Best TWAS P=5.21e-09 · Best GWAS P=9.87e-09 conditioned to 0.0349
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | DNAJC12 | 0.05 | 0.04 | enet | 9 | 0.02 | 2.7e-03 | 4.7 | 5.8 | 5.2e-09 | 0.74 | 0.19 | 0.76 | TRUE |
| 2 | GTEx | Whole Blood | SIRT1 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.3e-06 | 5.2 | 5.2 | 2.0e-07 | 0.97 | 0.10 | 0.90 | FALSE |
| 3 | YFS | Blood | SIRT1 | 0.10 | 0.20 | lasso | 5 | 0.20 | 1.4e-63 | 5.4 | 5.5 | 5.0e-08 | 0.95 | 0.10 | 0.90 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SIRT1 | 0.02 | 0.02 | blup | 42 | 0.01 | 6.3e-02 | 5.4 | 5.2 | 1.9e-07 | 0.94 | 0.02 | 0.69 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | HERC4 | 0.03 | 0.02 | blup | 77 | 0.01 | 6.7e-03 | 5.6 | 5.3 | 1.3e-07 | 0.98 | 0.02 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIRT1 | 0.05 | 0.06 | enet | 8 | 0.06 | 1.7e-06 | 5.2 | 5.8 | 5.9e-09 | 0.94 | 0.04 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SIRT1 | 0.04 | 0.05 | lasso | 1 | 0.04 | 2.0e-04 | 5.4 | 5.4 | 5.8e-08 | 0.94 | 0.02 | 0.97 | FALSE |