Best TWAS P=1.09e-08 · Best GWAS P=7.45e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | KCTD21-AS1 | 0.16 | 0.11 | lasso | 3 | 0.11 | 4.6e-09 | -5.0 | 5.2 | 1.5e-07 | 0.82 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adrenal Gland | KCTD21-AS1 | 0.39 | 0.16 | lasso | 8 | 0.24 | 4.4e-09 | -5.0 | 5.4 | 7.1e-08 | 0.89 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Muscle Skeletal | KCTD21-AS1 | 0.07 | 0.05 | lasso | 5 | 0.03 | 1.0e-03 | -5.1 | 5.2 | 2.6e-07 | 0.73 | 0.05 | 0.93 | FALSE |
| 4 | GTEx | Nerve Tibial | ALG8 | 0.09 | 0.01 | lasso | 5 | 0.01 | 3.4e-02 | -4.6 | -5.6 | 2.8e-08 | -0.79 | 0.07 | 0.63 | FALSE |
| 5 | GTEx | Pituitary | AAMDC | 0.15 | 0.07 | enet | 7 | 0.06 | 1.2e-02 | 4.2 | -5.2 | 2.2e-07 | -0.31 | 0.06 | 0.53 | FALSE |
| 6 | GTEx | Pituitary | KCTD21-AS1 | 0.34 | 0.16 | enet | 18 | 0.15 | 1.6e-04 | -4.4 | 5.5 | 3.4e-08 | 0.75 | 0.10 | 0.54 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-7I15.3 | 0.07 | 0.01 | lasso | 3 | 0.02 | 3.5e-02 | -4.0 | -5.5 | 3.4e-08 | -0.41 | 0.18 | 0.23 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | RSF1 | 0.06 | 0.00 | enet | 16 | 0.00 | 3.4e-01 | 4.7 | -5.4 | 5.3e-08 | -0.43 | 0.06 | 0.73 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | RP11-91P24.7 | 0.11 | 0.10 | lasso | 7 | 0.11 | 1.4e-09 | 5.0 | -5.3 | 9.2e-08 | -0.27 | 0.05 | 0.94 | TRUE |
| 10 | GTEx | Whole Blood | INTS4 | 0.05 | 0.03 | lasso | 4 | 0.01 | 4.5e-02 | 5.4 | 5.7 | 1.1e-08 | 0.95 | 0.02 | 0.90 | TRUE |
| 11 | METSIM | Adipose | ALG8 | 0.08 | 0.06 | enet | 13 | 0.08 | 1.5e-11 | 5.4 | -5.3 | 9.6e-08 | -0.92 | 0.02 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C11orf67 | 0.07 | 0.06 | enet | 8 | 0.07 | 1.3e-04 | 5.0 | -5.1 | 3.0e-07 | -0.17 | 0.01 | 0.86 | TRUE |