[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr2:23,453,834-25,889,403

Best TWAS P=1.48e-14 · Best GWAS P=7.14e-15 conditioned to 0.0798

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	7.0	-7.7	1.5e-14	-0.81	0.04	0.92	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-6.7	7.5	4.8e-14	0.07	0.06	0.93	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-7.1	7.4	1.8e-13	0.13	0.01	0.99	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-6.7	7.3	3.1e-13	0.11	0.04	0.89	FALSE
12	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-5.2	-7.3	3.2e-13	-0.30	0.07	0.21	FALSE
14	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-5.9	7.2	9.0e-13	0.14	0.03	0.97	FALSE
20	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-7.1	-7.0	2.7e-12	-0.12	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-5.6	6.9	4.4e-12	0.07	0.04	0.93	FALSE
2	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-6.7	-6.8	1.5e-11	-0.12	0.02	0.98	FALSE
22	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-6.6	-6.7	2.2e-11	-0.13	0.02	0.98	FALSE
19	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-6.6	-6.6	3.4e-11	-0.09	0.03	0.97	FALSE
21	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-3.3	-6.6	3.7e-11	-0.84	0.04	0.96	FALSE
15	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-5.9	6.5	5.7e-11	0.15	0.04	0.95	FALSE
6	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-5.9	-6.5	9.5e-11	-0.14	0.41	0.59	FALSE
4	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	-6.2	-6.4	1.9e-10	-0.67	0.08	0.90	FALSE
11	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-5.9	-6.3	2.5e-10	-0.75	0.07	0.70	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-6.9	6.3	3.9e-10	0.15	0.05	0.95	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	ADCY3	0.36	0.14	enet	7	0.13	8.9e-05	-5.5	6.2	5.5e-10	0.05	0.02	0.43	FALSE
17	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-6.1	-6.0	1.7e-09	-0.84	0.03	0.90	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	-4.5	6.0	2.2e-09	0.09	0.54	0.42	FALSE
8	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-5.9	-5.7	1.3e-08	-0.11	0.07	0.92	FALSE
13	GTEx	Lung	UBXN2A	0.09	0.06	enet	7	0.07	6.1e-06	-3.4	-5.7	1.3e-08	-0.72	0.30	0.70	FALSE
7	GTEx	Artery Tibial	UBXN2A	0.12	0.06	enet	24	0.09	1.5e-07	-3.1	-5.7	1.6e-08	-0.72	0.81	0.19	FALSE
5	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-4.9	-5.6	1.8e-08	0.03	0.06	0.15	FALSE
3	GTEx	Adipose Subcutaneous	UBXN2A	0.06	0.04	lasso	5	0.04	5.2e-04	-5.9	-5.4	5.9e-08	-0.73	0.27	0.71	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY3	0.08	0.03	enet	16	0.03	1.5e-04	-4.4	5.2	1.6e-07	0.00	0.03	0.25	FALSE
16	GTEx	Skin Sun Exposed Lower leg	UBXN2A	0.08	0.04	enet	17	0.03	1.3e-03	-5.9	-5.2	1.9e-07	-0.62	0.57	0.34	FALSE