[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr17:60,821,100-63,531,331

Best TWAS P=1.06e-22 · Best GWAS P=5.39e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-9.1	9.8	1.1e-22	-0.98	0.00	1.00	TRUE
21	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	8.4	6.5	9.1e-11	-0.23	0.08	0.19	TRUE
11	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	8.2	-6.4	1.9e-10	0.21	0.13	0.13	TRUE
64	The Cancer Genome Atlas	Thyroid Carcinoma	PLEKHM1P	0.04	0.03	blup	7	0.05	1.2e-05	5.7	-6.2	5.7e-10	-0.02	0.00	0.99	TRUE
48	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	8.8	6.0	1.9e-09	-0.10	0.33	0.67	TRUE
10	GTEx	Brain Hippocampus	CYB561	0.33	0.24	enet	29	0.27	4.3e-07	-3.4	5.5	3.8e-08	-0.07	0.58	0.04	TRUE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-9.2	9.1	8.1e-20	-0.99	0.00	0.91	FALSE
41	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	8.8	-8.7	3.6e-18	0.37	0.25	0.73	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-8.7	8.6	9.6e-18	-0.70	0.03	0.45	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	8.5	-8.5	1.6e-17	0.33	0.16	0.25	FALSE
26	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	8.5	8.5	1.6e-17	-0.35	0.35	0.50	FALSE
31	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	8.5	8.5	1.6e-17	-0.35	0.36	0.64	FALSE
40	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	8.5	8.5	2.1e-17	-0.34	0.26	0.47	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-8.5	-8.5	2.5e-17	0.76	0.02	0.90	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	8.5	8.4	2.8e-17	-0.36	0.35	0.65	FALSE
13	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	8.5	8.4	2.9e-17	-0.36	0.39	0.59	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	8.4	-8.4	4.4e-17	0.36	0.23	0.32	FALSE
17	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	8.4	8.4	4.7e-17	-0.36	0.05	0.18	FALSE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	8.4	8.3	1.2e-16	-0.34	0.30	0.70	FALSE
29	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	8.3	8.3	1.2e-16	-0.36	0.36	0.62	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-9.2	-8.3	1.2e-16	0.74	0.02	0.96	FALSE
24	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-8.3	-8.3	1.4e-16	0.74	0.18	0.44	FALSE
25	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-8.6	-8.2	2.0e-16	0.74	0.26	0.52	FALSE
37	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	8.5	8.2	2.1e-16	-0.34	0.36	0.63	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-8.1	-8.1	4.4e-16	0.75	0.03	0.15	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	8.5	8.0	1.1e-15	-0.49	0.38	0.51	FALSE
47	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	7.8	-7.9	2.7e-15	0.42	0.86	0.14	FALSE
9	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	7.4	7.9	3.1e-15	-0.39	0.46	0.45	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	8.3	7.9	3.9e-15	-0.27	0.02	0.74	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-9.1	7.7	1.3e-14	-0.89	0.01	0.95	FALSE
33	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	8.5	7.7	1.3e-14	-0.27	0.12	0.28	FALSE
45	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	7.5	-7.7	1.3e-14	0.39	0.87	0.13	FALSE
16	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	7.8	7.6	2.1e-14	-0.29	0.07	0.10	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-8.1	-7.6	2.4e-14	0.68	0.30	0.69	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	8.8	7.5	4.5e-14	-0.26	0.00	1.00	FALSE
34	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	8.4	7.5	7.8e-14	-0.28	0.12	0.13	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-8.1	7.4	9.8e-14	-0.73	0.03	0.08	FALSE
23	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	5.3	7.3	2.8e-13	-0.29	0.22	0.28	FALSE
36	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	8.8	-7.2	4.6e-13	0.22	0.24	0.75	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	8.4	7.1	1.1e-12	-0.21	0.00	0.70	FALSE
22	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	8.5	-7.1	1.6e-12	0.19	0.35	0.63	FALSE
32	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	8.4	-6.9	3.9e-12	0.20	0.45	0.55	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	8.2	6.8	8.0e-12	-0.24	0.36	0.55	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	2.7	-6.6	3.7e-11	0.66	0.06	0.75	FALSE
8	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	8.5	-6.5	8.5e-11	0.13	0.32	0.68	FALSE
28	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	-1.7	6.5	1.1e-10	-0.28	0.06	0.26	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	2.1	6.5	1.1e-10	-0.70	0.09	0.16	FALSE
30	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-8.2	-6.4	1.6e-10	0.59	0.49	0.42	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	8.4	-6.4	1.8e-10	0.14	0.04	0.96	FALSE
14	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	8.3	6.3	2.1e-10	-0.13	0.13	0.21	FALSE
43	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-4.0	6.3	2.7e-10	-0.56	0.03	0.91	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	8.5	6.2	4.6e-10	-0.34	0.18	0.46	FALSE
44	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	7.5	-6.1	1.0e-09	0.42	0.50	0.50	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEKHM1P	0.08	0.03	enet	4	0.04	4.0e-05	5.7	-5.9	3.0e-09	-0.05	0.00	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLEKHM1P	0.24	0.26	lasso	6	0.27	8.0e-33	5.7	-5.8	7.4e-09	-0.02	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEKHM1P	0.02	0.02	blup	7	0.02	6.7e-03	5.0	-5.6	1.8e-08	-0.02	0.00	0.78	FALSE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	PLEKHM1P	0.08	0.04	blup	7	0.04	2.7e-02	5.6	-5.6	2.1e-08	-0.03	0.00	0.60	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	8.8	-5.6	2.7e-08	0.07	0.01	0.96	FALSE
38	GTEx	Skin Sun Exposed Lower leg	hsa-mir-6080	0.11	0.10	lasso	2	0.08	1.7e-07	5.1	-5.3	9.0e-08	-0.04	0.06	0.94	FALSE
39	GTEx	Spleen	FTSJ3	0.19	0.07	lasso	3	0.06	1.2e-02	7.8	5.3	1.4e-07	-0.03	0.32	0.18	FALSE
46	YFS	Blood	ICAM2	0.06	0.03	enet	21	0.04	1.3e-11	2.3	-5.2	2.2e-07	0.35	1.00	0.00	FALSE
27	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	8.4	5.2	2.3e-07	-0.04	0.36	0.33	FALSE
42	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-8.5	5.2	2.6e-07	-0.68	0.02	0.96	FALSE
20	GTEx	Cells Transformed fibroblasts	SMURF2	0.17	0.13	enet	8	0.13	3.7e-10	5.0	5.1	2.9e-07	0.03	0.07	0.93	FALSE