TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr6:25,035,920-26,689,223
Best TWAS P=7.82e-15 · Best GWAS P=6.88e-17 conditioned to 0.041
25M
25.2M
25.4M
25.6M
25.8M
26M
26.2M
26.4M
26.6M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Artery Tibial
U91328.21
0.09
0.01
lasso
8
0.01
0.03000
3.76
7.8
7.8e-15
-0.50
0.10
0.71
TRUE
3
GTEx
Skin Sun Exposed Lower leg
TRIM38
0.09
0.00
enet
21
0.02
0.00629
1.98
5.9
3.3e-09
-0.51
0.17
0.50
TRUE
1
GTEx
Artery Aorta
U91328.21
0.18
0.00
lasso
11
0.02
0.03530
-0.56
5.6
1.9e-08
-0.27
0.08
0.55
FALSE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LRRC16A
0.07
0.04
blup
288
0.03
0.00028
3.41
5.4
5.4e-08
-0.28
0.46
0.07
FALSE