Best TWAS P=4.05e-28 · Best GWAS P=4.79e-24 conditioned to 0.932
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FURIN | 0.12 | 0.14 | lasso | 2 | 0.13 | 1.2e-15 | -5.6 | 5.5 | 2.9e-08 | 0.62 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | FES | 0.21 | 0.09 | lasso | 5 | 0.05 | 1.3e-03 | 10.1 | -9.8 | 6.7e-23 | -0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | FES | 0.16 | 0.04 | lasso | 5 | 0.05 | 4.8e-05 | 8.8 | -10.3 | 1.1e-24 | -0.89 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | 10.1 | -10.1 | 7.7e-24 | -0.92 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Lung | FES | 0.24 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 8.8 | -10.2 | 1.3e-24 | -0.90 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | FES | 0.09 | 0.04 | lasso | 5 | 0.04 | 1.4e-04 | 10.1 | -9.4 | 4.8e-21 | -0.91 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Thyroid | FES | 0.33 | 0.19 | lasso | 6 | 0.18 | 4.3e-14 | 9.4 | -9.5 | 1.9e-21 | -0.95 | 0.01 | 0.99 | FALSE |
| 8 | METSIM | Adipose | FES | 0.08 | 0.06 | lasso | 3 | 0.05 | 6.8e-08 | 8.9 | -8.8 | 9.3e-19 | -0.88 | 0.14 | 0.86 | FALSE |
| 9 | YFS | Blood | FES | 0.31 | 0.11 | enet | 77 | 0.22 | 1.2e-68 | 10.1 | -7.5 | 6.7e-14 | -0.61 | 0.00 | 1.00 | FALSE |
| 10 | YFS | Blood | FURIN | 0.11 | 0.03 | enet | 37 | 0.06 | 8.3e-19 | -5.6 | -5.3 | 1.4e-07 | -0.48 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.06 | 1.9e-05 | 8.8 | -9.9 | 6.0e-23 | -0.74 | 0.02 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HDDC3 | 0.05 | 0.03 | blup | 59 | 0.03 | 1.3e-03 | -4.3 | -5.8 | 6.8e-09 | -0.33 | 0.03 | 0.09 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | 10.1 | -11.0 | 4.0e-28 | -0.88 | 0.00 | 1.00 | TRUE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FES | 0.06 | 0.02 | blup | 46 | 0.02 | 2.4e-02 | 10.1 | -8.5 | 1.5e-17 | -0.81 | 0.00 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | 8.1 | -8.7 | 3.4e-18 | -0.84 | 0.05 | 0.86 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | 8.9 | -8.8 | 1.1e-18 | -0.80 | 0.01 | 0.80 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | 8.9 | -10.2 | 1.8e-24 | -0.78 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | 8.7 | -8.4 | 5.5e-17 | -0.70 | 0.85 | 0.14 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | 10.1 | -10.3 | 1.1e-24 | -0.95 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FES | 0.08 | 0.07 | enet | 7 | 0.08 | 4.2e-09 | 10.1 | -9.7 | 4.2e-22 | -0.93 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FES | 0.13 | 0.16 | lasso | 2 | 0.14 | 6.1e-10 | 10.1 | -9.9 | 2.7e-23 | -0.99 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FES | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.1e-09 | 10.1 | -10.8 | 2.8e-27 | -0.95 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FES | 0.04 | 0.01 | blup | 46 | 0.02 | 1.7e-02 | 8.8 | -8.7 | 4.3e-18 | -0.75 | 0.01 | 0.54 | FALSE |
| 24 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FES | 0.32 | 0.26 | lasso | 2 | 0.25 | 2.0e-09 | 10.1 | -10.1 | 6.9e-24 | -0.96 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | 10.1 | -10.7 | 6.3e-27 | -0.95 | 0.00 | 1.00 | FALSE |