TWAS hub - GINS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0210	0.00014	0.020	0.035	0.031	0.034	0.026	0.0014	3.6e-05	0.0001	4.6e-05	0.0003
2	GTEx	Cells Transformed fibroblasts	0.0410	0.0230	0.00320	0.012	NA	0.004	NA	0.010	0.0400	NA	0.1500	NA	0.0520
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0342	0.0263	0.00330	0.007	0.015	0.017	NA	0.007	0.0460	6.5e-03	0.0043	NA	0.0540

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Forced expiratory volume in 1-second (FEV1), predicted percentage	14.2	29.9	33.0	-5.0	-5.7	-5.6
Forced expiratory volume in 1-second (FEV1), Best measure	7.1	22.8	28.4	-4.1	-5.3	-4.8
Forced expiratory volume in 1-second (FEV1)	6.9	23.4	27.7	-4.5	-5.3	-4.7
Body fat percentage	6.7	26.6	33.5	4.4	5.2	5.8
Trunk fat percentage	6.6	26.5	32.2	4.5	5.2	5.7
Lung FVC	6.4	32.4	39.8	-4.4	-6.2	-6.3
Leg fat percentage (right)	6.2	22.3	29.3	3.8	4.8	5.4
Age at First Birth	6.1	8.9	12.7	-3.6	-2.7	-2.6
Smoking Status	5.8	14.0	18.9	2.8	4.3	3.9
Leg fat percentage (left)	5.7	20.5	26.3	3.6	4.7	5.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.6	6.6	8.9	-2.3	-2.4	-3.0
Fasting Glucose	5.5	6.6	8.4	-2.9	-2.5	-2.3
Trunk fat mass	5.4	23.0	29.7	4.0	4.8	5.5
Number of live births	5.3	7.4	8.9	2.1	3.0	3.0
Peak expiratory flow (PEF)	5.1	11.8	15.8	-4.0	-3.4	-2.8
Whole body fat mass	5.1	21.3	28.5	3.7	4.7	5.3
Pack years adult smoking proportion	4.8	7.3	9.2	2.0	2.9	3.0
Leg fat mass (right)	4.7	18.2	25.3	3.3	4.3	5.0
Pack years of smoking	4.6	6.8	8.8	1.9	2.8	3.0
Arm fat percentage (right)	4.5	17.7	24.0	3.5	4.1	4.9
Diabetes (father)	4.3	5.3	7.4	-1.7	-2.7	-2.4
Leg fat mass (left)	4.3	16.6	22.8	3.1	4.2	4.8
Forced vital capacity (FVC), Best measure	4.2	15.5	19.2	-3.3	-4.4	-4.1
Wheeze or whistling in the chest in last year	4.2	7.5	9.9	1.8	3.1	3.0
Asthma (self-reported)	4.2	8.3	11.2	1.9	3.3	3.2
Other serious medical condition/disability diagnosed by doctor	4.1	5.3	5.8	-2.4	-2.4	-2.1
Chronic bronchitis/emphysema (father)	4.1	4.8	6.2	2.0	2.5	2.1
Forced vital capacity (FVC)	4.1	16.0	17.9	-4.0	-4.2	-3.8
Medication: Ventolin 100micrograms inhaler	4.1	5.2	8.0	1.7	2.8	2.2
Arm fat percentage (left)	4.1	16.2	22.4	3.3	3.9	4.7
Loneliness, isolation	4.1	5.6	9.3	1.0	2.6	3.0
Ever used hormone-replacement therapy (HRT)	3.9	5.0	6.6	2.6	2.3	1.8
Mouth/teeth dental problems: Dentures	3.9	6.6	7.0	2.6	2.5	2.5
Arm fat mass (right)	3.9	16.1	22.3	3.2	3.9	4.7
Asthma	3.8	7.4	9.7	1.8	3.1	3.0
Age at first live birth	3.8	6.7	7.4	-2.3	-2.7	-2.7
Arm fat mass (left)	3.8	15.6	22.1	3.1	3.9	4.7
Respiratory disease	3.7	8.2	10.9	1.8	3.3	3.2
Waist circumference	3.7	13.4	18.4	2.9	3.6	4.3
LDL Cholesterol	3.6	5.7	7.5	2.7	2.1	2.3
Chest pain or discomfort	3.6	5.2	7.7	1.0	2.6	2.8
Lung FEV1/FVC ratio	3.0	15.4	22.1	-2.5	-4.7	-4.2
Noisy workplace	3.0	3.7	6.6	-2.6	-1.7	-1.3
Weight	2.9	14.3	19.9	3.0	3.7	4.5
Comparative body size at age 10	2.9	7.9	10.6	1.7	3.2	3.3
Falls in the last year	2.8	3.7	5.9	-2.4	-1.6	-1.6
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	5.5	-1.9	-2.3	-2.1
Medication: Paracetamol	2.7	4.4	6.3	-1.4	-2.2	-2.5
Emphysema/chronic bronchitis	2.6	2.9	4.8	0.7	2.2	1.8
Commuting to job workplace: Walk	2.6	2.8	4.0	-2.0	-1.6	-1.4
Depressed Affect (Nagel 2018)	2.5	5.3	7.2	1.6	2.5	2.7
Mean Putamen Volume	2.5	2.9	3.1	-1.6	-1.8	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	4.4	2.1	1.9	1.5
Sitting height	2.5	17.5	20.4	3.9	4.1	4.5
Breast cancer (self-reported)	2.5	3.0	3.7	-1.9	-1.6	-1.7
BMI	2.4	14.0	18.8	3.1	3.7	4.3
Chronic bronchitis/emphysema (mother)	2.4	2.8	3.5	1.9	1.5	1.6
Smoking status: Current	2.4	3.8	4.8	2.2	1.9	1.8
Current tobacco smoking	2.3	3.8	5.1	2.3	1.8	1.7
Body mass index (BMI)	2.3	9.7	14.1	2.3	3.1	3.8
Breast Cancer	2.2	5.3	5.4	2.3	2.3	2.3
Exposure to tobacco smoke at home	2.2	2.5	3.3	1.1	1.8	1.7
Number of full sisters	2.2	2.6	4.7	0.5	2.2	1.7
Had major operations	2.2	2.6	3.2	-1.4	-1.6	-1.8
Unable to work because of sickness or disability	2.2	2.9	3.6	-1.5	-1.9	-1.6
Hayfever, allergic rhinitis or eczema	2.1	4.5	4.8	-2.0	-2.2	-2.1
Reaction Time	2.0	3.7	4.0	2.0	1.9	1.9
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	3.7	0.4	1.8	1.9
Mood swings	2.0	3.6	4.8	1.2	2.2	2.1
Medication: Aspirin	2.0	2.6	4.9	2.2	1.1	1.2
Alzheimer’s Disease (in father)	1.9	2.1	3.3	-1.8	-1.4	-1.0
Blood Platelet Count	1.9	21.9	41.0	6.4	3.7	3.3
Systolic Blood Pressure	1.9	9.6	11.5	-2.7	-3.4	-3.1
Vitamin and mineral supplements	1.9	2.6	3.7	1.9	1.4	1.4
Medication: Aspirin	1.9	2.6	5.1	2.3	1.2	1.1
Fractured/broken bones in last 5 years	1.9	2.5	5.6	-2.4	-1.1	-0.8
Prostate Cancer	1.8	2.6	4.3	-2.1	-1.3	-1.3
Blood Red Count	1.8	17.3	28.5	-0.9	-5.3	-4.8
Angina (self-reported)	1.8	2.4	3.5	0.9	1.7	1.9
Average weekly champagne plus white wine intake	1.8	2.4	3.3	-1.2	-1.8	-1.6
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.7	1.9	0.9	1.1
Maternal smoking around birth	1.7	2.4	2.9	1.3	1.7	1.6
Hip circumference	1.7	7.5	11.8	1.9	2.6	3.4
Mean time to correctly identify matches	1.7	3.2	3.4	1.8	1.8	1.7
Miserableness	1.7	2.9	3.4	1.5	1.8	1.8
Allergy or Eczema	1.6	4.3	5.1	-1.8	-2.3	-2.1
Mouth/teeth dental problems	1.6	2.4	3.1	-1.2	-1.8	-1.6
Glaucoma (self-reported)	1.6	1.9	2.6	-1.6	-1.2	-1.3
Medication: Blood pressure	1.6	2.8	3.7	-1.4	-1.6	-1.9
Long-standing illness, disability or infirmity	1.6	2.4	3.4	-1.8	-1.4	-1.4
Osteoarthritis (self-reported)	1.6	2.1	2.8	-1.0	-1.7	-1.6
Length of working week for main job	1.5	1.7	2.5	1.0	1.3	1.6
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.9	1.2	1.7	1.2
Headache pain in last month	1.5	2.6	3.6	-1.4	-1.9	-1.6
Qualifications: College or University degree	1.5	4.7	5.1	-2.1	-2.2	-2.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.1	-1.0	-1.5	-1.3
Ulcerative Colitis (UC)	1.3	2.4	2.8	-1.4	-1.7	-1.6
Blood White Count	1.3	9.9	11.2	2.8	3.3	3.2
Neuroticism	1.3	3.2	3.9	1.5	2.0	1.9
Angina	1.3	1.7	2.5	0.6	1.5	1.6
Past tobacco smoking	1.3	2.4	3.6	-0.5	-1.9	-1.8
Medication: Paracetamol	1.3	2.0	3.2	-0.5	-1.6	-1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.0	-1.4	-1.1	-1.2
Ulcerative Colitis	1.2	1.8	2.0	-1.1	-1.4	-1.4
Multivitamins +/- minerals	1.2	1.5	2.0	-1.4	-1.0	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	2.1	1.2	1.5	1.3
Neck or shoulder pain in last month	1.2	1.7	2.1	-1.4	-1.2	-1.2
Age at last live birth	1.2	1.7	2.1	-1.4	-1.4	-1.1
Qualifications: nursing, teaching	1.2	1.9	2.9	0.9	1.4	1.7
Guilty feelings	1.2	1.8	2.4	1.2	1.6	1.2
Hearing aid user	1.2	1.3	2.8	-1.7	-0.8	-0.6
Body Mass Index (BMI) (2010)	1.1	1.4	2.2	0.7	1.3	1.5
Medication: Levothyroxine sodium	1.1	1.9	3.2	-1.8	-1.1	-1.2
Leg predicted mass (left)	1.1	5.6	9.0	1.7	2.2	3.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	1.9	-1.3	-1.4	-0.8
Ever highly irritable/argumentative for 2 days	1.1	1.4	1.6	1.1	1.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.6	-0.7	-1.2	-1.3
Neuroticism (Nagel 2018)	1.0	2.3	2.7	1.6	1.5	1.4
Diabetes (mother)	1.0	1.3	1.9	-1.4	-1.1	-0.9
Leg fat-free mass (left)	1.0	5.5	8.8	1.7	2.2	3.0
Medication: Simvastatin	1.0	1.5	1.7	1.2	1.2	1.3
Lung cancer (father)	1.0	1.1	3.3	-1.8	-0.3	0.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	2.5	1.0	1.2	1.6
Number of full brothers	1.0	1.3	1.7	1.3	1.0	1.1
Eye problems/disorders: None of the above	1.0	1.2	1.6	-0.7	-1.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	0.3	1.0	1.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.0	-1.4	-1.0	-0.7
Commuting to job workplace: Public transport	1.0	1.2	1.9	-0.1	-1.4	-1.2
Myopia	1.0	1.5	2.4	0.0	-1.5	-1.4
Supplements: Calcium	1.0	1.1	1.3	-1.1	-1.1	-0.9
Rheumatoid Arthritis	0.9	1.3	1.6	1.3	1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	1.2	1.0	0.5
High blood pressure (mother)	0.9	1.3	1.9	-1.0	-1.4	-1.0
Father’s age at death	0.9	1.2	1.9	-1.4	-1.1	-0.7
Birth weight of first child	0.9	1.7	2.6	0.7	1.4	1.6
Smoking status: Previous	0.9	1.3	2.0	0.1	1.4	1.4
Wears glasses or contact lenses	0.9	1.0	1.3	-1.0	-1.1	-0.9
Age started oral contraceptive pill	0.9	1.2	2.0	-1.4	-0.9	-0.8
Depression (Nagel 2018)	0.8	1.2	2.3	1.5	0.9	0.7
Waist Hip Ratio (WHR)	0.8	3.5	4.1	1.6	2.0	2.0
Stomach or abdominal pain in last month	0.8	1.0	1.5	-0.5	-1.1	-1.2
Alcohol usually taken with meals	0.8	1.3	1.8	-1.2	-1.4	-0.8
Nervous feelings	0.8	1.6	2.4	-0.3	-1.5	-1.5
Happiness	0.8	1.0	2.0	-0.1	-0.9	-1.4
Breastfed as a baby	0.8	1.0	1.5	-0.8	-1.2	-0.9
Loud music exposure frequency	0.8	0.9	1.8	-0.3	-0.9	-1.3
Worry too long after embarrassment	0.8	1.3	2.1	0.5	1.4	1.3
Knee pain experienced in last month	0.8	1.2	1.7	0.4	1.3	1.3
Ever had bowel cancer screening	0.8	0.9	1.7	-1.3	-0.8	-0.7
Basal metabolic rate	0.8	4.3	6.9	1.4	2.0	2.6
Cholesterol lowering medication	0.8	1.2	1.7	0.9	1.1	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.8	0.7	1.7	1.4
Ovarian Cancer	0.7	0.9	1.3	1.2	0.8	0.8
Coronary Artery Disease (CAD)	0.7	0.8	1.5	0.4	1.2	0.9
Triglycerides	0.7	1.1	1.5	-1.0	-1.2	-0.9
Relative age of first facial hair	0.7	1.4	3.3	1.8	0.6	0.7
Severe depression (siblings)	0.7	0.8	1.1	0.8	1.0	0.9
Prospective memory result	0.7	0.9	1.3	-1.2	-0.9	-0.6
Exposure to tobacco smoke outside home	0.7	1.0	1.6	0.3	1.1	1.3
Shortness of breath walking on level ground	0.7	0.9	1.6	1.2	0.8	0.6
Illnesses of siblings: Diabetes	0.7	0.8	1.2	-0.5	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.2	0.5	1.4	1.5
Leg fat-free mass (right)	0.7	3.8	6.0	1.4	1.9	2.5
Medication: Gliclazide	0.7	0.8	1.3	-0.7	-0.7	-1.1
Leg predicted mass (right)	0.7	3.5	5.6	1.3	1.8	2.4
Medication: Blood pressure	0.7	1.4	1.5	-1.1	-1.2	-1.2
Medication: Lisinopril	0.7	1.0	1.7	-1.3	-0.6	-0.9
Arm fat-free mass (left)	0.7	3.5	5.5	1.2	1.9	2.3
Average weekly beer plus cider intake	0.7	1.1	1.9	-0.2	1.1	1.4
Arm predicted mass (left)	0.7	3.5	5.1	1.3	1.9	2.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	0.7	-0.8	-1.1
Crohns Disease (2017)	0.6	1.3	1.4	1.1	1.2	1.1
Neuroticism (2016)	0.6	0.9	1.6	-1.2	-0.5	-0.9
Height	0.6	11.6	11.7	3.4	3.4	3.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.6	-1.3	-0.9	-0.9
Hand grip strength (left)	0.6	1.5	2.8	-1.7	-1.0	-0.7
Number of treatments/medications taken	0.6	1.2	1.6	-0.9	-1.0	-1.3
Supplements: Zinc	0.6	0.7	1.5	-1.2	-0.6	-0.3
Townsend deprivation index at recruitment	0.6	0.8	1.4	0.7	0.8	1.2
High blood pressure	0.6	1.6	1.7	-1.2	-1.3	-1.2
Neuroticism score	0.6	1.2	1.5	0.9	1.2	1.1
Alcohol intake versus 10 years previously	0.6	1.0	1.6	-0.3	-1.1	-1.2
Depression (self-reported)	0.6	0.7	1.5	0.2	1.2	0.7
Pulse wave reflection index	0.6	0.8	2.3	-1.5	0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	-0.0	-0.9	-1.2
Number of children fathered	0.6	0.6	0.9	0.6	0.8	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-1.3	-0.7	-0.3
Ever smoked	0.6	1.0	1.6	0.4	1.3	1.1
Lupus	0.5	0.8	1.1	-0.9	-1.0	-0.8
Schizophrenia (2014)	0.5	1.2	2.0	0.6	-1.1	-1.4
Relative age voice broke	0.5	0.8	1.6	1.3	0.6	0.7
Qualifications: None of the above	0.5	1.2	1.9	0.9	1.4	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.2	0.1	-1.1	-1.1
Medication: Lansoprazole	0.5	0.6	0.6	-0.7	0.8	0.7
Health satisfaction	0.5	0.6	1.4	-1.2	-0.2	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.7	0.3	0.8	1.3
Leg pain on walking	0.5	0.6	1.5	-0.2	0.4	1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	0.9	-0.9	-0.5	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-1.1	-0.2	-0.7
Medication for cholesterol	0.5	0.7	0.9	0.8	0.8	1.0
Illnesses of father: High blood pressure	0.5	0.6	1.1	-0.6	-1.1	-0.6
Irritability	0.5	0.9	2.6	1.6	-0.1	-0.3
Commuting to job workplace: Cycle	0.5	0.6	1.0	-1.0	-0.7	-0.5
Schizophrenia (2018)	0.4	0.8	1.4	0.6	-0.8	-1.2
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	-0.8	0.6	0.5
Tanning	0.4	4.6	8.2	-0.8	2.9	2.2
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.4	-0.5	-1.0
Hand grip strength (right)	0.4	1.0	2.3	-1.5	-0.8	-0.2
Had other major operations	0.4	0.5	1.0	-1.0	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.4	-1.6	-0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-1.0	0.5	0.3
Diabetes (self-reported)	0.4	0.6	0.7	-0.8	-0.9	-0.7
Fluid intelligence score	0.4	0.8	1.1	0.8	1.0	0.8
Impedance of arm (right)	0.4	1.6	3.2	1.8	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.4	-1.0	-1.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	-1.0	-0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.2	0.9	0.6
Migraine (self-reported)	0.4	0.5	0.9	-0.2	-0.7	-1.0
Arm predicted mass (right)	0.4	2.1	3.6	0.7	1.5	1.9
Family relationship satisfaction	0.4	0.5	1.1	0.1	1.0	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.6	-0.7	-0.6	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	-0.7	-0.8	-0.7
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.0	0.7	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.8	-0.7	-0.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.6	-0.7	-0.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.6	-0.7	-0.7	-0.6
Alcohol drinker status: Never	0.4	0.5	0.7	0.9	0.4	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.3	-0.9	-0.7
Impedance of whole body	0.4	1.8	3.3	1.8	1.2	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	-1.1	0.1	0.3
Crohns Disease (2012)	0.3	0.5	0.9	0.2	0.8	0.9
Chronotype (morning person)	0.3	0.7	1.0	-0.2	-1.0	-1.0
Average weekly spirits intake	0.3	0.4	0.7	-0.1	0.9	0.7
Taking other prescription medications	0.3	0.5	1.2	-1.1	-0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	1.0	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.7	-1.3	-0.0	0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.3	-0.8	-0.7
Medication: Atenolol	0.3	0.3	0.5	-0.7	-0.4	-0.6
Had menopause	0.3	0.4	1.0	1.0	0.5	0.1
Heart attack	0.3	0.4	0.8	0.4	-0.9	-0.6
Pain all over the body in last month	0.3	0.3	0.7	0.8	0.5	0.0
Medication: Ramipril	0.3	0.4	0.5	-0.7	-0.7	-0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	-0.3	0.7	0.6
Standing height	0.3	3.1	3.5	1.9	1.6	1.8
Arm fat-free mass (right)	0.3	1.3	2.2	0.6	1.1	1.5
Heart disease (mother)	0.3	0.3	0.6	0.8	0.3	0.5
Suffer from ‘nerves’	0.3	0.5	1.5	1.2	0.3	-0.1
Overall health rating	0.3	0.6	0.8	-0.9	-0.6	-0.8
Hypertension (Self-reported)	0.3	0.9	1.0	-0.9	-1.0	-1.0
Whole body fat-free mass	0.3	1.9	3.5	0.7	1.3	1.9
Whole body water mass	0.3	1.8	3.2	0.8	1.2	1.8
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.0	0.6	0.8
Mother’s age at death	0.3	0.3	0.9	1.0	-0.2	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.7	1.3	0.2	0.1
Number of operations (self-reported)	0.3	0.5	1.1	-1.0	-0.5	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	0.8	0.9	0.9	0.9
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	0.6	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	0.9	-0.3	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	-1.1	-0.3	-0.8
Major Depression (MDD)	0.2	0.2	0.5	-0.7	0.4	0.1
Blood Eosinophil Count	0.2	1.5	3.3	1.8	0.8	0.6
Average weekly fortified wine intake	0.2	0.2	0.3	0.4	0.4	0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.9	-0.2	-0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	0.8	-0.1	-0.1
Pulse rate	0.2	0.3	0.6	0.2	-0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.6	-0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-1.1	-0.1	-0.3
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.6	0.2
Birth weight	0.2	0.4	1.0	1.0	-0.3	-0.1
Pulse wave peak to peak time	0.2	0.2	0.3	0.5	-0.5	-0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	0.6	0.4
Pulse rate, automated reading	0.2	0.7	1.1	0.6	-1.0	-0.8
Alcohol intake frequency.	0.2	0.5	0.5	0.7	-0.7	-0.7
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.7	-0.5	-0.5
Friendships satisfaction	0.2	0.3	0.5	0.5	0.7	0.3
Osteoporosis (self-reported)	0.2	0.2	0.6	0.8	0.1	-0.0
Ever depressed for a whole week	0.2	0.2	0.5	-0.2	0.7	0.2
Worry (Nagel 2018)	0.1	0.2	0.6	0.8	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.2	-0.2	-0.4	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	0.3	-0.2
HDL Cholesterol	0.1	0.2	0.5	0.0	0.7	0.4
Heel T-Score	0.1	0.8	2.3	-1.5	-0.2	0.5
Cardiovascular Disease	0.1	0.4	0.4	-0.6	-0.6	-0.6
Hypothyroidism (self reported)	0.1	0.1	0.2	-0.4	-0.4	-0.3
Hair Pigment	0.1	3.2	7.8	2.8	-1.1	-0.8
Sensitivity / hurt feelings	0.1	0.2	0.2	0.4	0.4	0.5
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.2	-0.9	-0.3
Medication: Co-codamol	0.1	0.1	0.3	-0.5	0.0	-0.2
Age when periods started (menarche)	0.1	0.3	0.9	0.9	-0.0	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.3	0.3	0.4
Supplements: Glucosamine	0.1	0.1	0.1	0.4	-0.4	-0.3
Impedance of leg (left)	0.1	0.4	0.6	0.8	0.7	-0.2
Number of incorrect matches in round	0.1	0.2	0.5	0.7	0.3	0.1
Financial difficulties in last 2 years	0.1	0.1	0.2	0.2	0.3	0.4
Illnesses of siblings	0.1	0.1	0.1	0.0	0.4	0.3
Trunk fat-free mass	0.1	0.7	1.5	0.2	0.7	1.2
Time employed in main current job	0.1	0.1	0.2	0.4	0.3	0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.7	0.3	0.2
Illnesses of mother	0.1	0.2	0.3	-0.5	0.5	0.1
Impedance of arm (left)	0.1	0.7	1.7	1.3	0.5	0.3
Trunk predicted mass	0.1	0.8	1.7	0.3	0.8	1.3
Tense / ‘highly strung’	0.1	0.2	0.4	0.6	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.4	-0.4	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.1	-0.4	-0.7
High blood pressure (siblings)	0.1	0.1	0.3	-0.6	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.5	0.0	0.4
Medication: Ibuprofen	0.1	0.1	0.2	-0.5	-0.1	-0.2
Medication: Omeprazole	0.1	0.1	0.2	0.4	0.5	0.2
Comparative height size at age 10	0.1	0.4	0.7	0.4	0.6	0.8
Illnesses of father: Heart disease	0.1	0.1	0.3	0.0	-0.6	-0.1
Mineral and other dietary supplements	0.1	0.1	0.1	0.3	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.4	0.2	-0.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.8	0.1	0.2
Financial situation satisfaction	0.1	0.1	0.4	0.2	0.6	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.1	-0.1
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.5	0.4	0.4
Medication: Atorvastatin	0.1	0.1	0.3	-0.2	-0.3	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.6	-0.3	-0.8	-0.0
Pain experienced in last month	0.1	0.2	0.3	0.6	0.5	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.3	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.0	-0.3	-0.6
Heart disease (siblings)	0.1	0.1	0.3	0.0	-0.5	-0.2
HbA1C	0.0	0.0	0.0	0.0	0.1	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.2	-0.1	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.2	0.0	-0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.4	-0.0	-0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.1	0.1	0.1
Medication: Metformin	0.0	0.0	0.1	0.2	-0.2	-0.1
Impedance of leg (right)	0.0	0.2	0.4	0.6	0.4	-0.1
Fed-up feelings	0.0	0.0	0.1	0.2	0.1	0.2
Allergy	0.0	0.0	0.1	0.3	-0.2	0.0
Worrier / anxious feelings	0.0	0.0	0.1	0.1	-0.2	-0.3
Medication: Cholesterol lowering	0.0	0.0	0.1	0.3	0.1	-0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.5	0.3	0.2
Gout (self-reported)	0.0	0.1	0.1	-0.2	0.3	0.1
Medication: Allopurinol	0.0	0.0	0.1	-0.2	0.2	0.0
Supplements: Vitamin C	0.0	0.1	0.1	-0.0	0.1	0.4
Average weekly red wine intake	0.0	0.1	0.2	-0.2	-0.0	0.4
Back pain experienced in last month	0.0	0.0	0.0	-0.1	0.1	0.0
Risk taking	0.0	0.1	0.1	0.3	0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	-0.2	0.3	0.0
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.2	-0.1	-0.2

Hub : Genes

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Trait associations