Hub : Genes

KIAA0467

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Head and Neck Squamous Cell Carcinoma 0.0665 0.0322 0.00016 0.029 0.031 0.035 NA 0.035 0.00032 0.00020 7.5e-05 NA 0.00008
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0252 0.0182 0.00570 0.003 0.019 0.004 NA 0.003 0.13000 0.00270 1.1e-01 NA 0.12000
3 TCGA Skin Cutaneous Melanoma 0.1680 0.0830 0.00015 0.081 0.127 0.097 NA 0.109 0.00340 0.00029 1.4e-03 NA 0.00075

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 1.7 0.1 -1.2 -1.3
Bipolar Disorder or Schizophrenia 3.8 9.3 11.1 2.7 -3.1 -3.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.2 0.7 0.3
Depression (Nagel 2018) 0.3 0.5 0.6 0.8 -0.5 -0.7
Intelligence (Savage-Jansen 2018) 5.3 16.2 22.2 -4.7 3.4 3.9
Neuroticism (Nagel 2018) 1.1 2.5 4.3 -0.0 2.1 1.8
Schizophrenia (2018) 4.9 10.2 11.3 3.4 -3.0 -3.2
Schizophrenia vs Biploar Disorder 1.5 2.0 3.8 1.9 -1.2 -0.9
Worry (Nagel 2018) 0.8 1.6 2.0 -0.9 1.4 1.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.3 -0.0 -0.4
Alzheimer’s Disease (in father) 0.5 0.6 1.5 -1.2 0.3 0.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 -0.6 0.1 -0.2
Crohns Disease (2017) 0.8 1.8 4.7 2.2 -0.4 -0.7
Irritable Bowel Disease (IBD) 0.7 1.6 3.1 1.8 -0.8 -1.1
Ulcerative Colitis (UC) 0.5 0.9 1.0 0.9 -0.9 -1.0
Major Depression (MDD) 0.4 0.5 0.9 0.3 -0.9 -0.8
Reaction Time 2.4 4.5 6.7 1.3 2.6 2.3
Verbal and Numeric Reasoning (VNR) 4.4 10.7 14.4 -3.8 2.7 3.2
Breast Cancer 0.9 2.1 4.0 2.0 -0.9 -1.2
Ovarian Cancer 1.5 1.9 2.9 1.2 1.7 1.2
Prostate Cancer 0.4 0.6 1.0 0.1 -0.9 -1.0
Age at First Birth 1.1 1.5 2.5 -0.5 1.4 1.6
Bipolar Disorder (2011) 0.4 0.4 0.9 -0.1 -0.6 -0.9
Body Mass Index (BMI) (2010) 0.4 0.5 0.7 0.8 0.8 0.5
Coronary Artery Disease (CAD) 4.6 5.5 8.3 -1.1 2.7 2.9
Crohns Disease (2012) 2.4 3.8 8.0 2.8 -1.2 -1.4
Mean Putamen Volume 0.1 0.1 0.2 0.5 -0.2 -0.3
Fasting Glucose 0.7 0.8 0.8 -0.9 0.9 0.9
HbA1C 0.1 0.1 0.1 0.4 -0.3 -0.2
HDL Cholesterol 0.4 0.6 0.8 -0.6 -0.8 -0.9
LDL Cholesterol 0.7 1.1 1.2 -1.0 -1.1 -1.0
Lupus 0.6 0.9 2.6 -1.6 -0.1 0.4
Neuroticism (2016) 2.9 4.2 6.2 0.5 2.5 2.5
Primary Biliary Cirrhosis 0.3 0.4 0.7 -0.8 0.6 0.5
Rheumatoid Arthritis 0.4 0.5 1.6 1.2 0.1 0.1
Schizophrenia (2014) 3.7 8.1 9.6 2.6 -3.1 -2.8
Triglycerides 0.1 0.2 0.7 -0.8 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.9 0.3 -0.9 -1.0
Ulcerative Colitis 0.5 0.8 1.1 0.4 -1.0 -1.1
Blood Eosinophil Count 0.6 4.4 4.7 2.2 2.0 2.1
Blood Platelet Count 0.2 2.5 6.9 -0.7 -0.1 2.6
Blood Red Count 4.6 44.0 65.6 -1.0 8.1 8.1
Blood White Count 2.3 16.7 25.7 -1.3 4.8 5.1
Heel T-Score 0.1 0.4 0.8 -0.4 -0.9 -0.6
BMI 0.6 3.7 5.0 -1.3 2.1 2.2
Height 1.5 28.0 36.1 -4.0 6.0 5.7
Waist Hip Ratio (WHR) 0.0 0.2 0.4 -0.3 -0.6 -0.4
Systolic Blood Pressure 11.3 56.4 79.7 -4.8 8.2 8.9
Smoking Status 4.0 9.6 16.7 0.4 -4.1 -3.5
Allergy or Eczema 0.1 0.2 0.5 -0.7 -0.4 -0.1
Cardiovascular Disease 3.5 11.6 12.5 -3.5 3.1 3.5
Hypothyroidism (self reported) 3.4 7.9 11.9 -1.1 3.2 3.5
Respiratory disease 0.6 1.2 2.2 -0.6 1.1 1.5
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.8 -0.3 -1.0 -1.3
Lung FEV1/FVC ratio 0.1 0.7 0.9 -1.0 0.6 0.9
Lung FVC 0.5 2.7 6.6 2.6 1.2 0.5
Neuroticism 1.3 3.2 5.6 0.2 2.4 2.0
Chronotype (morning person) 1.0 2.2 4.1 -0.2 2.0 1.6
Hair Pigment 0.0 0.5 0.9 -0.7 0.5 0.9
Tanning 0.3 4.0 11.0 3.3 -0.2 -0.9
Hand grip strength (left) 0.2 0.4 0.5 0.5 0.7 0.7
Number of treatments/medications taken 1.9 3.4 3.9 -1.7 1.9 2.0
Average weekly spirits intake 0.8 1.0 2.9 1.7 -0.1 -0.3
Sensitivity / hurt feelings 3.0 5.1 6.6 1.9 2.6 2.3
Frequency of depressed mood in last 2 weeks 0.5 0.6 1.1 1.1 -0.6 -0.7
Hearing difficulty/problems: Yes 1.1 1.7 2.0 1.1 -1.4 -1.3
Relative age of first facial hair 3.2 6.6 13.9 3.7 -1.2 -2.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.1 1.1 0.6 0.5
Ever used hormone-replacement therapy (HRT) 1.4 1.8 2.0 -1.2 1.4 1.4
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 -0.7 -0.5 0.0
Systolic blood pressure, automated reading 8.9 25.9 38.7 -2.6 5.7 6.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 -0.3 -1.4 -1.1
Angina 4.6 6.1 9.3 -0.7 2.9 3.0
Medication for hormone replacement therapy 1.5 1.7 2.2 1.3 -1.1 -1.5
Vitamin and mineral supplements 1.2 1.7 3.0 0.6 -1.3 -1.7
Supplements: Zinc 0.4 0.4 0.7 -0.5 -0.8 -0.6
Medication: Co-codamol 1.0 1.1 2.0 -0.0 1.1 1.4
Medication: Metformin 1.8 2.5 3.7 -1.0 -1.9 -1.7
Diabetes (father) 0.4 0.5 0.9 0.1 0.8 0.9
Diabetes (mother) 0.7 0.8 1.0 0.9 1.0 0.8
Severe depression (siblings) 1.6 1.7 4.6 -2.2 0.5 0.6
Pack years adult smoking proportion 2.2 3.3 4.0 1.4 -2.0 -2.0
Impedance of leg (right) 0.0 0.1 0.4 0.6 -0.1 -0.2
Leg fat-free mass (left) 1.3 6.8 8.0 -2.3 2.6 2.8
Trunk fat percentage 0.6 2.4 3.7 -1.4 1.3 1.9
Hand grip strength (right) 0.6 1.5 2.3 0.7 1.5 1.3
Townsend deprivation index at recruitment 3.6 5.1 7.1 1.3 -2.5 -2.7
Current tobacco smoking 4.0 6.6 9.8 1.3 -3.1 -2.9
Average weekly fortified wine intake 1.7 2.0 2.3 -1.5 -1.5 -1.3
Maternal smoking around birth 5.5 7.9 11.1 1.8 -3.3 -3.1
Fed-up feelings 0.8 1.5 4.4 2.1 0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 8.8 3.0 -1.0 -1.6
Relative age voice broke 2.3 3.5 8.2 2.9 -0.8 -1.3
Taking other prescription medications 0.1 0.1 0.2 -0.5 0.1 0.5
Age when periods started (menarche) 7.0 16.9 19.9 4.5 -3.6 -4.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.0 -1.0 0.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.0 -0.2 0.1 -0.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.3 -0.3 -1.0 -1.1
Qualifications: CSEs or equivalent 2.3 3.1 7.6 2.8 -0.8 -1.0
Serious illness, injury or assault to yourself 0.7 0.9 2.0 -1.4 0.5 0.6
High blood pressure 4.8 13.5 16.4 -3.3 3.6 4.0
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 -0.2 -0.3 0.0
Multivitamins +/- minerals 0.4 0.5 0.7 -0.8 0.5 0.8
Stomach or abdominal pain in last month 0.0 0.0 0.0 0.0 -0.1 -0.1
Supplements: Glucosamine 1.0 1.3 2.7 0.0 1.6 1.2
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.9 -0.2 -1.4 -1.3
Medication: Atenolol 2.7 3.4 4.5 -1.3 2.1 2.0
Medication: Levothyroxine sodium 2.4 4.0 6.0 -0.9 2.3 2.5
Sitting height 2.6 18.3 24.6 -5.0 3.9 3.9
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.4 -0.1 -0.4
High blood pressure (mother) 6.4 9.0 13.5 -3.7 2.1 3.0
Body mass index (BMI) 0.2 0.8 1.3 -0.7 0.8 1.1
Impedance of leg (left) 0.0 0.2 0.6 0.8 0.1 -0.1
Leg predicted mass (left) 1.3 6.7 7.9 -2.3 2.6 2.8
Trunk fat mass 1.0 4.2 5.9 -1.8 1.9 2.4
Waist circumference 0.5 1.8 2.7 -1.6 0.8 1.4
Number of incorrect matches in round 2.0 3.4 7.1 2.7 -1.1 -1.4
Past tobacco smoking 0.8 1.4 2.5 0.1 1.6 1.3
Alcohol usually taken with meals 11.9 19.2 23.0 -4.8 4.0 4.3
Nervous feelings 1.1 2.1 3.4 0.9 1.9 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 2.2 1.5 -1.0 -1.1
Hearing difficulty/problems with background noise 0.6 0.9 2.6 1.6 0.3 -0.1
Hair/balding pattern: Pattern 2 0.6 0.8 2.0 -1.4 -0.6 -0.3
Had menopause 2.0 2.5 3.7 -0.7 1.9 1.8
Had other major operations 4.5 5.5 5.9 -2.4 2.3 2.3
Forced vital capacity (FVC) 1.1 4.3 7.5 0.9 2.7 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 -0.4 -0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 2.3 0.7 -1.5 -1.4
Qualifications: None of the above 8.2 17.5 30.7 5.5 -3.2 -3.4
Financial difficulties in last 2 years 0.4 0.5 0.6 0.7 -0.8 -0.6
Mouth/teeth dental problems 1.9 2.9 3.0 -1.7 1.7 1.7
Heart attack 1.7 2.1 3.3 -0.8 1.6 1.8
Allergy 0.0 0.1 0.1 0.3 0.1 -0.4
Pain all over the body in last month 2.3 2.5 4.1 0.7 -2.0 -1.7
Diabetes (self-reported) 1.2 1.9 3.2 0.3 -1.5 -1.8
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 3.5 1.6 -1.3 -1.9
Medication: Ramipril 2.1 2.7 4.3 -2.1 1.1 1.6
Medication: Simvastatin 0.7 1.1 2.0 -0.0 -1.4 -1.1
Fluid intelligence score 4.9 10.1 18.2 -4.3 2.3 2.6
Illnesses of siblings 0.3 0.4 0.5 0.4 -0.6 -0.7
Neuroticism score 1.2 2.5 4.2 2.0 1.5 1.0
Weight 1.5 7.2 9.5 -2.2 2.7 3.1
Impedance of arm (right) 0.0 0.1 0.2 0.4 0.4 0.4
Arm fat percentage (right) 0.3 1.2 2.3 -0.5 1.0 1.5
Trunk fat-free mass 1.2 6.7 7.6 -2.2 2.8 2.8
Hip circumference 1.3 5.7 7.8 -1.9 2.4 2.8
Time employed in main current job 2.3 2.6 4.3 -0.3 1.9 2.1
Alcohol intake versus 10 years previously 1.9 2.9 8.5 2.9 -0.2 -0.2
Father’s age at death 0.1 0.1 0.2 -0.5 0.3 0.2
Worrier / anxious feelings 2.0 3.8 5.7 -0.9 2.4 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.7 0.7 -0.5 -0.8
Falls in the last year 0.3 0.4 0.7 0.9 -0.2 -0.6
Hair/balding pattern: Pattern 3 1.9 2.8 5.6 0.0 2.4 1.7
Number of live births 0.0 0.1 0.1 0.3 -0.1 0.3
Forced expiratory volume in 1-second (FEV1) 1.4 4.7 8.1 0.5 2.8 2.4
Pulse rate 0.7 1.3 1.6 0.9 1.3 1.2
Happiness 0.0 0.1 0.1 -0.2 -0.0 -0.3
Noisy workplace 3.7 4.5 4.9 2.1 -2.2 -2.1
Qualifications: A levels/AS levels or equivalent 6.5 14.4 30.5 -5.5 2.2 2.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 -1.0 0.1 0.2
Mouth/teeth dental problems: Dentures 3.6 6.0 16.8 4.1 -0.5 -1.0
Asthma 0.3 0.5 1.0 -1.0 0.2 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 0.7 0.4 0.2
Medication: Cholesterol lowering 0.8 1.2 2.1 -1.4 -1.2 -0.5
Depression (self-reported) 2.9 3.5 6.2 0.0 -2.5 -2.1
Medication: Lansoprazole 1.6 1.8 2.9 -0.4 -1.6 -1.7
Prospective memory result 0.1 0.2 0.4 0.3 -0.2 -0.6
Lung cancer (father) 3.8 4.5 6.2 1.5 -2.5 -2.2
Illnesses of mother 1.6 2.0 3.6 0.8 -1.3 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 7.6 1.0 2.8 2.2
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 0.3 0.9 1.1
Impedance of arm (left) 0.0 0.1 0.3 -0.1 0.4 0.5
Arm fat mass (right) 0.8 3.5 5.3 -1.3 1.9 2.3
Trunk predicted mass 1.2 6.7 7.9 -2.1 2.8 2.8
Standing height 1.7 16.7 19.7 -3.4 4.4 4.3
Length of working week for main job 0.3 0.3 0.6 -0.8 0.3 0.5
Exposure to tobacco smoke at home 0.4 0.5 1.4 1.2 0.1 -0.2
Breastfed as a baby 1.0 1.3 3.6 -1.9 -0.1 0.5
Tense / ‘highly strung’ 0.2 0.4 0.8 0.9 -0.5 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 7.4 -1.1 -2.7 -2.1
Hair/balding pattern: Pattern 4 0.9 2.3 3.8 -1.1 1.4 2.0
Birth weight of first child 1.0 1.7 2.2 1.5 -1.0 -1.4
Peak expiratory flow (PEF) 3.9 9.1 11.5 -2.3 3.2 3.4
Pulse wave reflection index 1.3 1.6 2.9 -0.6 1.2 1.7
Ever highly irritable/argumentative for 2 days 3.4 4.0 4.9 2.2 -1.9 -1.9
Loud music exposure frequency 0.8 0.8 2.5 1.6 0.2 0.1
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 8.1 -2.9 0.6 0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 -0.4 -0.3 -0.2
Blood clot in the leg (DVT) 0.0 0.1 0.1 0.2 -0.3 -0.2
Medication: Paracetamol 0.2 0.4 0.5 0.7 0.6 0.6
Headache pain in last month 0.1 0.2 0.4 -0.6 0.4 0.1
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 9.2 3.0 0.0 -0.8
Glaucoma (self-reported) 0.6 0.7 1.0 -0.8 1.0 0.8
Gout (self-reported) 0.5 0.7 1.0 -0.7 0.7 1.0
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 4.3 -0.3 1.8 2.1
Medication: Amlodipine 1.5 2.1 5.6 -2.4 0.6 0.7
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.4 -0.2 -1.6 -1.2
Birth weight 2.5 5.4 7.0 2.0 -2.2 -2.6
Chronic bronchitis/emphysema (mother) 4.9 5.8 7.8 1.3 -2.8 -2.8
High blood pressure (siblings) 1.3 1.9 3.9 -2.0 0.7 1.1
Forced vital capacity (FVC), Best measure 1.1 3.9 7.0 1.0 2.6 1.9
Body fat percentage 0.4 1.5 2.6 -0.9 1.0 1.6
Leg fat percentage (right) 0.2 0.9 1.5 -0.9 0.6 1.2
Arm fat-free mass (right) 1.3 6.6 8.1 -2.1 2.7 2.8
Exposure to tobacco smoke outside home 0.5 0.7 1.2 0.3 -1.1 -0.8
Comparative body size at age 10 3.7 10.1 10.7 3.0 -3.3 -3.2
Number of full brothers 0.1 0.2 0.4 0.6 0.3 0.1
Worry too long after embarrassment 5.9 9.9 16.4 1.4 4.0 3.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 3.3 -1.2 -1.8 -1.5
Wheeze or whistling in the chest in last year 0.2 0.4 0.5 0.5 -0.6 -0.7
Number of children fathered 1.1 1.2 2.1 -0.4 1.2 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 -0.9 0.0 1.0
Age at first live birth 0.6 1.0 1.4 -1.2 1.1 0.7
Pulse wave peak to peak time 0.4 0.5 0.8 -0.4 -0.7 -0.9
Health satisfaction 0.0 0.1 0.2 -0.1 0.1 0.4
Shortness of breath walking on level ground 0.4 0.5 0.9 0.9 0.6 0.5
Qualifications: College or University degree 7.2 22.7 40.4 -6.4 3.5 3.9
Eye problems/disorders: None of the above 0.3 0.3 0.6 0.3 0.8 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 1.0 -0.7 -0.5
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 -0.1 0.2
Medication for pain relief, constipation, heartburn 1.0 1.7 2.6 0.1 -1.6 -1.6
Neck or shoulder pain in last month 0.3 0.4 1.2 1.1 -0.0 0.1
Medication: Blood pressure 2.5 4.4 10.7 -3.3 0.8 1.4
Angina (self-reported) 4.3 5.7 8.8 -0.7 2.8 3.0
Migraine (self-reported) 0.9 1.2 2.3 -1.5 1.0 0.4
Medication: Ibuprofen 0.6 0.7 1.1 0.2 1.0 1.0
Medication: Allopurinol 0.0 0.0 0.1 -0.1 -0.2 0.2
Medication: Omeprazole 0.0 0.0 0.0 0.0 -0.1 0.2
Medication: Seretide 50 evohaler 1.0 1.1 2.1 0.3 1.5 1.1
Mean time to correctly identify matches 3.0 5.6 8.0 1.2 2.7 2.8
Heart disease (mother) 3.5 4.2 6.5 -1.1 2.2 2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 0.5 -0.3 0.0
Whole body fat mass 0.9 3.7 5.2 -1.6 1.8 2.3
Leg fat mass (right) 0.6 2.4 3.6 -1.2 1.4 1.9
Arm predicted mass (right) 1.1 5.6 6.5 -2.2 2.4 2.5
Pulse rate, automated reading 3.1 10.1 12.4 -3.5 2.5 3.4
Alcohol intake frequency. 2.6 6.1 12.6 3.5 -1.3 -2.0
Comparative height size at age 10 4.1 22.5 23.2 -4.8 4.6 4.8
Number of full sisters 0.1 0.1 0.2 0.5 -0.1 0.0
Suffer from ‘nerves’ 0.3 0.5 1.0 0.2 0.7 1.0
Overall health rating 0.3 0.6 0.9 0.4 -0.9 -0.9
Chest pain or discomfort 0.7 1.0 2.8 -1.7 -0.5 -0.3
Had major operations 0.0 0.0 0.0 -0.0 -0.1 -0.1
Age at last live birth 0.7 1.0 2.0 0.0 1.4 1.0
Family relationship satisfaction 0.1 0.1 0.1 -0.4 -0.2 -0.2
Leg pain on walking 0.2 0.2 0.5 0.7 -0.3 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 1.9 -0.8 1.1 1.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 0.3 -0.5 -0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.5 0.2 1.0 1.2
Medication: Aspirin 2.1 2.8 3.3 -1.7 1.5 1.8
Supplements: Vitamin C 0.6 0.7 1.1 -0.7 0.7 1.0
Knee pain experienced in last month 0.5 0.8 1.1 -0.6 1.1 0.9
Hypertension (Self-reported) 3.7 10.2 12.2 -2.9 3.2 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 1.8 0.3 -1.3 -1.3
Illnesses of father: Heart disease 6.8 9.4 13.7 -1.3 3.7 3.6
Illnesses of siblings: Diabetes 0.2 0.3 0.4 0.5 -0.4 -0.7
Smoking status: Previous 0.5 0.8 1.5 -0.5 -1.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.6 -0.5 1.2 1.2
Whole body fat-free mass 1.2 6.8 7.7 -2.3 2.7 2.8
Leg fat-free mass (right) 1.1 5.8 7.1 -2.0 2.5 2.7
Arm fat percentage (left) 0.5 1.8 3.5 -0.6 1.2 1.9
Average weekly red wine intake 4.2 6.2 8.5 -2.9 2.2 2.3
Handedness (chirality/laterality): Left-handed 3.1 3.7 5.5 1.3 -2.0 -2.3
Mood swings 0.3 0.6 1.6 1.3 0.1 -0.4
Loneliness, isolation 0.5 0.7 1.0 0.6 1.0 0.9
Long-standing illness, disability or infirmity 1.0 1.5 2.6 0.2 1.4 1.6
Ever had bowel cancer screening 0.0 0.0 0.0 -0.0 -0.0 -0.1
Diabetes diagnosed by doctor 0.7 1.2 1.7 -0.2 -1.3 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.4 -0.2 0.6 0.6
Friendships satisfaction 0.5 0.6 0.9 0.6 -0.9 -0.9
Qualifications: nursing, teaching 2.5 3.8 10.9 -3.3 0.6 0.4
Commuting to job workplace: Walk 0.7 0.7 1.2 0.5 -1.1 -0.9
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 -0.3 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 3.8 -0.9 -1.9 -1.5
Medication for cholesterol 1.3 2.0 3.6 -0.4 -1.9 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.9 0.1 0.8 0.9
Back pain experienced in last month 0.3 0.4 1.1 1.0 -0.1 -0.4
Mineral and other dietary supplements 2.1 2.8 4.5 -0.3 -2.1 -2.0
Breast cancer (self-reported) 1.0 1.2 1.6 -1.2 0.9 1.2
Asthma (self-reported) 0.3 0.7 1.3 -1.1 0.2 0.8
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.2 0.5 0.4
Osteoarthritis (self-reported) 0.5 0.6 1.5 -1.2 0.4 0.3
Medication: Aspirin 2.1 2.8 3.1 -1.7 1.5 1.8
Medication: Gliclazide 0.9 1.0 1.7 0.5 -1.0 -1.3
Illnesses of father: None of the above (group 1) 3.4 4.2 6.7 1.0 -2.6 -2.2
Smoking status: Current 3.4 5.4 7.9 1.3 -2.8 -2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.2 1.0 1.1 0.8
Whole body water mass 1.2 6.7 7.6 -2.3 2.7 2.8
Leg predicted mass (right) 1.2 6.2 7.6 -2.0 2.6 2.8
Arm fat mass (left) 0.9 3.8 5.9 -1.4 1.9 2.4
Number of self-reported non-cancer illnesses 1.2 2.1 2.9 -1.4 1.2 1.7
Average weekly champagne plus white wine intake 3.3 4.5 13.4 -3.7 -0.0 0.0
Miserableness 0.1 0.1 0.2 -0.4 -0.4 -0.3
Guilty feelings 4.5 6.8 9.4 2.0 3.1 2.6
Wears glasses or contact lenses 0.4 0.5 1.1 -1.1 0.4 0.3
Ever taken oral contraceptive pill 0.1 0.1 0.3 -0.6 0.1 0.2
Hearing aid user 0.9 1.0 1.9 1.4 0.9 0.7
Mother’s age at death 1.6 2.0 3.0 -0.7 1.7 1.6
Financial situation satisfaction 0.0 0.0 0.1 0.0 -0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.4 1.5 0.5 0.4
Commuting to job workplace: Public transport 3.0 3.5 5.6 -0.8 2.4 2.1
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 0.1 0.3 -0.1
Medication: Blood pressure 4.0 7.6 9.8 -2.1 2.9 3.1
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.0 -0.9 -1.4 -1.0
Supplements: Fish oil (including cod liver oil) 2.2 2.9 4.5 0.6 2.1 2.0
High cholesterol (Self-reported) 0.5 0.9 1.7 -1.3 -0.9 -0.4
Medication: Bendroflumethiazide 5.5 8.3 10.2 -3.2 2.5 2.9
Medication: Paracetamol 0.8 1.2 1.3 1.0 1.1 1.1
Medication: Lisinopril 0.6 0.7 0.8 -0.7 0.9 0.9
Medication: Atorvastatin 3.1 3.8 5.3 -1.4 2.0 2.3
Illnesses of father: High blood pressure 1.0 1.3 2.0 -0.9 0.9 1.4
Alcohol drinker status: Never 1.1 1.3 2.4 1.5 1.1 0.5
Ever smoked 0.6 1.0 1.6 -0.0 -1.3 -1.2
Basal metabolic rate 1.3 7.1 8.5 -2.3 2.8 2.9
Leg fat percentage (left) 0.2 0.9 1.6 -0.7 0.7 1.3
Arm fat-free mass (left) 1.3 6.5 7.5 -2.1 2.7 2.7
Number of operations (self-reported) 2.5 3.7 5.0 -1.6 1.9 2.2
Average weekly beer plus cider intake 2.6 3.7 7.4 2.7 -1.4 -1.4
Irritability 3.3 5.6 6.9 2.2 -2.3 -2.6
Risk taking 2.5 3.6 4.0 2.0 -1.8 -1.9
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.3 -0.6 1.5 1.5
Fractured/broken bones in last 5 years 1.1 1.4 1.6 -1.3 1.2 1.2
Age started oral contraceptive pill 0.1 0.1 0.2 0.3 0.5 0.1
Diastolic blood pressure, automated reading 8.6 26.6 39.3 -2.8 5.7 6.3
Ever depressed for a whole week 1.2 1.4 1.8 1.1 -1.1 -1.4
Unable to work because of sickness or disability 8.7 11.3 17.6 1.3 -4.2 -3.8
Commuting to job workplace: Cycle 0.1 0.1 0.2 0.4 -0.1 -0.1
Myopia 1.4 2.0 3.3 -1.8 1.0 1.3
Vascular/heart problems diagnosed by doctor 5.8 15.8 20.7 3.1 -4.1 -4.5
Cholesterol lowering medication 0.0 0.0 0.1 0.2 0.3 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.5 0.7 0.1 0.2
Pain experienced in last month 0.8 1.3 1.7 -1.1 0.9 1.3
Supplements: Calcium 1.4 1.5 2.3 -0.7 1.4 1.5
Basal cell carcinoma (self-reported) 1.9 2.3 3.8 -0.4 2.0 1.7
Heart attack/myocardial infarction (self-reported) 1.8 2.3 3.6 -1.0 1.6 1.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.0 -0.5 -0.4
Heart disease (siblings) 2.7 3.3 5.5 0.2 2.3 2.1
Alcohol drinker status: Previous 2.1 2.4 3.7 0.2 -1.9 -1.9
Pack years of smoking 1.6 2.4 3.0 1.1 -1.7 -1.7
Impedance of whole body 0.0 0.0 0.1 0.2 0.2 0.2
Leg fat mass (left) 0.7 2.7 4.2 -1.2 1.6 2.1
Arm predicted mass (left) 1.3 6.7 7.5 -2.3 2.7 2.7