Hub : Genes

HERC4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0470 0.0190 3.6e-04 0.030 0.024 0.019 0.034 0.024 1.2e-04 5.3e-04 1.9e-03 4.2e-05 5.3e-04
2 GTEx Breast Mammary Tissue 0.0680 0.0340 9.9e-03 -0.003 NA 0.000 NA 0.019 5.3e-01 NA 3.2e-01 NA 3.6e-02
3 GTEx Breast Mammary Tissue (Male) 0.0395 0.0499 2.5e-01 0.023 NA 0.017 NA -0.010 9.5e-02 NA 1.3e-01 NA 6.1e-01
4 GTEx Breast Mammary Tissue (Female) 0.1058 0.0700 5.3e-02 -0.006 NA 0.014 NA -0.008 5.3e-01 NA 1.2e-01 NA 6.7e-01
5 GTEx Heart Left Ventricle 0.0913 0.0429 4.8e-03 0.058 NA 0.071 NA 0.067 4.9e-04 NA 1.3e-04 NA 1.9e-04
6 GTEx Testis 0.1180 0.0530 5.7e-03 0.079 NA 0.050 NA 0.054 2.2e-04 NA 3.0e-03 NA 2.0e-03
7 YFS Blood 0.0310 0.0119 1.6e-07 0.022 0.029 0.026 0.029 0.028 9.2e-08 8.2e-10 3.9e-09 6.1e-10 1.6e-09
8 TCGA Lung Adenocarcinoma 0.0304 0.0200 1.0e-03 0.021 0.015 0.011 NA 0.010 1.5e-03 6.7e-03 1.6e-02 NA 2.1e-02
9 TCGA Thyroid Carcinoma 0.0390 0.0220 2.5e-04 0.021 0.021 0.008 NA 0.033 3.8e-03 3.5e-03 5.2e-02 NA 3.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.4 2.2 5.7 2.1 0.2 0.0 -0.7 -0.6 -1.5 -1.9 -1.8 -2.4
Bipolar Disorder or Schizophrenia 0.8 1.9 6.0 1.0 0.6 0.0 -0.5 -1.7 -0.7 -1.1 -2.1 -2.4
Depressed Affect (Nagel 2018) 0.1 0.3 1.0 0.8 0.3 0.0 -0.4 0.1 -1.0 -0.2 -0.3 -0.7
Depression (Nagel 2018) 0.3 0.4 0.9 -0.9 0.8 0.0 0.9 0.3 -0.4 0.6 0.5 0.5
Intelligence (Savage-Jansen 2018) 0.5 1.5 4.3 2.1 -1.0 0.0 -1.2 -2.0 -0.1 -0.9 -1.2 -0.8
Neuroticism (Nagel 2018) 1.1 2.7 6.8 0.6 1.9 0.0 0.1 -1.0 -1.5 -2.1 -2.3 -2.6
Schizophrenia (2018) 0.4 0.7 2.9 -0.4 0.7 0.0 -0.1 -1.7 0.3 0.1 -1.3 -1.2
Schizophrenia vs Biploar Disorder 0.7 1.0 2.3 -0.6 -1.0 0.0 -0.8 0.1 0.7 1.4 1.5 1.5
Worry (Nagel 2018) 0.7 1.4 6.3 -0.7 2.5 0.0 1.3 0.3 -0.5 -1.5 -0.6 -1.0
Alzheimer’s Disease (in mother) 1.0 1.2 4.1 -2.0 1.4 0.0 1.3 0.6 1.2 0.1 -1.0 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 0.8 -0.3 0.8 0.0 0.7 0.7 -0.8 -0.7 -0.6 -0.9
Alzheimer’s Disease (including proxy) 0.6 0.8 2.2 -1.5 1.5 0.0 1.0 0.9 0.3 -0.2 -0.9 -0.6
Crohns Disease (2017) 1.1 2.4 5.6 1.8 -1.1 0.0 -1.7 2.3 -2.4 -0.7 1.6 0.1
Irritable Bowel Disease (IBD) 0.8 1.9 4.2 1.8 -1.3 0.0 -1.7 1.7 -2.0 -1.1 1.1 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.8 0.4 -0.9 0.0 -0.6 0.4 -0.2 -0.1 0.4 0.5
Major Depression (MDD) 1.9 2.3 9.3 0.1 0.1 0.0 -0.1 1.5 0.1 1.1 2.8 3.1
Reaction Time 0.6 1.1 5.2 -0.7 2.3 0.0 1.4 -0.1 -1.3 -0.3 -0.2 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.3 1.5 -0.9 0.0 -0.6 -1.1 -0.4 -0.8 -0.1 0.3
Breast Cancer 0.9 2.3 4.8 -1.8 1.9 0.0 2.2 0.7 0.9 1.7 2.0 0.8
Ovarian Cancer 0.5 0.6 2.4 -0.7 0.2 0.0 0.4 0.0 1.1 1.6 0.6 0.9
Prostate Cancer 0.2 0.2 1.6 -0.2 -0.5 0.0 0.0 1.2 0.4 -0.2 -0.1 -0.4
Age at First Birth 0.5 0.7 2.0 -0.7 1.3 0.0 1.4 -1.0 0.0 0.4 -0.9 -0.7
Bipolar Disorder (2011) 0.9 0.9 1.8 1.2 -0.6 0.0 -1.3 1.3 -0.8 -0.8 -0.7 -0.9
Body Mass Index (BMI) (2010) 3.1 4.3 14.3 0.5 -0.5 0.0 -0.1 -2.3 -0.4 -2.6 -3.8 -3.3
Coronary Artery Disease (CAD) 0.4 0.4 2.5 -0.2 0.9 0.0 0.4 1.6 -0.4 -0.4 0.3 -0.2
Crohns Disease (2012) 1.2 1.9 6.4 1.4 0.3 0.0 -0.7 2.5 -2.1 -0.5 1.6 0.6
Mean Putamen Volume 1.1 1.2 3.3 -0.1 0.7 0.0 0.4 1.8 0.0 1.6 1.6 1.4
Fasting Glucose 0.7 0.8 4.3 0.5 -2.1 0.0 -0.9 -0.1 -0.6 -0.8 -0.7 -0.5
HbA1C 0.4 0.4 1.6 0.3 -1.3 0.0 -1.0 0.3 -0.6 -0.7 -0.1 -0.4
HDL Cholesterol 0.8 1.3 4.0 0.2 2.0 0.0 0.9 -1.4 -1.6 -0.7 -0.9 -1.1
LDL Cholesterol 0.3 0.4 1.6 1.0 -0.3 0.0 -0.5 -0.5 -1.3 -0.5 0.3 -0.5
Lupus 1.4 2.1 4.5 -2.1 2.1 0.0 2.0 -0.5 2.1 0.6 -0.7 -0.2
Neuroticism (2016) 0.3 0.4 1.2 0.3 0.9 0.0 0.3 -0.3 -1.1 -0.8 -0.4 -1.0
Primary Biliary Cirrhosis 0.5 0.6 2.2 0.3 -1.5 0.0 -1.0 0.9 0.6 0.1 1.0 0.7
Rheumatoid Arthritis 2.1 2.8 6.8 -1.1 -0.4 0.0 0.3 2.4 1.5 1.9 2.6 2.4
Schizophrenia (2014) 0.3 0.7 2.2 0.1 0.1 0.0 -0.9 -0.9 -0.3 -0.3 -1.4 -1.5
Triglycerides 0.3 0.4 1.7 -0.2 -0.8 0.0 -0.6 1.3 0.5 -0.1 0.5 0.7
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.9 0.3 -1.0 0.0 -0.7 0.2 -0.1 0.2 0.7 0.3
Ulcerative Colitis 0.2 0.4 1.1 0.7 -0.2 0.0 -0.6 0.2 -1.1 -0.9 -0.1 -0.6
Blood Eosinophil Count 0.2 1.6 4.6 -2.1 1.8 0.0 1.7 0.4 0.1 -0.2 -1.4 -1.0
Blood Platelet Count 0.7 8.0 21.5 1.9 0.7 0.0 -0.3 -2.6 -3.1 -3.2 -4.6 -4.4
Blood Red Count 0.6 5.6 14.7 2.3 -2.0 0.0 -1.5 -1.6 -1.6 -3.3 -3.8 -2.9
Blood White Count 2.6 19.2 42.2 4.3 0.6 0.0 -2.2 -3.8 -5.2 -5.6 -5.7 -6.5
Heel T-Score 0.5 3.9 9.2 2.9 -3.0 0.0 -2.5 0.0 -1.1 0.9 2.4 1.9
BMI 0.5 2.7 6.2 2.4 -1.2 0.0 -1.3 -0.5 -2.5 -1.5 -1.9 -1.6
Height 1.4 26.6 125.4 5.1 -11.2 0.0 -6.8 -2.7 4.1 2.1 1.3 3.3
Waist Hip Ratio (WHR) 0.5 2.1 9.4 0.8 -0.1 0.0 -0.6 -0.2 -1.0 -2.2 -1.8 -3.1
Systolic Blood Pressure 4.5 22.8 42.5 -5.5 2.2 0.0 3.5 4.8 5.2 6.0 6.5 5.5
Smoking Status 0.5 1.2 4.1 -2.0 1.8 0.0 1.1 0.8 0.6 1.1 0.3 0.7
Allergy or Eczema 0.3 0.8 3.2 -0.1 1.2 0.0 1.8 -1.0 -0.9 -0.0 -0.1 -0.7
Cardiovascular Disease 0.6 2.1 4.1 -1.9 2.0 0.0 1.7 0.9 1.1 1.9 1.3 0.9
Hypothyroidism (self reported) 0.8 1.9 6.2 -0.1 0.5 0.0 -0.0 2.1 -1.4 0.5 2.5 1.9
Respiratory disease 0.6 1.4 5.6 -1.4 2.4 0.0 1.8 -1.2 0.3 0.4 0.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 8.7 -0.2 -0.2 0.0 0.1 3.0 -0.1 0.7 1.4 0.9
Lung FEV1/FVC ratio 0.7 3.5 8.8 3.0 -2.0 0.0 -2.7 -0.0 -2.3 -1.9 -1.1 -1.1
Lung FVC 1.1 5.5 15.2 -3.9 3.6 0.0 3.7 2.1 0.5 0.7 1.0 1.5
Neuroticism 0.5 1.3 3.2 0.9 1.0 0.0 -0.6 0.1 -1.4 -1.8 -1.3 -1.7
Chronotype (morning person) 2.0 4.7 14.3 0.7 0.2 0.0 -0.4 -3.0 -0.8 -2.8 -3.8 -3.1
Hair Pigment 0.1 1.5 6.2 0.8 1.1 0.0 0.1 0.6 -2.5 -1.6 -0.9 -1.3
Tanning 0.1 1.4 3.4 -1.6 1.4 0.0 1.8 1.0 1.0 0.9 1.0 1.1
Hand grip strength (left) 0.2 0.6 2.2 -0.1 -1.5 0.0 -0.8 -0.6 1.2 0.8 0.5 0.6
Number of treatments/medications taken 1.1 1.9 5.3 -1.1 1.9 0.0 1.4 1.5 -0.1 1.3 2.3 1.0
Average weekly spirits intake 0.8 1.0 2.2 1.5 -0.4 0.0 -0.8 1.4 -1.3 -0.9 1.0 0.7
Sensitivity / hurt feelings 1.0 1.7 3.9 -1.6 2.0 0.0 1.8 -1.0 1.0 0.4 -1.3 -1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.9 -1.1 1.4 0.0 1.3 0.6 -0.1 0.7 0.8 0.4
Hearing difficulty/problems: Yes 0.4 0.6 2.4 -0.5 0.8 0.0 0.7 0.4 -0.6 0.2 1.6 1.0
Relative age of first facial hair 0.4 0.9 3.1 -0.5 0.1 0.0 0.0 0.4 0.7 1.1 1.6 1.8
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 4.2 -0.6 2.0 0.0 0.9 -0.1 0.1 0.7 0.5 0.0
Ever used hormone-replacement therapy (HRT) 0.7 0.8 4.8 0.5 -1.0 0.0 -1.0 2.2 -0.5 0.1 0.4 -0.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.8 0.1 -0.3 0.0 -0.9 0.4 0.5 -0.1 0.5 0.3
Systolic blood pressure, automated reading 4.5 13.1 27.9 -4.1 0.7 0.0 1.9 3.4 4.0 4.6 5.3 4.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 3.7 0.8 0.1 0.0 -0.2 1.9 -1.4 -0.3 0.7 -0.1
Angina 1.0 1.3 5.6 -0.9 1.0 0.0 0.6 2.4 0.1 1.0 1.2 1.2
Medication for hormone replacement therapy 0.5 0.6 1.6 0.4 -1.3 0.0 -1.3 1.1 0.3 -0.7 0.5 -0.0
Vitamin and mineral supplements 0.2 0.3 1.1 0.5 -0.1 0.0 0.2 1.1 -0.5 -0.4 -0.3 0.9
Supplements: Zinc 0.6 0.7 2.4 -0.7 -1.1 0.0 -0.1 -1.1 1.6 0.6 0.0 0.5
Medication: Co-codamol 0.9 1.0 2.9 -0.1 -0.8 0.0 -0.1 1.7 0.5 0.7 1.5 1.7
Medication: Metformin 1.5 2.1 5.7 -0.3 -0.3 0.0 -0.1 1.9 0.5 1.9 2.4 2.3
Diabetes (father) 0.5 0.6 3.2 -0.7 -1.0 0.0 -0.2 1.8 0.5 0.5 0.4 0.4
Diabetes (mother) 0.4 0.5 1.3 0.3 -0.7 0.0 -0.7 1.1 -0.5 0.6 0.8 0.7
Severe depression (siblings) 0.2 0.2 1.0 0.6 0.5 0.0 -0.3 -0.2 -0.4 -0.1 0.5 -1.0
Pack years adult smoking proportion 0.8 1.3 5.6 -0.4 2.4 0.0 1.9 0.4 -0.8 -0.3 -0.2 -1.1
Impedance of leg (right) 0.6 2.7 11.0 -0.8 -0.2 0.0 0.2 3.3 -0.6 0.7 2.8 2.1
Leg fat-free mass (left) 0.8 4.2 13.5 2.6 -3.7 0.0 -2.0 -3.0 0.8 -0.3 -2.0 -0.7
Trunk fat percentage 0.4 1.4 6.4 1.1 -1.2 0.0 -0.8 2.5 -1.5 -0.3 0.7 0.7
Hand grip strength (right) 0.3 0.9 4.6 0.6 -2.1 0.0 -1.1 -1.3 0.7 -0.1 -0.5 -0.0
Townsend deprivation index at recruitment 0.8 1.2 2.2 -1.3 -0.0 0.0 0.5 1.1 1.4 1.3 1.2 1.5
Current tobacco smoking 0.5 0.8 4.3 -0.6 2.1 0.0 0.8 1.1 -0.1 0.4 0.2 0.3
Average weekly fortified wine intake 0.6 0.7 1.8 -0.5 0.4 0.0 0.2 1.1 0.7 -1.0 -1.3 -1.3
Maternal smoking around birth 1.0 1.4 6.0 -0.9 0.0 0.0 0.0 2.4 1.4 0.4 1.3 1.5
Fed-up feelings 0.2 0.4 1.8 0.6 -0.4 0.0 -0.6 1.4 -0.3 0.4 0.9 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.3 -1.4 1.5 0.0 1.5 0.7 0.5 1.3 1.3 1.2
Relative age voice broke 0.7 1.1 4.0 -0.4 -0.4 0.0 -0.5 1.2 0.6 0.8 2.0 1.8
Taking other prescription medications 2.9 4.5 9.5 -2.5 3.1 0.0 2.0 2.4 0.8 2.1 2.5 1.8
Age when periods started (menarche) 1.4 3.2 9.3 -2.7 2.2 0.0 3.1 1.4 1.2 1.4 1.3 0.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 -0.8 0.3 0.0 0.3 0.9 0.5 0.5 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.3 1.5 -1.0 0.0 -1.4 -0.1 -0.7 0.1 1.8 1.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.9 1.6 0.3 0.0 -0.7 -0.2 -2.2 -1.5 0.1 -0.7
Qualifications: CSEs or equivalent 0.8 1.1 3.6 -0.5 -1.1 0.0 -0.5 1.4 -0.1 1.0 1.9 1.4
Serious illness, injury or assault to yourself 0.8 0.9 3.4 1.1 -1.8 0.0 -1.8 -0.1 0.1 -0.7 0.2 0.4
High blood pressure 0.9 2.5 6.0 -1.4 1.2 0.0 1.0 1.4 0.9 2.2 2.4 2.3
Hayfever, allergic rhinitis or eczema 1.0 2.2 6.6 0.1 1.1 0.0 1.5 -2.6 -1.2 -1.0 -1.6 -2.0
Multivitamins +/- minerals 0.4 0.5 2.6 -0.4 0.2 0.0 0.0 -1.6 0.5 0.9 0.4 -0.5
Stomach or abdominal pain in last month 0.4 0.5 1.6 -0.5 0.3 0.0 0.1 1.3 0.2 1.0 0.9 1.0
Supplements: Glucosamine 0.2 0.2 0.8 -0.4 0.4 0.0 0.0 0.6 0.4 0.9 0.6 0.2
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 4.2 1.4 -1.5 0.0 -1.2 2.0 -0.4 1.1 2.0 1.9
Medication: Atenolol 0.9 1.1 5.1 1.3 0.6 0.0 -0.2 0.1 -2.3 -1.0 -0.0 -1.5
Medication: Levothyroxine sodium 0.5 0.9 2.8 -0.1 0.9 0.0 0.2 1.5 -0.9 0.3 1.7 1.1
Sitting height 2.0 14.0 70.2 3.2 -8.4 0.0 -4.4 -1.1 4.1 1.5 0.3 2.5
Chronic bronchitis/emphysema (father) 2.7 3.1 15.4 -2.0 1.0 0.0 1.0 3.9 1.1 1.1 2.0 0.6
High blood pressure (mother) 1.4 1.9 5.0 1.7 -0.1 0.0 -1.7 -0.7 -2.2 -1.6 -0.7 -1.7
Body mass index (BMI) 0.2 0.8 3.1 1.1 -0.7 0.0 -0.5 0.6 -1.8 -0.8 -0.6 -0.6
Impedance of leg (left) 0.7 3.3 14.0 -1.0 -0.3 0.0 0.3 3.7 -0.4 1.0 2.9 2.1
Leg predicted mass (left) 0.8 4.2 13.6 2.5 -3.7 0.0 -2.0 -3.0 0.8 -0.3 -2.0 -0.7
Trunk fat mass 0.4 1.7 7.6 1.7 -2.8 0.0 -1.4 1.4 -0.8 -0.1 0.0 0.4
Waist circumference 0.5 1.7 4.9 1.9 -2.2 0.0 -1.5 0.7 -1.5 -0.7 -0.7 -0.8
Number of incorrect matches in round 1.2 2.0 8.5 0.4 0.9 0.0 0.2 -2.9 -1.0 -0.8 -2.0 -1.6
Past tobacco smoking 1.0 1.9 4.7 0.9 0.3 0.0 0.5 -2.0 -0.6 -1.7 -2.0 -2.2
Alcohol usually taken with meals 1.4 2.2 6.5 0.2 0.6 0.0 0.6 -2.1 -0.4 -1.9 -2.5 -2.1
Nervous feelings 1.5 2.8 9.0 -2.0 3.0 0.0 2.4 1.6 0.5 0.9 1.6 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.0 0.1 1.2 0.0 0.7 1.7 -1.1 0.0 1.4 0.1
Hearing difficulty/problems with background noise 0.6 1.0 4.8 0.9 0.6 0.0 0.1 -0.2 -2.2 -1.4 0.0 -1.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.0 -0.7 -0.7 0.0 0.0 0.7 1.0 0.6 0.9 1.0
Had menopause 2.7 3.3 10.6 -1.6 -0.3 0.0 0.2 3.2 1.4 1.7 2.6 2.3
Had other major operations 0.7 0.9 3.2 -1.0 -0.8 0.0 -0.2 1.8 1.1 0.8 0.4 1.0
Forced vital capacity (FVC) 0.2 0.9 2.6 -1.0 -0.9 0.0 -0.4 1.1 1.2 0.5 1.0 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 5.6 2.4 -1.0 0.0 -1.5 -0.1 -1.6 -0.4 1.7 0.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.1 1.4 -0.6 0.0 -1.4 -0.2 -1.2 -0.3 0.1 -0.8
Qualifications: None of the above 2.3 4.8 11.0 -3.0 1.0 0.0 1.8 3.3 2.5 1.8 2.5 2.0
Financial difficulties in last 2 years 0.4 0.6 2.1 0.2 -0.4 0.0 -0.6 0.9 -0.0 0.5 1.4 1.3
Mouth/teeth dental problems 0.7 1.0 3.6 -0.4 -1.6 0.0 -0.2 -1.9 1.6 0.4 -0.7 -0.3
Heart attack 1.8 2.3 5.6 2.4 -2.0 0.0 -2.0 -0.2 -1.0 -2.0 -1.1 -1.0
Allergy 0.6 1.5 4.1 1.0 -1.8 0.0 -2.0 1.2 0.4 0.3 1.2 1.3
Pain all over the body in last month 1.9 2.0 6.3 -0.6 1.6 0.0 1.6 0.5 0.2 2.1 2.5 1.4
Diabetes (self-reported) 1.4 2.1 8.9 1.6 -0.2 0.0 -0.8 3.0 -1.7 0.1 1.8 0.9
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.9 1.6 -0.9 0.0 -0.8 -2.0 -1.6 -1.0 -1.4 -1.3
Medication: Ramipril 0.9 1.1 3.0 -1.1 0.7 0.0 1.7 0.4 1.4 1.0 1.0 1.1
Medication: Simvastatin 2.4 3.5 10.1 -1.3 0.3 0.0 -0.2 3.0 1.0 1.4 3.2 2.7
Fluid intelligence score 0.6 1.3 4.5 2.1 -0.8 0.0 -1.1 -1.6 -1.2 -0.9 -0.5 0.3
Illnesses of siblings 0.4 0.5 1.8 1.3 -1.1 0.0 -0.5 -1.1 -0.5 0.3 -0.1 0.0
Neuroticism score 0.8 1.6 6.2 0.2 2.5 0.0 0.8 0.2 -1.2 -1.5 -0.9 -1.7
Weight 0.5 2.7 14.7 2.3 -3.8 0.0 -2.0 -0.5 -0.1 0.2 -0.5 0.3
Impedance of arm (right) 0.4 1.7 4.0 -1.1 1.9 0.0 1.3 2.0 0.1 0.3 1.7 1.4
Arm fat percentage (right) 0.3 1.0 3.9 1.1 -0.4 0.0 -0.3 1.6 -2.0 -0.9 -0.1 -0.2
Trunk fat-free mass 1.1 6.3 27.4 2.5 -5.2 0.0 -2.6 -3.2 1.8 0.7 -1.5 -0.1
Hip circumference 0.4 1.6 6.4 1.5 -2.5 0.0 -1.1 0.9 -0.6 0.8 1.0 1.4
Time employed in main current job 1.4 1.7 5.3 -2.3 0.9 0.0 1.8 -1.1 1.7 0.4 -1.2 -0.5
Alcohol intake versus 10 years previously 0.3 0.5 0.9 -0.2 -0.9 0.0 0.0 -1.0 0.9 0.7 -0.9 0.4
Father’s age at death 0.7 1.0 3.2 -0.2 1.8 0.0 0.9 -0.1 -0.8 -1.5 -1.0 -1.1
Worrier / anxious feelings 0.8 1.5 4.2 -0.9 2.0 0.0 1.8 -0.5 -0.6 -0.8 -1.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 3.3 0.5 1.8 0.0 1.2 -0.7 -1.1 0.1 1.0 -0.3
Falls in the last year 0.8 1.1 3.4 1.3 -0.0 0.0 -1.4 -0.1 -1.2 -1.9 -0.4 -1.1
Hair/balding pattern: Pattern 3 0.6 0.8 2.9 0.7 -0.2 0.0 -0.7 -0.4 -0.3 1.4 1.2 1.7
Number of live births 1.9 2.7 9.5 -1.0 1.1 0.0 0.9 3.1 0.1 1.2 2.7 1.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.5 0.4 -1.6 0.0 -1.4 0.9 0.1 -0.5 0.4 0.7
Pulse rate 1.0 1.6 4.2 2.0 0.4 0.0 -1.2 -0.2 -2.0 -1.9 -0.2 -0.9
Happiness 0.8 0.9 3.1 -0.5 -0.5 0.0 0.3 1.0 0.8 1.2 1.8 1.3
Noisy workplace 1.1 1.4 7.9 0.3 -0.3 0.0 -0.2 2.8 -1.1 0.2 1.6 0.9
Qualifications: A levels/AS levels or equivalent 1.7 3.7 12.0 1.6 0.1 0.0 -0.4 -2.8 -1.3 -1.8 -2.4 -3.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.9 -0.4 0.8 0.0 0.6 -0.1 0.2 0.4 1.4 1.2
Mouth/teeth dental problems: Dentures 1.4 2.4 4.2 -1.4 2.0 0.0 1.6 1.4 1.4 1.6 1.9 1.7
Asthma 1.0 1.9 8.2 -1.3 2.9 0.0 1.8 -0.8 -0.8 -0.5 -0.7 -1.4
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.9 2.0 -0.7 0.0 -1.8 -2.0 -1.8 -0.9 -0.7 -0.5
Medication: Cholesterol lowering 0.3 0.5 2.2 -0.3 0.6 0.0 0.2 0.9 -0.4 0.1 1.5 0.8
Depression (self-reported) 0.7 0.8 3.8 0.8 0.8 0.0 -0.7 0.8 -1.9 -0.2 0.0 -0.9
Medication: Lansoprazole 1.6 1.8 6.4 -2.0 2.5 0.0 1.5 1.7 -0.1 -0.2 0.5 0.2
Prospective memory result 0.1 0.2 0.9 -0.4 -0.3 0.0 0.2 -1.0 0.2 -0.0 0.2 -0.1
Lung cancer (father) 0.8 0.9 3.6 -0.0 0.9 0.0 -0.1 1.2 -0.3 1.9 1.1 1.3
Illnesses of mother 0.8 1.0 2.9 -0.0 -1.6 0.0 -0.4 -0.6 1.4 0.6 0.6 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.7 0.2 -0.5 0.0 -0.6 0.8 -0.7 -0.7 0.2 0.1
Pulse wave Arterial Stiffness index 1.8 2.0 5.9 1.5 -1.1 0.0 -1.2 -0.7 -1.1 -1.3 -2.1 -2.4
Impedance of arm (left) 0.3 1.3 3.5 -1.2 1.7 0.0 1.1 1.9 0.3 -0.2 1.2 1.0
Arm fat mass (right) 0.3 1.2 4.2 1.7 -2.0 0.0 -1.1 0.6 -1.2 -0.5 -0.5 -0.2
Trunk predicted mass 1.1 6.2 26.9 2.6 -5.2 0.0 -2.6 -3.2 1.7 0.6 -1.5 -0.1
Standing height 1.0 10.2 48.3 2.5 -7.0 0.0 -3.2 -2.2 3.7 2.2 0.1 1.9
Length of working week for main job 0.6 0.7 3.0 1.4 -0.3 0.0 -0.6 -0.2 -1.7 -0.9 -0.1 -0.5
Exposure to tobacco smoke at home 1.7 2.0 5.0 -0.9 2.2 0.0 1.3 2.0 0.0 1.2 1.9 1.1
Breastfed as a baby 0.3 0.3 1.1 0.1 -1.1 0.0 -0.7 1.0 0.3 -0.3 -0.2 0.4
Tense / ‘highly strung’ 0.8 1.4 3.9 -0.3 1.9 0.0 0.8 -0.2 -0.3 -1.8 -0.9 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.8 16.3 -1.3 0.8 0.0 0.2 3.1 1.5 2.6 4.0 2.4
Hair/balding pattern: Pattern 4 0.7 1.6 5.2 2.3 0.1 0.0 -1.0 0.8 -2.0 -0.5 1.7 0.6
Birth weight of first child 2.4 4.4 14.6 0.4 -0.1 0.0 -0.5 -2.7 -0.9 -2.0 -3.8 -3.6
Peak expiratory flow (PEF) 0.7 1.6 5.5 1.2 -2.3 0.0 -1.8 1.0 -0.7 -1.6 0.1 0.3
Pulse wave reflection index 0.2 0.3 0.8 -0.7 -0.8 0.0 0.2 -0.3 0.9 0.4 -0.2 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 0.1 0.3 0.0 -0.6 0.2 -0.4 -0.3 0.3 0.3
Loud music exposure frequency 0.4 0.4 1.5 -0.3 0.2 0.0 -0.0 0.6 0.7 0.4 1.2 1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.5 0.5 -1.2 0.0 -0.7 0.6 0.5 0.7 0.4 0.7
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 8.1 2.1 -1.0 0.0 -1.5 0.3 -2.8 -2.0 -0.8 -0.9
Blood clot in the leg (DVT) 0.8 1.0 3.7 -0.8 0.2 0.0 0.3 1.9 1.4 0.9 0.3 1.3
Medication: Paracetamol 0.9 1.4 5.2 -0.3 -0.5 0.0 -0.4 2.3 0.1 0.4 2.1 1.6
Headache pain in last month 1.5 2.5 6.3 1.1 0.3 0.0 -0.8 -2.0 -1.5 -1.7 -2.3 -2.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.9 -0.7 -0.1 0.0 0.1 -0.1 0.8 -0.2 -0.9 -0.3
Glaucoma (self-reported) 0.4 0.5 2.7 0.6 1.6 0.0 -0.6 0.7 -0.7 -0.1 0.6 -0.3
Gout (self-reported) 0.3 0.5 1.9 -1.1 0.8 0.0 0.3 1.4 0.3 0.1 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 9.6 0.2 0.6 0.0 -0.5 2.9 -1.5 0.6 3.1 2.1
Medication: Amlodipine 0.9 1.3 3.4 0.8 -0.1 0.0 -1.2 1.8 -0.6 0.2 1.6 1.8
Medication: Ventolin 100micrograms inhaler 0.8 1.0 4.8 -1.4 2.2 0.0 1.3 0.7 -0.0 0.2 0.3 -0.3
Birth weight 2.4 5.2 15.3 1.1 -0.7 0.0 0.0 -3.9 -0.6 -2.1 -3.7 -3.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.3 0.4 0.2 0.0 -1.1 0.8 -0.6 -0.5 -0.2 -0.3
High blood pressure (siblings) 1.0 1.5 3.4 -1.8 1.5 0.0 1.5 -1.2 1.2 -0.2 -1.4 -0.9
Forced vital capacity (FVC), Best measure 0.0 0.1 0.5 -0.7 -0.0 0.0 0.4 0.2 0.3 0.2 0.3 0.5
Body fat percentage 0.4 1.7 7.3 1.1 -1.6 0.0 -0.8 2.7 -1.7 -0.3 0.8 0.7
Leg fat percentage (right) 0.7 2.5 11.3 0.7 -1.8 0.0 -0.6 3.4 -2.0 0.0 1.2 1.0
Arm fat-free mass (right) 1.1 5.8 26.0 2.9 -5.1 0.0 -2.8 -2.6 0.7 0.1 -1.6 -0.6
Exposure to tobacco smoke outside home 2.0 2.7 5.5 2.2 -0.8 0.0 -2.1 -1.1 -1.5 -2.3 -1.6 -1.7
Comparative body size at age 10 0.5 1.4 3.2 1.1 -0.9 0.0 0.0 -1.4 -1.2 -1.3 -1.8 -1.6
Number of full brothers 0.4 0.5 1.4 0.3 0.7 0.0 0.1 1.0 -0.6 -0.1 0.8 1.2
Worry too long after embarrassment 1.3 2.3 8.4 0.5 1.1 0.0 0.2 -1.5 -0.9 -1.9 -1.9 -2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.6 1.6 -0.1 0.0 -1.5 -0.5 -1.1 -0.4 1.2 0.1
Wheeze or whistling in the chest in last year 1.0 1.7 3.8 -0.8 1.9 0.0 0.7 1.9 -0.5 1.7 1.8 0.5
Number of children fathered 0.1 0.1 0.2 -0.1 0.0 0.0 0.4 0.5 -0.4 -0.0 -0.2 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.1 -0.0 -0.1 0.0 -0.1 -0.9 -0.2 -0.3 -1.1 -0.9
Age at first live birth 0.8 1.5 5.5 -0.1 -0.9 0.0 -0.5 -1.4 0.6 -1.3 -2.4 -1.7
Pulse wave peak to peak time 1.7 2.0 6.9 -1.2 0.7 0.0 1.0 0.3 1.2 1.4 2.2 2.6
Health satisfaction 1.2 1.5 4.1 1.7 -2.0 0.0 -1.6 0.7 -0.4 0.3 1.7 0.8
Shortness of breath walking on level ground 0.8 1.0 3.5 -1.2 0.6 0.0 1.0 0.5 1.0 0.7 1.0 1.9
Qualifications: College or University degree 4.8 15.1 37.5 2.6 -0.1 0.0 -1.2 -6.1 -1.6 -4.1 -6.0 -5.9
Eye problems/disorders: None of the above 0.4 0.5 1.3 -0.7 -0.7 0.0 -0.2 0.4 0.2 1.1 0.8 0.9
Mouth/teeth dental problems: Loose teeth 3.3 4.0 14.0 -0.9 0.9 0.0 0.5 3.3 -0.7 1.2 3.7 2.7
Emphysema/chronic bronchitis 1.2 1.4 3.2 -1.0 0.3 0.0 0.4 1.4 0.7 1.8 1.7 1.6
Medication for pain relief, constipation, heartburn 0.7 1.2 4.0 1.0 -0.6 0.0 -0.3 -2.0 -0.4 -0.8 -1.6 -1.4
Neck or shoulder pain in last month 0.3 0.4 1.2 0.4 -0.1 0.0 -0.2 0.7 -1.1 -1.1 -0.7 -0.7
Medication: Blood pressure 0.2 0.4 1.0 1.0 -0.2 0.0 -0.3 0.2 -1.0 0.2 1.0 0.5
Angina (self-reported) 1.2 1.6 5.7 -1.2 1.1 0.0 0.6 2.4 0.6 1.3 1.5 1.4
Migraine (self-reported) 4.2 5.2 10.1 3.2 -3.0 0.0 -3.1 -1.8 -1.5 -2.5 -1.9 -1.8
Medication: Ibuprofen 2.1 2.5 5.4 2.3 -0.5 0.0 -2.0 -2.2 -2.1 -1.1 -1.2 -1.0
Medication: Allopurinol 1.2 1.6 3.5 -1.9 0.2 0.0 0.9 1.1 1.9 1.4 1.1 1.6
Medication: Omeprazole 2.0 2.4 6.4 -1.2 1.6 0.0 1.1 2.5 -0.0 1.6 2.4 1.3
Medication: Seretide 50 evohaler 0.5 0.6 2.7 -0.5 1.0 0.0 1.2 -1.7 -0.1 -0.1 -0.3 -0.3
Mean time to correctly identify matches 0.4 0.8 3.5 -0.8 1.9 0.0 0.8 0.6 -1.1 0.2 0.1 -0.6
Heart disease (mother) 1.0 1.2 4.7 -0.7 0.5 0.0 0.2 2.2 0.0 1.1 1.7 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.1 0.4 -0.6 0.0 -0.5 -0.0 -0.5 -0.7 -0.9 -1.0
Whole body fat mass 0.4 1.5 7.1 1.4 -2.7 0.0 -1.3 1.4 -0.8 0.0 0.1 0.4
Leg fat mass (right) 0.5 1.8 9.2 1.3 -3.0 0.0 -1.2 1.5 -1.0 0.1 0.2 0.6
Arm predicted mass (right) 1.1 5.7 26.0 2.7 -5.1 0.0 -2.8 -2.6 1.0 0.2 -1.6 -0.6
Pulse rate, automated reading 0.8 2.6 7.5 2.0 1.1 0.0 -0.9 0.5 -2.7 -2.7 -0.3 -1.5
Alcohol intake frequency. 0.1 0.1 0.8 0.2 -0.9 0.0 0.4 0.0 -0.2 0.2 -0.3 0.3
Comparative height size at age 10 1.0 5.4 24.3 1.4 -4.9 0.0 -1.8 -1.7 3.1 2.2 0.2 1.2
Number of full sisters 0.6 0.8 3.5 -0.7 1.9 0.0 1.1 0.4 -0.1 0.8 0.4 0.7
Suffer from ‘nerves’ 0.9 1.4 4.5 -1.1 2.1 0.0 1.2 1.7 -0.2 -1.5 0.1 -0.1
Overall health rating 0.5 1.1 4.1 -0.6 0.6 0.0 0.3 2.0 0.5 0.9 1.8 0.9
Chest pain or discomfort 0.8 1.1 3.6 -0.9 1.7 0.0 0.7 1.9 -0.8 -0.3 1.1 0.3
Had major operations 1.4 1.7 9.6 1.2 -3.1 0.0 -1.6 -0.3 0.5 0.7 0.5 0.4
Age at last live birth 0.4 0.5 2.1 0.5 -0.6 0.0 -0.8 -0.6 -0.6 -1.4 -0.5 -0.8
Family relationship satisfaction 0.6 0.7 2.0 -0.3 0.2 0.0 0.4 -0.9 0.2 1.3 1.2 1.4
Leg pain on walking 0.9 1.1 4.3 0.8 -2.1 0.0 -1.5 1.3 0.5 0.2 0.6 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.2 0.6 0.6 0.0 0.3 1.3 -1.6 0.9 2.0 0.7
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.1 0.1 -1.8 0.0 -0.1 1.6 0.5 0.6 1.0 1.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.6 0.9 -0.1 0.0 0.3 -0.9 -1.0 -0.9 -1.5 -1.6
Medication: Aspirin 1.1 1.4 3.8 -1.9 1.6 0.0 2.0 1.1 0.7 0.6 0.5 0.5
Supplements: Vitamin C 0.2 0.2 0.6 0.2 0.7 0.0 -0.2 -0.4 -0.4 -0.5 0.5 -0.8
Knee pain experienced in last month 0.9 1.5 3.8 0.0 -1.8 0.0 -1.7 1.9 1.0 0.3 0.6 1.2
Hypertension (Self-reported) 0.9 2.4 5.6 -1.3 0.9 0.0 0.9 1.0 1.2 2.3 2.4 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 10.5 -2.1 1.0 0.0 0.6 3.2 0.1 0.8 1.1 0.4
Illnesses of father: Heart disease 0.3 0.4 1.3 -1.1 0.6 0.0 1.1 -0.5 -0.3 0.6 -0.4 -0.5
Illnesses of siblings: Diabetes 1.9 2.3 8.1 -0.4 -0.1 0.0 -0.6 2.8 0.6 1.5 2.3 2.1
Smoking status: Previous 1.0 1.6 4.1 -1.1 -0.1 0.0 0.2 1.5 0.4 1.7 1.9 2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 5.3 1.4 -2.3 0.0 -1.5 -0.3 0.8 0.1 0.4 0.2
Whole body fat-free mass 1.0 5.6 22.8 2.6 -4.8 0.0 -2.4 -3.2 1.5 0.3 -1.8 -0.4
Leg fat-free mass (right) 0.8 4.2 13.2 2.3 -3.6 0.0 -1.9 -3.0 1.2 -0.2 -2.1 -0.8
Arm fat percentage (left) 0.2 0.9 3.1 1.0 -0.5 0.0 -0.3 1.4 -1.8 -1.2 -0.5 -0.5
Average weekly red wine intake 2.8 4.1 15.8 0.4 0.9 0.0 0.5 -4.0 -0.4 -1.7 -3.2 -2.7
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.8 0.2 0.5 0.0 -0.9 0.3 -0.4 -0.3 -0.3 -0.3
Mood swings 0.9 1.7 4.8 -0.2 2.2 0.0 1.1 -1.3 -0.9 -1.1 -1.6 -1.8
Loneliness, isolation 0.9 1.3 3.7 -0.4 1.8 0.0 0.8 1.4 -0.8 0.7 1.9 0.9
Long-standing illness, disability or infirmity 2.4 3.7 12.3 -1.0 1.6 0.0 1.4 2.2 0.3 2.0 3.5 2.6
Ever had bowel cancer screening 1.7 2.0 5.5 2.2 -2.0 0.0 -2.3 0.1 -1.6 -0.9 -0.1 -0.5
Diabetes diagnosed by doctor 1.2 2.0 12.2 0.3 -0.5 0.0 -0.4 3.5 -0.7 0.6 1.8 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 -0.2 0.8 0.0 1.0 -0.8 1.0 0.4 0.7 0.7
Friendships satisfaction 0.2 0.2 1.0 0.4 0.3 0.0 0.0 0.8 -1.0 -0.1 0.4 0.4
Qualifications: nursing, teaching 1.6 2.4 9.9 0.3 0.7 0.0 0.1 -3.1 -0.1 -0.9 -2.4 -2.2
Commuting to job workplace: Walk 1.0 1.1 2.7 -0.3 1.4 0.0 0.7 -1.5 -0.4 -0.9 -1.6 -1.3
Eye problems/disorders: Cataract 1.5 1.8 4.3 1.4 -0.3 0.0 -0.7 -1.1 -0.9 -2.0 -2.1 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.8 0.3 0.9 0.0 -0.4 1.1 -1.3 -1.1 -1.3 -1.2
Medication for cholesterol 1.1 1.7 7.0 0.6 -1.1 0.0 -0.3 -2.7 -0.0 -0.8 -2.3 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 4.2 1.3 -1.7 0.0 -2.1 1.7 -0.5 0.6 1.0 0.4
Back pain experienced in last month 0.5 0.7 2.2 0.5 0.7 0.0 0.1 -0.9 -1.5 -0.8 -0.6 -1.1
Mineral and other dietary supplements 1.4 1.9 4.2 1.7 -0.2 0.0 -0.4 -1.4 -2.0 -1.6 -2.0 -1.2
Breast cancer (self-reported) 0.8 0.9 4.0 -1.4 -1.3 0.0 0.4 -0.2 2.0 0.4 0.1 0.5
Asthma (self-reported) 1.0 2.0 8.6 -1.0 2.9 0.0 1.6 -0.9 -1.2 -0.7 -0.8 -1.5
Osteoporosis (self-reported) 2.8 3.4 13.7 -1.5 3.7 0.0 3.2 1.6 -0.5 -0.0 1.1 -0.2
Osteoarthritis (self-reported) 0.7 0.8 2.1 1.1 1.1 0.0 -0.6 0.9 -1.4 -1.1 0.9 -0.1
Medication: Aspirin 1.1 1.4 3.9 -1.9 1.7 0.0 2.0 0.9 0.8 0.7 0.5 0.4
Medication: Gliclazide 0.1 0.1 1.0 -0.1 0.3 0.0 0.1 -0.0 0.4 1.0 0.0 -0.3
Illnesses of father: None of the above (group 1) 0.4 0.6 2.5 1.6 -1.0 0.0 -0.6 -0.3 0.1 -0.3 -0.2 0.9
Smoking status: Current 0.4 0.7 3.7 -0.7 1.9 0.0 0.5 1.1 0.0 0.4 0.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.7 -0.8 0.7 0.0 0.4 1.7 -0.3 -0.2 0.9 0.4
Whole body water mass 1.0 5.7 22.3 2.7 -4.7 0.0 -2.5 -3.1 1.3 0.1 -1.9 -0.5
Leg predicted mass (right) 0.8 4.2 13.5 2.3 -3.7 0.0 -2.0 -3.0 1.2 -0.1 -2.1 -0.8
Arm fat mass (left) 0.3 1.1 3.7 1.5 -1.9 0.0 -1.1 0.7 -1.0 -0.6 -0.6 -0.2
Number of self-reported non-cancer illnesses 1.7 3.0 10.0 -0.7 1.5 0.0 0.8 2.2 -0.1 2.1 3.2 2.1
Average weekly champagne plus white wine intake 3.5 4.8 8.4 2.8 -1.5 0.0 -0.6 -2.5 -2.4 -2.9 -2.6 -2.5
Miserableness 0.5 0.8 2.2 0.9 1.3 0.0 -0.1 0.0 -1.5 -0.6 -0.4 -1.4
Guilty feelings 3.2 4.8 13.9 0.4 1.6 0.0 0.4 -1.2 -1.0 -3.2 -3.7 -3.7
Wears glasses or contact lenses 1.8 2.0 5.8 -2.0 1.2 0.0 1.5 0.6 2.4 1.4 1.5 0.3
Ever taken oral contraceptive pill 0.8 0.9 2.3 1.0 -0.1 0.0 -1.1 1.3 -1.5 -0.5 1.2 -0.1
Hearing aid user 0.4 0.4 1.5 0.6 -0.1 0.0 0.3 0.6 -0.8 0.6 1.2 0.8
Mother’s age at death 0.8 1.0 3.3 -0.6 0.8 0.0 0.6 -1.8 0.5 -0.3 -1.8 -1.0
Financial situation satisfaction 0.7 0.9 3.4 0.8 -0.5 0.0 -0.7 1.0 -0.7 0.3 1.8 1.3
Tinnitus: Yes, now most or all of the time 1.6 1.8 7.7 -0.4 -0.2 0.0 0.0 1.4 0.2 1.6 2.8 1.9
Commuting to job workplace: Public transport 0.7 0.8 1.8 1.3 0.2 0.0 -0.6 -1.2 -1.4 -0.7 -0.9 -0.8
Eye problems/disorders: Glaucoma 0.4 0.5 2.0 0.7 0.4 0.0 -0.9 0.9 -0.1 0.3 1.4 0.4
Medication: Blood pressure 0.5 1.0 1.8 -1.3 1.4 0.0 1.2 1.2 0.6 1.0 1.1 0.5
Pain type(s) experienced in last month: Hip pain 2.3 2.9 7.9 -0.6 0.3 0.0 -0.1 2.8 -0.1 2.4 2.8 2.0
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.6 -1.6 0.1 0.0 0.2 1.6 1.5 1.4 1.5 0.7
High cholesterol (Self-reported) 0.9 1.5 4.9 -0.5 1.6 0.0 0.6 1.9 -0.2 0.7 2.2 1.2
Medication: Bendroflumethiazide 0.4 0.6 2.2 1.4 -0.1 0.0 -0.9 0.5 -1.5 -0.2 0.4 -0.4
Medication: Paracetamol 0.6 1.0 3.3 0.1 -0.9 0.0 -0.9 1.8 0.0 0.3 1.4 1.3
Medication: Lisinopril 0.4 0.5 1.8 -0.8 -0.9 0.0 -0.2 1.4 -0.2 1.1 0.1 0.1
Medication: Atorvastatin 1.2 1.5 8.0 -0.1 2.8 0.0 1.4 0.5 -1.5 -0.7 0.3 -0.3
Illnesses of father: High blood pressure 0.9 1.1 2.7 -1.6 0.0 0.0 0.6 0.2 1.1 1.6 1.2 1.4
Alcohol drinker status: Never 0.3 0.4 1.5 0.5 -1.2 0.0 -1.1 0.3 0.1 -0.5 0.0 -0.2
Ever smoked 0.8 1.3 4.5 -1.0 -0.4 0.0 -0.6 2.1 1.1 1.0 1.2 1.5
Basal metabolic rate 0.9 4.8 21.1 2.6 -4.6 0.0 -2.4 -2.5 1.0 0.2 -1.5 -0.2
Leg fat percentage (left) 0.7 2.6 12.7 0.6 -1.9 0.0 -0.6 3.6 -1.8 0.3 1.4 1.0
Arm fat-free mass (left) 1.1 5.3 25.4 2.9 -5.0 0.0 -2.8 -2.2 0.7 0.5 -0.8 0.1
Number of operations (self-reported) 1.2 1.8 4.8 0.3 -2.2 0.0 -1.6 1.3 1.1 1.2 1.6 1.5
Average weekly beer plus cider intake 1.2 1.7 6.1 -0.8 -0.7 0.0 -0.3 2.5 0.8 0.4 2.1 1.6
Irritability 3.7 6.3 13.7 2.5 0.4 0.0 -0.9 -2.4 -2.7 -3.2 -3.5 -3.7
Risk taking 0.9 1.3 2.7 -1.6 0.9 0.0 0.8 1.1 1.4 1.0 0.8 1.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.2 1.1 -0.5 0.0 -0.8 -0.2 -0.6 -0.5 -0.1 -0.3
Fractured/broken bones in last 5 years 2.6 3.3 7.9 2.8 -2.4 0.0 -2.5 -1.8 -1.5 -1.8 -1.0 -0.5
Age started oral contraceptive pill 0.2 0.2 0.7 -0.4 0.7 0.0 0.4 0.9 -0.2 -0.2 0.6 0.0
Diastolic blood pressure, automated reading 1.4 4.2 13.7 -1.7 0.2 0.0 0.7 2.6 1.5 2.4 3.7 2.3
Ever depressed for a whole week 0.4 0.5 1.5 -0.2 0.9 0.0 0.3 1.2 -0.7 0.0 0.6 -0.9
Unable to work because of sickness or disability 2.0 2.6 6.7 -2.5 0.6 0.0 2.2 0.8 2.6 1.7 0.5 1.3
Commuting to job workplace: Cycle 1.1 1.3 4.9 0.8 1.0 0.0 0.1 -2.2 -0.8 -1.0 -1.1 -1.5
Myopia 0.2 0.3 1.5 0.3 0.0 0.0 -0.0 -0.6 -0.0 -0.2 -0.8 -1.2
Vascular/heart problems diagnosed by doctor 1.0 2.8 6.4 1.3 -0.9 0.0 -0.8 -1.9 -1.2 -2.1 -2.5 -2.4
Cholesterol lowering medication 2.7 4.0 9.9 -1.6 2.2 0.0 0.9 3.1 0.7 1.6 3.1 2.3
Medication: Omeprazole (e.g. Zanprol) 3.9 4.7 11.5 -2.0 1.7 0.0 1.4 3.4 0.7 2.6 3.2 2.1
Pain experienced in last month 0.1 0.2 1.2 0.2 -0.4 0.0 0.2 -1.1 0.6 -0.2 -0.3 0.1
Supplements: Calcium 1.1 1.2 3.7 -1.9 0.8 0.0 1.6 0.2 1.8 0.7 0.2 0.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.5 -1.1 0.9 0.0 1.2 0.3 0.7 0.6 0.5 1.2
Heart attack/myocardial infarction (self-reported) 1.9 2.4 6.2 2.5 -2.0 0.0 -2.2 -0.3 -1.0 -1.9 -1.0 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 5.0 -1.0 0.6 0.0 0.6 2.2 1.4 0.9 0.2 1.2
Heart disease (siblings) 0.5 0.6 2.2 1.0 -0.5 0.0 -1.5 1.0 -0.7 -0.1 0.5 -0.0
Alcohol drinker status: Previous 0.4 0.4 0.9 -0.5 -0.4 0.0 1.0 -0.7 0.8 0.6 0.7 0.9
Pack years of smoking 0.8 1.1 5.0 -0.4 2.2 0.0 1.9 0.4 -0.8 -0.3 -0.0 -0.9
Impedance of whole body 0.3 1.6 6.8 -0.8 0.9 0.0 0.5 2.6 -0.5 0.2 1.9 1.3
Leg fat mass (left) 0.5 2.0 9.7 1.3 -3.1 0.0 -1.2 1.8 -0.9 0.3 0.4 0.6
Arm predicted mass (left) 1.0 4.9 23.3 2.6 -4.8 0.0 -2.6 -2.2 0.9 0.7 -1.1 -0.1