TWAS hub - ELOVL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.036	0.016	0.00270	0.013	0.006	0.014	0.007	0.008	0.0087	0.0610	0.0063	0.045	0.0340
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.064	0.039	0.00071	0.045	0.034	0.026	NA	0.033	0.0014	0.0047	0.0110	NA	0.0052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic Blood Pressure	15.7	78.4	79.9	-8.9	-8.8
Alcohol usually taken with meals	11.8	19.0	20.8	-4.6	-4.2
Systolic blood pressure, automated reading	11.2	32.5	36.0	-5.4	-6.0
Diastolic blood pressure, automated reading	10.5	32.5	33.8	-5.6	-5.8
Heart disease (mother)	8.8	10.7	13.5	-3.7	-2.8
Angina	8.6	11.2	11.6	-3.3	-3.4
Illnesses of father: Heart disease	8.5	11.7	13.2	-3.2	-3.6
Angina (self-reported)	8.2	10.8	10.9	-3.3	-3.3
Age when periods started (menarche)	8.1	19.4	27.1	5.2	3.4
Chronic bronchitis/emphysema (mother)	7.7	9.0	9.8	2.8	3.1
Schizophrenia (2018)	7.6	15.8	20.1	4.5	3.4
Vascular/heart problems diagnosed by doctor	7.6	20.7	21.3	4.5	4.6
Bipolar Disorder or Schizophrenia	7.0	17.0	21.8	4.7	3.5
Coronary Artery Disease (CAD)	6.6	7.8	8.9	-2.6	-3.0
Medication: Bendroflumethiazide	6.6	10.1	13.1	-3.6	-2.6
Qualifications: None of the above	6.3	13.6	15.8	4.0	3.4
Unable to work because of sickness or disability	6.3	8.2	12.4	2.0	3.5
High blood pressure (mother)	6.1	8.5	9.5	-3.1	-2.7
High blood pressure	5.9	16.4	16.8	-4.1	-4.0
Maternal smoking around birth	5.7	8.3	8.9	2.8	3.0
Average weekly red wine intake	5.7	8.5	11.3	-3.4	-2.4
Noisy workplace	5.6	6.9	6.9	2.6	2.6
Qualifications: College or University degree	5.6	17.6	23.8	-4.9	-3.4
Cardiovascular Disease	5.3	17.4	20.9	-4.6	-3.7
Schizophrenia (2014)	5.1	11.4	13.7	3.7	3.0
Peak expiratory flow (PEF)	5.1	11.9	13.0	-3.6	-3.3
Blood Red Count	4.8	46.6	57.3	-6.0	-7.6
Comparative body size at age 10	4.7	12.9	13.2	3.6	3.5
Pulse rate, automated reading	4.6	14.8	18.7	-4.3	-3.3
Comparative height size at age 10	4.5	24.7	28.5	-5.3	-4.6
Medication: Atorvastatin	4.3	5.3	5.5	-2.3	-2.3
Intelligence (Savage-Jansen 2018)	4.2	12.9	14.6	-3.8	-3.4
Qualifications: A levels/AS levels or equivalent	4.2	9.3	13.1	-3.6	-2.3
Hypertension (Self-reported)	4.1	11.5	11.6	-3.4	-3.4
Medication: Blood pressure	4.1	7.8	8.0	-2.8	-2.8
Verbal and Numeric Reasoning (VNR)	3.9	9.4	9.6	-3.1	-3.0
Relative age of first facial hair	3.7	7.6	9.8	3.1	2.3
Time employed in main current job	3.7	4.2	4.3	-2.1	-2.1
Birth weight	3.7	8.1	10.1	3.2	2.5
Friendships satisfaction	3.7	4.6	6.2	2.5	1.7
Illnesses of father: None of the above (group 1)	3.7	4.6	5.9	1.8	2.4
Townsend deprivation index at recruitment	3.6	5.1	6.9	1.8	2.6
Major Depression (MDD)	3.5	4.2	5.9	2.4	1.6
Lung cancer (father)	3.5	4.1	4.4	1.9	2.1
Had menopause	3.4	4.2	4.6	-1.9	-2.1
Medication: Levothyroxine sodium	3.3	5.6	7.5	-1.9	-2.7
Blood White Count	3.2	24.1	29.5	-4.3	-5.4
Hypothyroidism (self reported)	3.2	7.4	10.4	-2.1	-3.2
Current tobacco smoking	3.2	5.3	6.9	1.9	2.6
Medication: Ramipril	3.2	4.1	5.6	-2.4	-1.6
Fluid intelligence score	3.2	6.6	7.3	-2.7	-2.4
Heart attack/myocardial infarction (self-reported)	3.2	4.1	4.8	-2.2	-1.8
Depression (self-reported)	3.1	3.7	4.9	1.6	2.2
Had other major operations	3.0	3.6	3.7	-1.9	-1.9
Diabetes (self-reported)	2.9	4.5	5.3	2.3	1.9
Worry too long after embarrassment	2.9	4.9	7.4	-1.6	-2.7
Mean time to correctly identify matches	2.8	5.2	6.7	-2.0	-2.6
Irritability	2.8	4.8	4.9	2.2	2.2
Heart attack	2.7	3.4	3.9	-2.0	-1.7
Illnesses of mother	2.7	3.3	3.6	1.7	1.9
Alcohol intake frequency.	2.7	6.3	7.6	2.8	2.2
Guilty feelings	2.5	3.7	5.7	-1.3	-2.4
Heart disease (siblings)	2.5	3.1	4.1	-1.4	-2.0
Vitamin and mineral supplements	2.4	3.3	3.8	1.7	1.9
Medication: Co-codamol	2.3	2.6	2.7	-1.6	-1.6
Medication: Atenolol	2.3	2.9	3.6	-1.5	-1.9
Pulse wave reflection index	2.3	2.9	3.1	-1.8	-1.6
Smoking status: Current	2.3	3.6	5.0	1.5	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	5.1	1.3	2.3
Alcohol drinker status: Previous	2.2	2.5	3.7	1.2	1.9
Reaction Time	2.1	3.9	5.1	-1.6	-2.3
Neuroticism (2016)	2.1	3.0	4.9	-1.1	-2.2
Number of treatments/medications taken	2.1	3.8	4.0	-1.9	-2.0
Weight	2.1	10.1	11.4	-3.0	-3.4
Medication: Blood pressure	2.1	3.7	5.3	-2.3	-1.4
Medication: Aspirin	2.1	2.8	2.8	-1.7	-1.7
Handedness (chirality/laterality): Left-handed	2.1	2.6	2.6	1.6	1.6
Number of operations (self-reported)	2.1	3.1	3.9	-1.5	-2.0
Medication: Metformin	2.0	2.9	3.2	1.6	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	2.5	1.6	1.5
Medication: Paracetamol	2.0	3.0	4.7	-2.2	-1.2
Ever used hormone-replacement therapy (HRT)	1.9	2.4	2.6	-1.5	-1.6
Leg fat-free mass (left)	1.9	10.2	10.2	-3.2	-3.2
Leg predicted mass (left)	1.9	10.0	10.0	-3.1	-3.2
Mouth/teeth dental problems	1.9	2.9	3.0	-1.7	-1.7
Hip circumference	1.9	8.1	9.6	-2.6	-3.1
Worrier / anxious feelings	1.9	3.5	3.8	-1.9	-1.8
Standing height	1.9	18.5	19.6	-4.2	-4.4
Hair/balding pattern: Pattern 4	1.9	4.6	5.2	-2.0	-2.3
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.1	1.2	1.8
Medication for pain relief, constipation, heartburn	1.9	3.3	3.7	1.9	1.7
Myopia	1.9	2.8	3.5	-1.9	-1.5
Smoking Status	1.8	4.3	7.3	1.2	2.7
Hearing difficulty/problems: Yes	1.8	2.8	3.1	1.6	1.8
Relative age voice broke	1.8	2.8	4.2	2.0	1.2
Pain all over the body in last month	1.8	1.9	2.4	1.2	1.6
Supplements: Vitamin C	1.8	2.2	3.0	-1.7	-1.1
Medication: Aspirin	1.8	2.3	2.5	-1.4	-1.6
Arm fat mass (left)	1.8	7.5	7.9	-2.7	-2.8
Mother’s age at death	1.8	2.3	2.3	-1.5	-1.5
Supplements: Fish oil (including cod liver oil)	1.8	2.4	4.1	-0.8	-2.0
Sitting height	1.7	12.1	12.6	-3.4	-3.5
Medication: Lansoprazole	1.7	2.0	2.3	1.3	1.5
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	2.4	-1.3	-1.5
Ulcerative Colitis	1.6	2.4	3.0	1.7	1.3
Height	1.6	31.5	35.6	-5.2	-6.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	2.7	1.6	1.3
Trunk fat mass	1.6	6.8	6.9	-2.6	-2.6
Number of incorrect matches in round	1.6	2.6	3.7	1.9	1.2
Arm fat mass (right)	1.6	6.4	6.9	-2.4	-2.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	4.7	-1.3	-2.2
Basal metabolic rate	1.6	8.9	10.0	-2.8	-3.2
Ever depressed for a whole week	1.6	2.0	2.0	1.4	1.4
Bipolar Disorder (2018)	1.5	2.4	3.1	1.8	1.3
Pack years adult smoking proportion	1.5	2.3	3.6	1.0	1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	2.4	1.1	1.6
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	6.5	-1.9	-2.5
Whole body fat mass	1.5	6.2	6.4	-2.5	-2.5
Leg fat-free mass (right)	1.5	7.9	8.5	-2.7	-2.9
Mineral and other dietary supplements	1.5	2.0	3.5	0.7	1.9
Leg predicted mass (right)	1.5	8.2	8.8	-2.8	-3.0
Basal cell carcinoma (self-reported)	1.5	1.8	2.4	-1.1	-1.6
Breast Cancer	1.4	3.3	4.9	2.2	1.3
Bipolar Disorder (2011)	1.4	1.3	2.7	1.6	0.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	1.8	1.2	1.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.1	1.3	1.5
Leg fat mass (right)	1.4	5.3	5.4	-2.3	-2.3
Whole body fat-free mass	1.4	7.9	9.2	-2.6	-3.0
Long-standing illness, disability or infirmity	1.4	2.2	2.7	-1.3	-1.6
Whole body water mass	1.4	7.7	9.0	-2.5	-3.0
Arm fat-free mass (left)	1.4	7.1	8.6	-2.4	-2.9
Risk taking	1.4	2.0	2.5	1.3	1.6
Leg fat mass (left)	1.4	5.5	5.8	-2.3	-2.4
Arm predicted mass (left)	1.4	7.2	8.6	-2.4	-2.9
Age at First Birth	1.3	1.9	2.4	-1.2	-1.6
Crohns Disease (2012)	1.3	2.1	3.1	1.8	1.0
Sensitivity / hurt feelings	1.3	2.3	4.5	-0.4	-2.1
Medication for hormone replacement therapy	1.3	1.4	1.6	1.3	1.1
Trunk predicted mass	1.3	7.2	9.1	-2.3	-3.0
Medication: Paracetamol	1.3	2.2	4.0	-2.0	-0.7
Arm fat-free mass (right)	1.3	6.8	8.6	-2.3	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	3.0	-1.6	-1.7
Number of self-reported non-cancer illnesses	1.3	2.3	2.6	-1.4	-1.6
Illnesses of father: High blood pressure	1.3	1.6	1.9	-1.4	-1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.8	-0.4	-1.7
Qualifications: CSEs or equivalent	1.2	1.6	2.3	1.5	1.0
Trunk fat-free mass	1.2	7.0	8.8	-2.3	-3.0
Medication: Ibuprofen	1.2	1.4	1.8	-1.4	-1.0
Arm fat percentage (left)	1.2	4.8	4.9	-2.1	-2.2
Medication for cholesterol	1.2	1.8	2.4	1.1	1.5
Commuting to job workplace: Public transport	1.2	1.5	2.7	-0.5	-1.7
Worry (Nagel 2018)	1.1	2.3	3.2	-1.8	-1.2
Respiratory disease	1.1	2.5	2.9	-1.4	-1.7
Type 2 Diabetes (T2D) (2018)	1.1	2.1	2.3	1.5	1.4
Trunk fat percentage	1.1	4.3	4.8	-2.2	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	4.9	-1.5	-2.2
Birth weight of first child	1.1	2.0	2.2	1.5	1.4
Glaucoma (self-reported)	1.1	1.3	1.9	-1.4	-0.9
Arm predicted mass (right)	1.1	5.8	7.3	-2.1	-2.7
Illnesses of siblings: Diabetes	1.1	1.4	2.2	1.5	0.8
Diabetes diagnosed by doctor	1.1	1.8	1.8	1.4	1.4
Medication: Gliclazide	1.1	1.3	1.3	1.1	1.1
Pain experienced in last month	1.1	1.8	2.6	-1.6	-1.0
Prostate Cancer	1.0	1.4	1.5	1.2	1.1
BMI	1.0	5.8	7.6	-2.0	-2.8
Hand grip strength (right)	1.0	2.7	2.7	-1.6	-1.6
Waist circumference	1.0	3.7	4.0	-2.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.1	1.4	1.0
Forced vital capacity (FVC)	1.0	3.7	5.4	-1.4	-2.3
Happiness	1.0	1.3	2.1	1.5	0.6
Pulse wave Arterial Stiffness index	1.0	1.1	1.2	-1.0	-1.1
Exposure to tobacco smoke at home	1.0	1.1	1.9	1.4	0.5
Medication: Amlodipine	1.0	1.4	2.3	-1.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.2	-1.1	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.7	0.7	1.7
Average weekly beer plus cider intake	1.0	1.5	1.7	1.1	1.3
Neuroticism (Nagel 2018)	0.9	2.0	2.2	-1.5	-1.4
Schizophrenia vs Biploar Disorder	0.9	1.2	1.4	1.0	1.2
Chronotype (morning person)	0.9	2.0	2.1	-1.4	-1.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.6	1.3	0.9
Supplements: Zinc	0.9	1.0	1.5	1.2	0.7
Arm fat percentage (right)	0.9	3.6	3.7	-1.9	-1.9
High blood pressure (siblings)	0.9	1.3	1.5	-1.2	-1.0
Knee pain experienced in last month	0.9	1.4	1.6	-1.3	-1.1
Pack years of smoking	0.9	1.4	2.4	0.6	1.5
Ulcerative Colitis (UC)	0.8	1.6	1.9	1.1	1.4
HDL Cholesterol	0.8	1.4	1.4	1.2	1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.5	0.4	1.2
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	-0.6	-1.4
Length of working week for main job	0.8	0.9	1.5	-1.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.1	1.5	0.8
Gout (self-reported)	0.8	1.1	1.3	-0.9	-1.2
Body fat percentage	0.8	3.0	3.1	-1.8	-1.7
Number of children fathered	0.8	0.9	1.2	-0.7	-1.1
Fractured/broken bones in last 5 years	0.8	1.0	1.2	-1.1	-0.9
Irritable Bowel Disease (IBD)	0.7	1.7	1.7	1.3	1.2
Ovarian Cancer	0.7	1.0	1.9	0.1	-1.4
Blood Platelet Count	0.7	8.4	9.8	-3.1	-2.6
Neuroticism	0.7	1.6	2.1	-1.0	-1.5
Stomach or abdominal pain in last month	0.7	0.9	1.8	1.3	0.1
Financial difficulties in last 2 years	0.7	0.9	1.4	1.2	0.6
Medication: Simvastatin	0.7	1.1	1.1	1.0	1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	4.1	-1.2	-2.0
Leg fat percentage (right)	0.7	2.4	2.4	-1.6	-1.6
Number of full brothers	0.7	0.9	1.7	1.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	1.5	0.6	1.2
Medication: Seretide 50 evohaler	0.7	0.8	1.6	-0.1	-1.2
Family relationship satisfaction	0.7	0.8	1.0	1.0	0.8
Financial situation satisfaction	0.7	0.8	1.4	1.2	0.5
Supplements: Calcium	0.7	0.8	1.4	-0.5	-1.2
Diabetes (father)	0.6	0.8	1.1	-0.7	-1.0
Fed-up feelings	0.6	1.2	2.1	1.4	0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	1.2	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	-1.1	-0.4
Neck or shoulder pain in last month	0.6	0.8	1.6	1.3	-0.0
Overall health rating	0.6	1.3	1.4	1.1	1.2
Supplements: Glucosamine	0.5	0.7	0.9	0.7	-0.9
Alcohol intake versus 10 years previously	0.5	0.8	1.5	1.2	0.2
Father’s age at death	0.5	0.6	1.0	1.0	0.5
Asthma	0.5	1.0	1.6	-1.2	-0.7
Pulse wave peak to peak time	0.5	0.6	0.7	0.7	0.9
Health satisfaction	0.5	0.7	1.2	1.1	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.7	0.8	0.7
Mood swings	0.5	0.9	1.5	1.2	0.5
Breast cancer (self-reported)	0.5	0.6	0.6	-0.8	-0.8
Leg fat percentage (left)	0.5	2.0	2.3	-1.3	-1.5
Depression (Nagel 2018)	0.4	0.6	0.8	0.7	0.9
LDL Cholesterol	0.4	0.6	1.1	-0.3	1.0
Hand grip strength (left)	0.4	1.2	1.2	-1.1	-1.1
Average weekly fortified wine intake	0.4	0.4	0.8	-0.4	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	0.5	0.8
Multivitamins +/- minerals	0.4	0.5	0.7	-0.5	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.9	0.3
Body mass index (BMI)	0.4	1.6	2.0	-1.1	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	0.4	0.9
Age at last live birth	0.4	0.6	1.2	-0.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.5	-0.7	-0.5
Qualifications: nursing, teaching	0.4	0.6	1.1	-1.1	-0.4
Back pain experienced in last month	0.4	0.6	0.9	0.9	0.5
Asthma (self-reported)	0.4	0.9	1.2	-1.1	-0.8
Hearing aid user	0.4	0.4	0.4	0.7	-0.6
Ever smoked	0.4	0.7	0.9	0.7	0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	0.5	0.7
Crohns Disease (2017)	0.3	0.7	1.0	1.0	0.7
Lupus	0.3	0.4	0.7	-0.8	-0.2
Waist Hip Ratio (WHR)	0.3	1.2	2.3	-1.5	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	-0.5	-0.7
Hearing difficulty/problems with background noise	0.3	0.4	0.8	0.9	0.3
Illnesses of siblings	0.3	0.4	0.7	0.4	0.9
Impedance of arm (right)	0.3	1.2	2.2	-1.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	0.6	0.8
Pulse rate	0.3	0.5	0.8	-0.5	-0.9
Exposure to tobacco smoke outside home	0.3	0.3	0.4	0.6	0.6
Age at first live birth	0.3	0.5	0.6	-0.6	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	0.2	0.8
Medication: Lisinopril	0.3	0.4	0.7	-0.4	-0.8
Alcohol drinker status: Never	0.3	0.4	0.8	0.9	0.1
Commuting to job workplace: Cycle	0.3	0.3	0.5	0.7	0.4
Fasting Glucose	0.2	0.3	0.3	-0.5	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.4	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.0	0.6
Blood Eosinophil Count	0.2	1.3	2.6	-0.2	-1.6
Lung FEV1/FVC ratio	0.2	1.2	1.3	-1.1	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.3	-0.7
Diabetes (mother)	0.2	0.2	0.3	0.5	-0.5
Severe depression (siblings)	0.2	0.2	0.3	-0.5	-0.4
Nervous feelings	0.2	0.3	0.6	-0.2	-0.8
Falls in the last year	0.2	0.3	0.5	0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.5	-0.3
Impedance of arm (left)	0.2	1.1	1.9	-1.4	-0.5
Breastfed as a baby	0.2	0.3	0.5	-0.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.3	-0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.1	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.7	0.0
Headache pain in last month	0.2	0.4	0.7	-0.9	-0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.8	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.2	-0.6
Commuting to job workplace: Walk	0.2	0.3	0.3	0.5	0.5
Osteoporosis (self-reported)	0.2	0.2	0.4	0.7	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.7	-0.2
Miserableness	0.2	0.3	0.5	0.2	0.7
Wears glasses or contact lenses	0.2	0.2	0.3	-0.6	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.7	-0.3
Age started oral contraceptive pill	0.2	0.2	0.4	0.1	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.5	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.2	0.5
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.3	-0.5
Mean Putamen Volume	0.1	0.1	0.1	0.2	0.4
Lung FVC	0.1	0.6	1.1	1.0	-0.3
Tanning	0.1	1.4	1.7	1.3	1.0
Average weekly spirits intake	0.1	0.1	0.1	0.3	0.3
Taking other prescription medications	0.1	0.2	0.3	-0.4	-0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	-0.2
Past tobacco smoking	0.1	0.2	0.3	-0.2	-0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.6	-0.1
Neuroticism score	0.1	0.2	0.4	0.3	-0.6
Number of live births	0.1	0.1	0.2	0.4	0.1
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.2	0.4
Prospective memory result	0.1	0.1	0.2	0.4	0.3
Tense / ‘highly strung’	0.1	0.1	0.2	0.3	0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.0	-0.4
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.2	-0.5
Migraine (self-reported)	0.1	0.2	0.2	-0.5	-0.3
Medication: Allopurinol	0.1	0.1	0.1	0.1	-0.4
Number of full sisters	0.1	0.2	0.3	-0.6	-0.1
Suffer from ‘nerves’	0.1	0.1	0.2	-0.4	-0.4
Chest pain or discomfort	0.1	0.2	0.4	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.1	0.5
Loneliness, isolation	0.1	0.2	0.3	-0.1	-0.5
Ever had bowel cancer screening	0.1	0.1	0.3	0.5	0.0
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.2	0.4	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.3	0.2
Cholesterol lowering medication	0.1	0.1	0.2	0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.5	0.2
Impedance of whole body	0.1	0.3	0.6	-0.8	-0.0
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.1	0.1
HbA1C	0.0	0.0	0.0	0.1	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	-0.1
Triglycerides	0.0	0.0	0.0	-0.1	-0.1
Heel T-Score	0.0	0.2	0.4	0.2	0.6
Allergy or Eczema	0.0	0.0	0.0	-0.0	-0.0
Hair Pigment	0.0	0.3	0.4	-0.3	-0.6
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.2	-0.1
Impedance of leg (right)	0.0	0.0	0.1	-0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	0.2
Impedance of leg (left)	0.0	0.1	0.1	0.2	0.4
Allergy	0.0	0.0	0.0	0.2	0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.1	-0.1
Medication: Omeprazole	0.0	0.0	0.0	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.2	-0.2
Had major operations	0.0	0.0	0.0	0.2	0.1
Leg pain on walking	0.0	0.1	0.1	-0.3	-0.0
Smoking status: Previous	0.0	0.0	0.1	-0.1	0.3
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.1	-0.3
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.1	-0.3
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

ELOVL1

Models

Trait associations