Hub : Genes

ALG8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1490 0.0380 1.4e-12 0.123 0.119 0.118 0.122 0.123 9.5e-15 2.4e-14 3.8e-14 1.3e-14 9.2e-15
2 GTEx Adipose Visceral Omentum 0.1050 0.0490 2.5e-03 0.010 NA 0.018 NA 0.012 8.9e-02 NA 3.7e-02 NA 7.5e-02
3 GTEx Brain Caudate basal ganglia 0.2840 0.0890 4.6e-04 0.105 NA 0.091 NA 0.095 6.3e-04 NA 1.4e-03 NA 1.1e-03
4 GTEx Brain Cerebellar Hemisphere 0.2450 0.0950 2.0e-03 0.155 NA 0.125 NA 0.128 8.6e-05 NA 4.2e-04 NA 3.6e-04
5 GTEx Brain Cerebellum 0.3360 0.0880 3.5e-05 0.282 NA 0.221 NA 0.261 5.6e-09 NA 3.7e-07 NA 2.5e-08
6 GTEx Brain Frontal Cortex BA9 0.2138 0.0874 7.9e-03 0.170 NA 0.101 NA 0.131 3.0e-05 NA 1.3e-03 NA 2.5e-04
7 GTEx Brain Nucleus accumbens basal ganglia 0.2140 0.0840 3.8e-03 0.042 NA 0.054 NA 0.126 2.8e-02 NA 1.5e-02 NA 3.0e-04
8 GTEx Brain Putamen basal ganglia 0.2980 0.1280 4.9e-03 0.041 NA 0.060 NA 0.105 3.9e-02 NA 1.6e-02 NA 1.9e-03
9 GTEx Cells Transformed fibroblasts 0.2290 0.0620 4.5e-08 0.090 NA 0.103 NA 0.121 2.8e-07 NA 3.8e-08 NA 2.6e-09
10 GTEx Esophagus Mucosa 0.1180 0.0450 2.0e-04 0.022 NA 0.019 NA 0.020 1.2e-02 NA 1.8e-02 NA 1.5e-02
11 GTEx Muscle Skeletal 0.0918 0.0455 4.7e-03 0.003 NA 0.016 NA 0.009 1.6e-01 NA 9.5e-03 NA 4.1e-02
12 GTEx Nerve Tibial 0.0915 0.0421 1.6e-03 0.013 NA 0.009 NA 0.014 4.0e-02 NA 6.7e-02 NA 3.4e-02
13 GTEx Testis 0.1320 0.0590 3.2e-03 0.055 NA 0.034 NA 0.074 1.8e-03 NA 1.2e-02 NA 3.3e-04
14 GTEx Thyroid 0.0800 0.0360 4.5e-03 0.029 NA 0.042 NA 0.056 2.5e-03 NA 3.7e-04 NA 4.0e-05
15 METSIM Adipose 0.0835 0.0269 1.6e-07 0.063 0.053 0.076 0.063 0.076 9.3e-10 1.8e-08 1.5e-11 1.0e-09 1.9e-11
16 ROSMAP Brain Pre-frontal Cortex 0.1871 0.0440 2.2e-15 0.146 0.117 0.138 0.120 0.143 2.8e-18 9.4e-15 2.4e-17 3.4e-15 5.2e-18
17 YFS Blood 0.0130 0.0072 2.7e-03 0.014 0.007 0.008 0.006 0.010 1.2e-05 2.3e-03 1.2e-03 3.5e-03 1.6e-04
18 TCGA Colon Adenocarcinoma 0.0550 0.0360 5.2e-03 0.052 0.037 0.023 NA 0.027 5.5e-04 3.1e-03 1.7e-02 NA 1.0e-02
19 TCGA Head and Neck Squamous Cell Carcinoma 0.0684 0.0264 1.6e-10 0.114 0.106 0.108 NA 0.110 1.1e-12 5.8e-12 4.0e-12 NA 2.7e-12
20 TCGA Brain Lower Grade Glioma 0.0314 0.0158 3.2e-04 0.035 0.029 0.030 NA 0.028 6.3e-05 2.6e-04 2.1e-04 NA 3.1e-04
21 TCGA Lung Squamous Cell Carcinoma 0.0324 0.0184 8.6e-04 0.032 0.025 0.027 NA 0.024 1.2e-04 6.3e-04 3.8e-04 NA 8.2e-04
22 TCGA Pheochromocytoma and Paraganglioma 0.1740 0.1430 6.5e-03 0.072 0.027 0.011 NA 0.022 8.1e-04 3.1e-02 1.1e-01 NA 4.5e-02
23 TCGA Rectum Adenocarcinoma 0.3300 0.1280 4.3e-04 0.046 0.093 0.073 NA 0.038 3.1e-02 3.4e-03 8.8e-03 NA 4.6e-02
24 TCGA Stomach Adenocarcinoma 0.0500 0.0270 5.8e-04 0.041 0.025 0.025 NA 0.028 5.5e-04 6.2e-03 6.1e-03 NA 3.7e-03
25 TCGA Testicular Germ Cell Tumors 0.1320 0.0630 1.7e-03 0.091 0.060 0.062 NA 0.066 4.1e-04 3.6e-03 3.3e-03 NA 2.4e-03
26 TCGA Thyroid Carcinoma 0.0930 0.0420 1.1e-08 0.093 0.092 0.067 NA 0.091 2.6e-09 2.9e-09 3.9e-07 NA 3.8e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
Bipolar Disorder (2018) 0.9 1.4 6.2 1.3 -1.1 0.6 0.9 0.9 1.2 1.0 1.1 -1.4 -1.2 -1.2 1.4 1.2 1.0 1.4 1.3 -0.9 -0.9 -1.2 1.2 -1.0 1.2 -2.5 -1.2 -1.1 0.6
Bipolar Disorder or Schizophrenia 1.9 4.7 8.8 2.5 -3.0 2.6 0.4 0.3 2.1 2.8 2.5 -2.1 -2.3 -0.9 1.9 2.3 2.8 1.6 2.3 -2.3 -1.5 -2.2 2.3 -2.2 2.5 -2.5 -2.4 -1.1 1.8
Depressed Affect (Nagel 2018) 0.5 1.0 7.5 -0.7 -1.6 -1.0 -0.3 -0.2 -0.4 -0.8 -0.8 0.7 0.6 0.8 -1.2 -1.6 -0.8 -0.6 -1.1 2.7 1.1 0.7 -0.5 0.9 -0.9 1.0 1.0 -0.0 -0.7
Depression (Nagel 2018) 0.3 0.5 3.7 -0.4 -0.8 -1.1 0.2 0.3 -0.1 -0.8 -0.4 0.4 0.3 1.4 -0.5 -1.0 -0.7 -0.2 -0.7 1.9 0.6 0.3 -0.2 0.3 -0.5 0.3 0.7 0.0 -0.5
Intelligence (Savage-Jansen 2018) 0.1 0.3 2.3 -0.2 1.2 -1.5 0.7 0.7 0.1 -1.1 -0.2 0.1 0.6 0.9 0.3 -0.3 -0.4 0.5 0.2 0.1 -0.3 -0.1 0.1 -0.2 -0.1 0.8 0.1 -0.1 0.1
Neuroticism (Nagel 2018) 0.3 0.7 9.4 0.3 -3.1 0.1 0.3 0.5 0.5 0.5 0.4 -0.4 -0.4 0.6 0.1 -0.5 0.2 0.4 -0.0 2.2 0.4 -0.2 0.4 0.0 0.3 0.1 -0.0 -0.9 0.2
Schizophrenia (2018) 1.8 3.7 8.7 2.2 -2.9 2.9 -0.2 -0.4 1.7 2.9 2.4 -1.6 -2.0 -0.1 1.3 2.0 2.8 1.0 1.8 -2.2 -1.2 -1.9 1.9 -2.0 2.3 -1.2 -2.2 -0.6 1.8
Schizophrenia vs Biploar Disorder 2.7 3.5 5.6 2.3 -0.2 1.2 1.4 1.2 2.3 1.7 2.1 -1.9 -2.1 -0.4 1.9 2.3 1.9 2.0 2.1 -1.8 -2.3 -2.3 2.4 -2.3 1.9 -1.4 -2.0 -0.9 2.2
Worry (Nagel 2018) 0.4 0.8 4.0 0.9 -2.0 1.3 -0.0 0.2 0.7 1.7 1.1 -0.8 -1.0 0.1 0.8 1.0 1.1 0.5 0.7 -0.0 -0.1 -0.6 0.7 -0.7 1.1 -0.6 -0.8 -0.9 0.5
Alzheimer’s Disease (in mother) 0.8 0.9 4.1 0.7 -0.3 0.8 0.1 -0.1 -0.2 0.5 0.2 0.6 -0.9 1.8 0.8 1.8 -0.0 0.7 1.3 -2.0 -1.6 -0.2 0.3 -0.2 -0.3 -0.4 -0.4 1.7 0.6
Alzheimer’s Disease (in father) 1.5 1.7 5.0 1.1 0.5 -0.1 1.7 1.6 1.7 0.3 0.8 -1.9 -1.7 -0.5 1.3 0.1 0.6 1.7 1.2 0.3 -1.4 -1.5 1.5 -1.3 1.2 -1.1 -1.3 -2.2 1.2
Alzheimer’s Disease (including proxy) 0.7 1.1 3.5 1.3 -0.8 0.8 0.9 0.8 0.7 0.8 0.7 -0.3 -1.7 0.8 0.9 1.6 0.4 1.2 1.5 -0.9 -1.9 -0.9 1.0 -0.6 0.4 -1.4 -1.1 0.5 1.0
Crohns Disease (2017) 0.2 0.3 1.6 0.4 0.8 0.6 -0.6 -0.5 0.5 0.8 0.8 -0.6 -0.2 0.4 0.2 0.2 0.7 -0.1 -0.1 0.3 0.6 -0.3 0.3 -0.1 1.0 1.3 -0.3 -0.8 0.7
Irritable Bowel Disease (IBD) 0.2 0.4 5.6 -0.2 2.4 -0.2 -0.5 -0.4 0.1 0.1 -0.1 -0.3 0.5 -0.6 -0.2 0.1 0.0 -0.3 -0.5 0.4 0.9 0.2 -0.2 0.4 0.3 1.4 0.3 -0.6 0.2
Ulcerative Colitis (UC) 0.4 0.8 8.5 -0.7 2.9 -1.1 -0.1 -0.2 -0.3 -0.7 -0.9 -0.0 0.9 -1.5 -0.6 -0.2 -0.7 -0.3 -0.8 0.2 1.0 0.6 -0.5 0.7 -0.4 1.0 0.7 -0.6 -0.4
Major Depression (MDD) 0.5 0.6 3.3 1.0 -0.5 0.3 0.5 0.5 0.8 0.6 0.8 -0.4 -0.6 0.2 0.5 0.3 1.0 0.6 1.0 1.8 -0.8 -0.9 0.9 -0.6 0.8 -0.9 -0.7 0.8 0.8
Reaction Time 0.3 0.6 4.3 -0.5 2.1 -0.7 -0.3 -0.4 -0.5 -0.9 -0.6 0.7 0.5 0.6 -0.6 -1.0 -0.8 -0.5 -0.7 1.1 0.7 0.6 -0.6 0.6 -0.7 1.0 0.7 0.4 -0.6
Verbal and Numeric Reasoning (VNR) 1.1 2.5 9.6 1.2 -0.8 -1.4 3.0 3.1 1.8 -0.4 0.8 -1.5 -1.1 0.7 2.3 0.4 0.4 2.4 1.8 -0.5 -2.0 -1.7 1.8 -1.7 1.1 -0.9 -1.2 -1.4 1.3
Breast Cancer 0.2 0.4 1.3 0.7 1.1 0.9 -0.4 -0.4 0.4 0.9 0.8 -0.5 -0.4 -0.8 0.4 1.1 0.8 0.2 0.3 -0.9 0.0 -0.4 0.4 -0.3 0.5 -0.1 -0.3 -0.5 0.4
Ovarian Cancer 0.8 1.0 7.8 -1.2 -0.7 -0.6 -0.0 0.1 -0.7 -0.8 -0.9 0.6 0.9 2.8 -0.6 -1.2 -0.9 -0.8 -1.0 1.8 0.9 0.9 -0.9 0.7 -1.0 1.2 0.7 -0.0 -0.7
Prostate Cancer 0.3 0.4 2.6 0.5 1.2 0.5 0.0 -0.1 0.6 0.2 0.6 -0.6 -0.4 0.0 0.2 -0.6 0.6 0.2 0.2 1.6 0.1 -0.6 0.5 -0.2 0.7 -0.7 -0.4 -0.7 0.4
Age at First Birth 1.6 2.3 4.0 1.9 -0.4 1.6 1.0 1.0 1.4 1.7 1.7 -1.3 -1.6 1.7 1.7 1.6 1.9 1.5 1.8 -0.9 -2.0 -1.7 1.8 -1.9 1.5 -0.7 -1.4 -0.3 1.8
Bipolar Disorder (2011) 2.8 2.7 5.3 2.0 0.0 1.8 0.3 0.1 1.3 1.7 2.0 -1.1 -2.0 1.8 1.2 1.8 2.0 1.2 2.3 -1.7 -2.0 -1.8 1.7 -1.9 1.9 -1.9 -2.1 0.4 1.6
Body Mass Index (BMI) (2010) 0.9 1.2 8.8 1.0 -3.0 2.3 -0.5 -0.3 0.2 1.9 1.1 -0.2 -0.8 1.4 0.1 1.0 1.5 -0.0 0.8 1.2 -0.5 -0.6 0.5 -0.7 0.8 0.5 -0.7 0.4 1.1
Coronary Artery Disease (CAD) 0.8 1.0 6.2 0.4 -2.4 -0.2 1.1 1.0 1.1 0.0 0.3 -0.9 -0.6 -1.6 0.7 0.2 0.1 0.9 0.5 -1.2 -0.4 -0.7 0.8 -0.4 0.7 -2.5 -0.8 -1.1 -0.0
Crohns Disease (2012) 0.1 0.2 1.2 -0.0 -0.2 0.5 -0.8 -0.8 -0.1 0.5 0.3 0.1 0.0 0.5 0.2 0.4 0.2 -0.4 -0.2 -0.6 0.5 0.2 -0.2 0.3 0.3 1.1 -0.0 0.1 0.2
Mean Putamen Volume 0.1 0.1 0.5 -0.0 0.7 0.4 -0.3 -0.3 -0.2 0.1 0.1 0.3 -0.2 0.5 -0.2 -0.1 0.0 -0.3 0.2 0.3 -0.2 0.1 -0.1 -0.2 -0.1 0.1 -0.1 0.6 -0.0
Fasting Glucose 0.7 0.8 3.6 0.1 0.0 -0.8 -0.5 -0.5 -0.6 -1.2 -1.2 -0.1 0.2 -1.3 -1.2 -1.9 -0.5 -0.9 -1.2 0.3 1.4 0.6 -1.0 0.8 -0.4 1.0 1.1 -0.5 -0.8
HbA1C 2.0 2.2 11.2 0.5 -3.3 2.5 -0.4 -0.3 0.2 2.4 1.8 0.1 0.6 2.2 1.1 2.4 1.7 0.6 1.6 1.1 -1.2 -0.7 1.2 -1.2 1.3 -0.4 -1.5 1.0 1.2
HDL Cholesterol 1.3 2.2 4.4 1.8 0.5 0.7 1.1 1.0 1.4 1.3 1.6 -1.5 -1.7 -1.7 1.3 2.1 1.3 1.6 1.9 -0.3 -1.9 -1.7 1.6 -1.4 1.6 -1.9 -1.5 -0.4 1.5
LDL Cholesterol 0.9 1.5 18.7 0.7 -4.3 2.0 -1.0 -0.8 -0.4 1.6 0.9 0.7 -0.4 1.1 -0.2 1.4 1.1 -0.6 0.5 -1.0 -0.1 -0.1 0.1 0.1 0.5 -0.1 -0.5 1.5 0.5
Lupus 2.7 4.0 8.2 2.7 0.8 0.8 1.9 1.6 2.6 0.9 2.4 -2.1 -2.4 0.9 2.0 1.2 1.7 2.2 2.1 -0.1 -2.8 -2.6 2.9 -2.6 2.2 -1.4 -2.1 -1.3 2.4
Neuroticism (2016) 0.6 0.9 2.4 0.9 -1.5 -0.6 1.5 1.5 1.0 0.1 0.6 -0.9 -0.6 0.4 1.4 0.4 0.6 1.6 1.0 0.9 -1.0 -1.0 1.1 -0.8 0.5 -0.4 -0.3 -0.4 0.9
Primary Biliary Cirrhosis 0.9 1.3 3.2 1.8 -0.6 1.7 -0.2 -0.3 0.9 1.8 1.7 -0.8 -1.1 0.6 0.9 1.7 1.6 0.5 1.0 0.2 -0.9 -1.1 1.3 -0.9 1.5 -0.6 -1.2 -0.1 1.4
Rheumatoid Arthritis 0.4 0.5 6.8 -0.1 0.2 -1.1 0.6 0.4 -0.0 -0.6 -0.4 -0.3 0.4 -2.6 0.3 0.8 -0.7 0.9 0.0 -0.2 0.0 0.2 0.0 0.5 -0.3 -1.0 0.5 -0.5 -0.4
Schizophrenia (2014) 2.6 5.7 10.1 2.8 -2.3 2.8 0.8 0.6 2.4 3.0 2.8 -2.3 -2.6 -0.4 2.1 2.3 3.2 1.9 2.7 -1.9 -2.2 -2.7 2.7 -2.7 2.9 -2.5 -2.9 -1.1 2.4
Triglycerides 0.3 0.5 7.7 -0.8 -2.8 0.2 -0.1 0.1 -0.4 -0.3 -0.5 0.5 0.6 -0.3 -0.3 -0.5 -0.4 -0.4 -0.6 -0.4 0.8 0.6 -0.6 0.7 -0.4 1.1 0.4 -0.2 -0.4
Type 2 Diabetes (T2D) (2012) 0.2 0.3 2.6 0.0 1.1 0.2 -0.6 -0.5 -0.3 -0.1 0.0 -0.3 0.1 -1.6 -0.7 -0.4 -0.1 -0.5 -0.6 -0.0 0.6 0.2 -0.2 0.3 -0.1 -0.4 0.1 -0.6 -0.3
Ulcerative Colitis 0.6 0.8 5.0 -0.9 2.2 -1.1 -0.4 -0.5 -0.7 -1.0 -1.1 0.6 1.0 -1.2 -0.8 -0.4 -1.0 -0.4 -0.7 0.1 0.8 0.8 -0.8 1.0 -0.9 0.6 1.0 0.6 -0.8
Blood Eosinophil Count 0.4 3.0 7.0 -2.2 1.1 -2.1 0.3 0.3 -1.3 -2.3 -2.4 1.2 1.4 -2.6 -1.8 -2.0 -2.5 -0.7 -1.6 1.0 1.5 1.7 -1.7 2.1 -2.2 -0.9 1.9 0.1 -2.4
Blood Platelet Count 0.3 3.3 9.8 1.9 -2.4 2.1 0.5 0.8 1.7 2.9 2.3 -1.6 -2.0 -0.3 -0.3 1.1 2.7 0.7 1.5 3.1 -0.7 -1.9 1.7 -1.8 2.3 -1.0 -2.3 -1.2 1.7
Blood Red Count 0.1 1.0 14.4 0.7 3.8 -0.4 0.3 0.3 0.5 0.3 0.7 -0.3 0.1 1.2 0.8 1.1 0.5 0.5 0.5 0.0 -0.6 -0.4 0.6 -0.9 0.5 1.9 -0.3 0.0 1.0
Blood White Count 0.1 0.6 2.1 0.5 1.4 1.2 -0.4 -0.3 0.5 1.2 0.7 -0.6 -0.6 0.9 -0.3 0.2 1.2 -0.2 0.2 1.3 0.0 -0.5 0.4 -0.9 0.8 0.3 -0.9 -0.7 0.5
Heel T-Score 0.6 5.1 16.1 -2.6 -4.0 -1.6 -1.9 -1.9 -2.4 -1.6 -2.3 2.0 2.4 -1.0 -2.7 -1.4 -2.2 -2.3 -2.6 0.7 2.7 2.6 -2.7 2.5 -2.3 0.9 2.4 1.2 -2.8
BMI 0.3 1.6 12.1 -1.1 -3.5 -1.5 0.3 0.5 -1.0 -1.3 -1.4 0.9 1.1 0.2 -0.7 -0.7 -1.4 -0.2 -0.7 2.4 0.7 1.1 -1.1 1.3 -1.4 0.4 1.4 0.6 -1.0
Height 0.4 7.5 21.2 2.8 2.6 1.2 2.6 2.1 2.8 0.8 2.2 -2.4 -2.8 1.3 3.8 2.1 1.9 3.1 3.5 -4.6 -4.0 -3.1 3.1 -3.3 2.6 -2.0 -2.9 -0.9 3.0
Waist Hip Ratio (WHR) 1.1 4.9 13.6 -2.9 2.4 -1.8 -0.2 0.1 -1.4 -2.3 -2.7 0.8 2.1 -1.8 -2.5 -3.7 -2.4 -1.8 -3.0 2.2 3.1 2.1 -2.3 2.4 -1.9 0.3 2.2 -1.5 -2.8
Systolic Blood Pressure 0.5 2.7 7.1 -1.2 -1.8 1.3 -2.7 -2.4 -2.1 1.1 -0.6 1.9 1.1 1.4 -1.9 0.5 -0.3 -2.4 -1.6 -0.3 2.0 1.8 -1.9 1.5 -1.0 1.9 1.2 1.9 -1.3
Smoking Status 0.3 0.6 5.8 -0.9 2.4 -0.8 0.9 0.9 0.0 -1.1 -0.9 -0.0 -0.0 0.5 -0.4 -1.7 -0.7 -0.1 -0.3 0.1 0.1 0.1 -0.3 -0.2 -0.7 -0.2 -0.0 -0.6 -0.6
Allergy or Eczema 0.3 0.9 6.5 -0.6 2.6 -2.1 0.7 0.6 0.2 -1.1 -0.7 -0.3 0.6 -2.3 -0.1 -0.8 -0.8 0.4 -0.6 0.4 0.3 0.1 -0.1 0.1 -0.5 0.2 0.6 -0.6 -0.4
Cardiovascular Disease 1.4 4.6 12.3 -2.2 -1.9 -1.5 -1.6 -1.4 -2.2 -1.2 -1.9 2.0 2.5 -0.3 -2.4 -1.1 -1.9 -2.1 -2.6 3.5 3.0 2.5 -2.4 3.0 -2.1 1.0 2.6 1.1 -2.5
Hypothyroidism (self reported) 0.7 1.7 7.0 -1.4 -0.5 -1.3 -0.3 -0.5 0.0 -1.4 -1.1 0.1 0.6 -1.9 -1.4 -2.6 -1.4 -0.7 -1.9 2.0 1.9 0.7 -0.7 1.4 -0.7 -0.8 1.2 -1.3 -1.5
Respiratory disease 0.6 1.2 6.0 -0.9 2.5 -0.8 -0.5 -0.2 -0.6 -0.5 -0.7 0.4 1.0 -1.8 -1.2 -1.1 -0.8 -1.0 -1.4 1.2 1.6 0.9 -0.8 1.0 -0.8 1.7 1.3 -0.2 -0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 -0.6 -0.3 -0.6 -0.2 -0.0 -0.7 -0.7 -0.5 0.7 0.9 -0.3 -0.6 -0.7 -0.4 -0.5 -0.4 1.2 0.7 0.7 -0.7 1.0 -0.6 0.6 0.5 0.6 -0.3
Lung FEV1/FVC ratio 1.4 6.9 52.4 -2.4 -7.2 -0.6 -1.9 -1.6 -2.9 -1.3 -2.3 2.6 2.4 2.7 -2.8 -1.4 -1.9 -2.5 -2.3 2.1 2.1 2.7 -2.8 2.4 -2.3 2.2 2.2 2.3 -2.0
Lung FVC 0.1 0.7 2.2 0.8 0.5 0.6 0.7 0.6 1.0 0.3 0.9 -0.8 -0.9 -0.9 0.5 -0.2 0.9 0.6 0.7 -0.3 -0.8 -1.0 1.0 -1.1 1.0 -1.5 -1.1 -0.4 0.5
Neuroticism 1.1 2.7 15.1 1.8 -3.9 1.7 0.5 0.6 1.5 2.0 1.9 -1.4 -1.7 1.6 1.2 1.1 2.0 1.2 1.4 2.0 -1.1 -1.6 1.7 -1.7 1.7 -0.7 -1.6 -0.9 1.5
Chronotype (morning person) 0.6 1.3 4.8 1.0 -2.2 -0.2 1.7 1.7 1.4 0.6 0.7 -1.2 -1.3 0.7 1.4 0.7 0.3 1.6 1.0 -0.1 -1.2 -1.1 1.3 -0.7 0.6 -1.8 -0.7 -1.3 0.8
Hair Pigment 0.7 20.5 299.3 -1.1 -17.3 4.5 -4.8 -4.3 -3.1 2.9 -0.0 3.4 0.5 5.4 -4.6 0.4 0.5 -4.0 -1.9 4.9 2.4 2.4 -2.5 2.4 -1.3 0.9 1.2 3.9 -1.5
Tanning 0.2 2.0 26.9 0.8 5.2 -0.3 1.4 1.1 1.2 -0.6 0.6 -0.9 -0.9 1.5 0.9 -0.8 0.5 1.1 1.0 -0.6 -1.4 -1.1 1.2 -1.5 0.9 -0.1 -1.1 -0.7 1.0
Hand grip strength (left) 0.9 2.3 15.6 1.5 -4.0 1.3 0.5 0.3 0.8 1.0 1.3 -0.7 -0.8 0.4 1.8 2.7 1.1 1.2 1.6 -2.6 -1.6 -1.1 1.1 -1.1 1.2 -0.4 -1.2 0.9 1.5
Number of treatments/medications taken 1.6 2.9 5.6 -1.6 1.8 -1.6 -1.1 -1.1 -1.3 -1.8 -1.5 1.5 1.7 -1.3 -2.4 -2.4 -1.8 -1.6 -2.2 1.6 2.0 1.7 -1.5 2.1 -1.7 0.4 2.1 0.7 -1.9
Average weekly spirits intake 0.4 0.5 1.7 -0.8 1.3 0.3 -0.9 -0.9 -0.3 -0.1 -0.5 0.1 0.6 -1.1 -0.9 -1.3 0.0 -0.9 -1.0 -0.2 1.1 0.6 -0.6 0.5 -0.3 0.8 0.4 -0.7 -0.4
Sensitivity / hurt feelings 0.5 0.9 7.1 0.6 -2.7 1.3 -0.3 -0.2 0.3 1.2 0.7 -0.2 -0.6 2.5 0.0 0.3 0.8 -0.0 0.1 1.6 0.0 -0.3 0.4 -0.2 0.6 0.5 -0.3 -0.1 0.6
Frequency of depressed mood in last 2 weeks 1.2 1.6 5.8 -1.3 -1.0 -0.9 -0.6 -0.5 -0.6 -1.1 -1.0 0.8 0.9 1.6 -1.8 -2.4 -1.1 -1.4 -1.9 2.0 1.6 1.1 -1.0 0.7 -1.1 1.5 1.3 -0.5 -1.1
Hearing difficulty/problems: Yes 1.4 2.1 4.1 1.7 0.6 0.5 1.5 1.5 1.5 1.0 1.5 -1.3 -1.5 -0.5 1.9 1.0 1.4 1.6 1.9 -1.8 -2.0 -1.7 1.7 -1.6 1.4 -1.3 -1.5 -0.3 1.6
Relative age of first facial hair 0.2 0.5 2.5 -0.3 1.6 -1.1 1.2 1.1 0.2 -0.9 -0.5 -0.3 0.2 -0.5 0.6 -0.5 -0.7 0.6 0.2 -1.1 -0.7 -0.2 0.2 -0.3 -0.3 -0.9 0.0 -0.4 -0.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 3.3 -0.7 1.0 0.2 -1.0 -0.9 -0.1 -0.2 -0.3 -0.0 0.7 0.2 -1.3 -1.5 0.2 -1.2 -1.2 -0.1 1.4 0.4 -0.5 0.1 -0.1 1.8 0.2 -1.0 -0.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 2.1 -0.7 0.1 -0.2 0.2 0.1 -0.2 -0.6 -0.7 0.1 -0.3 -1.4 0.1 -0.6 -0.6 0.1 0.1 -0.7 -0.3 0.2 -0.4 0.3 -0.6 -0.7 0.1 0.0 -0.4
Ever had hysterectomy (womb removed) 0.3 0.4 1.4 0.6 0.3 1.2 -0.6 -0.8 0.2 0.6 0.8 -0.1 -0.5 0.0 -0.5 0.3 1.0 -0.3 0.4 -0.3 -0.6 -0.5 0.4 -0.7 0.6 0.5 -0.7 0.5 0.9
Systolic blood pressure, automated reading 0.7 1.9 6.6 -1.3 -1.2 1.1 -2.6 -2.4 -1.8 0.8 -0.6 1.2 1.0 -0.3 -1.8 -0.4 -0.1 -2.4 -1.6 -0.0 2.0 1.6 -1.8 1.2 -0.7 1.4 0.8 0.6 -1.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 2.0 0.2 -0.2 -0.3 -0.1 -0.1 0.2 -0.3 0.3 -0.1 0.1 -0.3 -0.4 -0.5 0.2 -0.1 -0.1 1.4 0.0 -0.2 0.2 -0.0 0.2 -0.6 -0.1 0.0 -0.0
Angina 0.8 1.0 2.8 1.4 -1.2 0.6 0.7 0.7 0.7 0.9 1.2 -0.9 -1.0 0.7 1.5 1.7 0.9 1.2 1.4 -0.1 -1.4 -0.9 1.1 -1.0 0.9 -0.2 -0.8 -0.2 1.3
Medication for hormone replacement therapy 0.6 0.6 2.7 -0.9 1.2 -1.2 0.5 0.6 0.0 -1.0 -0.8 -0.3 0.5 -1.6 0.1 -1.2 -0.9 0.1 -0.7 0.9 0.9 0.3 -0.4 0.7 -0.4 -0.1 0.6 -1.4 -0.7
Vitamin and mineral supplements 0.4 0.6 3.0 -0.6 -0.6 -1.7 0.4 0.4 -0.6 -1.1 -0.7 0.7 1.0 0.6 0.0 0.2 -1.1 0.0 -0.5 0.0 0.1 0.6 -0.5 0.6 -1.1 0.6 1.2 1.0 -0.5
Supplements: Zinc 0.2 0.2 1.1 0.3 -0.7 1.0 -0.8 -0.6 -0.5 0.8 0.3 0.1 0.0 -0.4 0.2 1.0 0.5 -0.4 0.1 -0.5 0.1 0.1 -0.2 -0.1 0.1 0.5 0.1 0.7 0.2
Medication: Co-codamol 0.2 0.3 0.9 0.1 0.6 0.7 -0.8 -0.9 0.3 0.4 0.5 -0.3 -0.3 -0.8 -0.8 -0.6 0.6 -0.5 -0.3 -0.4 0.3 -0.1 0.2 -0.4 0.5 0.8 -0.4 -0.9 0.3
Medication: Metformin 1.3 1.9 3.6 -1.5 -0.8 -0.8 -1.1 -1.2 -1.4 -1.4 -1.5 1.8 1.4 0.5 -1.9 -1.9 -1.1 -1.4 -1.4 0.8 1.3 1.3 -1.5 1.4 -1.5 0.9 1.2 1.8 -1.3
Diabetes (father) 1.1 1.3 3.0 -1.3 0.8 0.4 -1.1 -0.9 -1.7 -0.5 -1.2 1.4 1.1 1.1 -1.3 -1.1 -0.9 -1.3 -1.1 1.3 1.1 1.6 -1.6 1.2 -1.2 0.8 1.1 0.9 -1.2
Diabetes (mother) 0.1 0.2 1.1 -0.0 0.4 -0.2 0.8 0.8 0.4 0.2 -0.1 -0.6 -0.4 -0.1 0.5 0.0 0.1 0.7 0.3 0.0 -0.2 -0.3 0.1 -0.2 0.2 -0.1 -0.4 -1.1 0.4
Severe depression (siblings) 0.7 0.8 4.4 -1.0 1.2 -1.0 0.3 0.5 -0.4 -0.7 -0.9 0.1 0.7 0.2 -0.6 -1.9 -0.8 -0.6 -0.9 2.1 0.9 0.7 -0.7 0.6 -0.6 1.3 0.6 -1.0 -0.4
Pack years adult smoking proportion 0.7 1.0 5.5 -0.9 2.4 -0.8 -0.2 -0.3 -0.2 -1.1 -0.8 0.0 1.0 -1.9 -0.7 -1.1 -0.5 -0.4 -0.9 2.2 1.2 0.6 -0.6 0.6 -0.5 0.3 0.7 -0.8 -0.9
Impedance of leg (right) 0.1 0.7 7.4 -0.4 1.0 0.5 -1.3 -1.3 -0.4 0.5 -0.1 0.3 0.4 -0.6 -0.1 0.4 -0.0 -0.8 -0.7 -2.7 0.9 0.5 -0.6 0.5 -0.2 1.0 0.4 0.2 -0.3
Leg fat-free mass (left) 0.1 0.3 1.1 0.4 -0.7 -0.3 0.9 0.9 0.2 -0.4 0.0 -0.1 -0.2 0.6 0.7 0.6 0.1 0.8 0.9 0.5 -1.1 -0.5 0.4 -0.5 0.1 -0.5 -0.5 0.3 0.5
Trunk fat percentage 0.6 2.3 6.7 -1.7 1.9 -2.6 0.1 0.1 -1.4 -2.3 -2.1 1.1 1.9 -1.5 -0.7 -1.3 -2.1 -0.4 -1.2 -0.1 1.0 1.6 -1.5 1.9 -2.0 0.7 1.8 0.5 -1.5
Hand grip strength (right) 2.2 5.9 18.8 2.8 -4.2 2.8 0.7 0.5 1.8 2.5 2.6 -1.5 -2.2 0.6 2.7 4.3 2.5 2.0 2.7 -3.1 -2.5 -2.2 2.3 -2.0 2.6 -0.5 -2.4 0.5 2.9
Townsend deprivation index at recruitment 0.9 1.3 9.4 -0.8 3.1 -1.9 0.8 0.6 0.2 -1.6 -0.9 0.0 0.5 -1.6 -0.8 -2.3 -1.0 0.1 -0.7 1.9 0.4 0.2 -0.2 0.4 -0.6 -0.3 0.6 -0.7 -0.8
Current tobacco smoking 1.2 1.9 6.9 -1.8 1.5 -0.7 -0.9 -0.8 -1.0 -1.4 -1.5 0.8 1.4 0.1 -1.9 -2.6 -1.1 -1.7 -2.0 0.7 2.0 1.3 -1.4 0.9 -1.1 0.9 1.2 -0.6 -1.7
Average weekly fortified wine intake 0.4 0.5 4.5 0.5 2.1 0.4 0.5 0.4 0.6 0.6 0.4 -0.6 -0.5 -0.3 0.4 0.1 0.5 0.4 0.6 -0.3 -0.6 -0.6 0.6 -0.8 0.8 -0.1 -0.6 -0.7 0.7
Maternal smoking around birth 1.0 1.5 2.8 1.1 0.0 0.0 1.3 1.1 1.7 0.8 1.0 -1.6 -1.4 -1.3 1.5 0.6 1.0 1.5 1.2 0.5 -0.9 -1.5 1.4 -1.1 1.4 -1.6 -1.5 -1.5 1.0
Fed-up feelings 1.5 2.8 7.1 -1.9 -0.7 -0.9 -1.2 -1.1 -1.0 -1.2 -1.4 1.0 1.6 -0.5 -2.2 -2.6 -1.4 -1.7 -2.5 2.6 2.7 1.7 -1.6 1.8 -1.4 1.6 1.9 -0.5 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 4.9 -1.1 -0.8 -1.1 -0.4 -0.3 -0.8 -1.3 -1.0 1.0 1.1 1.5 -1.6 -1.8 -1.1 -1.0 -1.5 2.2 1.4 1.0 -1.0 0.8 -1.1 1.2 1.3 0.3 -1.2
Relative age voice broke 0.1 0.2 1.6 -0.5 0.6 -0.1 0.4 0.5 0.0 -0.3 -0.4 -0.1 0.2 -0.9 -0.1 -0.8 -0.3 -0.2 -0.2 -1.2 0.3 0.1 -0.2 0.2 -0.0 -0.9 -0.2 -0.4 -0.4
Taking other prescription medications 0.5 0.8 9.4 -0.8 3.1 -0.7 -0.1 0.0 -0.3 -1.0 -0.6 0.2 0.6 -1.2 -0.7 -1.7 -0.6 -0.5 -0.7 0.5 0.5 0.5 -0.5 0.6 -0.6 -0.0 0.6 -0.4 -0.6
Age when periods started (menarche) 2.4 5.7 18.1 2.6 3.4 2.6 0.8 0.4 2.6 2.3 2.5 -2.2 -2.5 0.3 2.0 2.4 2.6 1.7 2.4 -4.3 -2.4 -2.5 2.6 -2.6 2.6 -0.7 -2.7 -1.2 2.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 1.9 -0.0 -0.3 0.8 -0.7 -0.8 0.0 0.6 0.3 -0.1 -0.1 -1.4 -1.0 -0.0 0.4 -0.7 -0.5 -0.2 0.4 -0.0 -0.0 0.1 0.2 0.6 -0.1 -0.4 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 6.2 -1.9 -1.8 -0.8 -2.1 -2.0 -2.5 -0.9 -1.7 2.2 2.3 1.1 -1.4 -0.0 -1.5 -2.0 -1.8 0.3 2.0 2.2 -2.4 2.1 -1.9 1.5 1.9 2.2 -1.9
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.1 -1.2 -0.8 0.4 -1.0 -0.9 -1.0 -0.1 -0.9 1.0 0.5 0.4 -1.3 -1.3 -0.8 -1.5 -1.4 0.3 1.2 1.2 -1.1 0.7 -1.0 1.2 0.9 0.0 -1.0
Qualifications: CSEs or equivalent 1.0 1.3 4.2 -1.3 -2.0 -0.3 -0.3 -0.0 -1.2 -0.4 -1.2 1.1 1.1 -0.2 -0.5 -0.6 -1.2 -1.0 -1.4 -1.4 1.5 1.4 -1.4 1.6 -1.1 0.5 1.4 0.5 -1.4
Serious illness, injury or assault to yourself 0.5 0.6 2.4 0.1 1.5 0.4 -0.1 -0.1 0.7 0.2 0.4 -0.5 -0.2 1.0 -0.6 -1.3 0.6 -0.5 -0.2 1.5 0.4 -0.4 0.4 -0.7 0.6 1.2 -0.5 -1.3 0.5
High blood pressure 0.8 2.1 9.0 -1.4 -1.0 -0.9 -1.0 -0.8 -1.2 -0.7 -1.2 1.0 1.4 -0.4 -1.8 -1.3 -1.4 -1.4 -1.9 3.0 2.0 1.6 -1.5 2.1 -1.4 -0.2 1.9 0.1 -1.7
Hayfever, allergic rhinitis or eczema 0.2 0.4 4.5 -0.4 2.1 -1.1 0.0 -0.0 -0.2 -0.3 -0.5 0.1 0.6 -1.2 -0.1 0.2 -0.4 0.0 -0.4 -0.2 0.4 0.3 -0.3 0.1 -0.5 0.9 0.4 -0.1 -0.3
Multivitamins +/- minerals 0.3 0.3 2.8 0.2 0.5 1.7 -0.5 -0.5 0.2 0.8 0.4 -0.2 -0.7 -0.5 -0.7 -0.8 0.7 -0.4 -0.0 -0.1 0.4 -0.2 0.2 -0.1 0.8 -0.2 -0.6 -0.8 0.1
Stomach or abdominal pain in last month 0.3 0.4 1.5 0.5 -0.2 1.2 -0.0 0.0 0.7 0.9 0.7 -0.7 -0.8 -0.7 0.7 0.2 0.9 0.2 0.5 0.1 0.2 -0.5 0.5 -0.0 0.9 -0.9 -0.9 -0.6 0.5
Supplements: Glucosamine 0.4 0.6 5.4 0.2 0.1 -0.1 0.3 0.1 0.3 -0.4 0.1 -0.1 -0.5 2.3 -0.1 -0.5 -0.1 0.2 0.3 -2.3 -0.9 -0.4 0.4 -0.9 0.1 -0.9 -0.4 0.1 0.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.9 0.4 -1.7 0.6 -0.9 -1.1 -0.2 0.1 0.6 0.6 -0.1 0.5 -0.2 0.1 0.6 -0.6 0.3 0.7 -0.9 -0.2 0.1 -0.6 0.1 0.3 -0.5 1.7 0.6
Medication: Atenolol 0.8 1.0 4.6 -0.4 -2.1 -0.2 -1.3 -1.4 -0.8 -0.2 -0.4 0.8 1.0 2.2 -0.6 0.5 -0.5 -0.7 -0.9 -0.3 1.0 1.0 -0.8 0.7 -0.6 1.4 1.1 0.8 -0.6
Medication: Levothyroxine sodium 0.7 1.2 11.4 -0.6 -0.5 -1.3 0.8 0.8 0.5 -0.9 -0.7 -1.0 0.2 -3.4 0.1 -1.4 -0.8 0.3 -0.8 1.2 1.0 0.1 -0.1 0.6 -0.1 -1.4 0.4 -2.3 -0.8
Sitting height 0.1 0.8 3.3 0.5 -0.2 -0.9 1.6 1.5 0.8 -0.6 0.1 -0.9 -0.2 -0.4 1.5 0.7 -0.0 1.4 0.8 -1.8 -1.0 -0.8 0.8 -0.9 0.4 -0.2 -0.5 -1.0 0.6
Chronic bronchitis/emphysema (father) 0.4 0.4 1.5 0.5 0.0 0.8 0.4 0.5 0.4 1.0 0.6 -0.6 -0.8 -0.3 1.0 0.7 0.8 0.5 0.9 -1.2 -0.5 -0.6 0.4 -0.5 0.6 -0.7 -0.8 -0.2 0.5
High blood pressure (mother) 1.7 2.3 4.6 1.7 -1.5 1.3 0.8 0.9 1.7 2.0 1.7 -1.9 -1.7 0.5 1.6 2.1 1.5 1.6 1.4 1.2 -1.2 -1.5 1.6 -1.4 1.7 -0.7 -1.5 -2.1 1.5
Body mass index (BMI) 0.6 2.4 4.2 -1.8 -2.0 -2.0 0.1 0.2 -1.6 -1.9 -2.0 1.3 1.7 -0.8 -1.3 -1.5 -2.0 -0.7 -1.4 2.0 1.2 1.6 -1.7 1.8 -1.9 0.6 1.8 0.6 -1.7
Impedance of leg (left) 0.1 0.6 9.8 -0.4 0.5 0.3 -0.9 -0.9 -0.3 0.2 -0.2 0.1 0.4 -1.2 0.1 0.3 -0.2 -0.5 -0.6 -3.1 0.8 0.5 -0.5 0.5 -0.2 0.3 0.3 -0.1 -0.4
Leg predicted mass (left) 0.1 0.3 1.1 0.4 -0.7 -0.3 0.9 0.9 0.1 -0.4 0.0 -0.1 -0.2 0.7 0.7 0.6 0.1 0.8 0.9 0.5 -1.0 -0.4 0.4 -0.4 0.1 -0.5 -0.4 0.4 0.4
Trunk fat mass 0.4 1.5 4.6 -1.4 0.9 -2.1 0.4 0.4 -1.2 -2.0 -1.8 1.0 1.6 -0.7 -0.4 -0.9 -1.8 -0.2 -0.9 -0.1 0.6 1.3 -1.3 1.6 -1.7 0.6 1.5 0.6 -1.1
Waist circumference 0.7 2.5 5.7 -2.2 -0.0 -2.3 0.5 0.6 -1.3 -2.3 -2.4 0.9 1.7 -1.4 -1.3 -2.3 -2.2 -0.7 -1.6 1.2 1.4 1.6 -1.7 1.8 -1.9 0.2 1.7 -0.3 -1.9
Number of incorrect matches in round 0.2 0.4 2.2 0.1 -1.5 1.5 -0.8 -0.8 -0.1 0.9 0.3 0.1 -0.3 0.5 -0.6 -0.1 0.5 -0.7 -0.1 -0.9 0.2 0.1 -0.1 0.2 0.4 0.7 -0.3 0.1 0.5
Past tobacco smoking 0.5 1.0 2.8 0.9 -1.1 0.7 0.1 0.1 0.9 0.9 0.9 -1.3 -0.5 -1.6 1.6 1.6 0.8 1.1 0.6 -1.7 -0.2 -0.6 0.8 -0.4 1.3 -0.4 -0.5 -1.4 0.7
Alcohol usually taken with meals 1.8 2.9 15.1 1.4 -3.8 3.9 -1.7 -1.3 -0.0 3.1 2.0 -0.1 -1.1 1.1 0.4 1.9 2.5 -0.7 1.0 -1.7 -0.4 -0.6 0.5 -0.9 1.5 0.8 -1.3 1.0 1.4
Nervous feelings 0.5 0.9 3.3 0.6 -0.6 1.5 -0.7 -0.6 0.7 1.6 1.0 -1.2 -0.9 -1.3 0.8 1.1 0.9 0.2 0.2 -1.4 0.4 -0.4 0.5 -0.6 1.0 -0.1 -0.7 -1.8 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 2.9 -0.4 -1.1 -1.0 0.7 0.7 0.2 -0.8 -0.5 -0.1 0.2 -0.4 -0.4 -1.7 -0.3 0.2 -0.4 1.4 0.4 -0.0 0.0 0.0 -0.1 -0.5 0.3 -0.7 -0.5
Hearing difficulty/problems with background noise 0.4 0.7 3.3 0.7 -1.0 -0.3 1.5 1.8 0.7 0.4 0.5 -0.8 -0.4 -0.2 1.5 0.4 0.5 1.2 0.9 -0.8 -0.9 -0.6 0.8 -0.6 0.4 -0.6 -0.3 -0.4 0.8
Hair/balding pattern: Pattern 2 0.4 0.6 10.2 0.5 3.2 -0.2 0.1 0.1 0.6 0.0 0.5 -0.6 -0.2 -0.6 0.2 0.2 0.3 0.2 -0.1 0.0 0.1 -0.4 0.4 0.1 0.6 0.6 -0.2 -0.9 0.8
Had menopause 0.7 0.8 3.1 -1.4 0.4 -1.2 0.2 0.2 -0.8 -1.2 -1.4 0.4 0.7 -0.6 -0.5 -1.8 -1.3 -0.4 -0.8 0.9 0.7 0.9 -1.0 0.7 -1.0 -0.1 0.7 -0.5 -1.2
Had other major operations 0.8 1.0 5.8 -0.4 -0.3 -2.4 1.8 1.6 0.3 -1.9 -1.0 -0.2 0.3 -0.0 0.5 -1.0 -1.1 1.3 0.5 0.8 -1.0 -0.2 0.2 -0.2 -0.8 -1.0 0.2 -0.3 -0.2
Forced vital capacity (FVC) 0.3 1.2 5.9 1.3 -1.2 1.7 -0.1 -0.3 0.5 0.9 1.4 0.0 -1.0 1.4 1.1 1.2 1.1 0.5 1.2 -2.4 -1.3 -0.9 1.0 -0.9 1.0 -0.3 -0.9 1.2 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 7.6 -0.9 -2.8 0.1 -1.5 -1.4 -1.6 -0.0 -0.7 1.4 1.1 0.7 -0.5 0.9 -0.5 -1.1 -0.6 -0.9 0.8 1.2 -1.4 1.1 -1.0 0.6 0.8 1.8 -0.9
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.5 -0.8 1.3 0.1 -1.5 -1.5 -0.8 0.2 -0.6 0.6 0.6 -1.2 -1.1 -0.5 -0.4 -1.2 -1.1 1.6 1.4 1.0 -1.0 1.1 -0.7 0.6 0.8 0.3 -0.8
Qualifications: None of the above 0.2 0.5 2.0 0.6 1.1 1.4 -0.4 -0.4 0.5 1.1 0.8 -0.9 -0.9 -1.4 -0.1 -0.0 0.8 -0.2 0.2 0.5 -0.1 -0.4 0.5 -0.4 0.6 -0.4 -0.4 -1.1 0.5
Financial difficulties in last 2 years 1.1 1.4 3.6 -1.3 1.9 -1.8 0.4 0.5 -0.9 -1.8 -1.6 1.1 1.2 -0.3 -0.6 -1.7 -1.6 -0.3 -1.0 -0.2 1.2 1.1 -1.1 1.4 -1.2 0.1 1.4 0.6 -1.5
Mouth/teeth dental problems 0.4 0.6 4.0 0.6 -1.7 0.3 0.4 0.2 0.5 0.1 0.4 -0.5 -0.3 0.2 1.1 1.2 0.4 1.1 0.9 -2.0 -0.9 -0.5 0.5 -0.6 0.5 -0.7 -0.6 0.1 0.5
Heart attack 0.3 0.4 1.7 -0.4 1.3 -0.9 -0.4 -0.6 -0.5 -1.0 -0.6 0.6 0.4 1.3 -0.2 -0.4 -0.7 -0.2 -0.2 0.2 -0.1 0.4 -0.4 -0.1 -0.9 0.7 0.5 0.7 -0.4
Allergy 0.4 0.9 6.9 0.8 -2.6 1.7 -0.4 -0.6 0.3 0.7 0.9 -0.0 -0.8 2.2 0.3 0.3 0.8 -0.0 0.6 -1.1 -0.7 -0.5 0.6 -0.5 0.8 -0.9 -0.7 0.3 0.7
Pain all over the body in last month 0.5 0.5 1.4 -0.9 1.0 -0.2 -0.5 -0.6 -0.5 -0.4 -0.8 0.3 0.6 -0.9 -0.8 -1.2 -0.5 -0.8 -1.0 -0.5 1.2 0.7 -0.7 0.9 -0.5 1.0 0.6 -0.5 -0.5
Diabetes (self-reported) 0.6 0.9 2.5 -0.7 -0.6 -0.4 -0.7 -0.4 -0.9 -0.6 -0.5 1.1 1.2 -0.9 -1.6 -1.4 -0.4 -1.1 -1.1 0.6 1.2 0.9 -0.9 1.5 -0.7 0.9 1.0 1.0 -0.5
Hayfever/allergic rhinitis (self-reported) 2.0 2.7 5.0 -1.9 -0.1 -0.8 -1.0 -0.7 -2.0 -0.7 -1.8 2.1 1.6 -1.0 -2.0 -0.8 -2.0 -1.6 -1.9 0.3 1.8 2.2 -2.0 2.2 -2.2 0.9 2.2 1.6 -2.1
Medication: Ramipril 0.6 0.8 3.2 -0.4 0.0 -0.9 -0.9 -1.1 -0.7 -1.3 -0.3 1.3 0.8 1.3 -1.1 -0.6 -0.7 -0.7 -0.5 1.2 0.3 0.6 -0.6 0.8 -0.6 0.8 0.7 1.8 -0.4
Medication: Simvastatin 0.3 0.4 1.2 -0.6 -0.1 -0.3 -0.8 -0.9 -0.3 -0.5 -0.5 0.6 0.7 0.3 -1.1 -0.7 -0.4 -0.8 -1.0 -0.9 0.9 0.6 -0.5 0.6 -0.5 1.1 0.6 0.3 -0.4
Fluid intelligence score 1.1 2.3 4.6 1.7 -0.9 -0.2 2.1 2.1 1.9 0.4 1.5 -1.2 -1.4 0.5 1.9 0.8 1.1 1.9 1.9 -1.6 -1.9 -1.9 2.0 -2.0 1.4 -1.2 -1.5 -0.6 1.4
Illnesses of siblings 0.9 1.3 6.9 0.8 -0.8 1.6 -1.1 -1.1 -0.4 1.1 0.9 1.1 -0.1 2.5 -0.4 1.8 0.8 -0.6 0.4 -1.9 -0.5 -0.1 0.1 -0.2 0.2 1.1 -0.2 2.6 0.7
Neuroticism score 0.2 0.3 2.7 0.1 -1.6 0.6 -0.5 -0.4 0.1 0.6 0.3 0.1 -0.2 1.4 -0.5 -0.2 0.2 -0.3 -0.4 1.3 0.5 0.1 0.0 -0.1 -0.0 0.5 0.2 -0.2 -0.1
Weight 0.1 0.7 2.4 -0.8 -1.3 -1.5 0.8 0.7 -0.7 -1.5 -1.2 0.6 0.9 -0.4 -0.0 -0.5 -1.2 0.2 -0.2 0.3 -0.0 0.6 -0.7 0.8 -1.1 -0.0 0.8 0.5 -0.7
Impedance of arm (right) 0.7 3.2 52.9 0.7 7.3 -1.2 1.2 0.9 1.1 -0.7 0.3 -1.1 -0.5 -1.9 1.7 0.1 0.1 1.4 0.9 -2.7 -1.2 -0.9 1.1 -0.8 0.4 -1.1 -0.7 -0.8 0.7
Arm fat percentage (right) 0.7 2.8 7.3 -1.9 1.3 -2.7 0.0 0.0 -1.6 -2.4 -2.2 1.4 2.1 -1.2 -1.3 -1.7 -2.2 -0.8 -1.6 1.2 1.3 1.7 -1.7 2.0 -2.2 0.9 2.0 0.8 -1.7
Trunk fat-free mass 0.2 0.9 13.5 0.6 -3.7 1.1 0.1 0.1 0.1 0.5 0.5 0.0 -0.5 1.6 0.5 1.2 0.6 0.3 0.9 -0.3 -0.8 -0.5 0.3 -0.5 0.4 -0.2 -0.6 0.7 0.6
Hip circumference 0.2 0.7 2.8 -0.9 -1.0 -1.7 0.3 0.3 -0.9 -1.5 -1.2 0.9 1.1 -0.3 -0.3 -0.5 -1.2 -0.0 -0.3 0.1 0.0 0.8 -0.8 0.8 -1.2 0.6 0.9 0.8 -0.6
Time employed in main current job 0.7 0.8 5.2 -0.5 1.2 -0.7 0.8 0.8 0.5 -0.7 -0.5 -1.0 -0.1 -2.0 -0.1 -1.8 -0.4 0.4 -0.5 0.9 0.6 -0.1 0.1 0.3 0.2 -0.4 0.1 -2.3 -0.3
Alcohol intake versus 10 years previously 0.4 0.6 2.3 -0.8 0.6 -0.9 0.5 0.2 0.2 -0.8 -1.0 -0.2 0.1 -1.3 -0.6 -1.5 -0.9 0.2 -0.6 1.2 0.5 0.4 -0.3 0.7 -0.5 -1.3 0.2 -1.3 -0.7
Father’s age at death 1.2 1.6 4.5 1.3 -0.9 1.9 0.2 0.3 0.9 1.6 1.5 -0.9 -1.1 1.9 1.2 1.5 1.6 0.9 1.3 -2.1 -1.1 -1.1 1.1 -1.0 1.2 -0.7 -1.1 0.1 1.3
Worrier / anxious feelings 0.5 1.0 4.1 -1.0 -2.0 -0.2 -0.9 -0.9 -0.7 -0.3 -0.8 0.7 0.6 1.4 -1.0 -0.8 -0.9 -1.0 -1.3 0.8 1.6 1.1 -1.0 0.9 -0.9 0.1 0.9 -0.2 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 5.1 -0.9 0.2 -0.1 -1.5 -1.1 -1.0 -0.1 -0.4 1.1 1.2 0.3 -1.7 -1.5 -0.4 -1.8 -1.6 1.6 2.0 1.2 -1.1 1.2 -0.5 2.3 1.3 0.4 -0.8
Falls in the last year 0.8 1.1 3.3 -1.0 1.2 -1.1 -0.7 -0.7 -1.0 -1.1 -1.0 0.8 1.0 -1.1 -1.2 -1.3 -0.9 -1.0 -1.1 1.8 1.2 1.0 -1.0 0.9 -0.9 0.3 0.9 0.3 -1.3
Hair/balding pattern: Pattern 3 0.4 0.5 1.7 0.7 -1.2 1.3 -0.2 -0.1 0.5 1.2 0.9 -0.6 -0.7 0.4 0.1 0.2 1.2 0.1 0.5 1.0 -0.5 -0.7 0.7 -0.9 0.9 -0.2 -0.7 -0.3 0.7
Number of live births 0.7 1.0 2.7 -0.8 1.6 -1.4 -0.1 -0.0 -1.1 -0.9 -0.9 1.1 1.2 -0.9 -0.7 0.1 -1.4 -0.8 -0.8 0.8 0.4 1.2 -1.0 1.1 -1.4 0.7 1.2 1.0 -0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 10.4 0.6 -3.2 1.4 -0.5 -0.6 -0.2 0.4 0.7 0.7 -0.4 2.2 0.4 0.7 0.5 -0.1 0.6 -1.7 -0.8 -0.2 0.2 -0.2 0.4 0.0 -0.4 1.7 0.6
Pulse rate 0.6 1.1 5.2 -1.0 2.0 -1.4 -0.0 0.2 -0.8 -1.3 -1.0 0.4 1.3 -2.3 -0.6 -1.2 -0.6 -0.7 -0.8 1.5 0.8 0.7 -0.8 0.4 -0.7 1.3 0.7 -0.1 -0.6
Happiness 1.0 1.2 3.6 -1.5 -1.7 -0.7 -0.1 -0.1 -0.8 -1.0 -1.4 1.0 0.9 0.1 -0.9 -1.9 -1.1 -0.8 -1.3 1.1 1.4 1.1 -1.2 1.2 -1.1 0.8 0.9 0.1 -1.2
Noisy workplace 0.3 0.4 1.5 0.3 1.2 0.9 0.1 0.2 0.5 1.1 0.4 -1.0 -0.6 -0.8 0.4 0.2 0.8 0.2 0.3 0.8 -0.1 -0.5 0.4 -0.1 0.7 -0.2 -0.7 -1.0 0.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.8 0.9 -1.5 0.4 -0.8 -0.8 -0.4 0.5 0.8 0.8 0.1 1.8 0.3 1.6 0.6 -0.2 0.6 -1.9 -0.5 -0.2 0.3 -0.3 0.5 0.9 -0.2 2.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 5.5 0.7 -0.7 0.4 0.7 0.8 0.6 0.7 0.6 -0.4 -0.8 0.5 -0.1 0.1 0.6 0.5 0.9 2.4 -0.8 -0.6 0.7 -0.5 0.5 -0.2 -0.7 -0.5 0.9
Mouth/teeth dental problems: Dentures 0.2 0.4 2.0 0.5 0.5 1.4 -0.8 -0.7 0.0 1.3 0.8 -0.0 -0.6 0.2 -0.7 0.2 1.0 -0.8 0.0 1.2 -0.0 -0.2 0.2 -0.1 0.2 -0.0 -0.4 0.2 0.5
Asthma 0.3 0.6 6.2 0.1 2.5 -0.5 0.3 0.6 0.3 0.4 0.2 -0.5 0.2 -2.4 0.2 0.3 0.2 0.1 -0.1 0.2 0.5 -0.1 0.1 -0.1 0.2 1.0 0.2 -0.7 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.3 -0.2 -0.6 0.8 -1.0 -1.1 -0.4 0.4 -0.1 0.6 -0.3 0.1 -1.0 -0.4 -0.1 -0.8 -0.4 -0.2 0.3 0.3 -0.4 0.2 -0.1 0.3 0.0 0.7 -0.3
Medication: Cholesterol lowering 0.2 0.3 1.2 -0.5 -0.8 0.4 -0.6 -0.6 -0.4 -0.0 -0.3 0.2 0.5 0.0 -0.7 -0.4 -0.1 -0.7 -0.8 -1.1 1.0 0.6 -0.6 0.7 -0.3 0.6 0.5 -0.3 -0.4
Depression (self-reported) 0.4 0.5 2.3 0.3 -0.8 0.5 0.9 1.0 0.7 0.7 0.3 -1.0 -0.6 -0.3 0.8 0.3 0.5 0.7 0.4 -0.6 -0.3 -0.5 0.6 -0.7 0.6 -0.1 -0.5 -1.5 0.5
Medication: Lansoprazole 0.9 1.0 4.8 0.0 -2.2 1.2 -1.5 -1.2 -1.0 1.2 0.5 0.9 0.4 1.2 -0.9 1.1 0.5 -1.2 -0.4 -0.1 0.5 0.7 -0.6 0.5 -0.1 2.1 0.4 1.5 0.3
Prospective memory result 0.8 1.0 1.9 -1.1 -1.4 -0.9 -0.6 -0.7 -0.9 -1.1 -1.1 0.9 0.8 0.2 -1.3 -1.3 -1.2 -0.8 -1.2 1.0 1.0 1.0 -1.0 1.4 -1.1 0.5 1.2 0.6 -0.9
Lung cancer (father) 0.7 0.8 3.6 -0.4 -0.8 0.3 -1.2 -1.2 -0.9 -0.1 -0.3 1.1 0.8 1.1 -1.0 -0.3 -0.0 -1.0 -0.7 1.6 0.7 0.6 -0.7 0.7 -0.4 1.9 0.7 1.5 -0.1
Illnesses of mother 3.0 3.7 7.0 -2.4 0.7 -2.1 -0.8 -0.6 -2.2 -2.4 -2.4 1.9 2.4 -1.0 -1.5 -2.4 -2.1 -1.6 -2.0 0.9 2.1 2.1 -2.2 2.0 -2.3 0.4 2.2 1.4 -2.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 6.1 0.1 -2.5 0.5 -0.5 -0.5 -0.7 -0.2 0.0 1.1 0.1 1.7 -0.0 0.4 -0.3 -0.3 0.2 -0.8 -0.5 0.3 -0.2 0.2 -0.4 0.2 0.2 2.0 -0.0
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 0.3 0.5 -0.3 0.9 0.9 0.7 -0.2 0.2 -1.0 -0.3 -0.7 0.6 -0.7 0.7 0.8 0.6 -0.1 -0.5 -0.8 0.6 -0.8 0.8 -1.0 -0.8 -1.2 0.3
Impedance of arm (left) 0.5 2.4 42.8 0.1 6.5 -1.6 0.7 0.4 0.5 -1.2 -0.3 -0.6 0.3 -2.1 1.3 -0.4 -0.6 0.9 0.2 -2.3 -0.4 -0.3 0.4 -0.1 -0.1 -0.5 0.0 -0.7 0.0
Arm fat mass (right) 0.4 1.8 4.4 -1.6 -0.4 -2.1 0.1 0.1 -1.4 -2.0 -1.9 1.2 1.6 -0.8 -1.0 -1.2 -1.9 -0.5 -1.1 0.9 0.9 1.4 -1.4 1.7 -1.8 0.6 1.6 0.8 -1.4
Trunk predicted mass 0.2 0.9 13.0 0.6 -3.6 1.2 -0.0 -0.0 0.0 0.6 0.5 0.1 -0.4 1.6 0.4 1.2 0.6 0.2 0.8 -0.2 -0.7 -0.4 0.3 -0.5 0.4 -0.1 -0.6 0.8 0.6
Standing height 0.3 3.4 13.6 1.9 1.0 1.2 1.4 1.2 1.6 0.8 1.5 -1.4 -1.6 1.2 2.7 2.1 1.4 1.9 2.4 -3.7 -2.6 -2.0 1.9 -2.1 1.6 -1.1 -2.0 -0.1 2.0
Length of working week for main job 0.6 0.7 3.5 -0.2 1.1 -1.1 1.3 1.1 0.5 -0.8 -0.5 -0.5 -0.1 -1.2 0.9 -0.4 -0.6 1.2 0.3 1.9 -0.2 -0.1 0.2 0.1 -0.2 -1.4 -0.0 -0.8 -0.4
Exposure to tobacco smoke at home 2.2 2.5 4.5 -1.7 1.2 -1.6 -1.2 -1.3 -1.2 -1.7 -1.5 1.3 1.7 -0.7 -1.5 -2.0 -1.7 -1.3 -2.0 2.1 2.0 1.6 -1.5 1.6 -1.6 0.6 1.9 0.3 -2.0
Breastfed as a baby 0.4 0.5 3.1 0.0 0.2 1.2 -1.3 -1.4 -0.4 0.1 0.2 0.7 -0.0 1.8 -1.1 -0.3 0.4 -1.0 -0.1 0.5 -0.0 0.1 -0.2 -0.2 0.1 0.3 -0.1 0.8 -0.2
Tense / ‘highly strung’ 0.2 0.3 1.2 0.3 0.6 0.6 -0.1 0.1 0.4 0.8 0.6 -0.6 -0.3 -1.1 -0.1 -0.4 0.5 -0.2 -0.3 0.9 0.6 -0.1 0.3 0.1 0.5 -0.3 0.1 -1.0 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 9.1 -0.4 -0.0 1.0 -1.5 -1.3 -1.0 0.6 -0.1 1.1 0.6 2.2 -0.7 -0.1 0.2 -1.4 -0.8 -0.5 0.8 0.8 -0.8 0.1 -0.4 3.0 0.6 1.0 -0.1
Hair/balding pattern: Pattern 4 0.4 0.9 3.6 0.5 -1.8 -0.4 1.4 1.4 0.6 0.2 0.1 -0.8 -0.8 0.6 1.4 0.7 -0.2 1.4 1.0 -0.5 -1.3 -0.7 0.7 -0.7 0.0 -1.9 -0.4 -0.7 0.3
Birth weight of first child 1.4 2.6 7.7 1.7 0.1 -0.5 2.0 1.8 1.4 0.2 1.0 -1.1 -1.4 1.1 2.7 2.0 0.8 2.5 2.4 0.6 -2.8 -1.8 1.8 -1.8 1.0 -1.3 -1.5 0.2 1.6
Peak expiratory flow (PEF) 1.1 2.5 15.2 -1.4 -3.9 -0.3 -1.0 -1.0 -1.6 -1.2 -1.2 2.0 1.2 2.4 -1.0 -1.1 -1.7 -1.3 -1.4 -0.8 1.2 1.7 -1.5 1.7 -1.6 1.0 1.5 1.7 -1.4
Pulse wave reflection index 0.7 0.9 2.1 -0.9 0.3 -0.1 -1.2 -1.1 -1.0 -0.1 -0.7 0.8 1.0 0.6 -1.4 -0.9 -0.4 -1.2 -1.2 0.1 1.4 1.0 -1.0 1.0 -0.7 1.1 1.1 0.4 -1.0
Ever highly irritable/argumentative for 2 days 0.8 0.9 1.5 -0.9 -0.8 -0.1 -1.0 -1.0 -1.0 -0.3 -0.7 1.2 0.8 0.7 -1.1 -0.7 -0.7 -1.2 -1.1 1.2 1.2 1.0 -1.0 1.2 -0.9 0.9 1.0 1.0 -0.9
Loud music exposure frequency 0.5 0.5 2.2 0.4 0.1 1.5 -1.0 -1.0 -0.4 1.4 0.5 0.5 -0.4 -0.4 0.2 1.3 0.5 -0.6 0.3 -1.3 0.1 0.1 -0.1 0.5 -0.0 -0.5 -0.2 1.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.8 1.4 8.4 0.2 -1.6 0.8 -1.6 -1.6 -1.0 0.4 0.5 1.6 0.7 2.7 -0.4 0.9 0.5 -1.0 0.0 -1.5 0.5 0.4 -0.5 0.7 0.0 1.0 0.3 2.9 -0.1
Mouth/teeth dental problems: Bleeding gums 3.5 4.5 10.2 -2.3 0.6 -1.3 -1.9 -2.0 -2.0 -2.0 -2.0 2.3 2.0 -0.3 -3.0 -3.2 -2.0 -2.6 -2.7 1.8 2.7 2.2 -2.3 2.3 -2.0 1.6 2.1 1.2 -2.3
Blood clot in the leg (DVT) 0.3 0.4 2.3 -0.4 0.5 -1.1 1.2 1.5 -0.2 -0.5 -0.6 0.0 0.2 -1.2 0.4 -0.3 -0.7 0.5 0.0 0.5 -0.2 0.3 -0.2 0.3 -0.5 -0.7 0.3 -0.0 -0.5
Medication: Paracetamol 0.1 0.2 3.3 -0.2 0.2 -0.2 -0.1 -0.3 -0.1 -0.3 -0.2 0.4 -0.0 0.5 -0.9 -0.8 -0.1 -0.2 -0.3 1.8 0.3 0.0 -0.1 0.4 -0.0 0.4 0.1 0.2 -0.1
Headache pain in last month 0.4 0.8 2.8 0.9 1.0 0.4 0.4 0.2 1.3 0.5 1.0 -1.0 -1.1 0.1 0.1 -0.1 0.9 0.7 0.6 1.7 -0.4 -1.1 1.1 -0.9 1.2 -0.4 -1.0 -1.3 0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.4 0.9 0.0 0.5 0.7 0.6 0.5 0.5 0.7 -0.3 -1.0 0.5 0.9 0.7 0.6 0.8 1.3 -0.4 -1.6 -0.9 0.9 -1.4 0.6 -0.4 -1.0 0.4 0.8
Glaucoma (self-reported) 1.4 1.6 3.0 -1.4 -0.6 -1.2 -0.8 -0.8 -1.6 -1.5 -1.6 1.4 1.7 0.7 -1.1 -1.2 -1.3 -1.1 -1.3 0.4 1.2 1.5 -1.5 1.4 -1.5 0.6 1.5 1.4 -1.5
Gout (self-reported) 1.8 2.4 5.4 -2.0 0.8 -2.1 -0.0 0.0 -1.4 -2.3 -2.2 1.2 1.7 0.4 -1.0 -2.0 -2.2 -0.8 -1.6 1.3 1.7 1.7 -1.7 1.8 -1.8 0.9 1.8 0.4 -1.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 7.6 -0.8 0.3 -1.3 0.3 0.2 0.4 -1.0 -0.7 -0.6 0.3 -2.8 -0.5 -1.8 -0.9 -0.1 -1.3 1.6 1.3 0.3 -0.2 0.9 -0.3 -0.9 0.7 -1.9 -0.8
Medication: Amlodipine 0.1 0.2 0.8 0.4 -0.8 0.6 0.2 0.3 0.4 0.5 0.4 -0.2 -0.6 0.4 -0.2 -0.2 0.5 -0.0 0.2 0.6 -0.1 -0.4 0.3 -0.1 0.3 -0.9 -0.3 -0.1 0.2
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.5 -0.0 1.1 0.7 -1.9 -1.9 -0.8 0.7 0.3 1.0 0.6 0.0 -1.0 0.7 0.2 -1.2 -0.6 0.3 0.8 0.7 -0.6 0.7 -0.2 1.4 0.6 1.6 -0.2
Birth weight 0.6 1.4 3.6 1.4 1.3 0.7 0.7 0.8 0.8 0.6 1.3 -0.9 -0.7 -0.8 1.9 1.6 1.2 1.1 1.8 -1.2 -1.5 -1.2 1.1 -1.1 1.1 -1.0 -1.2 0.5 1.3
Chronic bronchitis/emphysema (mother) 3.3 3.9 6.3 2.2 2.0 1.0 1.4 1.2 2.5 1.4 2.2 -2.4 -2.5 -1.3 1.8 1.6 2.0 1.9 2.1 -1.2 -2.1 -2.4 2.4 -2.3 2.2 -1.9 -2.3 -1.4 2.2
High blood pressure (siblings) 0.5 0.7 2.9 0.7 0.7 -0.2 0.7 0.5 1.1 0.3 0.7 -1.4 -1.0 -1.4 0.7 0.1 0.5 0.8 0.6 0.6 -0.4 -0.9 0.8 -0.5 0.9 -0.6 -0.8 -1.7 0.9
Forced vital capacity (FVC), Best measure 0.2 0.8 2.7 1.1 -0.3 1.0 0.2 0.1 0.4 0.4 1.0 0.2 -0.8 1.2 0.9 1.0 0.7 0.5 1.2 -1.6 -1.6 -0.8 0.9 -1.0 0.6 -0.3 -0.8 1.4 1.0
Body fat percentage 0.7 2.8 7.0 -2.0 1.1 -2.6 0.0 0.0 -1.6 -2.4 -2.3 1.3 2.1 -1.4 -1.0 -1.6 -2.3 -0.7 -1.6 0.4 1.3 1.8 -1.8 2.1 -2.2 0.8 2.0 0.5 -1.8
Leg fat percentage (right) 0.7 2.6 5.2 -2.1 -1.1 -2.1 -0.0 0.1 -1.7 -1.8 -2.3 1.4 1.9 -0.8 -1.2 -1.5 -2.1 -0.9 -1.6 1.2 1.4 1.8 -1.9 1.9 -2.2 1.2 1.9 0.6 -1.8
Arm fat-free mass (right) 0.1 0.7 14.3 -0.1 -3.8 0.7 -0.2 -0.2 -0.4 0.2 -0.1 0.3 0.1 0.9 -0.0 0.7 0.1 -0.2 0.2 -0.0 0.1 0.1 -0.3 0.2 0.0 0.3 -0.1 0.5 -0.0
Exposure to tobacco smoke outside home 0.3 0.4 2.1 0.2 0.8 0.1 0.3 0.3 0.6 0.6 0.2 -1.0 -0.4 -1.1 0.6 0.3 0.4 0.6 0.2 0.7 0.2 -0.3 0.3 -0.4 0.6 -1.1 -0.4 -1.4 -0.1
Comparative body size at age 10 0.9 2.5 8.5 -0.5 -1.2 0.8 -2.3 -2.2 -2.0 0.1 -0.3 2.2 1.4 2.5 -2.0 0.7 -0.4 -2.1 -1.2 -0.1 1.0 1.5 -1.4 1.2 -1.2 2.6 1.4 2.9 -0.7
Number of full brothers 1.2 1.5 5.6 1.1 -1.6 0.2 2.0 2.0 1.1 0.5 0.6 -0.8 -1.5 -0.9 1.2 0.8 0.1 1.6 1.4 -0.9 -2.0 -1.1 1.3 -0.8 0.4 -2.4 -0.6 -0.1 0.8
Worry too long after embarrassment 0.5 0.8 6.4 0.6 -2.5 0.6 0.4 0.4 0.6 0.6 0.6 -0.7 -0.7 0.9 1.3 0.9 0.5 1.0 0.7 -2.0 -0.7 -0.5 0.6 -0.7 0.4 -0.3 -0.3 -0.6 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.4 -0.1 1.4 0.5 -1.4 -1.5 -0.4 -0.0 0.2 1.0 0.5 1.5 -1.2 -0.7 0.1 -1.3 -0.8 0.7 0.5 0.5 -0.3 0.0 -0.5 1.3 0.5 1.0 -0.2
Wheeze or whistling in the chest in last year 1.9 3.4 5.7 -2.3 2.1 -1.1 -1.1 -0.8 -2.0 -1.0 -2.1 1.6 1.8 -1.4 -2.1 -1.6 -1.9 -1.9 -2.1 2.0 2.3 2.2 -2.3 2.0 -2.1 1.2 1.9 0.6 -2.4
Number of children fathered 0.5 0.6 5.6 0.5 -0.6 0.8 -0.7 -0.7 -0.3 0.4 0.5 0.6 -0.1 2.4 -0.2 0.7 0.5 -0.3 0.5 1.4 -0.6 -0.1 0.1 -0.2 0.2 1.1 -0.2 1.3 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 1.4 0.2 0.2 -0.4 -0.1 -0.3 -0.1 -0.2 0.0 0.5 0.2 -0.6 -0.2 0.6 -0.1 -0.1 0.1 0.2 -0.4 -0.0 0.1 0.0 -0.4 -0.8 0.2 1.2 -0.1
Age at first live birth 0.2 0.3 0.8 0.3 -0.8 -0.9 0.9 0.9 0.2 -0.7 0.0 -0.0 0.4 0.8 0.8 0.5 -0.0 0.6 0.4 -0.6 -0.7 -0.4 0.4 -0.5 -0.1 -0.2 0.1 0.4 0.2
Pulse wave peak to peak time 0.3 0.3 1.3 -0.1 -0.6 0.4 -0.7 -0.7 -0.5 0.3 -0.0 0.9 0.1 0.7 -0.4 0.9 -0.5 -0.6 -0.4 -0.2 0.2 0.6 -0.4 0.6 -0.7 0.9 0.5 1.2 -0.1
Health satisfaction 0.5 0.6 3.1 -1.0 -0.2 0.0 -0.6 -0.4 -0.7 0.1 -0.7 0.3 0.6 -1.8 -0.7 -1.0 -0.2 -1.0 -1.1 0.5 1.5 0.8 -0.9 0.9 -0.6 0.5 0.6 -0.6 -0.9
Shortness of breath walking on level ground 0.9 1.1 1.9 -1.2 1.2 -1.3 -0.4 -0.3 -1.1 -1.3 -1.2 1.0 1.2 -1.4 -0.8 -1.3 -1.2 -0.8 -1.0 1.1 0.8 1.1 -1.1 1.0 -1.3 0.7 1.1 0.7 -1.0
Qualifications: College or University degree 1.4 4.3 9.2 2.3 -0.7 -0.1 2.9 3.0 2.0 0.8 1.6 -1.9 -2.0 -0.6 2.9 2.1 1.4 2.9 2.8 -0.3 -3.0 -2.3 2.4 -2.4 1.6 -2.4 -1.8 -0.5 1.9
Eye problems/disorders: None of the above 0.7 0.8 1.8 -1.3 0.5 -1.2 0.1 0.1 -0.7 -1.3 -1.3 0.7 0.9 0.8 -0.3 -1.1 -1.3 -0.4 -0.8 0.9 0.6 0.8 -0.9 0.5 -1.2 1.2 0.9 0.1 -0.8
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.9 -1.2 1.4 -0.8 -0.7 -0.6 -0.8 -0.8 -1.0 0.3 1.0 -1.0 -0.5 -1.3 -0.6 -1.0 -1.1 0.4 1.4 0.8 -1.0 0.5 -0.7 0.4 0.5 -0.4 -1.1
Emphysema/chronic bronchitis 0.7 0.8 2.6 -1.2 0.7 -0.5 -0.5 -0.5 -0.3 -0.6 -0.8 -0.1 0.8 -0.3 -1.2 -1.6 -0.5 -1.1 -1.2 1.2 1.4 0.7 -0.8 0.0 -0.3 1.6 0.5 -1.4 -0.8
Medication for pain relief, constipation, heartburn 0.8 1.4 5.3 0.8 1.4 -0.6 1.8 1.9 1.0 0.0 0.5 -1.2 -0.7 -0.0 2.3 1.3 0.4 1.7 1.5 -1.1 -1.6 -1.1 1.0 -1.2 0.6 -1.3 -1.0 -0.6 0.9
Neck or shoulder pain in last month 0.7 0.9 6.2 -1.0 1.7 -0.3 -0.4 -0.2 -0.5 -0.6 -0.8 0.2 0.4 -0.9 -1.1 -2.1 -0.4 -0.9 -0.9 2.5 1.1 0.7 -0.8 0.6 -0.4 -0.0 0.3 -0.5 -0.9
Medication: Blood pressure 0.4 0.7 1.9 -0.8 0.8 -0.1 -1.1 -1.2 -0.7 -0.4 -0.6 0.7 0.9 0.6 -1.2 -0.7 -0.6 -1.0 -1.2 0.1 1.4 1.0 -0.9 1.2 -0.6 0.4 0.9 0.2 -0.9
Angina (self-reported) 0.8 1.1 3.3 1.5 -1.2 0.8 0.5 0.5 0.8 1.0 1.3 -0.8 -1.0 0.7 1.4 1.8 1.0 1.1 1.4 -0.1 -1.4 -1.0 1.1 -1.0 1.0 -0.4 -0.8 -0.1 1.3
Migraine (self-reported) 0.9 1.1 2.9 0.9 1.7 0.5 1.2 1.3 1.2 0.6 0.9 -1.1 -1.0 -0.7 1.1 0.3 0.9 0.9 1.2 -0.6 -1.1 -1.2 1.1 -1.2 1.2 -0.4 -1.3 -1.1 1.2
Medication: Ibuprofen 0.2 0.3 1.0 0.6 -0.2 1.0 -0.2 -0.4 0.3 0.9 0.6 -0.0 -0.9 -0.0 -0.1 0.5 0.5 0.0 0.5 -0.9 -0.6 -0.4 0.4 -0.5 0.5 -0.4 -0.7 0.3 0.4
Medication: Allopurinol 3.5 4.7 8.0 -2.5 2.2 -1.8 -1.5 -1.3 -2.2 -1.9 -2.4 2.0 2.5 0.9 -2.0 -2.0 -2.4 -2.1 -2.7 1.6 2.8 2.6 -2.5 2.6 -2.3 2.2 2.6 1.0 -2.5
Medication: Omeprazole 0.2 0.3 1.9 0.2 0.3 0.8 -0.6 -0.5 -0.3 0.7 0.3 0.3 -0.0 0.4 -0.7 -0.0 0.4 -0.7 -0.2 1.4 0.3 0.2 -0.1 0.4 0.2 0.6 0.1 0.7 0.2
Medication: Seretide 50 evohaler 1.6 1.8 6.1 -1.5 1.9 -2.3 0.3 0.5 -0.9 -1.7 -1.7 0.7 1.8 -2.5 -0.7 -1.2 -1.6 -0.6 -1.4 1.2 1.2 1.2 -1.1 1.5 -1.3 0.4 1.5 0.0 -1.4
Mean time to correctly identify matches 0.3 0.6 4.7 -0.6 2.2 -1.1 0.4 0.5 -0.3 -1.1 -0.8 0.2 0.3 0.9 -0.3 -1.5 -0.9 -0.1 -0.4 1.0 0.2 0.4 -0.4 0.2 -0.7 0.7 0.5 -0.5 -0.4
Heart disease (mother) 0.5 0.6 2.4 1.0 1.1 0.3 -0.2 -0.1 0.4 0.7 1.0 -0.6 -0.1 0.8 0.7 1.2 0.9 0.2 0.5 0.7 -0.5 -0.7 0.6 -0.5 1.0 1.5 -0.3 0.3 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 2.0 5.3 1.4 -0.3 0.6 1.4 1.5 1.2 1.1 1.1 -1.4 -1.4 2.3 2.1 1.2 1.2 1.7 1.7 0.0 -1.9 -1.5 1.5 -1.8 1.3 0.3 -1.2 -0.9 1.7
Whole body fat mass 0.4 1.6 4.6 -1.5 0.1 -2.1 0.3 0.3 -1.2 -2.0 -1.8 1.0 1.6 -0.7 -0.6 -1.1 -1.9 -0.3 -1.0 0.2 0.8 1.3 -1.3 1.6 -1.7 0.6 1.6 0.5 -1.2
Leg fat mass (right) 0.4 1.6 3.2 -1.6 -1.0 -1.7 0.1 0.2 -1.3 -1.7 -1.8 1.1 1.5 -0.3 -0.9 -1.1 -1.7 -0.6 -1.1 1.1 1.0 1.3 -1.4 1.6 -1.7 1.0 1.5 0.6 -1.2
Arm predicted mass (right) 0.1 0.7 16.0 0.1 -4.0 0.9 -0.1 -0.1 -0.2 0.3 0.0 0.3 -0.1 1.1 0.0 0.7 0.2 -0.1 0.3 0.0 -0.1 0.0 -0.1 0.0 0.1 0.2 -0.2 0.4 0.2
Pulse rate, automated reading 0.4 1.4 15.4 -0.3 3.9 -0.7 0.8 0.9 0.6 -0.1 -0.2 -1.1 -0.0 -3.2 0.2 -0.3 0.2 0.3 -0.2 0.8 0.3 -0.4 0.1 -0.4 0.4 0.2 -0.5 -1.9 0.1
Alcohol intake frequency. 0.2 0.4 2.9 -0.4 -0.3 0.2 -0.4 -0.3 0.1 0.1 -0.2 -0.4 0.2 -1.7 -0.7 -1.0 0.1 -0.4 -0.7 1.6 1.2 0.2 -0.3 0.7 0.2 -0.3 0.2 -1.1 -0.3
Comparative height size at age 10 0.1 0.4 1.2 -0.7 0.3 -0.1 -1.0 -1.1 -0.7 -0.6 -0.6 0.5 0.7 -0.2 -0.5 -0.5 -0.4 -0.8 -0.8 0.3 0.8 0.6 -0.7 0.7 -0.5 0.7 0.6 0.0 -0.5
Number of full sisters 1.5 1.8 4.7 -1.8 1.6 -1.5 0.1 0.0 -0.8 -1.7 -1.9 0.6 1.2 -2.0 -1.0 -2.2 -1.6 -0.5 -1.3 1.3 1.4 1.3 -1.3 1.3 -1.3 -0.1 1.1 -0.4 -1.8
Suffer from ‘nerves’ 0.6 0.9 2.3 1.2 -1.1 1.4 0.1 0.2 0.9 1.5 1.4 -1.0 -1.0 0.0 0.9 1.1 1.3 0.6 0.8 -0.5 -0.6 -0.9 1.0 -1.0 1.2 -0.8 -0.9 -0.8 0.9
Overall health rating 2.2 4.8 12.7 -2.4 2.6 -2.1 -1.4 -1.3 -1.5 -2.1 -2.0 1.5 2.2 -0.7 -2.7 -3.6 -1.9 -2.2 -2.9 3.4 3.0 2.1 -2.1 1.9 -1.8 2.1 2.1 -0.3 -2.2
Chest pain or discomfort 1.2 1.7 6.3 -1.3 -0.0 -1.4 -0.7 -0.5 -1.0 -1.4 -1.1 0.9 1.4 0.1 -1.2 -1.3 -1.4 -0.9 -1.7 2.5 1.9 1.5 -1.3 1.4 -1.3 1.1 1.6 -0.2 -1.6
Had major operations 3.0 3.5 5.9 1.7 0.5 0.9 2.1 2.1 2.2 1.1 1.6 -2.4 -2.2 -0.8 2.0 0.7 1.8 2.1 2.1 -1.4 -2.1 -2.2 2.1 -2.1 2.0 -2.1 -2.3 -2.0 1.9
Age at last live birth 0.7 1.0 5.8 -0.5 1.2 -2.4 1.1 1.3 -0.6 -1.6 -0.8 0.5 1.5 -0.9 0.7 0.3 -1.3 0.4 -0.3 0.6 -0.1 0.6 -0.5 0.8 -1.2 -0.1 1.3 0.7 -0.5
Family relationship satisfaction 0.3 0.3 2.6 -0.5 -1.1 0.8 0.2 0.3 -0.0 0.5 -0.4 -0.2 -0.6 -1.6 -0.1 -0.4 -0.1 -0.1 -0.1 -0.6 0.5 0.2 -0.3 0.4 -0.1 -0.9 -0.1 -0.8 -0.4
Leg pain on walking 0.3 0.4 5.7 -0.0 1.3 -0.4 0.2 0.3 0.0 -0.3 -0.0 -0.3 0.1 -0.8 0.1 -0.7 0.1 -0.0 -0.1 2.4 0.2 -0.1 -0.0 0.1 0.1 0.3 -0.0 -0.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 2.6 -1.4 -1.4 -0.7 -0.9 -1.1 -1.3 -1.3 -1.4 1.6 1.0 1.4 -1.4 -1.2 -1.4 -1.1 -1.1 0.8 0.8 1.3 -1.3 1.3 -1.4 0.7 1.1 1.5 -1.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.2 0.1 0.4 -1.1 0.8 1.0 -0.0 -0.4 -0.2 -0.3 0.6 -1.0 0.9 0.6 -0.3 0.8 0.1 0.3 -0.2 0.1 0.0 0.5 -0.2 -0.3 0.7 0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 4.3 0.7 -1.6 0.5 -0.2 -0.3 0.2 0.7 0.7 -0.5 -0.5 -0.9 1.0 1.9 0.6 0.6 0.7 -2.1 -0.7 -0.5 0.4 -0.5 0.4 -1.0 -0.5 0.2 0.4
Medication: Aspirin 1.1 1.4 2.5 -1.2 -1.2 -1.0 -0.9 -1.0 -1.1 -1.5 -1.2 1.3 1.4 -0.5 -1.4 -1.4 -1.4 -1.1 -1.5 0.1 1.3 1.3 -1.1 1.4 -1.4 0.9 1.6 0.7 -1.3
Supplements: Vitamin C 1.4 1.6 3.2 1.4 -0.9 1.2 1.1 1.2 1.2 1.2 1.3 -1.1 -1.7 0.3 0.9 0.8 1.4 1.1 1.7 -0.9 -1.6 -1.5 1.4 -1.6 1.4 -1.5 -1.8 -0.6 1.3
Knee pain experienced in last month 1.2 1.8 3.9 -1.4 1.1 -0.4 -1.4 -1.4 -1.3 -0.9 -1.1 1.3 1.1 0.3 -1.5 -1.9 -1.0 -1.7 -1.7 1.9 1.7 1.4 -1.4 1.4 -0.9 2.0 1.3 0.6 -1.1
Hypertension (Self-reported) 0.8 2.2 7.2 -1.4 -0.7 -0.7 -1.2 -1.1 -1.4 -0.6 -1.1 1.4 1.4 0.1 -2.0 -1.2 -1.3 -1.6 -1.8 2.7 1.8 1.7 -1.6 2.1 -1.5 0.4 2.0 0.9 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 6.2 -1.4 -1.1 0.5 -2.4 -2.2 -1.9 -0.1 -0.9 1.7 1.8 0.4 -2.3 -1.1 -0.8 -2.3 -2.2 1.2 2.2 1.9 -1.8 2.0 -1.2 2.5 1.8 0.9 -1.2
Illnesses of father: Heart disease 0.5 0.7 3.1 -0.7 1.1 -1.8 -0.0 -0.2 -0.7 -1.7 -1.0 0.7 0.9 -0.1 -0.4 -1.0 -1.2 -0.2 -0.5 -0.4 -0.0 0.7 -0.6 0.6 -1.0 -0.6 0.7 0.7 -0.9
Illnesses of siblings: Diabetes 1.6 1.9 4.1 -1.7 0.2 -1.2 -0.8 -0.7 -1.3 -1.0 -1.5 1.1 1.5 -0.9 -1.5 -1.7 -1.5 -1.2 -1.8 1.1 2.0 1.6 -1.6 1.9 -1.5 0.5 1.8 0.1 -1.7
Smoking status: Previous 0.2 0.3 1.6 -0.3 0.5 -0.4 0.4 0.4 -0.5 -0.3 -0.5 0.8 0.0 0.9 -0.6 -0.3 -0.5 -0.2 0.2 0.8 -0.5 0.2 -0.3 0.1 -0.8 -0.4 0.1 1.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.3 1.3 -0.9 0.7 1.3 1.2 1.2 0.8 1.1 -0.9 -1.2 0.6 1.8 1.4 0.7 1.6 1.2 -1.3 -1.1 -1.1 1.3 -0.7 1.1 -0.9 -0.7 -0.5 1.1
Whole body fat-free mass 0.1 0.6 7.4 0.5 -2.7 0.7 0.4 0.4 0.1 0.2 0.3 -0.0 -0.3 1.3 0.6 1.0 0.5 0.4 0.9 0.1 -0.8 -0.5 0.4 -0.5 0.3 -0.3 -0.6 0.6 0.5
Leg fat-free mass (right) 0.1 0.4 1.3 0.4 -1.0 -0.3 1.1 1.0 0.2 -0.5 0.0 -0.2 -0.2 0.6 0.8 0.5 0.1 0.9 1.0 0.5 -1.1 -0.5 0.5 -0.5 0.1 -0.8 -0.5 0.2 0.4
Arm fat percentage (left) 0.8 3.1 8.0 -2.1 1.1 -2.8 0.0 -0.0 -1.7 -2.6 -2.4 1.4 2.2 -1.4 -1.2 -1.9 -2.4 -0.8 -1.7 1.4 1.5 1.8 -1.9 2.2 -2.2 1.0 2.1 0.6 -1.8
Average weekly red wine intake 0.4 0.5 2.3 -0.6 -0.0 0.0 -0.8 -0.5 -1.1 -0.2 -0.4 1.1 0.9 0.8 -0.6 -0.0 -0.4 -0.9 -0.5 0.3 0.6 0.9 -0.9 0.8 -0.8 0.5 0.8 1.5 -0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.9 0.1 0.9 0.9 -0.7 -0.7 -0.1 0.9 0.3 0.0 -0.0 -0.6 -0.3 0.3 0.6 -0.4 -0.1 -0.7 0.1 0.0 -0.1 0.2 0.1 0.2 -0.1 0.3 0.2
Mood swings 0.3 0.5 4.1 -0.3 -0.6 -0.6 -0.3 -0.4 0.3 -0.5 -0.1 0.1 0.1 -0.4 -1.4 -1.4 -0.3 -0.6 -1.0 2.0 1.0 0.2 -0.1 0.3 -0.3 0.2 0.5 -0.5 -0.4
Loneliness, isolation 1.4 1.9 4.3 -1.6 0.5 -2.0 0.3 0.3 -0.9 -2.1 -1.6 1.1 1.5 0.1 -1.2 -2.1 -1.7 -0.6 -1.5 1.9 1.4 1.2 -1.2 1.2 -1.6 0.3 1.7 0.4 -1.8
Long-standing illness, disability or infirmity 0.6 0.9 8.5 0.5 2.9 -0.6 1.4 1.3 1.2 -0.3 0.5 -1.1 -0.5 0.5 0.6 -0.7 0.4 1.1 0.5 0.6 -0.7 -0.9 1.0 -0.9 0.5 -0.2 -0.4 -1.2 0.8
Ever had bowel cancer screening 0.3 0.3 2.4 0.4 0.9 0.7 -0.4 -0.7 0.4 0.4 0.4 -0.4 -0.5 1.6 -0.0 -0.3 0.7 -0.2 0.2 0.7 -0.6 -0.5 0.5 -0.8 0.4 -0.1 -0.5 -0.1 0.5
Diabetes diagnosed by doctor 0.9 1.4 3.1 -1.2 -0.6 -0.8 -0.7 -0.5 -1.2 -1.1 -1.1 1.3 1.4 -0.3 -1.6 -1.6 -0.9 -1.2 -1.3 1.3 1.5 1.2 -1.2 1.8 -1.2 1.1 1.3 1.1 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 2.4 0.0 0.3 -1.2 1.5 1.6 0.2 -1.1 -0.3 0.3 0.0 0.5 0.3 -0.9 -0.5 0.6 0.6 0.7 -1.0 -0.4 0.3 -0.3 -0.3 -1.2 -0.1 0.6 -0.0
Friendships satisfaction 0.6 0.7 9.8 -0.1 -3.1 1.6 -0.5 -0.4 -0.1 1.3 0.2 0.1 -0.4 -1.0 -0.6 0.1 0.7 -0.7 -0.0 -1.0 0.4 -0.1 -0.2 -0.1 0.4 -0.0 -0.5 0.2 -0.0
Qualifications: nursing, teaching 0.1 0.2 0.8 -0.6 -0.1 -0.6 0.0 -0.0 -0.5 -0.7 -0.8 0.3 0.5 -0.9 0.2 -0.2 -0.6 0.1 -0.2 -0.4 0.2 0.4 -0.5 0.6 -0.6 -0.5 0.5 0.2 -0.5
Commuting to job workplace: Walk 0.4 0.4 3.3 -0.4 -1.8 1.3 -0.6 -0.5 -0.2 1.0 -0.1 0.0 -0.4 -0.2 -0.8 -0.4 0.7 -0.8 -0.0 -0.9 0.4 0.1 -0.4 -0.5 0.3 0.6 -0.8 -0.4 -0.1
Eye problems/disorders: Cataract 4.9 5.7 8.6 2.8 -0.3 1.6 2.4 2.5 2.7 2.3 2.6 -2.6 -2.9 -0.6 2.3 2.0 2.4 2.6 2.8 -1.0 -2.9 -2.8 2.9 -2.7 2.6 -2.2 -2.6 -1.7 2.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.9 -0.9 1.2 -0.3 -0.3 -0.1 -0.8 -0.1 -0.9 0.4 0.7 -0.2 -0.5 -0.7 -0.7 -0.7 -1.0 1.4 1.0 0.9 -0.8 0.7 -0.6 1.2 1.1 -0.5 -0.8
Medication for cholesterol 2.6 4.0 6.3 2.3 0.4 2.3 1.3 1.3 2.0 2.1 2.2 -1.8 -2.5 0.8 1.8 1.9 2.2 1.7 2.3 -2.5 -2.4 -2.2 2.2 -2.3 2.2 -1.6 -2.4 -0.8 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 5.6 -0.5 1.1 1.4 -2.3 -2.3 -1.3 0.5 -0.1 1.3 0.6 2.4 -1.9 -0.1 0.1 -2.0 -1.0 0.5 1.2 1.1 -1.1 0.9 -0.5 2.3 0.6 1.6 -0.3
Back pain experienced in last month 1.2 1.8 3.8 -1.5 0.4 -0.1 -1.3 -1.2 -1.4 -0.7 -1.2 1.4 1.0 0.8 -1.7 -2.0 -1.2 -1.7 -1.6 1.9 1.4 1.6 -1.5 1.2 -1.5 1.4 1.3 0.4 -1.2
Mineral and other dietary supplements 0.4 0.6 2.7 0.3 -1.5 -0.4 1.0 0.9 0.9 0.2 0.2 -0.8 -0.6 -1.5 0.5 0.7 0.0 1.0 0.4 1.6 -0.3 -0.6 0.6 -0.1 0.3 -0.4 -0.3 -1.0 0.5
Breast cancer (self-reported) 0.1 0.2 1.8 0.1 -1.4 0.4 0.2 0.4 0.3 0.5 0.0 -0.2 -0.2 0.1 0.1 0.1 0.2 -0.1 -0.1 0.8 0.4 0.0 -0.0 0.1 0.1 -0.5 -0.3 -0.7 -0.0
Asthma (self-reported) 0.3 0.6 6.7 -0.1 2.6 -0.6 0.2 0.5 0.1 0.3 0.1 -0.4 0.3 -2.3 0.1 0.4 0.1 0.0 -0.2 0.4 0.6 0.0 -0.0 0.1 0.1 1.2 0.4 -0.5 0.0
Osteoporosis (self-reported) 0.6 0.7 2.9 0.8 1.7 0.3 -0.0 -0.1 1.0 0.3 1.0 -1.2 -0.7 -1.1 0.6 -0.1 1.0 0.5 0.5 0.5 -0.5 -1.0 0.9 -1.2 0.9 -1.1 -0.8 -1.1 0.6
Osteoarthritis (self-reported) 0.1 0.2 1.5 -0.2 1.2 -0.5 0.4 0.4 0.0 -0.7 -0.1 0.0 0.1 -0.4 -0.4 -0.7 -0.3 -0.2 -0.1 -0.7 -0.2 -0.1 -0.0 -0.2 -0.1 -0.5 -0.0 -0.0 -0.2
Medication: Aspirin 2.0 2.6 4.5 -1.8 -1.1 -1.1 -1.3 -1.4 -1.6 -1.6 -1.7 1.7 1.9 -1.0 -2.0 -1.7 -1.8 -1.6 -2.1 -0.1 2.0 1.9 -1.7 2.0 -1.9 0.9 2.0 0.8 -1.9
Medication: Gliclazide 1.0 1.2 3.3 -1.0 -0.7 -0.5 -0.9 -1.0 -1.2 -1.0 -0.9 1.5 1.1 0.7 -1.8 -1.4 -0.7 -1.3 -1.1 1.2 0.9 1.0 -1.1 1.2 -1.2 0.3 1.0 1.5 -0.9
Illnesses of father: None of the above (group 1) 0.3 0.4 1.8 0.1 0.1 0.8 -1.0 -1.1 -0.1 0.5 0.3 0.6 0.3 0.7 -1.1 0.4 0.4 -1.0 -0.6 0.4 0.5 0.1 -0.1 0.1 0.1 1.4 0.2 1.0 0.2
Smoking status: Current 1.1 1.8 6.7 -1.7 1.7 -0.6 -0.9 -0.9 -0.8 -1.2 -1.3 0.8 1.2 0.2 -1.9 -2.6 -1.1 -1.7 -1.9 0.7 1.9 1.2 -1.3 0.9 -1.1 1.1 1.1 -0.6 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 7.9 -1.6 -1.5 -1.4 -1.3 -1.5 -2.1 -2.1 -1.6 2.5 2.1 2.0 -1.5 -1.2 -1.9 -1.5 -1.7 2.0 1.2 2.0 -1.8 1.9 -2.1 1.3 2.1 2.8 -1.8
Whole body water mass 0.1 0.6 7.5 0.6 -2.7 0.7 0.4 0.4 0.1 0.3 0.4 -0.1 -0.4 1.3 0.6 1.1 0.5 0.5 1.0 0.0 -0.9 -0.5 0.4 -0.6 0.4 -0.4 -0.7 0.6 0.6
Leg predicted mass (right) 0.1 0.4 1.3 0.4 -1.0 -0.3 1.1 1.0 0.2 -0.5 0.0 -0.2 -0.2 0.6 0.8 0.5 0.0 0.9 1.0 0.5 -1.2 -0.5 0.5 -0.5 0.1 -0.8 -0.5 0.2 0.4
Arm fat mass (left) 0.4 1.6 3.9 -1.5 -0.5 -2.0 0.0 0.0 -1.2 -1.9 -1.7 1.1 1.6 -0.8 -0.8 -1.0 -1.8 -0.5 -1.1 1.0 1.0 1.3 -1.3 1.6 -1.6 0.7 1.6 0.6 -1.3
Number of self-reported non-cancer illnesses 0.9 1.6 3.9 -1.2 2.0 -1.6 -0.4 -0.2 -0.8 -1.3 -1.0 0.6 1.6 -1.3 -1.3 -1.8 -1.1 -1.1 -1.7 0.7 1.6 1.2 -1.0 1.4 -1.2 1.0 1.7 -0.3 -1.1
Average weekly champagne plus white wine intake 0.4 0.5 1.8 0.2 0.0 1.3 -0.6 -0.3 -0.7 1.3 0.3 0.7 -0.1 1.1 0.2 1.3 0.4 -0.5 0.4 -1.3 -0.3 0.3 -0.3 0.1 -0.2 1.0 0.1 1.3 0.4
Miserableness 1.9 3.2 5.2 -2.0 -1.6 -1.4 -0.8 -0.8 -1.8 -1.8 -2.0 2.1 1.6 2.0 -2.2 -2.0 -2.1 -1.5 -1.9 1.4 1.7 1.9 -1.8 1.9 -2.3 1.6 2.1 1.5 -1.9
Guilty feelings 0.2 0.4 5.4 -0.3 -2.3 -0.1 -0.2 -0.1 -0.0 -0.2 -0.3 0.2 -0.1 0.6 -0.4 -0.9 -0.4 -0.2 -0.5 1.2 0.4 0.2 -0.2 0.3 -0.2 0.7 0.4 -0.1 -0.1
Wears glasses or contact lenses 1.2 1.4 5.5 0.7 1.7 -0.7 1.7 1.7 1.1 -0.2 0.6 -1.4 -0.6 -2.3 1.4 -0.2 0.6 1.6 1.0 -0.6 -1.1 -1.1 1.1 -0.9 0.9 -1.7 -0.7 -1.3 0.7
Ever taken oral contraceptive pill 0.3 0.3 1.6 0.2 0.8 -1.0 0.8 1.0 0.5 -0.6 0.2 -0.5 0.2 -1.3 0.8 0.2 -0.1 0.6 0.0 -0.6 0.2 -0.3 0.3 0.1 0.3 -0.3 -0.1 -0.9 0.1
Hearing aid user 0.8 1.0 3.9 1.0 0.9 1.4 -0.3 -0.3 0.4 1.1 1.2 -0.3 -1.0 2.0 0.2 0.3 1.4 -0.2 0.9 -0.3 -1.2 -0.9 0.8 -1.1 1.0 0.7 -1.3 0.3 1.5
Mother’s age at death 1.0 1.2 7.5 1.3 -0.2 0.7 0.8 0.9 0.9 0.7 1.3 -0.3 -1.1 2.7 1.1 1.1 0.7 1.0 1.3 0.1 -1.6 -1.0 1.2 -0.9 0.8 0.3 -0.6 0.5 1.5
Financial situation satisfaction 0.3 0.3 2.9 0.3 0.6 0.2 0.3 0.2 0.2 0.3 0.2 0.1 -0.2 0.4 0.4 0.6 0.3 0.4 0.6 -1.7 -0.6 -0.3 0.3 -0.3 0.1 -1.4 -0.4 0.7 -0.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.0 1.1 1.0 1.3 -0.3 -0.3 0.7 1.2 1.1 -0.8 -0.8 0.3 0.5 1.1 1.4 0.2 0.9 -1.7 -0.8 -0.9 0.8 -1.1 1.1 0.7 -1.0 -0.4 1.3
Commuting to job workplace: Public transport 1.7 2.1 5.2 -1.8 0.5 -2.3 -0.5 -0.6 -1.1 -2.1 -1.8 1.6 1.4 0.4 -1.5 -1.7 -2.0 -1.0 -1.6 1.1 1.4 1.4 -1.4 1.1 -1.8 1.2 1.5 0.5 -1.8
Eye problems/disorders: Glaucoma 0.7 0.9 2.6 -1.0 -0.9 -1.1 -0.1 -0.2 -0.9 -1.6 -1.2 0.9 1.1 -0.0 -0.7 -1.6 -1.0 -0.5 -0.8 0.6 0.8 0.9 -0.9 1.2 -0.9 -0.4 1.0 0.9 -1.1
Medication: Blood pressure 0.6 1.2 2.5 -0.8 -1.3 -0.8 -0.9 -0.9 -1.2 -0.7 -0.8 1.6 1.2 0.8 -1.3 -0.5 -1.2 -1.1 -1.0 1.2 1.0 1.3 -1.1 1.4 -1.2 0.9 1.4 1.5 -1.1
Pain type(s) experienced in last month: Hip pain 1.0 1.3 6.0 -1.1 2.1 -1.3 -0.2 -0.0 -0.7 -1.3 -1.2 0.5 1.0 1.0 -0.6 -1.9 -1.0 -0.7 -1.1 1.9 1.0 0.9 -0.9 0.5 -0.9 2.5 0.7 -0.7 -0.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.8 -0.2 1.1 1.1 -1.4 -1.3 -1.1 0.4 0.0 1.1 0.6 1.9 -0.6 -0.1 0.2 -1.2 -0.3 -1.7 0.4 0.8 -0.8 0.4 -0.2 1.1 0.2 1.6 -0.2
High cholesterol (Self-reported) 1.7 3.1 8.6 -1.4 -1.6 0.4 -2.8 -2.9 -2.0 -0.4 -1.1 2.1 1.5 2.6 -1.9 -0.3 -0.9 -2.3 -1.6 -0.9 1.8 1.9 -1.9 1.5 -1.5 2.6 1.4 1.8 -1.1
Medication: Bendroflumethiazide 0.2 0.3 2.1 0.0 0.7 -0.3 -0.9 -1.0 -0.4 -0.2 0.1 0.5 0.5 -1.5 -0.7 0.1 -0.2 -0.6 -0.4 0.6 0.4 0.4 -0.3 0.5 -0.1 -0.0 0.4 0.7 -0.4
Medication: Paracetamol 0.5 0.7 4.9 -0.6 1.2 -0.5 -0.2 -0.2 -0.7 -0.6 -0.7 1.1 0.5 0.4 -1.4 -1.0 -0.7 -0.6 -0.6 2.2 0.5 0.6 -0.6 0.9 -0.7 0.3 0.7 1.0 -0.7
Medication: Lisinopril 0.4 0.6 2.2 -0.8 -0.3 -0.8 -0.1 -0.2 -0.4 -0.6 -0.8 0.6 0.3 -1.5 -0.8 -0.7 -1.0 -0.4 -0.9 -1.0 1.1 0.7 -0.7 1.2 -0.8 -0.3 0.7 0.0 -0.9
Medication: Atorvastatin 1.1 1.3 4.4 -0.1 -1.6 1.9 -2.1 -1.9 -1.3 1.3 0.3 1.2 0.2 1.7 -1.1 1.1 0.7 -1.4 -0.2 -0.5 0.4 0.7 -0.8 0.3 -0.2 1.7 0.1 1.7 0.1
Illnesses of father: High blood pressure 2.3 2.8 4.8 1.9 0.3 0.4 2.0 2.2 1.7 1.2 1.7 -1.9 -1.6 0.7 2.1 1.7 1.5 2.0 2.2 -0.5 -2.2 -1.9 1.9 -1.9 1.8 -0.9 -1.8 -1.4 2.0
Alcohol drinker status: Never 0.8 0.9 4.0 -1.2 0.2 -1.2 0.7 0.9 -0.4 -0.8 -1.2 -0.0 0.9 -1.1 -0.1 -1.2 -1.1 0.1 -1.0 2.0 1.2 0.8 -0.8 1.1 -0.7 -0.0 1.0 -1.3 -1.0
Ever smoked 0.8 1.3 4.3 -1.0 0.9 -0.5 -0.6 -0.5 -1.2 -0.8 -0.9 1.7 0.7 2.1 -1.8 -1.4 -0.8 -1.4 -0.7 1.6 0.3 0.8 -1.0 0.6 -1.5 0.4 0.8 2.0 -1.0
Basal metabolic rate 0.1 0.4 5.9 0.3 -2.4 0.2 0.5 0.5 -0.0 -0.2 0.0 0.1 -0.1 0.9 0.5 0.8 0.1 0.5 0.7 0.2 -0.7 -0.3 0.2 -0.2 0.1 -0.3 -0.3 0.6 0.3
Leg fat percentage (left) 0.7 2.4 5.1 -2.1 -1.5 -2.1 0.2 0.3 -1.6 -1.9 -2.2 1.2 1.9 -1.1 -1.0 -1.5 -2.1 -0.7 -1.4 0.9 1.3 1.7 -1.8 1.8 -2.1 0.9 1.8 0.3 -1.8
Arm fat-free mass (left) 0.1 0.7 12.2 0.2 -3.5 0.8 -0.1 -0.0 -0.3 0.4 0.1 0.3 -0.1 1.5 0.1 1.0 0.3 0.1 0.5 0.1 -0.5 -0.1 0.0 -0.1 0.0 0.1 -0.2 0.9 0.3
Number of operations (self-reported) 0.7 1.1 2.6 1.1 -0.1 0.3 1.2 1.0 1.3 0.2 0.8 -1.1 -1.3 -0.5 0.7 0.0 0.9 1.3 1.2 -0.9 -1.6 -1.3 1.4 -1.4 0.8 -0.7 -1.1 -0.8 1.4
Average weekly beer plus cider intake 1.6 2.4 6.1 1.2 0.2 -0.4 2.5 2.5 2.1 0.4 1.0 -2.0 -1.8 -0.5 1.4 0.1 0.7 2.1 1.4 1.2 -1.5 -1.8 1.8 -1.7 1.4 -1.3 -1.4 -2.5 1.3
Irritability 0.3 0.5 5.7 0.3 -1.1 0.5 -0.5 -0.3 -0.0 0.6 0.5 0.4 -0.1 2.4 -0.8 -0.2 0.5 -0.5 -0.2 2.0 0.2 -0.0 0.1 -0.1 0.1 0.5 0.1 0.4 0.2
Risk taking 0.7 1.0 2.9 -1.0 1.4 -1.7 0.4 0.8 -0.6 -1.0 -1.2 -0.0 1.2 -1.6 -0.1 -1.1 -0.9 -0.0 -0.9 1.2 1.2 0.8 -0.8 0.9 -0.9 0.4 1.2 -0.7 -1.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 4.6 0.8 -0.3 0.9 0.4 0.2 1.1 0.3 0.9 -0.9 -1.2 2.1 0.1 -0.6 0.9 0.5 0.9 0.2 -1.2 -1.1 1.1 -1.3 1.0 -0.5 -1.1 -0.6 1.1
Fractured/broken bones in last 5 years 0.2 0.2 1.4 -0.0 0.6 -0.0 -0.4 -0.3 -0.6 -0.1 -0.3 0.6 0.5 0.1 0.5 0.7 -0.3 -0.1 0.2 -0.1 -0.1 0.5 -0.4 0.5 -0.5 0.5 0.6 1.2 -0.1
Age started oral contraceptive pill 0.6 0.7 3.8 -0.7 1.3 -1.4 0.9 0.9 0.1 -1.3 -0.9 -0.5 0.4 -1.4 0.3 -2.0 -0.8 0.3 -0.5 -0.2 0.3 0.2 -0.2 0.2 -0.2 -0.1 0.3 -1.6 -0.4
Diastolic blood pressure, automated reading 5.0 15.5 30.9 -4.3 -2.8 -0.7 -4.8 -4.5 -4.8 -1.6 -3.4 4.4 4.1 0.9 -5.6 -2.8 -2.9 -5.3 -4.8 2.0 5.0 4.7 -4.9 4.3 -3.8 3.3 3.9 3.0 -4.3
Ever depressed for a whole week 0.4 0.5 1.6 0.1 1.3 1.3 -1.3 -1.2 -0.4 1.1 0.4 -0.1 0.0 -0.9 -0.2 0.7 0.6 -0.8 -0.2 0.7 0.6 0.3 -0.3 0.4 0.1 0.5 0.0 0.1 0.1
Unable to work because of sickness or disability 0.4 0.5 3.4 0.8 1.9 -0.2 0.8 0.9 0.7 0.4 0.7 -0.6 -0.7 -0.3 0.0 0.5 0.4 0.7 0.5 1.1 -0.5 -0.7 0.8 -0.4 0.5 -0.4 -0.3 -0.4 0.6
Commuting to job workplace: Cycle 0.7 0.9 2.9 0.7 0.7 0.1 1.3 1.1 0.8 0.3 0.3 -0.8 -1.2 0.1 1.3 0.8 0.2 1.5 1.3 -0.1 -1.7 -0.9 1.0 -1.1 0.3 -1.5 -0.9 -0.6 0.5
Myopia 0.2 0.2 1.3 0.6 -0.8 0.6 -0.3 -0.2 -0.0 0.8 0.7 -0.3 -0.1 0.5 0.6 1.1 0.7 0.0 0.3 -0.2 -0.3 -0.3 0.2 -0.5 0.4 0.0 -0.3 0.1 0.3
Vascular/heart problems diagnosed by doctor 1.2 3.2 6.7 1.8 1.1 1.3 1.5 1.4 1.9 1.1 1.6 -1.6 -2.0 0.3 2.0 1.1 1.8 1.8 2.3 -2.5 -2.3 -2.2 2.0 -2.6 2.1 -0.3 -2.5 -0.8 2.2
Cholesterol lowering medication 3.1 4.5 7.2 -2.1 -1.0 -1.0 -2.5 -2.5 -2.5 -1.6 -1.8 2.7 2.4 0.7 -2.6 -1.6 -1.6 -2.7 -2.4 0.8 2.3 2.4 -2.4 2.0 -2.2 2.6 2.2 2.4 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.9 -0.0 -0.1 1.1 -1.1 -1.0 -0.3 0.7 0.3 0.3 0.1 -0.2 -1.1 -0.8 0.5 -1.2 -0.6 1.4 0.8 0.2 -0.2 0.5 0.3 0.6 0.1 0.3 -0.0
Pain experienced in last month 0.9 1.4 4.5 0.8 -2.0 -1.1 1.7 1.5 0.8 -0.3 0.2 -1.0 -0.4 -0.2 1.8 1.6 0.1 2.0 1.2 -2.1 -1.6 -1.0 1.0 -0.8 0.5 -1.6 -0.5 -0.4 0.6
Supplements: Calcium 0.4 0.5 4.0 0.2 2.0 -0.7 0.5 0.7 0.2 0.1 0.2 -0.6 0.5 -1.8 0.6 0.5 -0.1 0.4 -0.2 0.2 0.3 -0.0 0.2 0.3 0.3 -0.1 0.4 -1.0 0.0
Basal cell carcinoma (self-reported) 0.7 0.8 2.7 -0.5 -0.8 0.2 -1.1 -1.2 -1.1 -0.3 -0.6 1.1 0.7 1.5 -0.5 0.5 -0.5 -1.0 -0.5 -0.9 0.3 0.8 -0.9 0.7 -0.8 1.7 0.8 1.7 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.5 -0.3 0.8 -0.5 -0.6 -0.9 -0.6 -0.8 -0.4 0.7 0.3 1.6 -0.2 -0.2 -0.6 -0.3 -0.2 0.0 -0.1 0.4 -0.4 -0.1 -0.8 0.8 0.4 0.8 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.3 -0.5 0.4 -0.9 0.8 1.2 -0.5 -0.4 -0.7 0.3 0.3 -1.0 0.1 -0.2 -0.7 0.2 -0.1 0.5 -0.0 0.5 -0.4 0.5 -0.6 -0.5 0.4 0.3 -0.6
Heart disease (siblings) 0.9 1.1 6.7 0.3 0.7 -0.5 1.0 0.9 1.0 -0.3 0.3 -1.5 -0.4 -2.6 1.2 -0.7 0.4 1.1 0.6 1.1 -0.2 -0.7 0.7 -0.7 0.8 -1.6 -0.9 -2.2 0.3
Alcohol drinker status: Previous 0.8 0.9 4.9 -1.0 0.4 -1.2 -0.4 -0.6 -0.1 -1.3 -0.8 -0.1 0.8 -2.2 -1.3 -2.0 -0.6 -0.7 -1.2 -0.0 1.4 0.4 -0.6 0.9 -0.4 0.3 0.6 -0.9 -0.7
Pack years of smoking 0.6 0.9 5.9 -0.7 2.4 -0.5 -0.3 -0.4 -0.1 -0.8 -0.7 -0.2 0.8 -2.1 -0.6 -0.9 -0.2 -0.4 -0.7 2.2 1.1 0.4 -0.5 0.4 -0.3 0.2 0.4 -0.9 -0.7
Impedance of whole body 0.3 1.4 19.4 0.0 4.4 -0.9 0.2 -0.0 0.4 -0.5 -0.1 -0.4 0.2 -1.8 1.0 0.1 -0.3 0.5 0.0 -3.2 -0.1 -0.1 0.2 -0.0 0.0 -0.1 0.0 -0.5 0.1
Leg fat mass (left) 0.5 1.8 3.8 -1.7 -1.2 -1.8 0.1 0.2 -1.4 -1.8 -2.0 1.2 1.6 -0.5 -0.9 -1.2 -1.8 -0.6 -1.2 1.0 1.1 1.5 -1.6 1.7 -1.8 1.0 1.6 0.6 -1.4
Arm predicted mass (left) 0.1 0.7 13.0 0.3 -3.6 0.7 0.1 0.2 -0.2 0.4 0.2 0.2 -0.2 1.3 0.2 0.9 0.3 0.2 0.6 0.2 -0.5 -0.2 0.1 -0.2 0.1 -0.0 -0.3 0.7 0.4