Best TWAS P=1.12e-10 · Best GWAS P=5.87e-14 conditioned to 0.000927
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CACFD1 | 0.10 | 0.03 | lasso | 4 | 0.03 | 1.7e-03 | 2.6 | -5.6 | 2.3e-08 | 0.69 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Testis | CACFD1 | 0.26 | 0.05 | enet | 25 | 0.10 | 5.3e-05 | -7.5 | -5.1 | 2.8e-07 | 0.70 | 0.00 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | -6.1 | -6.1 | 1.3e-09 | 0.35 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | -6.1 | -5.9 | 3.4e-09 | 0.35 | 0.01 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | -6.4 | -5.7 | 1.1e-08 | 0.36 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | -6.1 | -5.3 | 1.4e-07 | 0.36 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | -6.4 | -6.4 | 1.2e-10 | 0.37 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | -6.1 | -6.1 | 9.5e-10 | 0.35 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | -6.1 | -6.0 | 2.1e-09 | 0.35 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | -6.4 | -5.4 | 6.3e-08 | 0.32 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | -6.1 | -5.9 | 4.6e-09 | 0.35 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | -6.5 | -5.7 | 9.2e-09 | 0.45 | 0.00 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ABO | 0.32 | 0.18 | enet | 10 | 0.20 | 2.3e-12 | -6.1 | -5.4 | 7.5e-08 | 0.25 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ABO | 0.41 | 0.17 | enet | 12 | 0.25 | 3.0e-09 | 5.3 | -6.5 | 1.1e-10 | 0.27 | 0.05 | 0.94 | TRUE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | ABO | 0.44 | 0.57 | enet | 18 | 0.60 | 1.9e-73 | -6.1 | -5.6 | 2.7e-08 | 0.32 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ABO | 0.23 | 0.07 | blup | 44 | 0.12 | 4.3e-04 | -6.4 | -5.4 | 8.5e-08 | 0.35 | 0.00 | 0.78 | FALSE |