Best TWAS P=2.36e-20 · Best GWAS P=4.32e-25 conditioned to 0.000194
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FBXO38 | 0.05 | 0.01 | blup | 489 | 0.02 | 1.5e-03 | 7.0 | -7.8 | 9.2e-15 | -0.72 | 0.02 | 0.97 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | HTR4 | 0.06 | 0.03 | lasso | 4 | 0.03 | 4.3e-05 | 9.7 | 9.2 | 2.4e-20 | 0.79 | 0.01 | 0.98 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | FBXO38 | 0.18 | 0.05 | enet | 35 | 0.10 | 1.1e-07 | 7.0 | -5.9 | 3.6e-09 | -0.60 | 0.62 | 0.35 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | ABLIM3 | 0.32 | 0.34 | bslmm | 589 | 0.33 | 1.1e-43 | -5.3 | 5.4 | 7.7e-08 | -0.02 | 0.00 | 1.00 | TRUE |
5 | ROSMAP | Brain Pre-frontal Cortex | SPINK9 | 0.08 | 0.07 | enet | 21 | 0.07 | 1.4e-09 | 6.0 | 5.9 | 4.0e-09 | 0.48 | 1.00 | 0.00 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FBXO38 | 0.04 | 0.04 | blup | 52 | 0.04 | 4.8e-03 | 6.5 | -8.3 | 1.4e-16 | -0.75 | 0.05 | 0.14 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | FBXO38 | 0.05 | 0.02 | lasso | 2 | 0.02 | 4.3e-02 | 6.1 | -8.9 | 6.5e-19 | -0.77 | 0.04 | 0.30 | TRUE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FBXO38 | 0.02 | 0.03 | enet | 2 | 0.03 | 1.9e-04 | -7.3 | -8.1 | 5.1e-16 | -0.76 | 0.04 | 0.60 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FBXO38 | 0.03 | 0.01 | enet | 6 | 0.01 | 5.0e-02 | 7.4 | -6.3 | 2.3e-10 | -0.53 | 0.08 | 0.04 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FBXO38 | 0.11 | 0.02 | blup | 52 | 0.04 | 8.2e-06 | 7.1 | -5.8 | 6.2e-09 | -0.53 | 0.69 | 0.08 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | FBXO38 | 0.03 | 0.02 | blup | 51 | 0.02 | 7.7e-04 | 6.0 | -7.1 | 1.5e-12 | -0.63 | 0.54 | 0.08 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBXO38 | 0.05 | 0.01 | blup | 51 | 0.02 | 7.9e-03 | -2.0 | -6.7 | 1.6e-11 | -0.66 | 0.05 | 0.17 | FALSE |
13 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FBXO38 | 0.13 | 0.17 | enet | 16 | 0.15 | 2.3e-04 | 7.1 | -7.4 | 1.3e-13 | -0.65 | 0.12 | 0.31 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FBXO38 | 0.06 | 0.01 | enet | 7 | 0.01 | 3.2e-02 | -3.5 | -6.8 | 8.4e-12 | -0.59 | 0.04 | 0.26 | FALSE |