[Hub]/) : Traits : Diastolic blood pressure, automated reading :

chr15:73,933,444-76,108,550

Best TWAS P=3.08e-28 · Best GWAS P=1.01e-27 conditioned to 0.00731

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MPI 0.13 0.11 blup 277 0.14 1.6e-16 9.6 -9.1 8.0e-20 -0.82 0.97 0.03 FALSE
2 GTEx Adipose Subcutaneous ULK3 0.22 0.10 enet 19 0.12 2.9e-10 10.7 8.5 2.0e-17 0.66 0.02 0.98 FALSE
3 GTEx Adipose Subcutaneous FAM219B 0.07 0.01 lasso 6 0.02 1.4e-02 7.9 -8.9 3.7e-19 -0.77 0.27 0.38 FALSE
4 GTEx Adipose Subcutaneous MPI 0.05 0.05 lasso 7 0.04 6.6e-04 7.8 -8.2 1.7e-16 -0.73 0.16 0.60 FALSE
5 GTEx Adipose Subcutaneous CTD-2235H24.2 0.09 0.01 lasso 13 0.01 1.2e-01 10.2 -10.2 2.5e-24 -0.82 0.27 0.29 FALSE
6 GTEx Adipose Visceral Omentum ULK3 0.13 0.12 enet 8 0.11 3.3e-06 10.6 10.5 9.6e-26 0.89 0.02 0.98 FALSE
7 GTEx Adipose Visceral Omentum FAM219B 0.10 0.02 enet 12 0.07 1.7e-04 -4.9 -5.2 2.0e-07 -0.36 0.06 0.37 FALSE
8 GTEx Artery Tibial ULK3 0.06 0.04 enet 12 0.03 1.7e-03 10.8 9.4 5.8e-21 0.73 0.02 0.92 FALSE
9 GTEx Artery Tibial MPI 0.08 0.03 lasso 5 0.04 8.3e-04 7.8 -7.3 3.2e-13 -0.68 0.35 0.40 FALSE
10 GTEx Brain Caudate basal ganglia MPI 0.23 0.25 lasso 4 0.23 3.1e-07 9.9 -10.0 1.2e-23 -0.81 0.08 0.90 FALSE
11 GTEx Brain Cerebellum SCAMP2 0.12 0.01 lasso 8 -0.01 5.9e-01 -7.5 -7.7 1.2e-14 -0.73 0.12 0.28 FALSE
12 GTEx Brain Cerebellum MPI 0.14 0.09 enet 13 0.09 9.7e-04 -5.0 -8.5 1.8e-17 -0.76 0.09 0.78 FALSE
13 GTEx Brain Cortex MPI 0.13 0.04 enet 27 0.06 9.3e-03 10.4 -8.4 2.8e-17 -0.78 0.04 0.72 FALSE
14 GTEx Brain Frontal Cortex BA9 MPI 0.29 0.12 lasso 10 0.19 9.7e-06 9.4 -11.0 3.1e-28 -0.87 0.04 0.95 TRUE
15 GTEx Brain Hippocampus MPI 0.13 0.07 lasso 3 0.06 1.7e-02 10.4 -10.0 1.2e-23 -0.81 0.04 0.42 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia MPI 0.33 0.12 enet 29 0.34 8.6e-10 10.3 -9.7 2.2e-22 -0.69 0.07 0.90 FALSE
17 GTEx Brain Putamen basal ganglia MPI 0.31 0.18 enet 26 0.23 2.9e-06 9.9 -10.4 3.1e-25 -0.80 0.06 0.92 FALSE
18 GTEx Breast Mammary Tissue ULK3 0.15 0.11 lasso 3 0.09 1.6e-05 9.9 9.9 5.4e-23 0.80 0.08 0.91 FALSE
19 GTEx Breast Mammary Tissue MPI 0.16 0.00 lasso 8 0.01 1.4e-01 7.1 -7.4 1.5e-13 -0.61 0.05 0.41 FALSE
20 GTEx Breast Mammary Tissue (Male) PPCDC 0.07 0.00 enet 8 -0.01 7.9e-01 6.2 8.1 3.9e-16 0.75 0.04 0.15 FALSE
21 GTEx Breast Mammary Tissue (Male) ULK3 0.19 0.19 lasso 2 0.15 2.4e-04 9.4 8.7 4.0e-18 0.68 0.07 0.20 FALSE
22 GTEx Breast Mammary Tissue (Male) MPI 0.06 0.01 enet 4 0.03 5.7e-02 6.5 -9.1 8.5e-20 -0.59 0.03 0.11 FALSE
23 GTEx Breast Mammary Tissue (Female) ULK3 0.08 0.01 lasso 2 0.01 1.8e-01 10.4 10.4 3.3e-25 0.83 0.03 0.39 FALSE
24 GTEx Cells EBV-transformed lymphocytes ULK3 0.19 0.04 lasso 2 0.08 1.2e-03 10.4 10.4 3.1e-25 0.82 0.06 0.83 FALSE
25 GTEx Cells EBV-transformed lymphocytes SCAMP2 0.26 0.06 lasso 9 0.06 6.2e-03 5.2 -6.0 2.7e-09 -0.50 0.06 0.07 FALSE
26 GTEx Cells EBV-transformed lymphocytes MPI 0.25 0.16 lasso 5 0.15 1.5e-05 7.8 -7.3 2.8e-13 -0.69 0.22 0.07 FALSE
27 GTEx Cells Transformed fibroblasts ULK3 0.12 0.04 lasso 5 0.10 8.4e-08 10.2 10.0 2.0e-23 0.82 0.29 0.71 FALSE
28 GTEx Cells Transformed fibroblasts MPI 0.21 0.16 enet 15 0.22 1.1e-16 9.4 -10.3 7.5e-25 -0.80 0.14 0.86 FALSE
29 GTEx Esophagus Mucosa SCAMP2 0.36 0.20 enet 20 0.27 1.8e-18 7.8 -6.5 5.9e-11 -0.60 1.00 0.00 FALSE
30 GTEx Esophagus Mucosa COX5A 0.11 0.02 enet 23 0.03 6.9e-03 9.4 -7.0 3.2e-12 -0.64 0.09 0.35 FALSE
31 GTEx Esophagus Mucosa MPI 0.11 0.11 lasso 7 0.10 2.3e-07 7.8 -8.7 3.3e-18 -0.77 0.59 0.40 FALSE
32 GTEx Esophagus Muscularis MPI 0.06 0.04 lasso 4 0.04 1.9e-03 -6.4 -6.3 2.3e-10 -0.61 0.39 0.14 FALSE
33 GTEx Heart Left Ventricle UBL7 0.06 -0.01 enet 11 0.00 5.5e-01 2.7 -5.4 6.5e-08 -0.70 0.07 0.14 FALSE
34 GTEx Liver PPCDC 0.26 0.02 lasso 12 0.01 1.4e-01 7.8 5.3 1.2e-07 0.63 0.08 0.24 FALSE
35 GTEx Lung CSK 0.09 0.06 lasso 3 0.05 1.4e-04 10.4 10.8 4.4e-27 0.86 0.06 0.94 FALSE
36 GTEx Lung CYP11A1 0.10 0.01 enet 21 0.02 9.5e-03 3.5 -5.1 2.9e-07 -0.52 0.15 0.55 FALSE
37 GTEx Lung MPI 0.12 0.08 lasso 5 0.10 8.8e-08 7.8 -7.5 4.5e-14 -0.70 0.99 0.01 FALSE
38 GTEx Muscle Skeletal UBL7 0.06 0.02 lasso 6 0.01 3.7e-02 10.5 -10.3 5.8e-25 -0.86 0.04 0.75 FALSE
39 GTEx Nerve Tibial UBL7 0.09 0.00 lasso 8 0.03 3.2e-03 7.1 -7.5 4.8e-14 -0.42 0.15 0.72 FALSE
40 GTEx Nerve Tibial MPI 0.10 0.12 enet 12 0.15 1.5e-10 7.1 -9.3 1.1e-20 -0.79 0.77 0.23 FALSE
41 GTEx Ovary ULK3 0.19 0.23 lasso 1 0.23 3.0e-06 10.4 10.4 3.4e-25 0.83 0.09 0.50 FALSE
42 GTEx Pancreas ULK3 0.12 0.10 lasso 4 0.07 6.9e-04 10.4 10.6 2.4e-26 0.85 0.05 0.93 FALSE
43 GTEx Skin Not Sun Exposed Suprapubic ULK3 0.12 0.02 enet 14 0.09 1.4e-05 -6.4 5.7 1.2e-08 0.53 0.53 0.05 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic SCAMP2 0.36 0.05 enet 31 0.14 5.8e-08 7.8 -6.4 1.7e-10 -0.50 0.34 0.18 FALSE
45 GTEx Skin Sun Exposed Lower leg MPI 0.04 0.01 lasso 4 0.02 7.4e-03 7.1 -8.7 2.3e-18 -0.71 0.26 0.58 FALSE
46 GTEx Stomach ULK3 0.16 0.13 lasso 2 0.11 9.7e-06 10.4 10.4 1.9e-25 0.82 0.09 0.91 FALSE
47 GTEx Testis ULK3 0.15 0.03 enet 24 0.06 1.6e-03 10.7 8.7 5.1e-18 0.64 0.04 0.92 FALSE
48 GTEx Testis SCAMP2 0.37 0.23 enet 30 0.22 3.6e-10 7.8 -5.5 4.0e-08 -0.57 0.98 0.01 FALSE
49 GTEx Testis MPI 0.09 0.08 enet 12 0.04 6.0e-03 7.9 -9.3 2.0e-20 -0.75 0.11 0.63 FALSE
50 GTEx Thyroid ULK3 0.11 0.09 lasso 4 0.13 5.9e-10 10.4 9.8 7.4e-23 0.77 0.10 0.90 FALSE
51 GTEx Thyroid MPI 0.06 0.07 enet 12 0.07 5.1e-06 7.9 -9.0 2.7e-19 -0.78 0.24 0.76 FALSE
52 GTEx Uterus ULK3 0.40 0.16 lasso 16 0.12 2.2e-03 10.2 9.8 8.0e-23 0.80 0.04 0.72 FALSE
53 GTEx Vagina COX5A 0.38 0.02 lasso 7 0.02 9.3e-02 10.6 -9.7 5.1e-22 -0.80 0.03 0.68 FALSE
54 GTEx Whole Blood ULK3 0.14 0.06 lasso 5 0.04 8.3e-05 10.4 10.1 3.5e-24 0.77 0.10 0.87 FALSE
55 GTEx Whole Blood MPI 0.04 0.04 lasso 2 0.01 1.7e-02 9.6 -9.7 4.8e-22 -0.81 0.20 0.20 FALSE
56 METSIM Adipose MPI 0.08 0.06 blup 273 0.07 3.1e-11 9.4 -7.5 8.0e-14 -0.68 1.00 0.00 FALSE
57 METSIM Adipose RPP25 0.04 0.06 lasso 7 0.05 1.4e-08 7.1 8.1 6.6e-16 0.77 0.61 0.39 FALSE
58 METSIM Adipose ULK3 0.14 0.14 lasso 10 0.15 3.2e-22 10.4 10.7 8.3e-27 0.87 0.06 0.94 FALSE
59 NTR Blood SCAMP2 0.01 0.01 blup 290 0.01 1.6e-03 -3.4 -5.5 4.0e-08 -0.65 0.19 0.18 FALSE
60 YFS Blood COX5A 0.01 0.01 lasso 3 0.01 1.9e-05 -7.7 -7.7 2.0e-14 -0.67 0.86 0.09 FALSE
61 YFS Blood CSK 0.13 0.15 lasso 11 0.16 6.7e-51 10.0 10.7 8.2e-27 0.93 0.95 0.05 FALSE
62 YFS Blood MPI 0.02 0.02 lasso 4 0.03 1.2e-09 10.3 -10.1 3.9e-24 -0.85 0.26 0.74 FALSE
63 YFS Blood SCAMP2 0.04 0.03 blup 287 0.03 6.2e-11 -7.7 -6.1 9.3e-10 -0.58 1.00 0.00 FALSE
64 YFS Blood ULK3 0.09 0.11 lasso 6 0.11 1.1e-33 10.4 10.7 8.1e-27 0.87 0.36 0.64 FALSE
65 The Cancer Genome Atlas Bladder Urothelial Carcinoma MPI 0.09 0.00 blup 36 0.02 7.9e-03 9.6 -8.1 4.0e-16 -0.77 0.01 0.52 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma ULK3 0.06 0.03 enet 6 0.05 6.2e-05 7.7 7.3 2.2e-13 0.65 0.10 0.33 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma C15orf17 0.02 0.02 lasso 1 0.02 1.9e-05 9.4 -9.3 8.4e-21 -0.71 0.03 0.96 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma MPI 0.04 0.07 enet 13 0.06 5.8e-13 7.8 -8.6 8.4e-18 -0.74 0.98 0.02 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma RPP25 0.02 0.01 blup 23 0.02 6.8e-05 9.6 8.2 2.2e-16 0.78 0.00 0.98 FALSE
70 The Cancer Genome Atlas Breast Invasive Carcinoma SEMA7A 0.02 0.00 blup 49 0.01 3.2e-03 3.4 -6.1 1.1e-09 -0.33 0.01 0.65 FALSE
71 The Cancer Genome Atlas Breast Invasive Carcinoma ULK3 0.02 0.02 blup 49 0.02 1.1e-05 10.4 10.8 4.6e-27 0.89 0.04 0.96 FALSE
72 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ULK3 0.21 0.02 enet 8 0.07 1.9e-04 10.7 8.8 1.2e-18 0.73 0.01 0.71 FALSE
73 The Cancer Genome Atlas Colon Adenocarcinoma MPI 0.07 0.03 blup 36 0.04 2.1e-03 9.6 -9.9 4.0e-23 -0.83 0.01 0.95 FALSE
74 The Cancer Genome Atlas Colon Adenocarcinoma SCAMP2 0.06 0.04 blup 56 0.01 9.4e-02 7.7 -5.5 3.1e-08 -0.60 0.05 0.23 FALSE
75 The Cancer Genome Atlas Glioblastoma Multiforme MPI 0.11 0.03 blup 36 0.02 8.4e-02 9.6 -10.1 6.4e-24 -0.83 0.01 0.73 FALSE
76 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MPI 0.02 0.01 blup 36 0.01 1.2e-02 9.4 -9.5 2.0e-21 -0.79 0.02 0.56 FALSE
77 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CSK 0.02 0.00 blup 57 0.01 1.8e-02 9.7 8.1 7.4e-16 0.74 0.03 0.41 FALSE
78 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MPI 0.04 0.04 enet 2 0.03 7.8e-05 -7.5 -7.6 3.8e-14 -0.71 0.80 0.10 FALSE
79 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPP25 0.04 0.07 lasso 3 0.06 2.2e-07 -6.4 6.9 6.6e-12 0.66 0.95 0.04 FALSE
80 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ULK3 0.03 0.03 lasso 3 0.03 5.3e-04 10.2 10.6 3.9e-26 0.86 0.03 0.94 FALSE
81 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MPI 0.06 0.04 blup 35 0.05 8.5e-04 9.9 -10.0 2.4e-23 -0.81 0.01 0.94 FALSE
82 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPP25 0.05 0.03 blup 23 0.04 3.7e-03 -6.4 7.5 6.3e-14 0.73 0.01 0.77 FALSE
83 The Cancer Genome Atlas Brain Lower Grade Glioma MPI 0.07 0.09 lasso 4 0.10 2.4e-11 9.4 -9.6 1.2e-21 -0.80 0.02 0.98 FALSE
84 The Cancer Genome Atlas Brain Lower Grade Glioma SCAMP2 0.18 0.04 enet 5 0.06 6.1e-07 10.9 -8.8 1.2e-18 -0.85 0.00 1.00 FALSE
85 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ULK3 0.10 0.02 blup 49 0.07 2.5e-04 10.6 9.8 1.4e-22 0.76 0.03 0.96 FALSE
86 The Cancer Genome Atlas Lung Adenocarcinoma C15orf17 0.02 0.03 lasso 1 0.02 1.5e-03 9.4 -9.4 3.8e-21 -0.72 0.01 0.82 FALSE
87 The Cancer Genome Atlas Lung Adenocarcinoma MPI 0.02 0.02 lasso 1 0.02 4.7e-03 7.7 -7.7 1.1e-14 -0.72 0.06 0.77 FALSE
88 The Cancer Genome Atlas Lung Adenocarcinoma ULK3 0.03 0.00 blup 50 0.00 8.1e-02 9.4 8.1 7.0e-16 0.58 0.03 0.23 FALSE
89 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MPI 0.04 0.03 blup 36 0.05 8.8e-07 9.4 -9.3 9.6e-21 -0.79 0.06 0.94 FALSE
90 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ULK3 0.04 0.06 lasso 4 0.04 7.6e-06 10.2 10.5 1.3e-25 0.85 0.03 0.97 FALSE
91 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MPI 0.09 0.07 blup 36 0.08 3.9e-06 -7.7 -8.1 5.1e-16 -0.71 0.78 0.20 FALSE
92 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C15orf17 0.06 0.06 enet 25 0.02 6.1e-02 7.9 -5.6 1.7e-08 -0.64 0.02 0.57 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma MPI 0.07 0.07 blup 36 0.10 3.3e-10 7.8 -9.0 3.1e-19 -0.75 0.23 0.77 FALSE
94 The Cancer Genome Atlas Soft Tissue Sarcoma ULK3 0.04 0.03 blup 49 0.02 3.3e-02 9.9 7.3 2.6e-13 0.51 0.02 0.42 FALSE
95 The Cancer Genome Atlas Stomach Adenocarcinoma COX5A 0.03 0.03 blup 32 0.03 2.9e-03 -6.4 -8.5 1.6e-17 -0.72 0.04 0.40 FALSE
96 The Cancer Genome Atlas Stomach Adenocarcinoma MPI 0.04 0.02 blup 36 0.03 1.7e-03 9.4 -9.3 1.4e-20 -0.77 0.14 0.48 FALSE
97 The Cancer Genome Atlas Stomach Adenocarcinoma SCAMP2 0.04 0.05 lasso 2 0.05 2.0e-04 -7.5 -7.5 5.1e-14 -0.70 0.20 0.48 FALSE
98 The Cancer Genome Atlas Testicular Germ Cell Tumors MPI 0.12 0.11 lasso 7 0.12 5.3e-05 9.4 -9.5 1.7e-21 -0.75 0.11 0.72 FALSE
99 The Cancer Genome Atlas Thyroid Carcinoma CSK 0.04 0.04 blup 57 0.04 4.6e-05 10.7 8.3 1.3e-16 0.57 0.03 0.93 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma MPI 0.13 0.18 enet 10 0.16 3.7e-15 7.9 -9.0 2.5e-19 -0.77 0.97 0.03 FALSE
101 The Cancer Genome Atlas Thyroid Carcinoma ULK3 0.08 0.11 lasso 5 0.10 4.6e-10 10.2 10.5 6.9e-26 0.86 0.09 0.91 FALSE