Best TWAS P=7.94e-13 · Best GWAS P=4.83e-11 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | SIPA1 | 0.34 | 0.17 | lasso | 6 | 0.20 | 1.6e-13 | -6.3 | 5.5 | 4.5e-08 | -0.21 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Muscularis | FIBP | 0.11 | 0.04 | lasso | 4 | 0.04 | 1.2e-03 | 4.8 | 5.4 | 6.2e-08 | -0.13 | 0.68 | 0.03 | TRUE |
| 3 | GTEx | Muscle Skeletal | CTSW | 0.09 | 0.06 | enet | 20 | 0.05 | 1.9e-05 | 4.4 | -5.6 | 2.7e-08 | 0.21 | 0.97 | 0.01 | FALSE |
| 4 | GTEx | Nerve Tibial | SIPA1 | 0.17 | 0.01 | enet | 19 | 0.06 | 6.8e-05 | -4.5 | 6.2 | 6.4e-10 | -0.42 | 0.06 | 0.82 | FALSE |
| 5 | METSIM | Adipose | FIBP | 0.05 | 0.02 | blup | 344 | 0.02 | 1.0e-03 | 4.4 | 6.8 | 1.4e-11 | -0.39 | 0.93 | 0.03 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 4.6 | -5.9 | 3.9e-09 | 0.46 | 0.45 | 0.26 | TRUE |
| 7 | YFS | Blood | FIBP | 0.04 | 0.02 | bslmm | 343 | 0.03 | 6.4e-09 | 4.5 | 5.7 | 1.4e-08 | -0.45 | 0.72 | 0.28 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASEH2C | 0.05 | 0.00 | blup | 32 | 0.02 | 1.1e-04 | 2.0 | -6.6 | 4.5e-11 | 0.42 | 0.00 | 0.35 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | CTSW | 0.40 | 0.34 | enet | 14 | 0.36 | 4.3e-22 | 4.7 | -5.2 | 2.1e-07 | 0.27 | 0.04 | 0.93 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | -5.1 | 7.2 | 7.9e-13 | -0.52 | 0.01 | 0.98 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP3K11 | 0.06 | 0.03 | lasso | 4 | 0.03 | 2.1e-04 | -5.1 | 5.5 | 3.0e-08 | -0.44 | 0.02 | 0.76 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RNASEH2C | 0.15 | 0.05 | blup | 32 | 0.05 | 3.1e-06 | 2.0 | -6.2 | 7.4e-10 | 0.48 | 0.10 | 0.01 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | -6.3 | 7.0 | 3.4e-12 | -0.59 | 0.00 | 0.70 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNX32 | 0.15 | 0.11 | blup | 60 | 0.15 | 6.0e-17 | 4.6 | 6.0 | 1.9e-09 | -0.32 | 0.99 | 0.01 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNX32 | 0.14 | 0.09 | blup | 60 | 0.13 | 8.8e-15 | 4.6 | 5.6 | 1.7e-08 | -0.36 | 0.99 | 0.01 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIPA1 | 0.09 | 0.03 | blup | 43 | 0.06 | 1.2e-07 | -6.3 | 5.5 | 4.8e-08 | -0.33 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CTSW | 0.16 | 0.10 | enet | 24 | 0.15 | 1.9e-06 | 4.7 | -5.5 | 3.3e-08 | 0.20 | 0.03 | 0.94 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAP3K11 | 0.06 | 0.02 | blup | 47 | 0.03 | 1.4e-04 | -6.3 | 6.9 | 4.0e-12 | -0.58 | 0.00 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SNX32 | 0.12 | 0.13 | blup | 60 | 0.13 | 1.2e-09 | 4.4 | 5.7 | 1.2e-08 | -0.44 | 0.99 | 0.01 | TRUE |
| 20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SNX32 | 0.23 | 0.15 | blup | 60 | 0.12 | 6.3e-05 | 4.6 | 5.1 | 3.0e-07 | -0.24 | 0.53 | 0.04 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | FIBP | 0.04 | 0.00 | blup | 45 | 0.02 | 8.0e-03 | 4.8 | 6.4 | 1.6e-10 | -0.34 | 0.01 | 0.40 | FALSE |