Best TWAS P=5.91e-15 · Best GWAS P=1.55e-11 conditioned to 0.114
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | VCL | 0.07 | 0.05 | lasso | 4 | 0.06 | 6.0e-08 | -5.9 | -6.1 | 9.6e-10 | -0.10 | 0.52 | 0.48 | FALSE |
2 | GTEx | Adipose Visceral Omentum | FUT11 | 0.11 | 0.06 | lasso | 6 | 0.11 | 1.9e-06 | 6.2 | -7.8 | 5.9e-15 | -0.72 | 0.05 | 0.85 | TRUE |
3 | GTEx | Colon Transverse | ADK | 0.25 | 0.14 | lasso | 9 | 0.12 | 1.6e-06 | 5.1 | 5.6 | 2.1e-08 | 0.08 | 0.84 | 0.15 | FALSE |
4 | GTEx | Heart Atrial Appendage | MYOZ1 | 0.43 | 0.25 | lasso | 11 | 0.38 | 5.4e-18 | 6.2 | 6.7 | 1.6e-11 | 0.84 | 0.03 | 0.97 | FALSE |
5 | GTEx | Heart Atrial Appendage | FUT11 | 0.13 | 0.02 | enet | 22 | 0.10 | 4.7e-05 | 5.2 | -5.8 | 5.7e-09 | -0.71 | 0.06 | 0.86 | FALSE |
6 | GTEx | Nerve Tibial | AP3M1 | 0.06 | 0.02 | lasso | 2 | 0.02 | 2.6e-02 | 5.1 | 5.2 | 2.1e-07 | 0.04 | 0.19 | 0.04 | FALSE |
7 | GTEx | Pancreas | AGAP5 | 0.13 | 0.05 | lasso | 5 | 0.06 | 1.8e-03 | 3.8 | 5.8 | 6.4e-09 | 0.28 | 0.12 | 0.16 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | MYOZ1 | 0.04 | 0.01 | blup | 235 | 0.02 | 2.6e-03 | 6.3 | -6.4 | 1.7e-10 | -0.70 | 0.05 | 0.87 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | AP3M1 | 0.02 | 0.01 | blup | 231 | 0.02 | 1.3e-03 | -6.0 | 7.2 | 5.2e-13 | 0.36 | 0.08 | 0.25 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SEC24C | 0.07 | 0.07 | blup | 29 | 0.07 | 9.4e-05 | 6.3 | -6.2 | 6.6e-10 | -0.85 | 0.01 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | SEC24C | 0.02 | 0.01 | enet | 4 | 0.01 | 8.5e-03 | 6.2 | -5.8 | 7.3e-09 | -0.82 | 0.01 | 0.80 | FALSE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BMS1P4 | 0.02 | 0.01 | blup | 23 | 0.01 | 8.6e-03 | 3.4 | -5.6 | 2.2e-08 | -0.73 | 0.01 | 0.47 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SYNPO2L | 0.01 | 0.02 | enet | 4 | 0.02 | 4.3e-03 | 6.7 | -6.9 | 6.3e-12 | -0.91 | 0.00 | 0.74 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NDST2 | 0.03 | 0.02 | blup | 37 | 0.02 | 3.3e-03 | 4.4 | 5.8 | 5.8e-09 | 0.82 | 0.01 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | BMS1P4 | 0.07 | 0.08 | blup | 23 | 0.10 | 8.3e-10 | 3.4 | -5.8 | 5.6e-09 | -0.73 | 0.22 | 0.78 | FALSE |