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chr1:752,566-2,544,640

Best TWAS P=4.19e-10 · Best GWAS P=2e-08 conditioned to 0.253

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CPSF3L	0.13	0.03	lasso	3	0.06	2.7e-05	-5.3	-5.8	7.7e-09	-0.02	0.02	0.96	FALSE
2	GTEx	Artery Tibial	CPSF3L	0.08	0.00	lasso	4	0.00	8.9e-01	-4.9	-5.6	2.2e-08	-0.03	0.04	0.56	FALSE
3	GTEx	Brain Caudate basal ganglia	ANKRD65	0.23	0.06	enet	18	0.10	1.0e-03	-5.2	5.2	2.5e-07	-0.01	0.03	0.65	FALSE
4	GTEx	Brain Cerebellar Hemisphere	CPSF3L	0.25	0.09	lasso	2	0.06	1.1e-02	-5.2	-5.3	1.1e-07	-0.02	0.02	0.82	FALSE
5	GTEx	Brain Cerebellar Hemisphere	ANKRD65	0.56	0.16	lasso	10	0.20	9.4e-06	-5.5	5.4	8.2e-08	-0.03	0.02	0.96	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP5-890O3.9	0.24	0.02	lasso	9	0.02	1.3e-01	5.0	-5.9	3.9e-09	0.85	0.03	0.47	TRUE
7	GTEx	Brain Frontal Cortex BA9	ANKRD65	0.19	0.17	lasso	5	0.12	5.7e-04	-5.5	5.5	2.9e-08	-0.01	0.02	0.91	FALSE
8	GTEx	Cells Transformed fibroblasts	ANKRD65	0.17	0.14	lasso	4	0.13	1.1e-09	-5.0	5.3	1.3e-07	0.00	0.04	0.96	FALSE
9	GTEx	Colon Transverse	ANKRD65	0.17	-0.01	enet	3	0.00	6.0e-01	-5.2	5.2	1.9e-07	0.01	0.03	0.63	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	ANKRD65	0.23	0.22	enet	22	0.18	3.4e-07	-5.2	5.2	1.5e-07	-0.07	0.03	0.97	FALSE
11	GTEx	Esophagus Mucosa	CPSF3L	0.10	0.00	enet	24	0.00	3.1e-01	-4.5	-5.4	7.1e-08	0.15	0.04	0.29	FALSE
12	GTEx	Heart Atrial Appendage	ANKRD65	0.11	0.08	enet	7	0.09	1.0e-04	-5.2	5.2	2.1e-07	0.00	0.02	0.96	FALSE
13	GTEx	Lung	NADK	0.07	0.03	lasso	3	0.02	8.5e-03	-5.0	5.5	3.6e-08	-0.92	0.02	0.94	FALSE
14	GTEx	Pancreas	TMEM52	0.19	0.00	enet	30	0.00	2.6e-01	1.2	5.2	2.4e-07	-0.58	0.04	0.60	FALSE
15	GTEx	Pituitary	NADK	0.21	0.09	enet	15	0.07	9.5e-03	4.7	5.8	8.7e-09	-0.65	0.03	0.43	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	TMEM52	0.19	0.18	lasso	4	0.14	2.6e-08	-5.0	-5.3	1.5e-07	0.87	0.03	0.97	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	ANKRD65	0.35	0.23	lasso	5	0.25	8.5e-14	-5.0	5.2	1.6e-07	-0.03	0.07	0.93	FALSE
18	GTEx	Skin Sun Exposed Lower leg	TMEM52	0.17	0.14	lasso	7	0.15	2.0e-12	-5.1	-5.2	1.5e-07	0.86	0.04	0.96	FALSE
19	GTEx	Stomach	ANKRD65	0.20	0.05	enet	33	0.10	1.7e-05	-5.2	5.5	3.4e-08	-0.15	0.02	0.92	FALSE
20	GTEx	Testis	PUSL1	0.19	0.02	lasso	6	0.05	3.8e-03	-4.7	6.2	4.2e-10	-0.41	0.06	0.30	TRUE
21	GTEx	Vagina	CPSF3L	0.29	0.00	lasso	6	0.00	4.3e-01	-5.0	-5.2	2.5e-07	-0.04	0.03	0.40	FALSE
22	METSIM	Adipose	ANKRD65	0.15	0.12	lasso	9	0.13	1.7e-18	-5.0	5.5	4.5e-08	0.03	0.06	0.94	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	SCNN1D	0.04	0.01	blup	240	0.02	4.0e-04	-3.1	-5.9	4.0e-09	0.18	0.16	0.82	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	ANKRD65	0.23	0.32	lasso	7	0.40	2.8e-55	-5.0	5.4	6.0e-08	0.02	0.07	0.93	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC441869	0.03	0.04	lasso	2	0.03	1.4e-07	-5.5	5.4	5.8e-08	-0.02	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC441869	0.10	0.10	lasso	2	0.06	5.1e-03	-5.5	5.3	1.4e-07	-0.02	0.00	0.84	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM52	0.02	0.01	blup	37	0.02	6.6e-03	5.0	-5.4	6.0e-08	0.86	0.01	0.76	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC441869	0.03	0.02	blup	16	0.02	8.5e-04	-5.2	5.6	2.2e-08	0.02	0.01	0.98	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC148413	0.11	0.09	lasso	2	0.06	3.5e-04	-5.5	5.6	2.6e-08	-0.02	0.00	0.98	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC441869	0.05	0.02	blup	16	0.04	4.1e-03	-3.8	5.2	1.8e-07	0.05	0.01	0.44	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC148413	0.03	0.03	lasso	3	0.03	2.7e-04	-5.2	5.4	6.0e-08	0.01	0.01	0.98	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC441869	0.08	0.10	blup	16	0.11	1.7e-12	-5.0	6.0	1.7e-09	0.01	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC441869	0.06	0.05	blup	16	0.05	1.3e-06	-4.9	5.3	1.4e-07	0.01	0.04	0.91	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC441869	0.11	0.09	lasso	3	0.10	5.6e-05	-5.0	5.3	1.0e-07	0.03	0.01	0.91	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC441869	0.10	0.04	lasso	6	0.04	1.5e-02	-5.0	6.2	6.7e-10	0.01	0.00	0.76	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC441869	0.06	0.11	lasso	4	0.11	2.5e-11	-5.2	5.3	1.1e-07	0.00	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Rectum Adenocarcinoma	LOC441869	0.37	0.23	lasso	4	0.19	2.6e-05	-5.2	5.6	2.5e-08	0.03	0.01	0.96	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC441869	0.04	0.07	lasso	5	0.06	4.3e-05	-5.2	5.3	8.9e-08	0.02	0.01	0.98	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	LOC441869	0.05	0.07	lasso	3	0.06	6.6e-07	-5.2	5.5	4.5e-08	0.01	0.01	0.99	FALSE