Hub : Genes

WWP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1000 0.0400 4.7e-06 0.035 0.059 0.049 0.062 0.053 3.7e-05 9.2e-08 1.3e-06 4.4e-08 5.0e-07
2 GTEx Artery Tibial 0.1282 0.0484 8.4e-05 0.007 NA 0.024 NA 0.014 7.8e-02 NA 4.9e-03 NA 2.5e-02
3 GTEx Testis 0.2980 0.0840 2.5e-05 0.099 NA 0.108 NA 0.164 3.6e-05 NA 1.6e-05 NA 9.2e-08
4 METSIM Adipose 0.0776 0.0303 9.2e-07 0.042 0.036 0.067 0.047 0.067 5.1e-07 3.3e-06 2.7e-10 1.4e-07 3.2e-10
5 NTR Blood 0.0484 0.0154 9.4e-08 0.019 0.024 0.022 0.025 0.023 6.9e-07 2.2e-08 8.6e-08 1.2e-08 3.7e-08
6 TCGA Thyroid Carcinoma 0.0380 0.0230 6.7e-03 0.003 0.006 0.003 NA 0.010 1.5e-01 8.4e-02 1.6e-01 NA 3.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 3.0 1.7 -0.1 -0.1 -0.6 -1.3 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 2.7 -0.2 -1.6 -0.5 -0.8 -0.8 -0.6
Depressed Affect (Nagel 2018) 0.7 1.5 5.5 -2.3 -0.4 -0.2 1.6 -0.2 0.8
Depression (Nagel 2018) 0.6 0.9 3.2 -1.8 -0.6 -0.5 1.1 -0.7 -0.2
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.8 0.6 0.4 2.2 -1.1 1.6 2.1
Neuroticism (Nagel 2018) 0.7 1.6 5.7 -2.4 0.2 -1.7 0.9 0.1 0.3
Schizophrenia (2018) 0.7 1.4 5.0 -1.7 -2.2 -0.6 -0.5 0.1 -0.5
Schizophrenia vs Biploar Disorder 1.1 1.5 2.8 -1.7 -1.1 0.2 -1.2 1.6 0.8
Worry (Nagel 2018) 1.1 2.2 8.0 -2.0 -0.2 -2.8 0.8 0.9 0.3
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.4 0.2 -0.3 -0.5 -0.3 -0.3
Alzheimer’s Disease (in father) 3.7 4.0 11.1 -3.3 -2.8 -0.8 1.7 1.2 -0.5
Alzheimer’s Disease (including proxy) 1.6 2.3 6.0 -2.5 -2.2 -1.0 0.7 0.1 -1.2
Crohns Disease (2017) 1.3 2.8 7.3 2.2 2.7 -0.4 -0.8 -1.7 -1.0
Irritable Bowel Disease (IBD) 0.9 2.1 6.2 2.5 1.5 -0.0 -0.9 -0.2 1.8
Ulcerative Colitis (UC) 1.1 2.0 8.2 1.6 -0.6 0.4 -0.6 0.5 2.9
Major Depression (MDD) 2.6 3.2 6.4 2.4 2.5 0.6 -2.3 -0.0 -1.0
Reaction Time 1.8 3.4 11.0 2.3 3.3 -0.8 -0.7 -1.3 -1.0
Verbal and Numeric Reasoning (VNR) 2.9 7.0 21.4 -0.6 0.6 4.6 -0.4 2.6 3.6
Breast Cancer 1.0 2.5 6.0 -2.5 -1.7 -1.7 0.7 0.3 -1.5
Ovarian Cancer 0.1 0.2 0.4 0.4 0.1 -0.4 -0.6 0.6 0.3
Prostate Cancer 0.4 0.6 2.7 0.7 0.3 1.6 0.1 0.4 0.5
Age at First Birth 0.5 0.8 2.3 -1.1 -1.5 0.1 0.4 -0.8 0.2
Bipolar Disorder (2011) 0.6 0.5 1.1 -0.1 -0.7 -0.7 1.1 -1.0 -0.3
Body Mass Index (BMI) (2010) 1.2 1.7 4.2 2.0 1.6 0.8 -1.4 -0.9 -0.4
Coronary Artery Disease (CAD) 1.1 1.4 2.3 1.4 1.2 -0.3 1.5 -1.5 0.5
Crohns Disease (2012) 1.0 1.5 4.3 1.3 2.1 0.2 -1.8 -0.2 0.1
Mean Putamen Volume 1.8 2.1 8.4 1.0 0.4 -0.1 -0.1 -2.9 -1.7
Fasting Glucose 1.3 1.6 4.0 0.6 1.1 2.0 -1.1 0.2 1.6
HbA1C 1.4 1.6 7.6 0.5 0.6 0.8 -2.8 0.7 -0.6
HDL Cholesterol 0.6 0.9 4.1 -0.9 0.2 -2.0 0.6 0.1 -0.5
LDL Cholesterol 0.1 0.2 1.0 1.0 0.4 -0.1 -0.1 0.2 0.4
Lupus 0.6 0.8 2.1 -1.5 -0.6 0.1 1.4 -0.0 0.7
Neuroticism (2016) 0.6 0.9 1.5 -1.2 1.1 0.5 0.4 0.8 1.2
Primary Biliary Cirrhosis 1.6 2.3 5.5 -0.1 -0.8 1.5 -1.1 2.3 2.0
Rheumatoid Arthritis 0.5 0.7 1.9 0.4 -0.3 -0.2 1.4 -1.2 -0.6
Schizophrenia (2014) 0.4 0.9 1.9 -1.3 -1.3 -0.0 -1.4 0.2 0.4
Triglycerides 1.8 2.9 8.6 2.0 1.3 2.9 -1.8 -0.4 0.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 3.1 0.1 0.9 1.8 0.2 0.0 0.4
Ulcerative Colitis 1.6 2.3 7.0 1.8 -0.1 0.3 -1.3 1.4 2.6
Blood Eosinophil Count 1.6 12.0 28.4 3.3 2.2 5.3 -1.8 2.5 4.3
Blood Platelet Count 0.3 3.8 11.0 -2.2 -0.3 -3.3 -0.6 1.0 -2.3
Blood Red Count 1.4 13.5 40.1 3.2 2.5 6.3 -3.8 2.0 2.4
Blood White Count 1.1 8.5 14.9 3.4 1.7 3.9 -3.4 1.8 2.6
Heel T-Score 0.5 3.6 8.8 1.6 -3.0 -2.1 -0.6 -1.8 -1.6
BMI 8.7 50.4 118.8 10.9 7.3 8.6 -7.3 -0.6 1.5
Height 1.8 33.8 87.0 -8.5 -2.5 -9.3 5.5 -1.0 -2.5
Waist Hip Ratio (WHR) 0.6 2.5 8.3 -1.2 1.1 1.2 -2.9 0.6 -1.6
Systolic Blood Pressure 1.3 6.3 21.8 1.2 0.4 2.9 0.2 -4.7 -2.4
Smoking Status 2.3 5.5 17.0 -0.4 2.0 -0.7 -4.1 3.2 1.2
Allergy or Eczema 0.3 0.8 3.7 -0.0 -0.6 -0.5 1.9 0.4 0.4
Cardiovascular Disease 2.0 6.7 11.0 3.3 2.2 3.3 -1.4 -2.7 -2.0
Hypothyroidism (self reported) 2.1 4.8 7.8 2.1 2.8 2.1 -2.6 1.3 1.9
Respiratory disease 1.5 3.3 9.9 1.7 1.0 -0.4 -0.6 2.3 3.1
Type 2 Diabetes (T2D) (2018) 5.5 10.3 23.7 4.4 2.8 4.9 -2.8 0.3 1.9
Lung FEV1/FVC ratio 0.5 2.6 8.2 -0.4 -1.4 1.8 -0.1 -1.3 -2.9
Lung FVC 5.6 28.7 65.0 -1.5 -2.7 -8.1 7.9 -4.6 -3.7
Neuroticism 1.0 2.5 8.2 -2.9 -0.8 -2.0 1.4 -0.4 0.2
Chronotype (morning person) 1.6 3.7 13.8 -0.8 -0.2 -3.7 2.2 -0.7 -1.4
Hair Pigment 0.1 2.1 5.5 -0.9 -0.2 -1.7 -0.4 2.3 1.7
Tanning 0.1 1.8 4.1 0.9 2.0 -1.6 -0.9 -0.1 -1.5
Hand grip strength (left) 6.1 16.0 25.3 -3.2 -4.2 -4.9 5.0 -2.8 -3.3
Number of treatments/medications taken 1.6 2.9 6.4 1.4 1.0 1.1 -2.4 -2.5 -1.1
Average weekly spirits intake 1.8 2.2 5.1 2.1 0.3 2.3 -0.6 0.9 1.6
Sensitivity / hurt feelings 1.4 2.4 5.9 -2.4 1.3 -1.2 2.4 -0.0 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.4 -1.6 -0.6 -0.7 0.5 -1.1 -0.0
Hearing difficulty/problems: Yes 1.3 2.1 5.6 2.4 0.2 2.3 -1.0 0.4 0.6
Relative age of first facial hair 2.0 4.1 8.2 -2.9 -2.0 -1.4 2.3 2.2 0.8
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.9 -0.9 0.3 1.7 -1.5 -0.3 0.3
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.8 -1.5 -0.5 -1.7 -0.3 -0.4 -2.0
Ever had hysterectomy (womb removed) 1.1 1.2 3.5 1.1 1.0 1.9 -0.8 -1.0 0.3
Systolic blood pressure, automated reading 2.5 7.2 17.8 3.0 1.9 3.0 -0.8 -4.2 -1.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.5 1.0 0.5 1.6 -0.5 -0.4 -0.0
Angina 1.7 2.2 4.1 1.0 2.0 1.1 -2.0 0.4 1.8
Medication for hormone replacement therapy 3.3 3.7 12.0 -3.5 -1.3 -2.1 1.9 0.3 0.2
Vitamin and mineral supplements 2.8 3.8 10.3 1.6 2.2 3.2 -1.0 1.8 0.8
Supplements: Zinc 1.8 2.0 4.2 -1.8 -0.1 -2.1 -0.7 -1.5 -1.3
Medication: Co-codamol 0.9 1.0 3.7 -1.1 1.9 0.4 0.4 0.2 1.0
Medication: Metformin 2.9 4.1 9.7 2.4 2.2 3.1 -1.8 -1.2 0.1
Diabetes (father) 1.3 1.7 6.8 0.2 1.4 2.6 -0.9 -0.2 0.7
Diabetes (mother) 2.0 2.5 8.1 1.8 0.4 1.7 -0.8 -2.8 -0.5
Severe depression (siblings) 1.3 1.5 5.1 -0.0 -0.5 2.2 1.7 -0.8 0.3
Pack years adult smoking proportion 3.8 5.8 18.4 4.3 2.2 2.4 -2.1 -0.2 1.1
Impedance of leg (right) 2.3 10.9 25.0 -5.0 -3.9 -2.6 3.9 1.8 0.6
Leg fat-free mass (left) 0.9 4.6 14.1 2.7 3.8 1.2 -1.6 -1.2 0.7
Trunk fat percentage 7.0 28.0 57.8 6.0 6.3 7.6 -4.9 0.5 3.2
Hand grip strength (right) 5.5 14.9 23.0 -3.7 -4.8 -4.0 4.8 -2.8 -2.5
Townsend deprivation index at recruitment 0.8 1.2 3.1 1.4 -0.0 0.9 -1.8 -0.8 -0.6
Current tobacco smoking 1.2 2.0 3.4 0.5 1.3 1.0 -1.8 1.7 1.8
Average weekly fortified wine intake 1.9 2.2 6.5 0.6 -0.1 -1.1 0.8 2.6 2.1
Maternal smoking around birth 3.5 5.1 14.1 2.4 3.8 2.1 -1.2 1.1 2.0
Fed-up feelings 0.4 0.8 1.6 -0.9 0.8 -1.2 1.2 -0.4 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.9 2.8 -1.7 -0.5 -0.7 0.7 -0.8 -0.7
Relative age voice broke 3.9 5.9 17.9 -2.6 -2.0 -2.6 4.2 0.5 0.4
Taking other prescription medications 2.0 3.1 9.5 1.3 2.0 1.0 -3.1 -1.3 -0.5
Age when periods started (menarche) 9.8 23.5 67.9 -4.9 -3.4 -6.1 8.2 -0.8 -0.5
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 4.1 -1.1 -0.7 -0.7 0.2 -1.0 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 2.9 1.7 -0.7 0.6 0.0 -0.0 0.1
Tinnitus: Yes, but not now, but have in the past 3.0 3.2 6.8 -0.4 -1.9 0.7 1.6 2.6 2.3
Qualifications: CSEs or equivalent 1.2 1.6 4.9 -1.1 -0.5 -2.2 0.9 -0.8 -1.3
Serious illness, injury or assault to yourself 4.3 5.2 10.2 2.5 2.7 3.2 -2.2 -0.5 1.5
High blood pressure 2.3 6.3 9.4 2.9 2.6 2.8 -0.7 -3.1 -2.2
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.4 -0.8 -1.4 -0.7 1.8 0.3 0.3
Multivitamins +/- minerals 2.8 3.6 8.5 -0.9 -2.9 -1.9 1.8 -2.1 -0.9
Stomach or abdominal pain in last month 1.1 1.3 3.0 -1.7 -0.2 -1.7 -0.7 -0.2 -1.2
Supplements: Glucosamine 0.7 0.9 1.8 1.3 -0.9 -0.4 0.4 -1.2 1.0
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 -1.5 -0.5 0.9 1.5 -1.2 -0.4
Medication: Atenolol 2.4 3.0 8.7 1.4 3.0 1.6 -2.0 -0.7 0.6
Medication: Levothyroxine sodium 1.5 2.6 4.8 1.9 2.1 2.2 -1.0 0.0 1.3
Sitting height 2.8 19.7 83.0 -3.0 0.3 -9.1 4.1 -1.6 -2.5
Chronic bronchitis/emphysema (father) 1.9 2.3 7.7 1.9 0.6 2.8 -0.2 -0.8 1.1
High blood pressure (mother) 0.3 0.4 1.4 1.2 -0.0 0.5 0.6 -0.4 0.2
Body mass index (BMI) 7.2 30.5 63.2 8.0 6.2 7.2 -4.9 -1.0 2.2
Impedance of leg (left) 2.7 13.2 31.5 -5.6 -4.1 -3.4 4.0 1.8 -0.1
Leg predicted mass (left) 0.9 4.6 14.3 2.8 3.8 1.1 -1.6 -1.2 0.7
Trunk fat mass 5.3 23.0 39.2 5.7 6.3 6.2 -4.4 0.1 2.7
Waist circumference 5.9 21.6 36.4 6.0 5.8 5.9 -4.6 -0.8 1.5
Number of incorrect matches in round 0.7 1.1 2.2 1.3 0.3 0.1 -1.4 -0.8 -1.5
Past tobacco smoking 3.0 5.6 17.9 0.1 -2.7 -0.2 4.2 -2.7 -1.1
Alcohol usually taken with meals 0.7 1.1 2.1 -1.1 -1.2 -1.2 0.2 -0.8 -1.4
Nervous feelings 0.9 1.7 4.8 -1.3 0.9 -2.2 0.5 1.4 0.9
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 4.1 -2.0 -1.9 0.3 1.3 -0.2 0.5
Hearing difficulty/problems with background noise 0.5 0.7 1.4 0.8 0.8 0.2 -0.9 -0.9 -1.2
Hair/balding pattern: Pattern 2 1.2 1.6 5.3 -1.0 -2.3 0.1 0.9 1.4 0.6
Had menopause 0.4 0.5 1.6 -0.2 1.3 -0.2 -0.5 -0.2 -1.0
Had other major operations 0.4 0.5 1.2 -0.9 0.0 -0.3 -0.2 -1.1 -1.0
Forced vital capacity (FVC) 6.3 24.2 63.2 -4.0 -2.4 -8.0 7.0 -2.1 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 4.0 2.0 -0.2 0.4 0.7 -0.7 0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.5 -0.5 0.6 0.9 -1.2 -0.9 -0.2
Qualifications: None of the above 0.4 0.8 1.9 1.4 1.1 0.2 1.0 0.3 0.7
Financial difficulties in last 2 years 0.4 0.6 1.7 0.7 0.5 1.3 0.2 -0.0 1.0
Mouth/teeth dental problems 0.5 0.8 3.8 1.9 -0.1 0.7 -0.4 -0.5 -0.5
Heart attack 1.4 1.7 4.3 1.2 1.7 0.2 -2.1 1.3 0.6
Allergy 0.3 0.6 2.2 -0.2 0.2 -0.2 -0.0 -1.2 -1.5
Pain all over the body in last month 1.0 1.0 3.2 -1.2 0.4 1.2 0.3 -1.8 -0.3
Diabetes (self-reported) 4.8 7.4 11.8 3.3 3.4 3.4 -2.9 -1.0 0.9
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.6 -1.0 -1.1 -0.2 1.9 0.7 0.8
Medication: Ramipril 0.5 0.6 1.4 0.4 -0.3 1.2 0.6 0.7 1.0
Medication: Simvastatin 3.6 5.3 8.3 2.9 2.5 2.9 -2.8 -0.8 0.7
Fluid intelligence score 2.3 4.7 15.6 0.7 1.4 4.0 -1.0 1.3 2.8
Illnesses of siblings 2.2 3.0 6.4 -2.5 -2.3 -2.2 0.7 1.1 -0.2
Neuroticism score 1.4 2.9 9.9 -3.1 -0.3 -1.4 2.2 0.1 0.8
Weight 2.3 11.4 24.9 4.5 5.0 3.6 -2.6 -0.8 1.8
Impedance of arm (right) 0.7 3.4 8.4 -2.9 0.1 0.8 0.5 2.8 1.9
Arm fat percentage (right) 9.9 38.9 73.8 7.8 7.2 8.6 -5.8 0.6 3.4
Trunk fat-free mass 0.4 2.0 7.5 0.3 1.0 -2.7 1.2 -1.4 -0.7
Hip circumference 4.1 17.6 34.6 5.9 5.2 5.5 -2.4 -1.1 2.7
Time employed in main current job 0.4 0.5 1.0 0.7 1.0 -0.8 -0.8 0.3 -0.4
Alcohol intake versus 10 years previously 3.1 4.6 11.6 3.4 1.2 3.3 -0.8 -1.7 -0.2
Father’s age at death 3.4 4.6 8.2 -2.4 -2.3 -2.5 -0.6 -1.4 -2.9
Worrier / anxious feelings 1.9 3.5 11.2 -3.3 -1.5 -1.5 1.9 1.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 7.2 -0.8 -0.4 2.7 1.0 -2.0 1.8
Falls in the last year 2.6 3.6 7.5 2.5 2.7 1.4 -2.1 0.4 1.0
Hair/balding pattern: Pattern 3 2.2 3.2 11.4 1.1 3.4 1.6 -1.9 0.5 0.6
Number of live births 0.8 1.2 1.7 -0.6 -1.3 0.8 1.3 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1) 5.6 18.8 40.2 -3.4 -2.8 -6.3 6.3 -2.2 -2.9
Pulse rate 2.0 3.3 8.1 2.1 1.7 2.0 -2.9 -0.1 0.6
Happiness 0.9 1.1 3.1 -1.1 -1.0 -1.8 1.0 -0.5 -0.3
Noisy workplace 1.6 1.9 7.7 0.7 0.3 -2.8 1.1 -1.1 -1.0
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.6 -1.0 -1.3 0.7 -0.1 0.8 0.5
Serious illness, injury or assault of a close relative in last 2 years 4.0 4.6 16.2 1.3 -0.5 4.0 -1.3 1.3 2.5
Mouth/teeth dental problems: Dentures 0.4 0.7 1.4 0.4 0.4 -1.0 -0.0 -1.2 -1.1
Asthma 1.3 2.5 8.4 0.5 1.5 0.1 -0.6 1.9 2.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.1 1.5 -1.1 0.5 0.4 -0.7 0.6
Medication: Cholesterol lowering 3.3 5.2 11.3 3.4 2.4 2.3 -2.4 -1.0 1.4
Depression (self-reported) 0.3 0.3 0.8 -0.5 -0.5 0.9 -0.1 -0.6 0.5
Medication: Lansoprazole 0.8 0.9 3.3 -0.1 1.8 -0.0 -1.3 -0.5 -0.4
Prospective memory result 0.8 1.0 4.0 -1.0 -0.1 -2.0 0.5 0.5 -0.5
Lung cancer (father) 0.8 1.0 4.5 2.1 0.8 -0.2 0.4 -0.2 0.6
Illnesses of mother 0.8 1.0 2.7 -1.6 -1.0 -0.2 0.8 1.0 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 5.4 17.1 39.3 -3.4 -3.2 -5.8 6.3 -1.3 -2.5
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 1.2 1.2 -0.4 -0.5 -0.5 -0.0
Impedance of arm (left) 0.8 3.7 9.2 -3.0 -0.0 1.6 0.4 2.5 2.0
Arm fat mass (right) 6.4 26.3 45.3 6.7 6.3 6.6 -4.7 -0.2 2.7
Trunk predicted mass 0.4 2.1 7.6 0.3 1.0 -2.8 1.1 -1.4 -0.8
Standing height 2.2 21.7 54.9 -7.0 -2.1 -7.4 4.6 0.4 -0.9
Length of working week for main job 1.6 1.8 5.3 0.6 -1.4 2.3 0.3 1.3 1.2
Exposure to tobacco smoke at home 2.1 2.3 5.9 2.4 0.7 -0.0 0.1 -2.4 -1.4
Breastfed as a baby 2.0 2.5 6.4 -1.7 -2.5 -1.5 1.7 -0.0 0.9
Tense / ‘highly strung’ 1.4 2.4 8.3 -1.5 0.9 0.3 -0.1 1.7 2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 2.8 1.0 0.7 0.7 -1.5 -1.7 -0.9
Hair/balding pattern: Pattern 4 0.8 2.0 5.1 -0.1 1.0 -0.0 -1.7 -1.7 -2.3
Birth weight of first child 1.2 2.2 6.1 -1.9 -2.5 0.4 -1.8 0.2 -0.4
Peak expiratory flow (PEF) 3.3 7.5 16.1 -2.1 -2.4 -3.9 4.0 -0.8 -1.7
Pulse wave reflection index 0.8 1.0 4.4 -0.3 0.7 -2.1 0.4 0.8 -0.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.8 0.2 0.4 0.3 0.0 -0.9 0.5
Loud music exposure frequency 0.6 0.6 1.0 0.7 0.8 -0.8 0.9 0.6 1.0
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.4 -0.2 -0.0 2.1 -1.1 1.3 1.7
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.0 -0.7 2.0 0.4 0.8 1.4 2.0
Blood clot in the leg (DVT) 1.0 1.3 2.8 0.4 0.3 1.6 -1.7 1.4 0.3
Medication: Paracetamol 1.1 1.8 3.4 0.8 1.8 0.4 -1.5 -1.5 -1.5
Headache pain in last month 0.6 1.0 3.3 0.6 1.8 0.9 -1.2 -0.0 0.1
Medication for cholesterol, blood pressure or diabetes 3.4 5.6 9.7 -3.1 -2.2 -2.9 2.4 2.3 0.1
Glaucoma (self-reported) 1.3 1.6 4.4 -0.7 0.1 1.4 -0.1 1.6 2.1
Gout (self-reported) 3.8 5.1 26.8 0.8 -0.3 5.2 -0.1 -0.4 1.8
Hypothyroidism/myxoedema (self-reported) 2.5 4.9 8.4 2.1 2.9 2.1 -1.8 1.2 2.8
Medication: Amlodipine 0.8 1.2 2.8 1.4 0.9 1.7 -0.4 -1.2 -0.3
Medication: Ventolin 100micrograms inhaler 1.1 1.5 4.1 -0.5 -0.7 -0.1 1.9 0.7 2.0
Birth weight 1.3 2.8 12.0 -1.9 -0.2 -3.5 -0.1 -0.2 -1.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.0 1.7 1.1 0.5 0.0 -0.4 0.7
High blood pressure (siblings) 1.5 2.1 6.7 2.6 1.4 1.3 0.4 -1.5 -0.1
Forced vital capacity (FVC), Best measure 6.6 24.1 55.9 -4.2 -3.2 -7.5 7.4 -1.4 -2.0
Body fat percentage 7.5 29.5 59.4 6.6 6.4 7.7 -4.8 0.3 3.1
Leg fat percentage (right) 5.9 21.5 44.0 6.3 5.1 6.6 -3.4 -0.2 2.5
Arm fat-free mass (right) 0.3 1.7 3.6 0.9 1.1 -1.9 0.6 -1.8 -0.8
Exposure to tobacco smoke outside home 1.6 2.1 5.3 -2.3 -1.7 -1.6 1.4 -0.0 -0.3
Comparative body size at age 10 1.6 4.3 9.2 3.0 2.3 1.4 -2.7 -0.8 -1.4
Number of full brothers 1.7 2.1 5.0 2.2 1.1 1.2 1.3 -1.8 -0.3
Worry too long after embarrassment 1.4 2.4 5.6 -1.3 -0.8 -1.5 2.4 -1.8 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.4 -0.5 -0.6 -0.8 -0.3 -0.6
Wheeze or whistling in the chest in last year 1.1 1.9 5.2 0.8 1.8 1.1 -0.2 1.1 2.3
Number of children fathered 1.8 2.1 8.8 -1.0 -0.1 0.3 3.0 0.5 1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 5.9 0.0 0.2 -0.2 -0.6 -1.9 -2.4
Age at first live birth 0.7 1.3 2.7 -1.6 -0.6 -0.9 0.4 1.2 1.5
Pulse wave peak to peak time 0.9 1.0 2.8 -1.7 -1.5 0.2 0.9 0.5 0.1
Health satisfaction 0.7 0.9 1.8 -1.2 -0.9 0.1 1.1 -1.3 -0.0
Shortness of breath walking on level ground 1.7 2.0 4.1 1.6 1.8 2.0 -1.0 -0.6 1.0
Qualifications: College or University degree 0.5 1.5 3.5 -1.4 -1.9 0.8 -1.1 -0.8 -0.9
Eye problems/disorders: None of the above 1.0 1.2 3.6 -0.7 0.4 -1.9 1.0 -0.6 -1.3
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.6 0.3 1.3 0.1 0.1 -0.7 0.7
Emphysema/chronic bronchitis 0.5 0.5 1.1 1.0 -0.6 -0.9 -0.9 0.1 -0.4
Medication for pain relief, constipation, heartburn 1.3 2.3 4.8 -2.2 -0.6 -0.4 2.1 1.4 1.4
Neck or shoulder pain in last month 0.7 1.0 3.3 -0.0 0.4 1.1 1.2 0.4 1.8
Medication: Blood pressure 1.7 3.1 7.0 1.9 1.4 2.6 -1.1 -2.1 -0.5
Angina (self-reported) 1.6 2.2 4.0 0.9 1.9 1.0 -1.8 0.6 2.0
Migraine (self-reported) 0.8 0.9 2.4 -0.3 0.7 0.3 -1.0 -1.2 -1.6
Medication: Ibuprofen 1.0 1.2 2.4 1.5 -1.3 0.5 1.0 -0.8 1.1
Medication: Allopurinol 2.7 3.6 18.5 0.9 -0.4 4.3 -0.1 -0.5 1.4
Medication: Omeprazole 1.3 1.5 2.6 1.2 -1.2 -0.2 -1.6 -1.3 -1.5
Medication: Seretide 50 evohaler 0.3 0.3 0.8 0.4 -0.0 0.6 -0.9 0.5 0.5
Mean time to correctly identify matches 1.7 3.2 11.6 2.3 3.4 -0.2 -1.3 -0.2 -0.5
Heart disease (mother) 0.5 0.6 2.3 -0.9 -0.1 -1.5 0.2 0.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 3.6 -0.4 0.6 -0.5 -1.9 -0.8 -1.3
Whole body fat mass 5.6 23.2 39.7 6.1 6.2 6.3 -4.1 -0.2 2.7
Leg fat mass (right) 5.2 20.2 37.9 6.2 5.6 5.8 -3.7 -0.8 2.1
Arm predicted mass (right) 0.3 1.5 2.9 1.0 1.4 -1.7 0.1 -1.6 -0.6
Pulse rate, automated reading 2.3 7.5 17.4 3.7 2.0 4.2 -3.0 -1.0 0.3
Alcohol intake frequency. 3.7 8.6 20.9 4.3 2.4 4.6 -0.2 -2.3 1.0
Comparative height size at age 10 0.3 1.5 6.2 -1.1 2.5 0.2 -0.4 0.7 1.0
Number of full sisters 0.6 0.8 3.4 0.8 1.8 0.5 0.3 -0.4 -0.2
Suffer from ‘nerves’ 0.4 0.7 1.6 -0.0 0.1 -1.2 0.3 1.1 1.0
Overall health rating 0.6 1.3 5.3 -0.3 1.1 0.6 0.8 -2.3 0.3
Chest pain or discomfort 1.2 1.8 4.7 -0.1 1.8 2.2 -0.3 -0.2 1.5
Had major operations 0.3 0.4 1.2 -1.1 -0.3 -0.3 -0.7 -0.5 0.2
Age at last live birth 0.6 0.9 3.2 -0.5 0.3 -0.6 -0.3 1.8 1.1
Family relationship satisfaction 0.4 0.5 1.2 0.5 0.7 0.3 -1.1 -0.8 -0.7
Leg pain on walking 1.1 1.4 3.6 -0.4 -1.3 1.2 1.0 -0.6 1.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.6 0.1 -0.0 0.3 -0.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 1.1 0.7 0.3 -1.0 0.5 0.7
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.6 -1.3 -0.4 -1.9 1.1 0.8 -0.7
Medication: Aspirin 1.1 1.5 4.5 1.3 1.0 1.2 -2.1 -0.0 -0.4
Supplements: Vitamin C 3.9 4.7 16.9 -2.5 -0.9 -4.1 -0.7 -0.2 -1.8
Knee pain experienced in last month 2.5 3.9 8.2 2.0 2.0 2.9 -1.5 0.3 2.1
Hypertension (Self-reported) 2.4 6.8 10.4 3.2 2.7 2.8 -0.7 -3.1 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.3 -0.5 -0.4 0.1 1.1 -0.6 0.5
Illnesses of father: Heart disease 2.0 2.8 7.8 0.1 1.0 -2.1 -0.5 -1.8 -2.8
Illnesses of siblings: Diabetes 1.8 2.2 7.1 1.4 1.8 2.7 -0.5 -0.5 0.7
Smoking status: Previous 3.3 4.9 16.2 0.4 2.8 0.0 -4.0 2.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 8.4 -2.0 -1.2 -2.9 2.6 -0.8 0.1
Whole body fat-free mass 0.3 1.6 4.3 1.1 2.1 -1.4 0.0 -1.4 -0.3
Leg fat-free mass (right) 0.6 3.5 12.0 2.2 3.5 0.4 -1.6 -1.0 0.2
Arm fat percentage (left) 10.4 41.3 82.3 8.0 7.4 9.1 -5.8 0.4 3.6
Average weekly red wine intake 0.5 0.8 2.3 -1.5 -1.1 -1.1 0.3 0.1 -0.4
Handedness (chirality/laterality): Left-handed 1.8 2.1 3.4 -1.7 -0.7 -1.8 1.7 -0.8 -1.5
Mood swings 1.3 2.3 7.6 -2.7 -1.2 -1.3 1.8 -0.3 0.1
Loneliness, isolation 0.7 0.9 4.1 -2.0 0.5 0.8 -0.2 0.4 0.7
Long-standing illness, disability or infirmity 3.0 4.6 10.1 1.8 1.8 3.2 -2.9 -0.7 1.4
Ever had bowel cancer screening 1.4 1.6 4.1 0.1 1.4 -2.0 -1.5 0.3 -1.0
Diabetes diagnosed by doctor 5.9 9.7 17.1 4.1 3.8 3.9 -3.0 -0.7 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.5 -0.6 -1.2 -0.2 0.9 -1.0 0.2
Friendships satisfaction 0.4 0.5 2.0 -1.4 -1.1 -0.3 0.1 -0.1 -0.1
Qualifications: nursing, teaching 1.6 2.5 7.8 -1.4 -2.8 -0.0 -0.1 -1.7 -1.5
Commuting to job workplace: Walk 0.6 0.6 1.1 -0.6 -1.0 -0.8 0.2 -1.0 -0.9
Eye problems/disorders: Cataract 1.9 2.2 4.6 1.8 1.1 2.2 -1.6 0.2 1.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.6 0.0 -0.7 -0.6 0.5 -0.1
Medication for cholesterol 0.8 1.2 3.2 1.6 -0.6 0.7 0.4 0.8 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.3 -1.4 -1.8 -1.2 0.8 -0.1 0.3
Back pain experienced in last month 2.1 3.0 8.1 -1.6 -1.7 -2.9 2.0 -0.5 0.0
Mineral and other dietary supplements 2.2 3.0 5.9 1.5 2.4 1.4 -1.6 -0.0 -2.3
Breast cancer (self-reported) 0.5 0.6 1.1 0.8 1.1 0.9 0.9 -0.4 0.4
Asthma (self-reported) 1.2 2.3 7.8 0.3 1.7 -0.0 -0.6 1.7 2.8
Osteoporosis (self-reported) 1.6 2.0 4.2 -1.1 0.8 -1.2 -2.1 0.2 -2.0
Osteoarthritis (self-reported) 2.5 3.3 6.6 1.4 1.9 1.0 -2.6 -2.2 -1.1
Medication: Aspirin 0.7 0.9 3.2 0.8 0.6 0.8 -1.8 -0.6 -0.5
Medication: Gliclazide 2.3 2.6 6.8 1.4 1.1 2.6 -0.4 -0.0 2.3
Illnesses of father: None of the above (group 1) 1.4 1.7 3.8 -2.0 -1.4 -1.1 0.1 1.4 1.2
Smoking status: Current 1.1 1.8 3.4 -0.2 1.0 0.7 -1.9 1.7 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.9 10.4 19.3 -1.1 -2.4 -4.4 3.5 -2.7 -4.1
Whole body water mass 0.3 1.7 4.5 1.1 2.1 -1.5 0.1 -1.5 -0.3
Leg predicted mass (right) 0.6 3.5 12.0 2.2 3.5 0.4 -1.5 -1.1 0.2
Arm fat mass (left) 6.7 27.5 46.2 6.8 6.6 6.7 -4.7 -0.0 2.8
Number of self-reported non-cancer illnesses 3.1 5.3 12.5 2.2 2.2 3.5 -2.7 -1.6 0.5
Average weekly champagne plus white wine intake 0.6 0.9 2.1 -0.9 -1.0 -1.4 0.2 0.7 -0.9
Miserableness 1.5 2.6 5.1 -1.9 -1.8 0.3 1.8 0.6 2.3
Guilty feelings 0.6 0.9 2.1 -1.4 -0.4 -1.4 0.8 -0.7 -0.2
Wears glasses or contact lenses 0.7 0.8 1.4 -0.1 -0.6 1.2 -1.0 -0.8 -1.2
Ever taken oral contraceptive pill 1.6 1.8 4.4 -0.0 0.9 0.9 -2.1 1.5 1.7
Hearing aid user 0.5 0.6 1.1 -0.3 -0.8 0.9 -0.3 1.1 0.9
Mother’s age at death 1.5 1.8 4.6 -1.7 0.4 -2.1 -0.2 -0.7 -1.8
Financial situation satisfaction 2.1 2.6 4.9 -2.2 -1.9 -0.3 2.2 0.8 1.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.2 0.2 -0.5 -0.7 -1.0 -0.7 -1.5
Commuting to job workplace: Public transport 1.4 1.6 5.3 -0.2 0.8 0.9 -0.2 2.3 1.7
Eye problems/disorders: Glaucoma 0.7 0.8 2.5 -0.2 0.7 0.2 0.1 1.3 1.6
Medication: Blood pressure 1.7 3.2 8.5 1.5 2.9 1.0 -1.8 -1.1 -1.8
Pain type(s) experienced in last month: Hip pain 0.7 0.9 4.1 -0.2 2.0 0.6 0.2 -0.2 0.9
Supplements: Fish oil (including cod liver oil) 3.6 4.7 8.2 -2.6 -2.9 -2.0 2.2 0.0 2.0
High cholesterol (Self-reported) 2.9 5.2 14.2 3.8 2.2 2.3 -1.8 -1.8 -0.1
Medication: Bendroflumethiazide 1.2 1.9 7.1 1.3 1.4 2.7 0.0 -0.4 -0.4
Medication: Paracetamol 0.7 1.0 2.3 0.4 0.8 0.9 -0.8 -1.5 -1.3
Medication: Lisinopril 0.9 1.1 2.9 1.4 1.1 1.7 -0.7 -0.2 -0.5
Medication: Atorvastatin 1.2 1.5 3.5 1.5 0.8 0.8 -1.9 -0.9 -1.0
Illnesses of father: High blood pressure 1.2 1.5 3.5 1.4 0.0 1.1 0.4 -1.5 -1.9
Alcohol drinker status: Never 2.3 2.8 7.8 2.8 2.1 1.5 0.3 -1.4 0.0
Ever smoked 2.6 4.5 10.8 -0.3 2.2 0.3 -3.1 3.3 1.2
Basal metabolic rate 0.4 2.4 8.0 2.1 2.8 -0.0 -0.6 -1.3 0.3
Leg fat percentage (left) 5.5 20.0 38.3 6.1 5.2 6.2 -3.7 -0.2 2.1
Arm fat-free mass (left) 0.3 1.3 2.8 1.1 1.5 -1.7 0.2 -1.2 -0.5
Number of operations (self-reported) 0.7 1.1 1.8 -0.7 0.9 -0.3 -1.2 -1.3 -1.3
Average weekly beer plus cider intake 0.8 1.2 4.9 0.1 -0.7 -0.5 0.3 2.2 1.2
Irritability 0.2 0.4 0.7 -0.9 0.9 -0.3 -0.2 -0.7 0.3
Risk taking 2.0 2.9 8.4 -1.3 -0.1 0.1 -2.9 -1.3 -2.4
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.9 0.4 -0.3 -1.3 1.2 -1.7 -1.1
Fractured/broken bones in last 5 years 0.8 1.0 2.4 -1.5 0.2 -1.6 -0.9 0.6 0.4
Age started oral contraceptive pill 0.8 1.1 2.6 -1.3 -0.3 -0.4 1.6 1.3 -0.1
Diastolic blood pressure, automated reading 1.6 5.0 11.9 1.5 3.4 -1.5 0.2 -3.1 -2.0
Ever depressed for a whole week 0.8 1.0 2.0 0.9 0.9 0.1 -1.1 -1.4 -1.2
Unable to work because of sickness or disability 0.9 1.1 4.6 0.3 1.0 2.1 -0.3 0.1 1.0
Commuting to job workplace: Cycle 0.6 0.8 1.8 1.3 0.5 -1.0 -0.6 0.7 -0.8
Myopia 2.2 3.2 6.3 -0.2 2.5 -1.5 -2.5 1.3 -1.7
Vascular/heart problems diagnosed by doctor 2.1 5.7 8.4 -2.8 -2.9 -2.8 1.6 2.3 1.6
Cholesterol lowering medication 1.3 1.9 4.4 0.9 0.5 2.1 -1.9 -1.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 4.7 0.4 -1.0 -0.5 -1.1 -1.9 -2.2
Pain experienced in last month 0.3 0.5 0.9 0.7 -0.7 -0.3 -0.9 0.2 -1.0
Supplements: Calcium 2.3 2.6 5.9 -2.4 -1.6 -2.4 0.2 -0.6 -1.0
Basal cell carcinoma (self-reported) 0.2 0.2 1.2 -0.2 -0.2 -0.0 0.1 -0.4 -1.1
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.6 0.8 1.4 0.1 -1.9 1.4 0.6
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.3 0.5 0.4 1.3 -1.5 1.3 0.3
Heart disease (siblings) 0.4 0.5 1.1 0.7 0.7 0.4 -0.3 -0.7 -1.1
Alcohol drinker status: Previous 1.1 1.3 3.0 1.2 0.5 1.5 -1.7 0.3 0.8
Pack years of smoking 3.8 5.6 17.6 4.2 2.3 2.2 -2.2 -0.1 0.9
Impedance of whole body 1.4 7.0 24.2 -4.9 -2.3 -1.0 2.1 2.4 1.0
Leg fat mass (left) 4.7 18.5 34.5 5.9 5.5 5.4 -3.6 -0.7 1.9
Arm predicted mass (left) 0.3 1.3 2.7 1.2 1.6 -1.4 0.1 -1.3 -0.4