[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr6:33,686,103-36,158,878

Best TWAS P=3.54e-27 · Best GWAS P=5.78e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPL10A	0.03	0.00	blup	54	0.02	6.0e-03	-9.4	-10.8	3.5e-27	0.01	0.01	0.74	TRUE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCP11	0.03	0.03	blup	49	0.04	6.6e-08	-8.4	-9.9	5.5e-23	0.01	0.02	0.98	TRUE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	RPL10A	0.02	0.02	lasso	2	0.02	3.8e-03	-9.5	-9.5	1.4e-21	-0.02	0.02	0.70	TRUE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TCP11	0.08	0.11	lasso	2	0.11	3.4e-05	-9.4	-9.5	2.0e-21	-0.02	0.01	0.95	TRUE
12	GTEx	Esophagus Mucosa	RPL10A	0.14	0.10	enet	17	0.09	2.1e-06	-9.2	-9.2	5.6e-20	-0.09	0.46	0.51	TRUE
32	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	5.1	7.6	3.5e-14	0.31	0.18	0.06	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	ZNF76	0.04	0.00	blup	424	0.02	2.1e-03	-7.6	7.2	5.7e-13	-0.08	0.45	0.18	TRUE
29	NTR	Blood	ZNF76	0.01	0.00	blup	424	0.00	3.8e-02	-8.0	10.6	3.0e-26	-0.08	0.06	0.73	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FANCE	0.03	0.02	bslmm	420	0.01	1.7e-02	-9.9	-10.4	1.9e-25	0.01	0.02	0.95	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TCP11	0.03	0.03	blup	49	0.03	3.5e-04	-9.6	-10.1	5.0e-24	-0.03	0.02	0.96	FALSE
11	GTEx	Colon Transverse	RPL10A	0.12	0.05	lasso	4	0.05	2.5e-03	-9.2	-9.9	2.7e-23	-0.04	0.08	0.72	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.6e-03	-9.4	-9.8	1.7e-22	-0.05	0.02	0.78	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.7e-03	-7.5	-9.7	4.2e-22	-0.03	0.05	0.87	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	RPL10A	0.05	0.07	enet	4	0.04	1.2e-04	-9.3	-9.6	6.9e-22	-0.05	0.06	0.92	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCP11	0.05	0.04	blup	49	0.06	1.3e-07	-9.6	-9.6	8.4e-22	-0.03	0.02	0.98	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	TEAD3	0.15	0.06	lasso	5	0.08	2.5e-05	-8.7	-9.5	1.8e-21	-0.09	0.55	0.30	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TCP11	0.05	0.07	lasso	2	0.07	1.9e-05	-9.4	-9.5	3.0e-21	-0.02	0.02	0.96	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL10A	0.07	0.07	lasso	2	0.06	9.9e-08	-9.2	-9.5	3.2e-21	-0.04	0.07	0.93	FALSE
5	GTEx	Artery Aorta	RPL10A	0.20	0.12	lasso	5	0.11	8.8e-07	-9.3	-9.4	3.5e-21	-0.05	0.32	0.66	FALSE
14	GTEx	Esophagus Muscularis	RPL10A	0.31	0.19	lasso	5	0.18	4.6e-11	-9.3	-9.3	1.1e-20	-0.03	0.63	0.37	FALSE
7	GTEx	Artery Tibial	RPL10A	0.11	0.08	lasso	2	0.09	1.5e-07	-9.2	-9.1	9.8e-20	-0.07	0.67	0.33	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TCP11	0.03	0.00	blup	49	0.01	8.8e-03	-9.6	-9.1	1.0e-19	0.02	0.01	0.87	FALSE
19	GTEx	Nerve Tibial	RPL10A	0.14	0.12	lasso	3	0.12	9.7e-09	-9.3	-8.9	3.9e-19	-0.03	0.64	0.36	FALSE
26	METSIM	Adipose	RPL10A	0.18	0.13	lasso	15	0.13	3.4e-19	-9.3	-8.8	1.5e-18	-0.03	0.64	0.36	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL10A	0.09	0.03	enet	19	0.07	1.1e-07	-9.3	-8.6	7.5e-18	-0.01	0.06	0.94	FALSE
15	GTEx	Lung	RPL10A	0.21	0.09	enet	53	0.09	1.2e-07	-9.3	-8.5	2.1e-17	-0.03	0.39	0.59	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TCP11	0.07	0.01	enet	8	0.01	8.2e-02	-9.4	-8.5	2.8e-17	-0.02	0.02	0.83	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCP11	0.03	0.03	lasso	3	0.04	3.8e-05	-8.4	-8.4	3.3e-17	0.04	0.02	0.92	FALSE
35	YFS	Blood	RPL10A	0.24	0.11	lasso	11	0.13	4.4e-39	-9.3	-8.3	8.1e-17	-0.02	0.64	0.36	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	-9.3	8.3	1.2e-16	-0.09	0.25	0.70	FALSE
4	GTEx	Adipose Subcutaneous	RPL10A	0.06	0.02	enet	27	0.03	2.6e-03	-8.1	-8.2	1.8e-16	-0.08	0.20	0.40	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	C6orf106	0.08	0.00	enet	15	0.05	2.5e-05	-5.2	8.1	5.4e-16	0.00	0.01	0.67	FALSE
24	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	-7.8	-8.0	1.3e-15	-0.11	0.78	0.12	FALSE
23	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	-7.2	7.9	2.3e-15	0.03	0.58	0.39	FALSE
16	GTEx	Muscle Skeletal	RPL10A	0.10	0.05	enet	17	0.04	3.9e-05	-9.2	-7.8	7.6e-15	-0.05	0.10	0.86	FALSE
36	YFS	Blood	ZNF76	0.05	0.08	lasso	4	0.07	6.7e-23	-7.6	7.6	3.4e-14	-0.08	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	TEAD3	0.36	0.29	enet	27	0.32	8.4e-25	4.3	-7.5	5.2e-14	-0.01	1.00	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	5.0	7.5	5.4e-14	0.06	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	DEF6	0.15	0.00	lasso	8	0.00	1.6e-01	-7.6	7.4	1.4e-13	0.00	0.17	0.07	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf81	0.05	0.00	blup	43	0.02	8.9e-04	5.5	-7.3	2.1e-13	0.02	0.02	0.38	FALSE
22	GTEx	Skin Sun Exposed Lower leg	C6orf106	0.09	0.04	enet	25	0.02	4.6e-03	-5.2	7.3	3.0e-13	0.08	0.38	0.02	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL10A	0.03	0.00	blup	55	0.01	1.4e-03	-9.3	-7.2	6.0e-13	-0.04	0.04	0.31	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF76	0.03	0.02	lasso	3	0.02	3.5e-03	-6.8	7.2	6.2e-13	-0.01	0.17	0.46	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	SCUBE3	0.03	0.01	blup	62	0.03	8.9e-04	-8.0	6.8	8.5e-12	-0.03	0.05	0.64	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF76	0.08	0.05	lasso	10	0.07	4.9e-04	-8.0	-6.8	1.4e-11	-0.01	0.03	0.61	FALSE
25	GTEx	Whole Blood	DEF6	0.14	0.05	lasso	4	0.03	9.9e-04	-7.4	6.6	4.0e-11	-0.07	0.84	0.04	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RPL10A	0.21	0.09	enet	30	0.11	2.6e-13	-9.2	-6.5	8.3e-11	-0.01	0.03	0.97	FALSE
18	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	4.6	6.4	1.3e-10	0.12	0.70	0.02	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	RPL10A	0.30	0.18	bslmm	409	0.19	2.6e-24	-9.2	-6.4	1.7e-10	0.09	0.58	0.42	FALSE
6	GTEx	Artery Tibial	C6orf106	0.07	0.02	lasso	4	0.02	8.8e-03	-5.8	6.2	7.8e-10	-0.07	0.10	0.05	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	DEF6	0.04	0.01	blup	50	0.03	6.2e-04	-7.7	5.9	4.0e-09	-0.13	0.06	0.68	FALSE
28	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	5.0	5.8	8.2e-09	0.09	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	5.0	5.6	2.5e-08	0.11	0.02	0.44	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	5.1	5.3	1.1e-07	-0.01	1.00	0.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	RPS10	0.21	0.08	lasso	3	0.06	8.6e-03	4.8	5.3	1.1e-07	0.40	0.12	0.06	FALSE
10	GTEx	Cells Transformed fibroblasts	RPS10	0.12	0.05	lasso	4	0.06	4.5e-05	5.1	5.3	1.3e-07	0.52	0.82	0.16	FALSE
20	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	2.4	5.2	1.5e-07	0.11	0.86	0.01	FALSE
13	GTEx	Esophagus Muscularis	TAF11	0.13	0.02	lasso	6	0.00	1.6e-01	-4.9	5.2	1.9e-07	-0.03	0.06	0.12	FALSE
27	METSIM	Adipose	ZNF76	0.11	0.07	blup	405	0.06	6.3e-10	-5.5	5.2	2.3e-07	-0.09	1.00	0.00	FALSE