[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr17:78,665,405-80,866,427

Best TWAS P=2.75e-15 · Best GWAS P=8.65e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	YFS	Blood	ASPSCR1	0.11	0.07	lasso	9	0.06	7.9e-20	-7.5	7.9	2.8e-15	-0.98	0.00	1.00	TRUE
9	GTEx	Brain Cerebellum	RP11-1055B8.4	0.25	0.27	lasso	2	0.27	1.3e-08	5.4	-5.4	7.7e-08	0.10	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PYCR1	0.02	0.01	blup	9	0.01	1.1e-02	-6.6	7.2	8.5e-13	-0.83	0.00	0.66	FALSE
17	GTEx	Thyroid	ASPSCR1	0.23	0.15	enet	19	0.09	1.2e-07	-6.5	7.1	1.1e-12	-0.81	0.47	0.53	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	DCXR	0.09	0.03	blup	38	0.09	9.5e-09	4.5	7.1	1.3e-12	-0.53	0.24	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DCXR	0.14	0.07	enet	17	0.10	3.4e-12	4.1	7.1	1.7e-12	-0.48	1.00	0.00	FALSE
12	GTEx	Heart Atrial Appendage	LRRC45	0.19	0.06	enet	9	0.12	6.7e-06	-6.2	7.0	2.1e-12	-0.85	0.30	0.60	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYADML2	0.03	0.03	blup	10	0.03	1.1e-04	-6.8	-7.0	3.7e-12	0.83	0.02	0.90	FALSE
4	GTEx	Adipose Subcutaneous	LRRC45	0.23	0.06	lasso	3	0.05	1.0e-04	-6.4	6.9	4.7e-12	-0.77	0.61	0.28	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	NOTUM	0.06	0.02	enet	2	0.02	4.7e-03	-5.8	-6.9	6.3e-12	0.79	0.01	0.60	FALSE
7	GTEx	Artery Tibial	LRRC45	0.09	0.07	lasso	4	0.04	2.0e-04	-6.4	6.8	1.3e-11	-0.84	0.43	0.49	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRC45	0.02	0.03	blup	36	0.02	1.5e-03	-6.4	6.7	2.2e-11	-0.76	0.02	0.59	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MYADML2	0.52	0.43	enet	15	0.45	3.6e-60	-6.6	-6.6	3.9e-11	0.74	0.55	0.45	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC45	0.10	0.02	blup	35	0.04	8.0e-03	-4.7	6.5	5.6e-11	-0.70	0.01	0.42	FALSE
10	GTEx	Cells Transformed fibroblasts	LRRC45	0.08	0.08	enet	3	0.08	2.6e-06	-6.4	6.5	6.1e-11	-0.78	0.26	0.73	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	STRA13	0.05	0.03	lasso	3	0.02	1.8e-03	-6.4	6.4	1.8e-10	-0.76	0.08	0.46	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	DCXR	0.12	0.00	enet	13	0.00	2.3e-01	4.5	6.3	3.0e-10	-0.39	0.08	0.15	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC45	0.05	0.07	lasso	6	0.06	9.5e-08	-6.4	6.2	5.8e-10	-0.77	0.09	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LRRC45	0.09	0.10	enet	7	0.10	1.2e-11	-6.4	6.1	1.3e-09	-0.74	0.81	0.19	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	NPB	0.03	0.01	enet	3	0.01	1.1e-02	-6.3	5.9	3.9e-09	-0.74	0.00	0.69	FALSE
11	GTEx	Esophagus Muscularis	DCXR	0.18	0.08	lasso	5	0.05	9.2e-04	4.6	5.8	7.4e-09	-0.33	0.63	0.11	FALSE
18	GTEx	Thyroid	DCXR	0.35	0.20	lasso	5	0.30	5.1e-23	4.5	5.4	5.6e-08	-0.25	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	LRRC45	0.18	0.03	enet	12	0.10	9.0e-06	-6.3	5.2	1.7e-07	-0.77	0.61	0.30	FALSE
6	GTEx	Artery Aorta	DCXR	0.34	0.17	enet	25	0.21	1.4e-11	4.6	5.2	1.7e-07	-0.32	1.00	0.00	FALSE
13	GTEx	Nerve Tibial	DCXR	0.19	0.06	enet	20	0.10	1.4e-07	4.1	5.2	1.7e-07	-0.22	0.86	0.03	FALSE
8	GTEx	Artery Tibial	CCDC57	0.08	0.03	enet	7	0.05	5.8e-05	-3.3	5.2	1.8e-07	-0.36	0.41	0.45	FALSE
16	GTEx	Skin Sun Exposed Lower leg	RP11-1055B8.4	0.21	0.10	lasso	3	0.10	7.4e-09	5.4	-5.2	1.8e-07	0.09	0.00	1.00	FALSE
15	GTEx	Skin Sun Exposed Lower leg	DCXR	0.08	0.11	lasso	7	0.09	4.6e-08	4.5	5.2	2.2e-07	-0.23	1.00	0.00	FALSE