Hub : Genes

RSF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.041	0.021	2.6e-03	0.006	0.026	0.007	0.027	0.013	4.8e-02	0.00033	3.7e-02	0.00026	7.8e-03
2	GTEx	Cells Transformed fibroblasts	0.076	0.034	1.2e-03	0.039	NA	0.050	NA	0.022	6.4e-04	NA	1.1e-04	NA	8.6e-03
3	GTEx	Esophagus Muscularis	0.115	0.044	4.8e-05	0.117	NA	0.078	NA	0.105	1.4e-07	NA	1.7e-05	NA	6.6e-07
4	GTEx	Skin Sun Exposed Lower leg	0.061	0.027	2.6e-03	-0.001	NA	0.000	NA	-0.002	4.2e-01	NA	3.4e-01	NA	5.9e-01
5	GTEx	Thyroid	0.045	0.021	5.7e-03	0.024	NA	0.033	NA	0.028	5.9e-03	NA	1.5e-03	NA	3.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.1	0.1	0.1	0.5	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.7	-0.3	0.1	0.2	0.5	-0.8
Depressed Affect (Nagel 2018)	2.3	4.9	7.2	2.6	-1.4	-2.7	-1.2	-2.7
Depression (Nagel 2018)	0.3	0.5	0.9	0.8	0.2	-0.9	0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	0.0	1.1	0.6	0.8	0.2
Neuroticism (Nagel 2018)	0.4	1.0	1.9	1.4	-0.2	-1.3	-0.3	-1.2
Schizophrenia (2018)	0.1	0.3	0.9	-0.5	0.1	-0.2	-0.3	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.2	0.7	0.9	0.7	0.2
Worry (Nagel 2018)	0.1	0.2	0.4	-0.1	0.6	0.2	0.6	0.1
Alzheimer’s Disease (in mother)	2.1	2.5	5.6	-2.4	1.0	1.7	0.8	1.5
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.8	0.9	-0.0	0.9	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	2.7	-1.6	1.0	0.9	0.6	1.0
Crohns Disease (2017)	0.7	1.6	2.8	1.3	-0.8	-1.6	-0.7	-1.7
Irritable Bowel Disease (IBD)	1.6	3.8	6.1	1.9	-1.6	-2.5	-1.6	-2.0
Ulcerative Colitis (UC)	2.1	4.0	5.2	2.1	-2.0	-2.3	-1.7	-1.8
Major Depression (MDD)	0.2	0.2	0.5	-0.7	0.5	0.1	0.6	0.0
Reaction Time	0.2	0.3	0.7	0.4	-0.5	-0.8	-0.7	-0.0
Verbal and Numeric Reasoning (VNR)	1.1	2.6	5.3	-0.5	1.9	1.8	2.3	0.9
Breast Cancer	0.7	1.6	2.2	1.4	-1.5	-1.1	-1.2	-1.1
Ovarian Cancer	0.2	0.3	0.7	-0.8	0.0	0.3	0.0	0.8
Prostate Cancer	0.4	0.5	2.0	-0.2	-0.7	0.2	0.1	1.4
Age at First Birth	1.6	2.3	3.7	-1.9	1.4	1.6	1.2	1.4
Bipolar Disorder (2011)	1.5	1.4	2.1	-1.5	0.8	1.2	1.4	0.9
Body Mass Index (BMI) (2010)	0.9	1.3	2.4	-0.2	-1.6	-1.3	-1.4	-0.6
Coronary Artery Disease (CAD)	0.3	0.4	0.8	0.4	0.6	0.8	0.9	0.2
Crohns Disease (2012)	0.3	0.4	1.7	0.5	-0.2	-0.3	-0.3	-1.3
Mean Putamen Volume	0.6	0.6	1.2	-1.1	0.4	0.4	0.7	1.1
Fasting Glucose	1.1	1.3	2.0	1.4	-1.4	-0.9	-1.3	-0.4
HbA1C	0.7	0.8	3.7	-1.9	0.2	0.3	-0.3	0.5
HDL Cholesterol	1.5	2.6	5.4	1.2	-1.4	-1.4	-1.4	-2.3
LDL Cholesterol	1.2	1.9	5.0	-2.2	1.2	0.9	0.6	1.2
Lupus	3.4	5.2	7.8	-1.9	1.2	2.4	2.8	2.7
Neuroticism (2016)	1.2	1.7	2.9	-0.5	1.7	1.4	1.7	0.7
Primary Biliary Cirrhosis	1.2	1.7	1.9	-1.4	1.3	1.4	1.3	1.1
Rheumatoid Arthritis	3.6	4.9	6.9	2.2	-2.6	-1.8	-1.8	-2.6
Schizophrenia (2014)	0.1	0.2	0.5	-0.3	0.4	0.1	0.4	-0.7
Triglycerides	0.2	0.3	0.8	-0.6	-0.4	0.2	-0.4	0.9
Type 2 Diabetes (T2D) (2012)	2.4	2.8	3.4	1.9	-1.8	-1.5	-1.5	-1.7
Ulcerative Colitis	1.6	2.3	2.8	1.4	-1.6	-1.7	-1.4	-1.4
Blood Eosinophil Count	0.9	6.9	8.3	2.9	-2.6	-2.8	-2.3	-2.5
Blood Platelet Count	3.4	39.3	56.0	5.8	-5.5	-7.5	-4.9	-7.3
Blood Red Count	0.0	0.2	0.5	-0.3	0.4	0.4	0.7	0.2
Blood White Count	0.3	2.5	4.6	1.1	-1.4	-2.1	-1.7	-1.4
Heel T-Score	2.1	16.4	24.8	3.8	-3.3	-4.2	-3.8	-5.0
BMI	1.0	6.0	8.2	2.5	-2.4	-2.4	-2.9	-1.9
Height	1.9	35.8	49.8	-5.9	4.4	7.1	5.3	6.9
Waist Hip Ratio (WHR)	1.9	8.4	11.4	3.4	-3.0	-3.3	-2.6	-2.1
Systolic Blood Pressure	0.3	1.6	3.9	-0.3	-0.7	-1.1	-2.0	-1.6
Smoking Status	0.2	0.6	1.8	1.3	-0.6	-0.6	-0.4	-0.4
Allergy or Eczema	1.6	4.2	9.1	3.0	-0.5	-2.1	-0.3	-2.7
Cardiovascular Disease	2.2	7.2	9.5	2.4	-2.6	-3.0	-3.1	-2.2
Hypothyroidism (self reported)	0.8	1.9	6.1	2.5	-0.7	-1.3	-0.6	-0.9
Respiratory disease	2.0	4.4	5.5	2.3	-1.7	-2.3	-1.9	-2.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.6	1.2	-1.6	-1.9	-1.7	-1.4
Lung FEV1/FVC ratio	0.7	3.7	7.8	0.0	-2.2	-2.0	-2.8	-1.5
Lung FVC	0.5	2.5	3.0	-1.1	1.6	1.7	1.7	1.7
Neuroticism	0.0	0.1	0.2	-0.4	0.3	-0.3	0.5	-0.0
Chronotype (morning person)	0.2	0.4	0.9	0.4	0.7	0.5	0.9	0.2
Hair Pigment	0.5	15.4	35.6	-1.8	-3.5	-4.7	-6.0	-1.9
Tanning	0.1	1.1	2.2	-0.4	0.8	1.0	1.5	1.2
Hand grip strength (left)	1.3	3.4	6.3	-2.5	0.2	2.5	0.1	2.1
Number of treatments/medications taken	2.1	3.7	5.2	2.2	-1.9	-2.3	-1.7	-1.4
Average weekly spirits intake	0.2	0.3	0.7	0.9	-0.5	-0.4	-0.6	-0.2
Sensitivity / hurt feelings	0.4	0.7	2.1	-1.4	0.2	0.6	-0.0	1.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	1.3	-0.1	-1.1	-0.1	-1.2
Hearing difficulty/problems: Yes	3.8	5.8	9.4	-1.9	3.1	2.4	2.8	1.5
Relative age of first facial hair	2.7	5.5	7.3	-1.5	2.4	2.7	2.6	2.4
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	7.0	2.6	-1.9	-2.1	-1.5	-2.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.3	0.1	0.3	0.4	0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.2	0.1
Systolic blood pressure, automated reading	0.7	2.0	3.1	1.0	-0.8	-1.5	-1.7	-1.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.5	1.1	-1.1	-1.6	-1.1	-1.3
Angina	1.1	1.5	2.1	-0.9	1.1	1.3	1.5	1.3
Medication for hormone replacement therapy	0.7	0.8	2.5	1.6	-0.0	-0.7	-0.2	-0.9
Vitamin and mineral supplements	0.1	0.1	0.4	-0.0	0.6	0.3	0.2	-0.0
Supplements: Zinc	0.7	0.7	1.5	-1.2	0.3	1.0	0.9	0.6
Medication: Co-codamol	1.3	1.5	2.2	1.5	-0.7	-1.3	-1.0	-1.4
Medication: Metformin	1.2	1.7	3.1	1.2	-0.8	-1.4	-1.1	-1.8
Diabetes (father)	0.4	0.4	1.0	-0.9	-0.2	-0.3	-1.0	0.4
Diabetes (mother)	1.3	1.7	2.9	1.7	-0.8	-1.4	-0.6	-1.6
Severe depression (siblings)	0.4	0.5	1.3	1.2	-0.8	-0.5	-0.2	-0.4
Pack years adult smoking proportion	3.8	5.8	7.6	2.4	-2.7	-2.8	-2.5	-1.4
Impedance of leg (right)	0.3	1.2	1.8	-1.1	1.3	1.1	1.3	0.4
Leg fat-free mass (left)	0.1	0.4	1.0	-0.4	-0.3	0.9	-0.3	1.0
Trunk fat percentage	0.2	0.9	3.4	1.9	-0.3	-0.2	-0.0	-0.9
Hand grip strength (right)	1.8	4.9	10.2	-3.2	0.3	2.9	0.4	2.4
Townsend deprivation index at recruitment	3.5	4.9	8.7	3.0	-1.2	-2.3	-0.7	-2.9
Current tobacco smoking	0.8	1.3	2.0	1.3	-1.1	-1.4	-1.3	-0.4
Average weekly fortified wine intake	0.1	0.2	0.3	-0.4	0.5	0.3	0.3	0.4
Maternal smoking around birth	0.7	1.0	3.3	1.8	0.1	-0.7	0.5	-1.0
Fed-up feelings	4.7	8.5	11.6	3.4	-2.5	-3.2	-2.2	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	3.7	1.7	-1.4	-1.9	-1.5	-1.9
Relative age voice broke	3.0	4.6	6.8	-1.5	1.9	2.6	1.9	2.6
Taking other prescription medications	1.0	1.5	2.3	1.5	-1.5	-1.4	-0.8	-0.4
Age when periods started (menarche)	0.2	0.5	0.9	-0.9	-0.4	0.9	0.3	0.8
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	3.2	1.5	-1.1	-1.8	-1.6	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.3	-0.2	-0.3	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.3	-0.0	0.0	0.2	-0.2
Qualifications: CSEs or equivalent	2.5	3.2	4.9	-2.0	1.2	2.2	1.0	2.2
Serious illness, injury or assault to yourself	0.7	0.8	1.1	1.0	-0.6	-1.0	-0.6	-1.0
High blood pressure	2.0	5.5	8.4	2.5	-2.1	-2.9	-2.2	-1.8
Hayfever, allergic rhinitis or eczema	1.6	3.4	6.6	2.1	-0.7	-2.1	-1.0	-2.6
Multivitamins +/- minerals	0.3	0.4	1.2	-0.0	-1.1	-0.6	-0.6	-0.2
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.5	-0.9	-0.7	-0.3	0.1
Supplements: Glucosamine	1.5	2.0	4.1	-1.2	0.8	1.5	1.3	2.0
Diverticular disease/diverticulitis (self-reported)	7.0	8.3	10.4	-2.7	3.1	3.2	3.2	2.2
Medication: Atenolol	0.6	0.7	1.7	0.4	-1.3	-1.0	-0.7	-0.5
Medication: Levothyroxine sodium	1.5	2.5	8.1	2.8	-0.2	-1.5	-0.1	-1.5
Sitting height	0.1	0.6	2.1	-0.2	-0.3	1.4	0.5	0.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	0.4	-0.8	0.3	0.1	-0.1
High blood pressure (mother)	2.0	2.9	4.5	1.1	-2.0	-2.1	-1.4	-1.6
Body mass index (BMI)	1.0	4.3	6.7	2.6	-2.0	-2.0	-2.0	-1.7
Impedance of leg (left)	0.3	1.7	2.6	-1.1	1.4	1.5	1.6	0.6
Leg predicted mass (left)	0.1	0.4	1.0	-0.4	-0.4	0.9	-0.3	1.0
Trunk fat mass	0.1	0.5	1.7	1.3	-0.6	0.1	-0.3	-0.4
Waist circumference	0.9	3.3	8.0	2.8	-1.9	-1.4	-1.2	-1.3
Number of incorrect matches in round	0.1	0.2	0.7	-0.8	-0.5	0.3	-0.3	0.1
Past tobacco smoking	0.2	0.4	0.8	-0.8	0.5	0.6	0.2	0.9
Alcohol usually taken with meals	2.2	3.5	9.0	-3.0	0.8	1.9	0.1	2.0
Nervous feelings	0.2	0.4	0.9	1.0	-0.3	-0.3	-0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.6	1.6	-0.3	-1.0	-0.1	-1.9
Hearing difficulty/problems with background noise	2.5	4.0	7.8	-1.2	2.8	2.2	2.4	0.6
Hair/balding pattern: Pattern 2	0.9	1.1	1.9	1.4	-1.0	-0.9	-0.6	-1.2
Had menopause	0.3	0.4	1.1	0.3	1.1	0.1	0.4	0.8
Had other major operations	0.3	0.4	1.0	1.0	0.1	-0.6	0.4	-0.5
Forced vital capacity (FVC)	3.8	14.5	21.1	-4.3	3.0	4.6	2.9	4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	-0.1	0.2	-0.4	-0.5
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	3.4	1.8	-0.9	-1.7	-1.4	-1.7
Qualifications: None of the above	0.8	1.8	2.5	1.2	-1.5	-1.6	-1.2	-1.1
Financial difficulties in last 2 years	0.7	0.9	2.0	-0.3	1.4	0.8	0.8	1.1
Mouth/teeth dental problems	0.6	0.9	1.5	-1.2	0.0	1.1	0.6	1.2
Heart attack	0.3	0.4	0.6	-0.2	0.7	0.6	0.7	0.7
Allergy	3.8	8.8	14.7	-3.3	1.8	3.2	2.0	3.8
Pain all over the body in last month	0.3	0.3	0.8	0.9	-0.2	-0.2	-0.1	-0.9
Diabetes (self-reported)	2.2	3.4	5.6	1.7	-1.5	-2.0	-1.4	-2.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	0.7	-0.8	-1.2	-1.0	-0.9
Medication: Ramipril	0.7	0.8	1.6	0.3	-0.7	-1.2	-1.1	-0.9
Medication: Simvastatin	0.1	0.1	0.2	0.5	0.2	0.1	0.0	-0.4
Fluid intelligence score	2.8	5.9	7.7	-1.8	2.7	2.7	2.8	1.9
Illnesses of siblings	2.8	3.9	9.4	-3.1	0.9	1.8	0.6	2.4
Neuroticism score	0.3	0.7	1.0	0.6	-0.9	-1.0	-0.6	-0.9
Weight	0.1	0.3	0.5	0.7	-0.7	0.4	-0.4	0.3
Impedance of arm (right)	1.9	9.0	17.6	-1.2	3.5	3.2	4.2	1.8
Arm fat percentage (right)	0.7	2.8	7.0	2.6	-1.2	-1.2	-0.9	-1.7
Trunk fat-free mass	0.3	1.5	2.3	-1.3	-1.1	1.0	-1.1	1.5
Hip circumference	0.1	0.4	1.5	1.2	-0.6	0.1	-0.3	-0.5
Time employed in main current job	3.3	3.8	8.6	2.9	-1.2	-2.1	-1.2	-1.9
Alcohol intake versus 10 years previously	2.7	4.1	7.7	2.8	-1.3	-2.1	-1.2	-2.3
Father’s age at death	1.5	2.0	4.6	-2.1	-0.1	1.2	0.7	1.9
Worrier / anxious feelings	0.1	0.2	0.5	0.7	-0.5	-0.4	-0.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	7.3	1.8	-1.3	-1.9	-1.3	-2.7
Falls in the last year	0.1	0.2	0.5	0.2	0.7	-0.4	0.3	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.3	0.3	0.2	0.5	0.3
Number of live births	1.2	1.7	2.5	1.5	-1.1	-1.6	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1)	3.6	12.1	19.4	-4.4	2.7	4.1	2.2	3.5
Pulse rate	1.5	2.6	4.8	1.8	-0.9	-1.6	-1.3	-2.2
Happiness	0.3	0.4	0.9	0.2	1.0	0.6	0.8	0.0
Noisy workplace	0.4	0.5	1.2	1.1	-0.5	-0.7	-0.4	-0.8
Qualifications: A levels/AS levels or equivalent	3.0	6.7	11.0	-3.3	1.9	2.9	2.0	2.5
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	4.8	1.1	-1.3	-1.9	-1.4	-2.2
Mouth/teeth dental problems: Dentures	1.3	2.2	3.2	1.1	-1.0	-1.8	-1.6	-1.8
Asthma	2.6	5.2	6.8	2.5	-2.1	-2.3	-1.8	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	0.2	-0.1	-0.4	-0.3
Medication: Cholesterol lowering	0.2	0.4	0.6	0.8	-0.6	-0.3	-0.6	-0.7
Depression (self-reported)	0.1	0.1	0.3	-0.1	-0.2	0.5	0.5	0.1
Medication: Lansoprazole	1.4	1.6	2.4	0.0	-1.4	-1.3	-1.4	-1.5
Prospective memory result	2.8	3.5	4.9	1.4	-2.0	-2.2	-2.1	-1.6
Lung cancer (father)	0.6	0.7	1.2	-0.3	-0.5	-1.1	-1.1	-0.8
Illnesses of mother	1.1	1.3	2.2	-0.3	1.4	1.5	1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	14.5	-3.8	2.3	3.5	1.7	3.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	0.0	1.4	0.5	1.1	0.3
Impedance of arm (left)	1.8	8.4	15.3	-1.4	3.4	3.1	3.9	1.8
Arm fat mass (right)	0.5	1.9	4.0	2.0	-1.5	-0.9	-1.3	-1.1
Trunk predicted mass	0.3	1.4	2.0	-1.2	-1.2	0.9	-1.2	1.4
Standing height	1.6	15.4	25.6	-4.2	2.4	5.1	3.0	4.4
Length of working week for main job	0.1	0.2	0.7	0.8	0.2	0.2	0.2	0.0
Exposure to tobacco smoke at home	1.6	1.8	3.5	1.9	-0.9	-1.5	-1.0	-1.2
Breastfed as a baby	1.3	1.6	4.0	-1.1	-1.3	-0.7	-2.0	0.7
Tense / ‘highly strung’	0.2	0.4	0.8	0.9	0.5	0.0	0.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	-1.2	0.6	0.6	-0.1	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	-0.3	0.4	0.6	1.0	0.6
Birth weight of first child	4.8	8.7	9.6	-3.0	2.7	3.1	2.9	3.0
Peak expiratory flow (PEF)	1.7	3.9	6.4	-2.5	1.1	2.5	0.9	2.1
Pulse wave reflection index	0.2	0.3	1.1	0.0	1.1	-0.4	0.3	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.1	0.4	0.1	0.3	-0.5
Loud music exposure frequency	3.4	3.7	5.0	-1.9	2.2	2.2	1.7	1.5
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	10.3	-3.2	0.7	1.9	1.1	1.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.8	-0.3	-0.9	-0.8	-0.7
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.3	1.2	0.0	0.8	-0.4
Medication: Paracetamol	1.1	1.8	3.3	1.1	-0.9	-1.8	-1.2	-1.5
Headache pain in last month	2.1	3.6	6.0	2.1	-1.6	-2.4	-1.5	-1.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.5	-1.6	0.7	1.2	0.7	1.4
Glaucoma (self-reported)	1.7	2.0	4.0	-1.3	2.0	1.5	1.0	1.1
Gout (self-reported)	0.3	0.5	1.3	1.1	-0.4	-0.6	-0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	6.6	2.6	-0.4	-1.2	0.0	-1.1
Medication: Amlodipine	0.1	0.1	0.4	-0.2	0.6	0.1	0.1	-0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.4	0.7	-1.1	-1.4	-1.5	-1.5
Birth weight	2.2	4.7	7.5	-2.3	1.1	2.7	1.6	2.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.3	1.1	-1.2	-1.5	-0.7	-0.9
High blood pressure (siblings)	1.7	2.5	4.4	2.0	-0.9	-1.5	-0.9	-2.1
Forced vital capacity (FVC), Best measure	3.3	12.1	17.4	-3.9	2.8	4.2	2.6	3.7
Body fat percentage	0.4	1.7	5.4	2.3	-0.8	-0.7	-0.5	-1.4
Leg fat percentage (right)	0.8	3.0	6.1	2.5	-1.4	-1.6	-1.2	-1.8
Arm fat-free mass (right)	0.2	1.1	2.8	-0.3	-1.5	0.0	-1.7	0.5
Exposure to tobacco smoke outside home	0.8	1.0	2.7	1.6	-0.4	-1.2	-0.2	-0.9
Comparative body size at age 10	0.8	2.1	4.6	-1.7	-1.3	-0.1	-2.1	1.1
Number of full brothers	1.3	1.7	2.6	-1.0	0.3	1.6	1.6	1.4
Worry too long after embarrassment	0.4	0.7	1.0	-0.9	0.8	1.0	0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.2	0.3	0.4	0.1	0.2
Wheeze or whistling in the chest in last year	6.2	11.1	13.1	3.3	-3.3	-3.6	-3.1	-3.3
Number of children fathered	0.6	0.7	1.9	-1.4	-0.1	0.2	-0.0	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	1.9	-0.9	1.4	1.2	1.4	1.1
Age at first live birth	4.3	7.6	9.8	-2.5	2.8	3.1	3.0	2.3
Pulse wave peak to peak time	0.4	0.4	1.5	-0.3	-1.2	-0.0	-0.8	0.0
Health satisfaction	1.0	1.2	2.1	1.3	1.4	0.2	1.2	-1.0
Shortness of breath walking on level ground	0.4	0.4	0.9	0.9	0.4	-0.7	0.2	-0.7
Qualifications: College or University degree	3.0	9.5	13.6	-2.5	3.7	3.1	3.7	2.1
Eye problems/disorders: None of the above	0.4	0.5	0.8	-0.5	0.5	0.8	0.7	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	1.3	-0.7	-0.6	-0.3	-0.7
Emphysema/chronic bronchitis	2.7	3.1	4.1	1.9	-1.3	-1.8	-1.7	-2.0
Medication for pain relief, constipation, heartburn	3.5	5.9	7.7	-1.8	2.5	2.8	2.5	2.5
Neck or shoulder pain in last month	0.5	0.7	2.0	1.4	-0.5	-1.0	-0.1	-0.5
Medication: Blood pressure	1.0	1.7	2.2	1.3	-1.4	-1.5	-1.1	-1.1
Angina (self-reported)	0.8	1.0	1.4	-0.9	0.8	1.0	1.2	1.1
Migraine (self-reported)	0.3	0.3	0.8	-0.5	0.3	0.4	0.4	0.9
Medication: Ibuprofen	0.2	0.2	0.5	-0.6	0.7	0.5	0.3	-0.0
Medication: Allopurinol	0.5	0.7	1.4	1.2	-0.7	-0.9	-0.6	-0.7
Medication: Omeprazole	0.5	0.6	1.2	0.2	-0.6	-1.1	-0.7	-0.8
Medication: Seretide 50 evohaler	0.5	0.6	1.4	1.1	0.4	-0.3	-0.2	-1.2
Mean time to correctly identify matches	0.0	0.1	0.2	0.4	-0.0	-0.4	-0.2	0.3
Heart disease (mother)	0.2	0.3	1.0	-1.0	0.3	0.2	0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.3	5.1	6.1	-2.5	2.1	2.4	2.2	2.2
Whole body fat mass	0.3	1.1	3.0	1.7	-1.1	-0.3	-0.7	-0.8
Leg fat mass (right)	0.6	2.3	4.0	2.0	-1.5	-1.2	-1.5	-1.2
Arm predicted mass (right)	0.2	1.0	2.2	-0.5	-1.4	0.2	-1.5	0.7
Pulse rate, automated reading	2.9	9.5	16.3	4.0	-2.5	-2.9	-1.7	-3.7
Alcohol intake frequency.	2.6	6.1	7.1	2.7	-2.2	-2.5	-2.4	-2.6
Comparative height size at age 10	0.0	0.2	0.5	0.1	-0.3	-0.0	-0.7	-0.7
Number of full sisters	1.8	2.2	3.7	1.9	-1.1	-1.6	-0.8	-1.7
Suffer from ‘nerves’	0.2	0.3	0.5	-0.5	0.7	0.5	0.7	0.2
Overall health rating	4.8	10.4	19.2	4.4	-2.0	-3.5	-2.1	-3.5
Chest pain or discomfort	3.2	4.5	6.4	2.5	-1.6	-2.5	-1.3	-2.4
Had major operations	0.3	0.3	0.8	0.6	0.1	0.0	0.9	-0.7
Age at last live birth	3.2	4.6	6.1	-1.6	2.4	2.2	2.5	1.9
Family relationship satisfaction	0.7	0.9	2.0	1.4	-0.7	-0.7	-0.4	-1.1
Leg pain on walking	0.3	0.4	1.2	0.3	1.1	-0.0	0.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	-0.7	-0.5	-0.4	-1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	0.3	0.2	0.0	0.8	-0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.3	-0.5	0.8	1.1	1.1	0.6
Medication: Aspirin	0.4	0.5	1.0	0.6	-1.0	-0.5	-0.8	-0.3
Supplements: Vitamin C	0.1	0.1	0.2	0.2	-0.2	-0.1	0.1	-0.4
Knee pain experienced in last month	0.1	0.2	0.6	-0.2	0.8	0.0	-0.1	0.6
Hypertension (Self-reported)	1.7	4.6	7.3	2.1	-1.9	-2.7	-2.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	5.9	1.0	-2.0	-2.0	-2.4	-1.3
Illnesses of father: Heart disease	1.6	2.2	4.0	-0.8	2.0	1.4	1.7	1.2
Illnesses of siblings: Diabetes	3.9	4.8	5.8	2.4	-1.9	-2.3	-1.8	-2.4
Smoking status: Previous	0.3	0.4	0.9	0.6	-0.7	-0.4	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	4.2	8.8	11.0	-3.1	2.5	3.2	2.5	3.3
Whole body fat-free mass	0.2	1.0	1.7	-1.0	-0.9	1.0	-0.8	1.3
Leg fat-free mass (right)	0.1	0.7	1.6	-0.6	-0.2	1.2	-0.1	1.3
Arm fat percentage (left)	0.6	2.6	6.8	2.6	-1.2	-1.1	-0.9	-1.6
Average weekly red wine intake	2.3	3.4	6.1	-2.2	1.2	1.9	0.8	2.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.2	-0.6	-0.4	-0.5	-0.3
Mood swings	6.5	11.8	17.3	3.8	-2.7	-3.8	-2.4	-4.2
Loneliness, isolation	0.2	0.2	0.6	0.8	-0.1	-0.7	0.2	-0.2
Long-standing illness, disability or infirmity	1.2	1.8	4.1	2.0	-1.3	-1.3	-0.2	-1.3
Ever had bowel cancer screening	0.4	0.5	1.1	-0.6	0.5	0.7	0.5	1.1
Diabetes diagnosed by doctor	2.9	4.8	7.3	2.0	-1.9	-2.4	-1.9	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.8	5.0	-1.8	1.7	1.8	2.2	2.2
Friendships satisfaction	0.3	0.3	1.0	0.1	-0.1	-0.2	-0.7	-1.0
Qualifications: nursing, teaching	0.4	0.6	0.9	-0.7	0.6	1.0	0.4	1.0
Commuting to job workplace: Walk	1.4	1.5	2.0	1.0	-1.0	-1.4	-1.2	-1.4
Eye problems/disorders: Cataract	0.2	0.2	0.9	0.0	0.4	0.2	0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.4	-0.6	1.8	1.1	1.4	0.9
Medication for cholesterol	1.8	2.7	4.3	-2.1	1.1	1.8	1.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.8	8.9	0.9	-2.7	-2.3	-3.0	-1.2
Back pain experienced in last month	0.1	0.1	0.3	-0.1	0.5	-0.2	-0.2	0.5
Mineral and other dietary supplements	4.9	6.6	10.7	2.8	-2.0	-2.6	-1.9	-3.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	0.5	0.2	0.1	0.3
Asthma (self-reported)	3.1	6.2	8.5	2.6	-2.2	-2.5	-2.0	-2.9
Osteoporosis (self-reported)	0.2	0.2	0.4	0.5	0.5	-0.3	0.6	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.2	-0.0
Medication: Aspirin	1.0	1.4	2.2	1.2	-1.5	-0.9	-1.4	-0.8
Medication: Gliclazide	0.3	0.4	1.0	0.1	0.0	-0.9	-1.0	-0.2
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	0.0	-1.6	-1.1	-1.7	-0.6
Smoking status: Current	0.5	0.8	1.2	1.1	-0.8	-1.1	-1.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	9.9	-3.1	1.9	2.5	1.5	3.0
Whole body water mass	0.2	0.9	1.6	-0.9	-0.8	0.9	-0.8	1.3
Leg predicted mass (right)	0.1	0.8	1.8	-0.7	-0.1	1.3	-0.1	1.3
Arm fat mass (left)	0.5	2.2	4.1	2.0	-1.6	-1.0	-1.4	-1.1
Number of self-reported non-cancer illnesses	2.0	3.4	6.9	2.6	-1.7	-1.9	-0.7	-1.8
Average weekly champagne plus white wine intake	1.9	2.6	5.1	-2.2	1.7	1.6	1.0	1.2
Miserableness	1.6	2.8	4.5	1.3	-1.5	-2.1	-1.3	-1.8
Guilty feelings	0.2	0.3	0.9	-0.0	0.9	0.3	0.5	0.2
Wears glasses or contact lenses	1.1	1.2	3.2	0.6	1.2	1.0	1.8	0.0
Ever taken oral contraceptive pill	0.3	0.4	1.2	1.1	-0.0	-0.3	0.2	-0.7
Hearing aid user	4.6	5.2	6.5	-2.4	2.4	2.3	2.6	1.6
Mother’s age at death	2.9	3.6	6.8	-2.6	1.2	1.5	1.1	2.5
Financial situation satisfaction	6.4	7.9	10.3	-2.1	3.2	2.8	3.2	2.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	0.6	-1.0	-0.5	-0.7	-1.3
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	-0.0	-0.7	-0.7	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	3.2	-0.7	1.8	1.1	0.8	0.9
Medication: Blood pressure	0.1	0.3	0.7	0.2	-0.6	-0.6	-0.8	0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	1.0	0.4	-0.6	-0.3	-0.6
Supplements: Fish oil (including cod liver oil)	3.6	4.7	8.0	-2.8	1.5	2.1	1.1	2.8
High cholesterol (Self-reported)	0.3	0.5	1.3	-1.1	0.0	0.7	-0.3	0.8
Medication: Bendroflumethiazide	0.6	0.9	1.4	1.0	-0.3	-1.1	-1.2	-0.9
Medication: Paracetamol	1.3	2.0	3.8	1.0	-1.2	-2.0	-1.5	-1.2
Medication: Lisinopril	4.7	6.0	9.3	3.1	-2.1	-2.2	-1.8	-2.9
Medication: Atorvastatin	0.7	0.9	2.0	-0.7	-1.4	-0.7	-1.2	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.6	-0.1	0.1	-0.1	0.8	0.0
Alcohol drinker status: Never	1.1	1.3	2.9	1.7	-1.1	-1.2	-1.0	-0.4
Ever smoked	0.1	0.2	0.6	0.4	-0.1	-0.6	-0.2	-0.8
Basal metabolic rate	0.1	0.7	1.0	-0.5	-0.9	0.7	-0.9	1.0
Leg fat percentage (left)	0.7	2.6	5.8	2.4	-1.4	-1.3	-1.1	-1.6
Arm fat-free mass (left)	0.2	1.2	3.0	-0.3	-1.7	-0.1	-1.7	0.4
Number of operations (self-reported)	0.3	0.5	0.9	0.7	-0.5	-0.9	-0.3	-0.7
Average weekly beer plus cider intake	3.6	5.3	9.8	2.9	-1.5	-2.4	-0.7	-3.1
Irritability	0.1	0.1	0.2	0.2	0.1	-0.5	0.0	-0.4
Risk taking	0.7	1.0	2.0	1.4	1.0	-0.3	0.8	-1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.6	-0.6	-0.2	-0.5	0.7
Fractured/broken bones in last 5 years	1.4	1.8	2.9	-1.7	1.1	1.5	1.0	1.3
Age started oral contraceptive pill	2.3	2.9	6.2	-0.2	1.9	1.7	2.5	1.4
Diastolic blood pressure, automated reading	6.4	19.8	29.6	3.1	-3.9	-4.9	-5.4	-4.6
Ever depressed for a whole week	0.1	0.1	0.4	-0.0	-0.1	-0.5	-0.2	-0.6
Unable to work because of sickness or disability	6.0	7.8	10.0	2.6	-2.3	-3.2	-2.7	-3.1
Commuting to job workplace: Cycle	1.3	1.6	1.9	-1.3	1.4	1.3	1.2	1.2
Myopia	1.1	1.5	2.2	-1.4	1.0	1.5	1.0	1.3
Vascular/heart problems diagnosed by doctor	2.2	6.0	8.1	-2.5	2.4	2.8	2.4	1.9
Cholesterol lowering medication	0.2	0.2	1.1	-0.2	-0.1	-0.2	-1.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	0.3	-0.5	-1.2	-0.7	-0.7
Pain experienced in last month	0.5	0.8	1.5	-0.6	0.7	1.2	1.2	0.1
Supplements: Calcium	0.1	0.2	0.4	0.6	0.0	-0.5	-0.3	-0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-1.2	-0.1	1.0	0.5	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-0.5	0.7	0.9	0.8	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	0.1	1.3	0.0	0.7	-0.4
Heart disease (siblings)	0.5	0.6	1.9	1.4	-0.5	-0.6	0.2	-0.6
Alcohol drinker status: Previous	5.3	6.0	10.9	3.3	-1.5	-2.1	-1.5	-3.2
Pack years of smoking	4.3	6.3	8.5	2.5	-2.8	-2.9	-2.6	-1.6
Impedance of whole body	1.3	6.5	11.8	-1.4	3.0	2.7	3.4	1.4
Leg fat mass (left)	0.5	2.1	3.6	1.9	-1.6	-1.1	-1.5	-1.1
Arm predicted mass (left)	0.2	1.1	2.7	-0.2	-1.6	-0.1	-1.6	0.4