[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr3:157,125,828-159,106,064

Best TWAS P=4.07e-13 · Best GWAS P=2.49e-11 conditioned to 0.405

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RSRC1	0.15	0.17	lasso	4	0.18	9.7e-15	-6.2	6.4	1.7e-10	-0.59	0.07	0.93	FALSE
2	GTEx	Adipose Subcutaneous	RP11-538P18.2	0.15	0.15	lasso	7	0.18	9.4e-15	-6.3	6.6	3.7e-11	-0.72	0.07	0.93	FALSE
3	GTEx	Adipose Visceral Omentum	RSRC1	0.16	0.08	enet	12	0.09	2.5e-05	-5.5	6.2	5.7e-10	-0.89	0.03	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-538P18.2	0.23	0.10	enet	22	0.16	1.2e-08	-5.5	6.0	1.5e-09	-0.85	0.04	0.96	FALSE
5	GTEx	Artery Aorta	RSRC1	0.09	0.04	lasso	5	0.03	1.4e-02	-6.5	6.3	2.5e-10	-0.91	0.02	0.97	FALSE
6	GTEx	Artery Aorta	RP11-538P18.2	0.11	0.09	lasso	3	0.08	2.9e-05	-6.1	6.9	4.8e-12	-0.80	0.02	0.98	FALSE
7	GTEx	Artery Coronary	RP11-538P18.2	0.11	0.16	lasso	4	0.10	3.2e-04	-6.6	6.6	3.1e-11	-0.98	0.02	0.97	FALSE
8	GTEx	Artery Tibial	RSRC1	0.13	0.13	lasso	6	0.11	3.5e-09	-6.2	6.6	3.6e-11	-0.66	0.09	0.91	FALSE
9	GTEx	Artery Tibial	RP11-538P18.2	0.17	0.14	enet	24	0.21	3.7e-16	-6.2	6.7	1.9e-11	-0.82	0.13	0.87	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RP11-538P18.2	0.17	0.11	lasso	4	0.04	4.1e-02	-6.3	6.7	2.6e-11	-0.86	0.03	0.77	FALSE
11	GTEx	Brain Cerebellum	RP11-538P18.2	0.19	0.06	enet	18	0.10	8.0e-04	4.9	6.0	2.5e-09	-0.85	0.03	0.92	FALSE
12	GTEx	Breast Mammary Tissue	RSRC1	0.14	0.10	lasso	6	0.13	4.9e-07	-6.2	6.2	5.9e-10	-0.60	0.11	0.89	FALSE
13	GTEx	Breast Mammary Tissue	RP11-538P18.2	0.17	0.14	lasso	6	0.16	1.2e-08	-6.3	6.4	1.3e-10	-0.63	0.13	0.87	FALSE
14	GTEx	Breast Mammary Tissue (Male)	RSRC1	0.24	0.10	lasso	5	0.19	3.4e-05	-6.2	6.5	7.8e-11	-0.62	0.07	0.31	FALSE
15	GTEx	Breast Mammary Tissue (Male)	RP11-538P18.2	0.30	0.11	lasso	6	0.10	3.3e-03	-6.2	5.8	8.1e-09	-0.58	0.04	0.37	FALSE
16	GTEx	Breast Mammary Tissue (Female)	RP11-538P18.2	0.20	0.14	enet	13	0.17	9.4e-06	-5.6	5.9	3.1e-09	-0.59	0.33	0.53	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-538P18.2	0.10	0.08	enet	10	0.13	5.1e-10	-6.3	7.2	4.1e-13	-0.86	0.02	0.98	TRUE
18	GTEx	Colon Transverse	RP11-538P18.2	0.07	0.10	lasso	6	0.08	8.4e-05	-6.3	5.5	4.3e-08	-0.43	0.03	0.93	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RP11-538P18.2	0.21	0.12	lasso	4	0.12	3.5e-05	-5.2	6.1	9.8e-10	-0.79	0.06	0.90	FALSE
20	GTEx	Esophagus Mucosa	RP11-538P18.2	0.12	0.10	lasso	5	0.14	1.9e-09	-6.2	5.8	4.8e-09	-0.72	0.03	0.97	FALSE
21	GTEx	Esophagus Muscularis	RSRC1	0.06	0.09	lasso	3	0.10	1.7e-06	-6.6	-6.5	5.7e-11	0.98	0.01	0.98	FALSE
22	GTEx	Esophagus Muscularis	RP11-538P18.2	0.11	0.16	lasso	5	0.15	1.2e-09	-6.6	-6.4	1.9e-10	0.98	0.01	0.99	FALSE
23	GTEx	Heart Atrial Appendage	RP11-379F4.7	0.07	0.09	enet	11	0.01	1.4e-01	-6.7	-5.2	1.7e-07	0.97	0.02	0.95	FALSE
24	GTEx	Lung	RSRC1	0.09	0.05	enet	12	0.06	3.5e-05	-6.1	6.6	5.3e-11	-0.56	0.16	0.82	FALSE
25	GTEx	Lung	RP11-538P18.2	0.16	0.11	enet	17	0.17	6.6e-13	-5.9	6.9	5.2e-12	-0.74	0.26	0.74	FALSE
26	GTEx	Lung	RP11-379F4.7	0.05	0.01	lasso	3	0.01	1.2e-01	-5.6	-5.8	6.9e-09	0.85	0.07	0.63	FALSE
27	GTEx	Muscle Skeletal	RSRC1	0.11	0.06	lasso	2	0.04	1.5e-04	-6.2	6.2	4.6e-10	-0.59	0.09	0.86	FALSE
28	GTEx	Muscle Skeletal	RP11-538P18.2	0.09	0.08	lasso	2	0.05	1.3e-05	-6.2	6.7	2.2e-11	-0.70	0.08	0.92	FALSE
29	GTEx	Nerve Tibial	RSRC1	0.10	0.15	lasso	3	0.12	9.9e-09	-6.2	6.5	8.3e-11	-0.62	0.09	0.91	FALSE
30	GTEx	Nerve Tibial	RP11-538P18.2	0.21	0.18	enet	16	0.20	2.1e-14	-6.2	6.9	6.6e-12	-0.70	0.08	0.92	FALSE
31	GTEx	Ovary	RP11-538P18.2	0.23	0.08	lasso	6	0.13	4.5e-04	-6.3	7.0	2.4e-12	-0.83	0.06	0.41	FALSE
32	GTEx	Pancreas	RP11-538P18.2	0.14	0.02	lasso	11	0.02	5.3e-02	-5.9	6.8	7.8e-12	-0.89	0.10	0.56	FALSE
33	GTEx	Pituitary	RP11-538P18.2	0.17	0.03	lasso	8	0.03	6.9e-02	-6.3	5.5	3.7e-08	-0.37	0.04	0.66	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	RSRC1	0.07	0.09	lasso	2	0.06	3.7e-04	-6.2	6.2	7.5e-10	-0.64	0.12	0.70	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	RP11-538P18.2	0.09	0.10	enet	13	0.12	6.8e-07	-5.6	6.6	4.1e-11	-0.82	0.29	0.71	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RSRC1	0.09	0.09	lasso	2	0.08	4.4e-07	-6.2	6.4	1.3e-10	-0.59	0.08	0.91	FALSE
37	GTEx	Skin Sun Exposed Lower leg	RP11-538P18.2	0.13	0.12	enet	11	0.14	7.8e-12	-6.2	6.8	1.3e-11	-0.83	0.05	0.95	FALSE
38	GTEx	Stomach	RSRC1	0.08	0.06	lasso	3	0.07	2.9e-04	-6.5	7.0	2.9e-12	-0.91	0.02	0.97	FALSE
39	GTEx	Stomach	RP11-538P18.2	0.06	0.04	lasso	2	0.04	3.4e-03	-6.3	6.4	1.7e-10	-0.61	0.06	0.83	FALSE
40	GTEx	Thyroid	RSRC1	0.07	0.04	lasso	7	0.02	8.5e-03	-5.5	5.9	3.8e-09	-0.90	0.04	0.95	FALSE
41	GTEx	Thyroid	RP11-538P18.2	0.14	0.13	lasso	5	0.12	1.2e-09	-6.2	6.5	7.8e-11	-0.67	0.09	0.91	FALSE
42	GTEx	Vagina	RP11-538P18.2	0.25	0.19	lasso	3	0.18	6.7e-05	-6.2	6.6	3.8e-11	-0.86	0.03	0.78	FALSE
43	METSIM	Adipose	RSRC1	0.14	0.19	blup	532	0.21	6.0e-31	-6.3	6.0	2.0e-09	-0.63	0.07	0.93	FALSE
44	YFS	Blood	RSRC1	0.13	0.13	enet	26	0.17	8.8e-54	-6.2	6.1	1.1e-09	-0.53	0.09	0.91	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSRC1	0.04	0.03	enet	11	0.04	4.5e-09	-5.8	6.3	2.6e-10	-0.82	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSRC1	0.05	0.03	blup	154	0.01	7.9e-03	-5.2	6.7	2.6e-11	-0.76	0.12	0.54	FALSE