Best TWAS P=3.54e-27 · Best GWAS P=5.78e-25 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C6orf106 | 0.29 | 0.21 | bslmm | 382 | 0.23 | 6.9e-28 | 5.1 | 5.3 | 1.1e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FANCE | 0.03 | 0.02 | bslmm | 420 | 0.01 | 1.7e-02 | -9.9 | -10.4 | 1.9e-25 | 0.01 | 0.02 | 0.95 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | RPL10A | 0.21 | 0.09 | enet | 30 | 0.11 | 2.6e-13 | -9.2 | -6.5 | 8.3e-11 | -0.01 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | RPL10A | 0.06 | 0.02 | enet | 27 | 0.03 | 2.6e-03 | -8.1 | -8.2 | 1.8e-16 | -0.08 | 0.20 | 0.40 | FALSE |
| 5 | GTEx | Artery Aorta | RPL10A | 0.20 | 0.12 | lasso | 5 | 0.11 | 8.8e-07 | -9.3 | -9.4 | 3.5e-21 | -0.05 | 0.32 | 0.66 | FALSE |
| 6 | GTEx | Artery Tibial | C6orf106 | 0.07 | 0.02 | lasso | 4 | 0.02 | 8.8e-03 | -5.8 | 6.2 | 7.8e-10 | -0.07 | 0.10 | 0.05 | FALSE |
| 7 | GTEx | Artery Tibial | RPL10A | 0.11 | 0.08 | lasso | 2 | 0.09 | 1.5e-07 | -9.2 | -9.1 | 9.8e-20 | -0.07 | 0.67 | 0.33 | FALSE |
| 8 | GTEx | Brain Frontal Cortex BA9 | RPS10 | 0.21 | 0.08 | lasso | 3 | 0.06 | 8.6e-03 | 4.8 | 5.3 | 1.1e-07 | 0.40 | 0.12 | 0.06 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | TEAD3 | 0.36 | 0.29 | enet | 27 | 0.32 | 8.4e-25 | 4.3 | -7.5 | 5.2e-14 | -0.01 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | RPS10 | 0.12 | 0.05 | lasso | 4 | 0.06 | 4.5e-05 | 5.1 | 5.3 | 1.3e-07 | 0.52 | 0.82 | 0.16 | FALSE |
| 11 | GTEx | Colon Transverse | RPL10A | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.5e-03 | -9.2 | -9.9 | 2.7e-23 | -0.04 | 0.08 | 0.72 | FALSE |
| 12 | GTEx | Esophagus Mucosa | RPL10A | 0.14 | 0.10 | enet | 17 | 0.09 | 2.1e-06 | -9.2 | -9.2 | 5.6e-20 | -0.09 | 0.46 | 0.51 | TRUE |
| 13 | GTEx | Esophagus Muscularis | TAF11 | 0.13 | 0.02 | lasso | 6 | 0.00 | 1.6e-01 | -4.9 | 5.2 | 1.9e-07 | -0.03 | 0.06 | 0.12 | FALSE |
| 14 | GTEx | Esophagus Muscularis | RPL10A | 0.31 | 0.19 | lasso | 5 | 0.18 | 4.6e-11 | -9.3 | -9.3 | 1.1e-20 | -0.03 | 0.63 | 0.37 | FALSE |
| 15 | GTEx | Lung | RPL10A | 0.21 | 0.09 | enet | 53 | 0.09 | 1.2e-07 | -9.3 | -8.5 | 2.1e-17 | -0.03 | 0.39 | 0.59 | FALSE |
| 16 | GTEx | Muscle Skeletal | RPL10A | 0.10 | 0.05 | enet | 17 | 0.04 | 3.9e-05 | -9.2 | -7.8 | 7.6e-15 | -0.05 | 0.10 | 0.86 | FALSE |
| 17 | GTEx | Nerve Tibial | DEF6 | 0.15 | 0.00 | lasso | 8 | 0.00 | 1.6e-01 | -7.6 | 7.4 | 1.4e-13 | 0.00 | 0.17 | 0.07 | FALSE |
| 18 | GTEx | Nerve Tibial | C6orf106 | 0.11 | 0.07 | enet | 17 | 0.07 | 1.3e-05 | 4.6 | 6.4 | 1.3e-10 | 0.12 | 0.70 | 0.02 | FALSE |
| 19 | GTEx | Nerve Tibial | RPL10A | 0.14 | 0.12 | lasso | 3 | 0.12 | 9.7e-09 | -9.3 | -8.9 | 3.9e-19 | -0.03 | 0.64 | 0.36 | FALSE |
| 20 | GTEx | Pancreas | C6orf106 | 0.14 | 0.11 | enet | 11 | 0.13 | 2.8e-06 | 2.4 | 5.2 | 1.5e-07 | 0.11 | 0.86 | 0.01 | FALSE |
| 21 | GTEx | Skin Not Sun Exposed Suprapubic | TEAD3 | 0.15 | 0.06 | lasso | 5 | 0.08 | 2.5e-05 | -8.7 | -9.5 | 1.8e-21 | -0.09 | 0.55 | 0.30 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | C6orf106 | 0.09 | 0.04 | enet | 25 | 0.02 | 4.6e-03 | -5.2 | 7.3 | 3.0e-13 | 0.08 | 0.38 | 0.02 | FALSE |
| 23 | GTEx | Testis | ZNF76 | 0.15 | 0.14 | enet | 8 | 0.12 | 4.4e-06 | -7.2 | 7.9 | 2.3e-15 | 0.03 | 0.58 | 0.39 | FALSE |
| 24 | GTEx | Thyroid | RPL10A | 0.16 | 0.09 | lasso | 11 | 0.07 | 8.9e-06 | -7.8 | -8.0 | 1.3e-15 | -0.11 | 0.78 | 0.12 | FALSE |
| 25 | GTEx | Whole Blood | DEF6 | 0.14 | 0.05 | lasso | 4 | 0.03 | 9.9e-04 | -7.4 | 6.6 | 4.0e-11 | -0.07 | 0.84 | 0.04 | FALSE |
| 26 | METSIM | Adipose | RPL10A | 0.18 | 0.13 | lasso | 15 | 0.13 | 3.4e-19 | -9.3 | -8.8 | 1.5e-18 | -0.03 | 0.64 | 0.36 | FALSE |
| 27 | METSIM | Adipose | ZNF76 | 0.11 | 0.07 | blup | 405 | 0.06 | 6.3e-10 | -5.5 | 5.2 | 2.3e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 28 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | 5.0 | 5.8 | 8.2e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 29 | NTR | Blood | ZNF76 | 0.01 | 0.00 | blup | 424 | 0.00 | 3.8e-02 | -8.0 | 10.6 | 3.0e-26 | -0.08 | 0.06 | 0.73 | FALSE |
| 30 | ROSMAP | Brain Pre-frontal Cortex | DEF6 | 0.04 | 0.02 | bslmm | 421 | 0.02 | 1.8e-03 | -9.3 | 8.3 | 1.2e-16 | -0.09 | 0.25 | 0.70 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | ZNF76 | 0.04 | 0.00 | blup | 424 | 0.02 | 2.1e-03 | -7.6 | 7.2 | 5.7e-13 | -0.08 | 0.45 | 0.18 | TRUE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | PACSIN1 | 0.09 | 0.00 | blup | 359 | 0.02 | 4.5e-04 | 5.1 | 7.6 | 3.5e-14 | 0.31 | 0.18 | 0.06 | TRUE |
| 33 | ROSMAP | Brain Pre-frontal Cortex | C6orf106 | 0.30 | 0.26 | bslmm | 372 | 0.33 | 9.3e-44 | 5.0 | 7.5 | 5.4e-14 | 0.06 | 1.00 | 0.00 | FALSE |
| 34 | ROSMAP | Brain Pre-frontal Cortex | RPL10A | 0.30 | 0.18 | bslmm | 409 | 0.19 | 2.6e-24 | -9.2 | -6.4 | 1.7e-10 | 0.09 | 0.58 | 0.42 | FALSE |
| 35 | YFS | Blood | RPL10A | 0.24 | 0.11 | lasso | 11 | 0.13 | 4.4e-39 | -9.3 | -8.3 | 8.1e-17 | -0.02 | 0.64 | 0.36 | FALSE |
| 36 | YFS | Blood | ZNF76 | 0.05 | 0.08 | lasso | 4 | 0.07 | 6.7e-23 | -7.6 | 7.6 | 3.4e-14 | -0.08 | 1.00 | 0.00 | FALSE |
| 37 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPL10A | 0.03 | 0.00 | blup | 54 | 0.02 | 6.0e-03 | -9.4 | -10.8 | 3.5e-27 | 0.01 | 0.01 | 0.74 | TRUE |
| 38 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL10A | 0.03 | 0.00 | blup | 55 | 0.01 | 1.4e-03 | -9.3 | -7.2 | 6.0e-13 | -0.04 | 0.04 | 0.31 | FALSE |
| 39 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.04 | 6.6e-08 | -8.4 | -9.9 | 5.5e-23 | 0.01 | 0.02 | 0.98 | TRUE |
| 40 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TCP11 | 0.07 | 0.01 | enet | 8 | 0.01 | 8.2e-02 | -9.4 | -8.5 | 2.8e-17 | -0.02 | 0.02 | 0.83 | FALSE |
| 41 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TCP11 | 0.03 | 0.00 | blup | 49 | 0.01 | 8.8e-03 | -9.6 | -9.1 | 1.0e-19 | 0.02 | 0.01 | 0.87 | FALSE |
| 42 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf106 | 0.04 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 5.0 | 5.6 | 2.5e-08 | 0.11 | 0.02 | 0.44 | FALSE |
| 43 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL10A | 0.07 | 0.07 | lasso | 2 | 0.06 | 9.9e-08 | -9.2 | -9.5 | 3.2e-21 | -0.04 | 0.07 | 0.93 | FALSE |
| 44 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.7e-03 | -7.5 | -9.7 | 4.2e-22 | -0.03 | 0.05 | 0.87 | FALSE |
| 45 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DEF6 | 0.04 | 0.01 | blup | 50 | 0.03 | 6.2e-04 | -7.7 | 5.9 | 4.0e-09 | -0.13 | 0.06 | 0.68 | FALSE |
| 46 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TCP11 | 0.05 | 0.04 | blup | 49 | 0.06 | 1.3e-07 | -9.6 | -9.6 | 8.4e-22 | -0.03 | 0.02 | 0.98 | FALSE |
| 47 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZNF76 | 0.08 | 0.05 | lasso | 10 | 0.07 | 4.9e-04 | -8.0 | -6.8 | 1.4e-11 | -0.01 | 0.03 | 0.61 | FALSE |
| 48 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf81 | 0.05 | 0.00 | blup | 43 | 0.02 | 8.9e-04 | 5.5 | -7.3 | 2.1e-13 | 0.02 | 0.02 | 0.38 | FALSE |
| 49 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL10A | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.8e-03 | -9.5 | -9.5 | 1.4e-21 | -0.02 | 0.02 | 0.70 | TRUE |
| 50 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.03 | 3.5e-04 | -9.6 | -10.1 | 5.0e-24 | -0.03 | 0.02 | 0.96 | FALSE |
| 51 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TCP11 | 0.05 | 0.07 | lasso | 2 | 0.07 | 1.9e-05 | -9.4 | -9.5 | 3.0e-21 | -0.02 | 0.02 | 0.96 | FALSE |
| 52 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TCP11 | 0.08 | 0.11 | lasso | 2 | 0.11 | 3.4e-05 | -9.4 | -9.5 | 2.0e-21 | -0.02 | 0.01 | 0.95 | TRUE |
| 53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL10A | 0.09 | 0.03 | enet | 19 | 0.07 | 1.1e-07 | -9.3 | -8.6 | 7.5e-18 | -0.01 | 0.06 | 0.94 | FALSE |
| 54 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TCP11 | 0.03 | 0.03 | lasso | 3 | 0.04 | 3.8e-05 | -8.4 | -8.4 | 3.3e-17 | 0.04 | 0.02 | 0.92 | FALSE |
| 55 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF76 | 0.03 | 0.02 | lasso | 3 | 0.02 | 3.5e-03 | -6.8 | 7.2 | 6.2e-13 | -0.01 | 0.17 | 0.46 | FALSE |
| 56 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf106 | 0.08 | 0.00 | enet | 15 | 0.05 | 2.5e-05 | -5.2 | 8.1 | 5.4e-16 | 0.00 | 0.01 | 0.67 | FALSE |
| 57 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL10A | 0.05 | 0.07 | enet | 4 | 0.04 | 1.2e-04 | -9.3 | -9.6 | 6.9e-22 | -0.05 | 0.06 | 0.92 | FALSE |
| 58 | The Cancer Genome Atlas | Thyroid Carcinoma | SCUBE3 | 0.03 | 0.01 | blup | 62 | 0.03 | 8.9e-04 | -8.0 | 6.8 | 8.5e-12 | -0.03 | 0.05 | 0.64 | FALSE |
| 59 | The Cancer Genome Atlas | Thyroid Carcinoma | TCP11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.6e-03 | -9.4 | -9.8 | 1.7e-22 | -0.05 | 0.02 | 0.78 | FALSE |