Best TWAS P=1.35e-09 · Best GWAS P=8.03e-12 conditioned to 0.00084
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATG7 | 0.07 | 0.07 | lasso | 3 | 0.07 | 3.3e-09 | -5.5 | 6.0 | 2.0e-09 | -0.78 | 0.38 | 0.62 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | VGLL4 | 0.04 | 0.02 | blup | 511 | 0.02 | 7.8e-04 | -6.6 | -6.1 | 1.4e-09 | 0.79 | 0.02 | 0.96 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | ATG7 | 0.18 | 0.06 | lasso | 4 | 0.06 | 2.9e-04 | -5.6 | 5.6 | 2.1e-08 | -0.77 | 0.52 | 0.33 | FALSE |
| 4 | GTEx | Muscle Skeletal | ATG7 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.6e-04 | -5.8 | 5.9 | 4.4e-09 | -0.81 | 0.03 | 0.95 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ATG7 | 0.06 | 0.05 | lasso | 3 | 0.04 | 2.4e-06 | -5.8 | 5.7 | 1.5e-08 | -0.64 | 0.30 | 0.69 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATG7 | 0.05 | 0.05 | lasso | 4 | 0.03 | 3.2e-04 | -5.9 | 5.6 | 1.6e-08 | -0.67 | 0.17 | 0.65 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATG7 | 0.07 | 0.00 | blup | 137 | 0.03 | 1.9e-04 | -6.4 | 5.3 | 1.3e-07 | -0.47 | 0.05 | 0.50 | FALSE |