0.2 0.2 0.6 0.0 -0.3 -0.2 -0.7 -0.8
Lung cancer (father) 2.6 3.0 5.4 2.1 -0.5 1.6 2.3 1.6
Illnesses of mother 1.1 1.3 2.0 -1.1 1.3 -0.8 -1.4 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.4 10.9 32.2 -3.4 5.7 2.9 -1.3 1.0
Pulse wave Arterial Stiffness index 1.1 1.3 3.8 0.5 -2.0 -0.6 1.4 0.1
Impedance of arm (left) 1.8 8.3 17.1 -3.1 2.2 -2.0 -4.1 -2.5
Arm fat mass (right) 2.7 11.0 23.1 2.8 -4.3 -1.6 4.8 1.8
Trunk predicted mass 0.4 2.3 5.0 0.5 1.3 1.6 2.2 1.4
Standing height 1.7 16.5 52.0 -3.7 7.2 1.5 -3.4 -1.8
Length of working week for main job 1.0 1.1 1.8 -1.0 0.9 -1.3 -0.7 -1.2
Exposure to tobacco smoke at home 4.1 4.7 9.0 1.2 -0.6 2.5 2.5 3.0
Breastfed as a baby 1.9 2.4 6.9 -1.8 2.6 -0.2 -0.9 -1.0
Tense / ‘highly strung’ 1.2 2.1 4.7 -0.6 -0.0 -2.0 -1.1 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.8 0.4 -0.0 1.6 1.1 1.9
Hair/balding pattern: Pattern 4 0.8 1.9 3.9 1.0 -0.1 2.0 1.6 1.5
Birth weight of first child 1.8 3.4 5.9 -0.9 1.8 -1.7 -2.0 -2.4
Peak expiratory flow (PEF) 2.1 4.9 12.7 -2.6 3.6 1.7 -1.4 0.8
Pulse wave reflection index 0.2 0.2 0.6 -0.4 0.2 -0.5 -0.1 -0.8
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 0.7 -0.9 -0.2 0.7 0.0
Loud music exposure frequency 0.2 0.2 0.6 -0.2 -0.8 -0.0 0.4 0.3
Qualifications: O levels/GCSEs or equivalent 1.5 2.3 5.9 -0.6 -0.8 -2.4 -1.0 -2.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -0.8 1.0 -1.2 0.1 -1.2
Blood clot in the leg (DVT) 0.1 0.2 0.7 0.2 0.0 -0.8 0.0 -0.4
Medication: Paracetamol 1.0 1.6 2.4 0.9 -1.4 0.9 1.6 1.4
Headache pain in last month 0.6 1.0 1.9 -0.6 -1.4 -1.1 1.3 -0.1
Medication for cholesterol, blood pressure or diabetes 3.1 5.1 12.4 -1.6 1.5 -1.4 -3.5 -2.5
Glaucoma (self-reported) 4.0 4.7 8.3 -2.9 0.2 -2.6 -1.9 -2.2
Gout (self-reported) 0.4 0.5 0.9 1.0 -0.3 0.6 0.9 0.6
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 3.2 0.7 -1.8 -1.5 0.4 -0.2
Medication: Amlodipine 0.6 0.8 2.0 -0.1 -0.4 0.5 1.2 1.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 0.2 -0.3 -0.5 -0.9 -0.9
Birth weight 0.5 1.2 3.6 -0.8 1.9 0.6 -0.9 -0.7
Chronic bronchitis/emphysema (mother) 2.0 2.3 5.6 1.5 -2.4 0.3 1.5 1.1
High blood pressure (siblings) 4.1 5.9 11.5 1.7 -1.1 2.7 2.6 3.4
Forced vital capacity (FVC), Best measure 3.2 11.9 35.7 -3.3 6.0 3.1 -1.4 0.9
Body fat percentage 2.6 10.1 20.7 2.7 -4.2 -1.3 4.5 2.0
Leg fat percentage (right) 3.0 10.8 23.3 2.6 -4.2 -0.6 4.8 2.5
Arm fat-free mass (right) 0.7 3.8 7.8 1.1 1.2 2.2 2.8 1.9
Exposure to tobacco smoke outside home 1.7 2.3 7.8 -1.6 2.8 0.6 -0.7 -0.5
Comparative body size at age 10 1.5 4.3 10.7 2.1 -2.0 -0.1 3.3 1.4
Number of full brothers 3.3 4.1 9.5 -0.9 -0.0 2.1 2.4 3.1
Worry too long after embarrassment 1.2 2.1 4.9 -0.3 0.9 2.2 1.1 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.3 0.6 0.5 0.3 0.3
Wheeze or whistling in the chest in last year 1.0 1.8 5.0 0.1 -1.6 -2.2 0.6 -1.1
Number of children fathered 0.3 0.4 0.6 -0.8 0.7 -0.4 -0.2 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.8 0.1 0.5 1.9 0.9 1.6
Age at first live birth 1.9 3.3 6.2 -1.2 -0.2 -2.3 -1.8 -2.5
Pulse wave peak to peak time 1.6 1.9 6.1 -0.7 2.5 0.7 -1.6 -0.2
Health satisfaction 1.1 1.5 4.1 -0.6 1.1 2.0 -0.6 1.2
Shortness of breath walking on level ground 1.2 1.4 3.5 1.0 -1.9 -0.1 1.4 0.6
Qualifications: College or University degree 0.4 1.2 2.3 -0.8 1.4 -0.6 -1.5 -0.8
Eye problems/disorders: None of the above 2.5 2.9 6.3 2.1 -0.9 2.5 -0.1 1.6
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.4 -0.3 -0.2 0.1 0.7 0.5
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.1 0.5 0.1 0.4 0.2
Medication for pain relief, constipation, heartburn 1.9 3.3 7.7 -1.4 0.6 -1.5 -2.8 -2.0
Neck or shoulder pain in last month 0.7 1.0 2.9 -1.7 0.7 -0.9 0.8 -0.3
Medication: Blood pressure 2.0 3.4 7.8 0.2 -0.1 1.8 2.8 2.5
Angina (self-reported) 2.1 2.7 5.2 2.2 -2.3 -1.5 0.8 -0.7
Migraine (self-reported) 0.5 0.6 1.6 -1.3 0.3 0.2 1.0 0.5
Medication: Ibuprofen 0.9 1.1 4.6 -0.4 0.4 -0.3 2.1 0.7
Medication: Allopurinol 0.6 0.7 1.1 1.1 -0.5 0.7 1.0 1.0
Medication: Omeprazole 0.5 0.6 2.1 0.0 0.5 0.6 1.4 0.7
Medication: Seretide 50 evohaler 0.5 0.5 1.3 0.3 -1.1 -0.9 -0.4 -0.7
Mean time to correctly identify matches 3.5 6.7 10.6 3.3 -3.2 2.1 1.9 2.2
Heart disease (mother) 0.2 0.2 0.7 0.4 0.3 0.3 -0.8 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.7 0.8 -1.3 0.3 0.3 0.2
Whole body fat mass 2.2 9.4 22.6 2.6 -3.5 -0.8 4.8 2.1
Leg fat mass (right) 2.8 10.9 25.8 2.8 -3.8 -0.4 5.1 2.6
Arm predicted mass (right) 0.7 3.5 8.1 1.5 0.8 1.9 2.9 1.6
Pulse rate, automated reading 1.8 5.8 11.2 2.5 -2.9 -0.4 3.3 1.7
Alcohol intake frequency. 4.5 10.4 15.5 3.3 -2.9 2.0 3.9 3.7
Comparative height size at age 10 0.2 1.1 1.9 -0.6 1.4 -1.2 0.2 -1.3
Number of full sisters 1.5 1.9 3.9 0.6 0.5 2.0 1.2 1.8
Suffer from ‘nerves’ 0.8 1.2 3.0 -0.7 1.7 1.0 -1.2 0.1
Overall health rating 0.9 1.9 3.9 0.3 0.4 2.0 1.2 1.9
Chest pain or discomfort 0.2 0.3 0.8 0.9 -0.2 -0.1 0.8 0.2
Had major operations 2.7 3.1 6.8 -2.6 0.8 -2.4 -0.3 -1.6
Age at last live birth 2.4 3.4 7.3 -0.7 -1.0 -2.7 -1.3 -2.6
Family relationship satisfaction 0.4 0.5 1.2 0.4 -1.1 -0.1 1.1 0.3
Leg pain on walking 0.3 0.3 0.6 -0.8 0.6 -0.6 0.2 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.8 1.7 0.1 1.3 0.6 0.7
Commuting to job workplace: Car/motor vehicle 1.2 1.4 3.7 1.2 -1.0 -0.6 1.9 -0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -0.7 0.3 -0.3 -1.4 -1.1
Medication: Aspirin 0.3 0.4 0.8 0.6 -0.8 -0.2 0.9 0.3
Supplements: Vitamin C 2.9 3.4 6.2 -2.5 1.2 -1.3 -2.1 -1.9
Knee pain experienced in last month 1.8 2.9 4.8 0.7 -2.2 -2.1 2.2 -0.4
Hypertension (Self-reported) 4.1 11.4 20.3 2.0 -1.5 3.4 4.5 4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.6 -0.4 1.3 0.7 0.5 0.4
Illnesses of father: Heart disease 0.5 0.7 2.0 0.5 -0.9 -0.1 1.4 0.6
Illnesses of siblings: Diabetes 1.2 1.4 3.2 1.0 -1.8 -0.1 1.6 0.7
Smoking status: Previous 2.4 3.6 9.9 -0.2 -1.2 -3.1 -0.3 -2.5
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 6.6 -1.1 2.6 1.0 -0.5 -0.0
Whole body fat-free mass 0.4 2.2 6.4 1.1 0.4 1.1 2.5 1.4
Leg fat-free mass (right) 0.5 2.6 6.7 1.9 -0.9 0.4 2.6 1.3
Arm fat percentage (left) 3.8 15.2 31.1 3.3 -5.6 -2.3 5.0 1.9
Average weekly red wine intake 0.7 1.1 2.1 -1.2 1.0 -0.5 -1.4 -0.9
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.8 -1.2 1.9 1.6 0.7 0.9
Mood swings 0.9 1.6 4.7 -1.7 2.2 0.3 -0.7 -0.4
Loneliness, isolation 0.4 0.5 1.7 0.1 -0.1 -0.5 -1.3 -0.7
Long-standing illness, disability or infirmity 0.6 0.9 3.0 0.3 -1.7 -1.1 0.2 0.2
Ever had bowel cancer screening 0.8 0.9 2.2 1.5 -0.8 1.2 0.0 0.5
Diabetes diagnosed by doctor 3.8 6.2 9.7 3.0 -3.1 -0.4 3.1 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 -0.5 1.1 0.6 -0.2 0.2
Friendships satisfaction 0.4 0.5 1.0 -0.8 0.5 -0.7 -0.6 -1.0
Qualifications: nursing, teaching 0.3 0.4 0.9 -0.6 1.0 -0.0 -0.8 -0.4
Commuting to job workplace: Walk 0.3 0.3 0.5 -0.6 0.6 0.7 -0.5 0.4
Eye problems/disorders: Cataract 1.0 1.1 3.8 -0.1 -0.1 -1.3 2.0 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.8 -0.2 0.7 -0.2 -1.3 -0.8
Medication for cholesterol 0.4 0.6 1.5 1.2 -0.7 -0.4 0.8 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.0 -1.3 1.7 0.0 -1.2 -0.5
Back pain experienced in last month 1.3 1.9 5.5 -1.4 2.3 1.5 -0.0 0.2
Mineral and other dietary supplements 2.5 3.4 5.8 2.4 -2.2 1.5 1.1 1.6
Breast cancer (self-reported) 0.9 1.1 2.3 0.6 -0.9 0.7 1.5 1.1
Asthma (self-reported) 0.9 1.7 4.4 -0.4 -1.4 -2.1 -0.6 -1.3
Osteoporosis (self-reported) 0.6 0.7 1.4 -0.9 0.2 -1.2 -0.6 -1.0
Osteoarthritis (self-reported) 1.5 2.0 3.2 1.8 -1.8 0.6 1.2 1.3
Medication: Aspirin 0.1 0.1 0.3 0.3 -0.1 -0.0 0.6 0.3
Medication: Gliclazide 0.7 0.8 1.7 1.1 -0.8 -0.7 1.3 -0.0
Illnesses of father: None of the above (group 1) 1.3 1.5 2.9 -0.3 1.4 -0.0 -1.7 -1.7
Smoking status: Current 4.0 6.4 16.2 -0.7 -1.4 -4.0 -1.4 -3.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.7 5.8 13.6 -1.1 2.7 3.7 0.1 2.6
Whole body water mass 0.4 2.4 6.7 1.1 0.4 1.2 2.6 1.5
Leg predicted mass (right) 0.5 2.7 7.2 1.9 -0.9 0.5 2.7 1.4
Arm fat mass (left) 2.7 11.1 24.5 2.9 -4.1 -1.5 5.0 1.8
Number of self-reported non-cancer illnesses 0.8 1.5 3.8 0.1 -0.7 0.4 2.0 1.7
Average weekly champagne plus white wine intake 0.1 0.2 0.4 0.2 0.4 0.3 -0.6 -0.5
Miserableness 1.1 1.9 3.3 -1.7 1.8 -1.0 -0.9 -1.3
Guilty feelings 0.4 0.7 1.8 -1.3 1.1 0.1 -0.6 -0.1
Wears glasses or contact lenses 0.6 0.6 1.5 -0.7 0.6 1.2 -0.2 0.9
Ever taken oral contraceptive pill 2.6 2.9 8.4 -0.3 -1.6 -2.9 -0.5 -1.9
Hearing aid user 0.5 0.5 1.0 -0.2 0.1 -0.8 -1.0 -1.0
Mother’s age at death 0.1 0.2 0.5 -0.5 -0.1 -0.2 -0.7 -0.1
Financial situation satisfaction 1.0 1.2 2.4 -1.0 1.6 0.2 -1.5 -0.7
Tinnitus: Yes, now most or all of the time 1.1 1.2 3.5 0.6 0.7 1.9 0.4 1.3
Commuting to job workplace: Public transport 2.3 2.7 5.0 -1.1 -0.1 -2.1 -2.2 -1.7
Eye problems/disorders: Glaucoma 3.6 4.3 10.9 -3.3 0.4 -2.4 -1.2 -1.8
Medication: Blood pressure 1.1 2.0 2.9 1.0 -1.7 0.9 1.6 1.7
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.9 -0.4 -0.8 0.7 -0.1
Supplements: Fish oil (including cod liver oil) 4.5 5.9 9.6 -3.1 3.0 -1.4 -2.1 -2.1
High cholesterol (Self-reported) 3.8 6.8 12.6 1.9 -1.7 2.2 3.1 3.6
Medication: Bendroflumethiazide 1.6 2.4 5.0 0.9 0.4 1.7 2.2 1.7
Medication: Paracetamol 0.8 1.2 2.1 0.4 -0.9 1.1 1.4 1.4
Medication: Lisinopril 1.0 1.4 4.6 1.2 -2.1 -0.8 0.3 0.1
Medication: Atorvastatin 0.5 0.6 1.6 0.6 -1.3 -0.3 0.9 0.5
Illnesses of father: High blood pressure 1.9 2.3 5.2 -1.4 1.2 1.4 1.0 2.3
Alcohol drinker status: Never 4.5 5.4 9.2 1.5 -1.9 1.8 3.0 3.0
Ever smoked 4.0 7.0 17.8 -0.9 -0.7 -4.2 -1.1 -3.9
Basal metabolic rate 0.6 3.1 9.5 1.4 -0.1 1.0 3.1 1.7
Leg fat percentage (left) 2.9 10.4 22.6 2.7 -4.1 -0.6 4.8 2.3
Arm fat-free mass (left) 0.5 2.5 7.5 1.1 0.7 1.3 2.7 1.4
Number of operations (self-reported) 0.3 0.5 1.6 -1.3 0.4 -0.2 0.7 0.1
Average weekly beer plus cider intake 1.2 1.7 3.6 -1.9 1.2 -1.2 -0.7 -1.3
Irritability 0.6 1.1 2.6 -0.6 -0.8 -1.6 0.6 -1.2
Risk taking 0.5 0.7 1.4 -0.8 0.4 -1.2 -0.3 -1.0
Ever had prostate specific antigen (PSA) test 1.6 1.8 4.6 -0.7 0.4 1.7 1.2 2.1
Fractured/broken bones in last 5 years 4.3 5.6 9.7 -2.6 0.6 -3.1 -1.6 -3.0
Age started oral contraceptive pill 0.5 0.6 2.2 0.2 0.4 0.9 -1.5 -0.1
Diastolic blood pressure, automated reading 1.3 4.0 9.3 -0.5 -1.5 1.3 3.1 2.6
Ever depressed for a whole week 1.7 2.1 3.4 1.8 -1.0 1.3 1.8 1.2
Unable to work because of sickness or disability 0.2 0.2 0.9 0.0 -0.1 -0.1 0.9 0.5
Commuting to job workplace: Cycle 0.6 0.7 2.8 0.8 -1.7 -0.3 0.1 0.0
Myopia 0.3 0.5 1.5 0.7 -1.2 -0.1 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 2.6 7.2 14.0 -1.9 1.8 -2.2 -3.7 -3.2
Cholesterol lowering medication 0.3 0.5 1.3 0.8 0.0 0.8 0.2 1.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 1.9 -0.3 1.2 1.4 1.0 1.3
Pain experienced in last month 0.5 0.8 2.4 1.6 -0.9 0.3 -0.9 0.1
Supplements: Calcium 2.7 2.9 7.4 -1.8 0.9 -1.0 -2.7 -1.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 -0.3 0.6 0.5 0.3 0.5
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.3 0.4 -1.8 -1.5 -0.3 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.9 0.2 -0.1 -1.0 0.3 -0.4
Heart disease (siblings) 1.1 1.3 2.9 1.7 -1.1 0.9 1.0 0.9
Alcohol drinker status: Previous 1.8 2.1 5.5 0.8 -2.3 -1.9 -0.1 -0.9
Pack years of smoking 4.3 6.3 11.4 2.7 -3.4 0.2 3.0 2.0
Impedance of whole body 2.5 12.6 20.9 -4.0 3.9 -1.4 -4.6 -3.0
Leg fat mass (left) 2.6 10.2 24.2 2.8 -3.6 -0.4 4.9 2.4
Arm predicted mass (left) 0.6 2.9 8.4 1.3 0.4 1.4 2.9 1.5