TWAS hub - TMEM133

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0230	6.4e-03	0.012	0.014	0.001	0.015	-0.001	1.2e-02	0.0060	2.1e-01	0.00470	5.1e-01
2	GTEx	Artery Aorta	0.2990	0.0620	1.2e-07	0.151	NA	0.193	NA	0.155	1.1e-08	NA	7.1e-11	NA	6.4e-09
3	GTEx	Artery Tibial	0.2609	0.0457	1.5e-13	0.253	NA	0.274	NA	0.258	7.6e-20	NA	1.3e-21	NA	3.1e-20
4	GTEx	Muscle Skeletal	0.1077	0.0394	5.6e-04	0.011	NA	0.011	NA	0.026	2.6e-02	NA	2.5e-02	NA	1.4e-03
5	GTEx	Skin Sun Exposed Lower leg	0.1080	0.0430	3.4e-03	0.004	NA	0.016	NA	0.004	1.3e-01	NA	1.7e-02	NA	1.4e-01
6	YFS	Blood	0.0255	0.0102	2.5e-03	-0.001	0.007	0.000	0.008	-0.001	9.1e-01	0.0015	3.0e-01	0.00063	8.3e-01
7	TCGA	Breast Invasive Carcinoma	0.0194	0.0100	1.6e-03	0.008	0.007	0.006	NA	0.005	6.4e-03	0.0093	1.9e-02	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	6	7
Systolic Blood Pressure	20.3	101.8	372.5	-7.8	-15.6	-19.3	-2.8	-4.5	-2.7
Systolic blood pressure, automated reading	17.0	49.2	171.6	-6.5	-10.9	-13.1	-1.6	-2.5	-1.7
Vascular/heart problems diagnosed by doctor	15.1	41.1	157.2	3.9	10.2	12.5	1.5	1.5	2.5
Hypertension (Self-reported)	14.1	39.0	158.8	-3.0	-9.8	-12.6	0.0	-1.5	-2.9
High blood pressure	13.8	38.6	153.8	-3.4	-9.8	-12.4	-0.6	-1.2	-2.5
Diastolic blood pressure, automated reading	13.4	41.6	158.8	-4.3	-10.0	-12.6	-1.1	-3.0	-2.0
Cardiovascular Disease	12.9	42.8	174.2	-1.4	-10.6	-13.2	0.4	-1.8	-2.8
Medication: Blood pressure	10.7	18.9	71.9	-3.1	-6.6	-8.5	-0.2	-1.0	-2.5
Medication: Blood pressure	10.0	19.1	78.2	-0.6	-7.1	-8.8	0.2	-1.3	-1.5
Medication for cholesterol, blood pressure or diabetes	9.7	16.0	56.5	3.1	6.3	7.5	1.0	1.3	1.8
Medication: Amlodipine	7.1	9.9	36.7	-1.0	-5.4	-6.1	0.1	-0.8	-1.3
Medication: Cholesterol lowering	6.2	9.6	28.6	-3.4	-4.9	-5.3	-1.6	-0.6	-0.5
Medication: Ramipril	5.6	7.2	27.4	-1.4	-3.9	-5.2	-0.4	-2.1	-1.2
High blood pressure (siblings)	5.6	8.1	24.2	-1.0	-4.7	-4.9	-0.5	-1.6	-2.5
Medication: Atenolol	5.5	6.8	18.0	-2.5	-3.9	-4.2	-1.5	-2.1	-1.3
Medication for cholesterol	4.9	7.4	29.1	-0.5	4.4	5.4	-1.1	0.1	1.3
Number of treatments/medications taken	4.5	8.1	27.4	-0.1	-5.2	-5.1	0.0	0.6	-1.6
Medication: Bendroflumethiazide	4.3	6.5	27.0	-2.2	-3.2	-5.2	-0.2	1.2	1.5
Illnesses of siblings	4.1	5.8	17.4	2.1	4.1	4.2	0.2	1.0	0.9
Angina	4.0	5.3	15.3	-2.2	-3.4	-3.9	-2.1	-0.5	-0.1
High cholesterol (Self-reported)	3.8	6.8	27.6	-1.3	-3.8	-5.2	0.0	-1.4	-1.4
Angina (self-reported)	3.7	4.9	13.4	-2.2	-3.3	-3.7	-2.2	-0.5	0.1
Heart attack	3.6	4.6	10.2	-2.8	-2.6	-2.6	-3.2	-0.5	-0.1
Illnesses of mother	3.6	4.5	15.2	1.0	3.6	3.9	-1.0	0.9	0.6
Heart attack/myocardial infarction (self-reported)	3.6	4.7	11.6	-3.0	-2.5	-2.3	-3.4	-0.7	0.1
Medication: Simvastatin	3.4	5.0	16.7	-2.0	-3.4	-4.1	-0.6	-1.0	-1.4
Illnesses of father: High blood pressure	3.4	4.1	15.1	-0.3	-3.3	-3.9	-0.8	-0.6	-1.4
Lung FEV1/FVC ratio	3.0	15.4	37.1	3.4	3.8	6.1	2.2	5.1	3.7
High blood pressure (mother)	3.0	4.2	15.9	-0.4	-3.0	-4.0	0.9	-1.4	-1.3
Medication: Lisinopril	3.0	3.9	16.8	-0.8	-2.9	-4.1	0.6	-0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	9.4	3.1	0.3	-0.1	1.9	-2.2	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	8.1	1.2	2.9	2.2	1.5	2.3	0.2
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	25.7	2.4	5.1	4.9	-0.6	1.4	1.7
Number of self-reported non-cancer illnesses	2.6	4.5	14.4	-1.2	-3.7	-3.8	0.4	1.2	-0.6
Illnesses of father: None of the above (group 1)	2.5	3.1	9.3	1.7	2.8	3.0	0.5	-0.5	-1.2
Health satisfaction	2.4	3.1	7.7	2.8	0.1	-0.4	2.0	-1.8	-2.6
Heart disease (siblings)	2.3	2.8	12.1	-1.9	-1.4	-1.3	-0.1	0.3	3.5
Loneliness, isolation	2.2	3.0	6.3	2.5	2.4	2.1	2.2	-0.2	0.3
Medication: Aspirin	2.2	2.9	8.5	-1.9	-2.9	-2.8	-0.2	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	12.3	-0.6	2.9	3.5	1.1	1.7	2.6
Hair/balding pattern: Pattern 2	2.1	2.6	7.0	2.6	2.2	1.7	1.6	-0.5	-1.1
Financial situation satisfaction	2.1	2.6	5.1	2.3	2.1	1.6	1.6	-0.7	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	18.6	2.2	4.3	4.2	-0.9	1.6	1.2
Medication: Aspirin	2.0	2.7	8.7	-1.5	-3.0	-2.7	0.1	0.6	-0.1
Happiness	1.9	2.3	7.0	2.6	0.7	1.1	1.6	-1.4	-1.8
Ever depressed for a whole week	1.9	2.3	6.6	2.1	-0.2	-0.5	1.5	-2.6	-1.6
Time employed in main current job	1.8	2.1	4.5	1.7	2.1	1.4	1.8	0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	7.8	2.7	1.9	2.8	-0.3	-1.0	0.1
Emphysema/chronic bronchitis	1.8	2.0	6.3	-2.5	-0.7	-2.0	1.4	-1.3	-0.1
Rheumatoid Arthritis	1.7	2.3	6.9	-1.7	2.0	0.8	1.2	-0.1	2.6
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	13.6	-1.3	-2.5	-3.7	-1.1	-1.6	-1.4
Forced vital capacity (FVC)	1.7	6.6	22.3	1.9	4.7	4.0	-1.5	-0.1	1.4
Length of working week for main job	1.7	1.9	5.7	1.0	2.4	2.0	0.3	0.8	1.3
Illnesses of siblings: Diabetes	1.7	2.1	10.2	-3.2	-1.5	-0.9	-0.1	1.2	-0.3
Medication: Atorvastatin	1.7	2.1	5.9	-1.1	-2.4	-2.4	-1.2	-0.5	0.0
Coronary Artery Disease (CAD)	1.6	1.9	4.5	-2.1	-1.4	-1.4	-1.9	-1.0	-0.0
Multivitamins +/- minerals	1.6	2.0	8.0	2.8	0.4	0.5	2.0	1.2	-0.1
Pain all over the body in last month	1.6	1.7	3.3	-1.8	-1.5	-0.8	-1.8	-1.0	1.1
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.9	1.8	0.0	-0.5	1.9	-2.2	-1.2
Eye problems/disorders: None of the above	1.6	1.9	4.4	2.0	0.9	0.4	-0.8	-2.1	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	14.1	-1.0	-2.8	-3.8	-0.7	-1.0	-0.0
Birth weight	1.5	3.2	9.0	1.4	3.0	3.0	-0.6	-1.6	-0.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.4	-0.6	-2.3	-2.2	-1.1	-0.0	-0.1
Heart disease (mother)	1.5	1.9	5.6	-0.9	-2.4	-2.3	-1.0	-0.5	-0.5
Number of full sisters	1.5	1.9	4.4	-2.1	-1.9	-1.9	-0.6	0.9	-0.2
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	10.3	0.4	0.3	0.5	1.0	0.9	3.2
Illnesses of father: Heart disease	1.5	2.1	8.1	-1.3	-2.1	-2.8	0.2	0.6	0.4
Alzheimer’s Disease (in mother)	1.4	1.6	4.3	-1.6	-2.1	-2.0	-0.5	-0.3	0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	6.5	0.8	1.2	1.5	1.3	2.5	-0.5
Had major operations	1.4	1.6	3.5	-0.7	-1.5	-1.6	-1.2	-1.1	-1.9
Age at last live birth	1.4	2.1	6.7	0.7	2.6	2.5	-0.2	0.2	1.0
Cholesterol lowering medication	1.4	2.0	7.3	-0.1	-2.2	-2.7	0.7	-0.6	-1.1
Qualifications: None of the above	1.3	2.8	7.0	-1.6	-1.7	-2.5	0.5	2.6	0.7
Hair/balding pattern: Pattern 3	1.3	1.9	6.9	-2.6	-0.6	0.1	-1.9	1.1	1.0
Exposure to tobacco smoke at home	1.3	1.4	4.2	-0.5	0.3	-0.9	2.0	1.9	1.0
Peak expiratory flow (PEF)	1.3	3.0	5.4	1.1	2.3	2.3	-2.1	1.9	1.1
Mood swings	1.3	2.3	8.4	2.2	0.8	-0.5	2.9	-1.1	-1.0
Eye problems/disorders: Cataract	1.3	1.5	4.7	-2.1	0.5	0.2	0.6	1.1	2.2
Body Mass Index (BMI) (2010)	1.2	1.6	9.4	1.2	0.4	-0.1	3.1	0.3	-0.0
Blood White Count	1.2	9.0	20.2	-4.4	-2.1	-4.5	-3.7	-0.0	2.3
Vitamin and mineral supplements	1.2	1.6	5.2	-1.6	0.4	1.1	-2.3	0.1	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	5.8	1.1	2.4	1.9	1.4	-0.5	0.1
Had other major operations	1.2	1.5	5.9	-0.3	0.9	2.4	-0.3	1.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	5.0	2.2	1.2	1.1	1.6	-1.5	-1.0
Gout (self-reported)	1.2	1.6	5.8	-2.4	-0.6	-1.5	0.6	0.8	1.4
Forced vital capacity (FVC), Best measure	1.2	4.3	12.2	1.7	3.5	3.1	-2.2	0.3	0.8
Back pain experienced in last month	1.2	1.8	3.9	-0.3	-1.6	-2.0	0.4	2.0	1.4
Commuting to job workplace: Cycle	1.2	1.5	4.1	1.6	-1.4	-1.2	0.3	-0.5	-2.0
Basal cell carcinoma (self-reported)	1.2	1.5	4.9	1.1	2.2	1.4	1.1	-0.1	-1.1
Relative age of first facial hair	1.1	2.2	8.5	0.7	2.9	2.5	0.6	0.4	0.0
Supplements: Zinc	1.1	1.2	3.9	0.0	-1.2	-0.9	-1.3	-2.0	-0.9
Average weekly fortified wine intake	1.1	1.2	3.2	0.7	1.5	1.5	1.8	-0.4	0.5
Maternal smoking around birth	1.1	1.6	3.5	-0.9	-1.7	-1.9	-1.0	0.3	1.8
Qualifications: CSEs or equivalent	1.1	1.5	5.5	1.3	-0.4	-0.7	0.9	-1.2	-2.4
Falls in the last year	1.1	1.4	5.7	-0.1	-0.1	0.3	1.4	1.5	2.4
Pulse wave peak to peak time	1.1	1.3	5.2	1.0	1.2	2.3	-0.7	-0.7	-0.6
Mean time to correctly identify matches	1.1	2.1	7.5	-0.5	-2.6	-2.7	-0.4	0.2	-0.0
Long-standing illness, disability or infirmity	1.1	1.6	5.3	-0.4	-2.3	-2.0	1.3	0.2	-0.2
Waist Hip Ratio (WHR)	1.0	4.7	13.0	-2.4	-3.6	-3.3	-0.6	1.7	0.3
Sensitivity / hurt feelings	1.0	1.8	5.0	0.7	2.2	2.2	1.1	1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.6	-1.2	-1.6	-1.4	0.9	-1.2	-0.5
Blood clot in the leg (DVT)	1.0	1.3	6.8	0.7	0.2	0.7	1.2	2.6	-0.1
Glaucoma (self-reported)	1.0	1.2	3.1	-1.5	-1.8	-1.6	0.5	-0.2	0.4
Medication: Allopurinol	1.0	1.3	3.6	-1.9	0.4	-0.0	1.0	1.0	1.8
Knee pain experienced in last month	1.0	1.6	3.3	0.7	-1.5	-1.3	0.8	1.8	1.7
Osteoarthritis (self-reported)	1.0	1.3	5.2	0.6	0.5	1.3	0.0	2.3	1.3
Average weekly beer plus cider intake	1.0	1.5	3.8	1.4	1.3	0.6	2.0	-1.3	-0.9
Irritability	1.0	1.7	4.1	1.3	2.0	1.0	2.0	-0.6	-0.9
Ulcerative Colitis (UC)	0.9	1.7	3.9	1.3	-1.5	-1.3	0.5	1.5	-2.0
Age at First Birth	0.9	1.4	3.2	0.2	1.6	1.8	1.2	0.4	1.4
Lupus	0.9	1.4	4.9	0.0	1.8	1.4	2.2	-0.0	0.3
Heel T-Score	0.9	7.1	27.7	-2.5	-3.9	-5.3	-0.6	-0.3	0.0
Allergy or Eczema	0.9	2.3	8.9	1.6	1.9	3.0	0.4	0.1	-0.9
Pulse wave Arterial Stiffness index	0.9	1.0	4.2	-0.9	-0.8	-2.0	0.7	0.8	0.6
Pulse wave reflection index	0.9	1.1	4.5	0.0	-1.5	-2.1	0.5	0.2	-0.6
Body fat percentage	0.9	3.6	10.7	-2.0	-3.3	-2.7	-0.9	1.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	5.6	0.2	0.1	0.7	-0.9	-2.4	-1.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.4	-1.2	1.2	0.2	1.2	1.8	-0.1
Commuting to job workplace: Walk	0.9	0.9	2.5	0.8	-1.0	-0.5	1.2	-1.6	-0.9
Guilty feelings	0.9	1.3	3.3	1.4	1.8	1.7	0.4	-0.7	0.7
Wears glasses or contact lenses	0.9	1.0	3.4	0.2	-1.8	-1.2	0.6	1.2	0.6
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.6	1.3	1.9	2.6	1.7	0.7	1.7
Alzheimer’s Disease (including proxy)	0.8	1.1	4.1	-1.1	-2.0	-1.1	-1.0	0.3	0.3
Crohns Disease (2017)	0.8	1.8	5.8	-0.9	-2.0	-2.4	0.4	-0.5	-1.3
Irritable Bowel Disease (IBD)	0.8	2.0	5.1	0.5	-2.3	-2.2	0.3	0.7	-1.7
Fasting Glucose	0.8	0.9	3.3	0.2	-1.4	-0.9	-0.4	-1.8	-0.3
Smoking Status	0.8	1.8	7.0	0.3	-0.8	-1.0	-1.2	-2.6	-1.5
Lung FVC	0.8	4.2	16.3	0.9	4.0	2.5	-1.0	-1.8	-1.4
Neuroticism	0.8	1.8	4.8	1.4	2.2	1.4	1.9	-0.9	0.3
Chronotype (morning person)	0.8	1.8	5.3	-1.8	-1.2	-1.7	-0.2	2.3	-0.0
Impedance of leg (right)	0.8	4.0	19.1	-1.3	-1.7	-4.4	0.8	-1.9	-0.3
Taking other prescription medications	0.8	1.3	3.8	-0.1	-1.7	-1.9	0.7	0.1	-1.3
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.5	0.4	0.6	-0.6	1.6	0.9	-1.6
Supplements: Glucosamine	0.8	1.0	2.7	-0.6	0.4	1.3	0.3	1.6	1.6
Impedance of leg (left)	0.8	3.8	19.3	-1.9	-1.4	-4.4	0.9	-1.3	-0.0
Neuroticism score	0.8	1.7	4.3	1.4	2.1	1.3	2.0	-0.2	0.2
Trunk fat-free mass	0.8	4.9	17.6	1.9	3.1	4.2	-0.8	1.4	0.8
Noisy workplace	0.8	1.0	2.5	-0.2	0.9	-0.2	1.1	1.6	1.5
Trunk predicted mass	0.8	4.7	16.6	1.8	3.1	4.1	-0.8	1.4	0.6
Leg fat percentage (right)	0.8	3.0	7.7	-1.8	-2.8	-2.8	-0.7	0.9	0.8
Worry too long after embarrassment	0.8	1.3	4.3	0.5	2.1	1.9	1.0	-0.7	0.2
Shortness of breath walking on level ground	0.8	1.0	3.0	1.7	-0.9	0.0	1.3	-1.1	0.2
Migraine (self-reported)	0.8	1.0	3.6	0.8	-0.4	0.1	1.0	1.2	1.9
Supplements: Vitamin C	0.8	0.9	2.3	-0.1	-1.4	-1.5	0.7	-0.7	-1.0
Whole body fat-free mass	0.8	4.3	16.3	2.0	2.6	4.0	-0.9	1.5	0.8
Leg fat-free mass (right)	0.8	4.2	17.0	1.9	2.0	4.1	-0.8	1.7	0.9
Qualifications: nursing, teaching	0.8	1.3	3.8	1.1	1.9	1.3	0.1	-1.1	1.0
Medication: Gliclazide	0.8	0.9	2.7	-0.0	0.9	1.7	1.3	-1.1	0.0
Whole body water mass	0.8	4.5	16.7	1.9	2.6	4.1	-0.8	1.7	0.8
Leg predicted mass (right)	0.8	4.1	16.8	2.0	2.0	4.1	-0.9	1.6	0.9
Leg fat percentage (left)	0.8	3.0	6.5	-2.1	-2.4	-2.5	-0.6	1.6	1.0
Pain experienced in last month	0.8	1.3	3.0	-1.0	1.3	1.5	-0.5	-1.7	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	6.0	0.7	-0.0	0.4	0.8	2.4	-0.3
Impedance of whole body	0.8	4.1	16.2	-1.6	-2.4	-4.0	0.4	-2.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.6	0.7	0.8	0.5	0.5	-1.2	-1.9
Severe depression (siblings)	0.7	0.8	3.1	0.2	-0.6	-1.2	-0.4	0.4	-1.8
Leg fat-free mass (left)	0.7	3.6	15.2	2.0	1.7	3.9	-0.9	1.3	0.9
Trunk fat percentage	0.7	2.9	9.0	-1.8	-3.0	-2.2	-1.0	1.0	1.1
Leg predicted mass (left)	0.7	3.6	15.1	2.0	1.7	3.9	-0.9	1.3	0.9
Waist circumference	0.7	2.5	6.3	-1.7	-2.2	-1.2	-0.6	2.5	1.3
Fluid intelligence score	0.7	1.4	2.9	1.1	1.3	1.7	1.6	0.3	1.2
Number of live births	0.7	0.9	2.2	-0.9	-0.8	-1.4	-0.7	0.8	1.5
Prospective memory result	0.7	0.8	2.7	0.4	1.2	1.6	0.9	0.6	0.5
Arm fat-free mass (right)	0.7	3.6	11.6	1.3	2.4	3.4	-0.4	2.1	0.9
Qualifications: College or University degree	0.7	2.2	7.5	1.1	2.0	2.7	-1.2	-0.7	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.2	3.9	0.1	1.2	2.0	-0.6	-1.0	-1.3
Arm predicted mass (right)	0.7	3.6	10.6	1.2	2.3	3.3	-0.6	2.3	1.5
Breast cancer (self-reported)	0.7	0.8	3.6	-0.2	0.9	1.9	-0.7	0.3	0.6
Arm predicted mass (left)	0.7	3.4	10.0	1.2	2.3	3.2	-0.5	2.2	1.3
Bipolar Disorder (2011)	0.6	0.6	1.7	1.3	-0.8	-0.3	-0.2	-1.1	0.6
Neuroticism (2016)	0.6	0.8	3.1	0.3	1.8	1.5	0.2	0.0	0.6
Ulcerative Colitis	0.6	0.9	2.7	0.8	-1.2	-1.6	0.3	1.1	-0.7
Hearing difficulty/problems: Yes	0.6	1.0	3.7	1.9	1.0	0.6	1.0	0.6	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.5	-0.8	-0.1	-0.3	0.1	1.9	0.8
Medication: Co-codamol	0.6	0.7	2.3	0.3	1.5	1.2	0.7	-0.3	0.7
Diabetes (father)	0.6	0.7	2.1	-0.4	-0.8	0.3	-0.9	-1.2	1.4
Pack years adult smoking proportion	0.6	0.9	2.1	0.5	-0.4	-0.9	0.8	-1.5	-1.4
Current tobacco smoking	0.6	0.9	5.5	0.6	-0.1	-0.2	-0.4	-2.4	-0.7
Impedance of arm (right)	0.6	2.7	8.1	-0.9	-2.3	-2.8	-0.0	-2.2	-0.3
Arm fat percentage (right)	0.6	2.2	6.9	-1.6	-2.6	-1.7	-1.3	1.0	0.8
Father’s age at death	0.6	0.8	2.4	1.0	0.8	1.6	0.6	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	1.3	0.5	1.0	1.7	-0.5	-1.2
Impedance of arm (left)	0.6	2.9	7.7	-1.0	-2.5	-2.8	0.2	-2.2	-0.7
Birth weight of first child	0.6	1.2	6.1	-0.4	1.2	2.5	-0.2	-0.1	0.6
Loud music exposure frequency	0.6	0.7	2.3	1.5	1.0	0.3	1.1	0.1	-0.1
Exposure to tobacco smoke outside home	0.6	0.8	3.2	0.1	0.6	0.4	1.0	0.7	1.8
Neck or shoulder pain in last month	0.6	0.8	4.0	-0.4	-0.4	0.0	-0.1	2.0	1.2
Medication: Omeprazole	0.6	0.7	2.1	-0.9	1.5	0.3	-0.0	0.5	1.3
Medication: Seretide 50 evohaler	0.6	0.6	2.9	0.7	0.2	0.6	-0.7	-1.7	-0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	0.0	1.3	1.1	-0.6	0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.1	1.5	-0.3	-1.1	1.0	1.3	-1.0
Commuting to job workplace: Public transport	0.6	0.7	4.0	-2.0	-0.2	0.3	-0.2	-0.9	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-0.9	-0.8	-0.7	1.1	1.0	0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	4.1	0.8	0.2	-0.4	0.2	2.0	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.3	0.0	0.4	0.4	0.6	1.5	1.5
Basal metabolic rate	0.6	3.3	12.2	1.6	2.0	3.5	-0.9	1.7	0.9
Major Depression (MDD)	0.5	0.6	2.0	0.8	1.4	0.5	1.2	0.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.9	0.6	1.1	1.4	0.7	0.8	1.7
Ovarian Cancer	0.5	0.6	1.8	-0.1	1.3	1.3	0.4	-0.4	0.6
LDL Cholesterol	0.5	0.8	2.1	-0.3	-0.9	-1.0	-1.5	-1.4	0.2
Schizophrenia (2014)	0.5	1.1	3.4	1.1	-1.4	-1.0	-0.3	-0.4	-1.9
Blood Red Count	0.5	4.5	15.3	-2.3	-3.9	-2.9	-1.7	-0.0	0.2
Respiratory disease	0.5	1.0	4.2	-1.4	-0.2	0.6	-0.7	2.1	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.8	-0.9	-1.0	-0.8	1.9	-0.2	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.4	1.6	0.2	0.2	1.3	-0.5	0.4
Sitting height	0.5	3.5	10.1	1.9	2.6	3.2	0.2	0.8	1.8
Number of incorrect matches in round	0.5	0.8	2.2	-0.6	-1.4	-1.5	-0.3	-0.3	1.1
Had menopause	0.5	0.6	1.7	-0.6	-0.7	-0.0	1.3	1.2	0.3
Financial difficulties in last 2 years	0.5	0.6	2.1	-1.4	1.0	0.8	0.1	0.7	-0.2
Pulse rate	0.5	0.9	3.1	0.2	1.6	1.8	0.8	0.0	0.1
Asthma	0.5	1.0	3.7	-1.4	-0.4	0.5	-0.7	1.9	-0.0
Depression (self-reported)	0.5	0.6	2.2	1.5	0.5	0.9	-0.1	0.3	-1.1
Comparative body size at age 10	0.5	1.5	3.8	-0.3	-1.4	0.2	-1.4	-1.6	-1.9
Age at first live birth	0.5	1.0	2.8	0.5	1.1	1.7	-1.4	-0.3	0.5
Medication: Ibuprofen	0.5	0.6	2.3	0.5	-0.8	-0.9	-0.3	0.1	1.5
Overall health rating	0.5	1.1	2.3	0.9	-1.3	-1.5	1.3	0.0	1.0
Smoking status: Previous	0.5	0.7	1.5	0.2	-1.2	-1.2	-1.1	-0.5	-0.9
Arm fat percentage (left)	0.5	2.1	7.0	-1.6	-2.6	-1.5	-1.2	1.0	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	1.0	0.7	0.4	0.5	0.9	0.7
Asthma (self-reported)	0.5	1.1	4.0	-1.4	-0.1	0.9	-0.8	2.0	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	2.2	0.9	0.1	0.7	-1.5	-0.2	-1.1
Miserableness	0.5	0.9	3.4	1.8	-0.1	-1.0	1.1	-0.7	0.5
Ever smoked	0.5	0.8	2.2	0.8	-1.0	-0.6	-1.3	-1.5	-0.3
Arm fat-free mass (left)	0.5	2.5	7.5	1.1	1.9	2.7	-0.8	1.9	0.9
Age started oral contraceptive pill	0.5	0.6	2.0	-1.4	-0.6	0.4	0.9	0.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.2	1.4	0.2	0.8	0.4	1.1
Supplements: Calcium	0.5	0.5	0.9	0.4	0.7	0.8	-0.7	-1.0	-1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.8	1.1	-1.7	-1.4	0.1	-0.5	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.2	1.2	1.0	-0.3	1.5	-0.5	0.8
Schizophrenia (2018)	0.4	0.9	2.9	0.7	-1.7	-1.3	0.2	-0.1	-1.1
Reaction Time	0.4	0.7	2.5	0.8	-1.0	-1.6	-0.1	0.1	-0.8
Prostate Cancer	0.4	0.6	2.0	1.4	-0.2	0.4	0.2	1.4	-0.2
Blood Eosinophil Count	0.4	2.9	6.0	-2.4	-2.1	-2.5	-2.0	-0.1	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-0.5	0.3	-0.6	1.2	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	1.0	-0.3	-0.0	1.1	1.0	0.3
Age when periods started (menarche)	0.4	1.0	3.0	0.3	1.6	1.7	0.0	-0.2	1.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	4.5	1.0	0.8	2.1	-0.6	0.3	-0.1
Stomach or abdominal pain in last month	0.4	0.4	1.7	0.4	-1.0	-1.3	0.6	0.2	-0.0
Past tobacco smoking	0.4	0.7	1.7	0.0	1.3	1.2	1.0	0.8	0.3
Diabetes (self-reported)	0.4	0.7	1.6	-1.0	-1.2	-0.9	1.3	-0.3	-0.0
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.9	0.0	-1.1	1.2	-0.0	1.0
Worrier / anxious feelings	0.4	0.7	2.3	0.6	-0.0	-0.1	0.7	-1.4	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.3	0.9	0.3	0.0	0.6	-0.3	1.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.4	-0.8	-0.2	-0.3	1.3	-0.8
Number of full brothers	0.4	0.5	1.9	-0.6	0.8	0.1	0.5	0.2	1.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.8	-0.6	-1.4	-1.0	-0.5	1.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.6	-0.8	0.8	-0.2	-0.3	-1.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.3	-0.6	0.4	0.4	0.4	0.4	1.5
Whole body fat mass	0.4	1.6	3.6	-1.4	-1.9	-1.1	-1.0	1.5	1.3
Leg pain on walking	0.4	0.4	1.6	0.7	-0.1	0.0	0.1	1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	1.6	1.4	0.7	-0.2	-0.4	0.4
Ever had bowel cancer screening	0.4	0.5	1.4	0.2	-1.0	-0.7	1.2	0.5	0.2
Diabetes diagnosed by doctor	0.4	0.7	2.8	-0.5	-0.9	-0.8	1.7	0.5	0.3
Mineral and other dietary supplements	0.4	0.6	1.9	-0.3	0.5	-0.2	0.0	-1.3	-1.4
Smoking status: Current	0.4	0.7	4.2	-0.1	-0.4	-0.5	-0.4	-2.0	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	1.3	-0.8	0.2	-0.3	-0.4	-0.8
Medication: Paracetamol	0.4	0.7	3.0	0.2	-1.2	-1.7	0.4	0.2	0.0
Unable to work because of sickness or disability	0.4	0.5	1.7	1.3	0.4	0.7	1.0	-0.0	-0.4
Alcohol drinker status: Previous	0.4	0.4	1.3	1.1	-0.6	0.6	0.0	0.3	-0.9
Pack years of smoking	0.4	0.6	1.5	0.3	-0.5	-0.8	1.0	-1.0	-1.2
Depression (Nagel 2018)	0.3	0.5	2.2	1.5	-0.2	-0.1	0.9	0.7	-0.0
Neuroticism (Nagel 2018)	0.3	0.8	2.0	1.4	1.2	0.7	0.8	-1.1	0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.4	-0.2	0.7	-0.1	0.8	0.8
Breast Cancer	0.3	0.8	3.1	-0.5	-1.8	-1.4	0.2	0.1	0.5
Crohns Disease (2012)	0.3	0.4	2.0	-0.0	-0.9	-1.4	0.1	-0.1	0.1
HbA1C	0.3	0.3	1.3	0.3	0.2	-0.9	0.3	0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.9	-0.1	-0.4	0.5	-0.9	-0.4
Blood Platelet Count	0.3	4.1	10.0	-2.6	0.7	-2.3	-2.2	1.0	3.2
Height	0.3	6.2	20.0	1.6	3.6	4.5	1.1	1.4	2.0
Tanning	0.3	4.1	13.1	0.2	-2.4	-3.6	-0.4	0.4	-3.1
Hand grip strength (left)	0.3	0.9	3.8	-0.9	0.1	0.4	-2.0	0.3	1.1
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.1	0.8	0.5	0.5	0.9	-0.6
Medication: Metformin	0.3	0.4	1.3	0.0	-0.8	-0.5	1.2	-0.8	0.1
Hand grip strength (right)	0.3	0.7	2.8	-0.7	0.2	0.3	-1.7	-0.2	1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.5	0.5	0.6	-0.1	0.1	0.2	-1.2
Serious illness, injury or assault to yourself	0.3	0.4	1.5	0.5	0.4	0.5	0.3	-0.4	-1.2
Body mass index (BMI)	0.3	1.1	4.2	-0.8	-1.1	-0.1	-0.9	2.1	0.8
Trunk fat mass	0.3	1.5	3.5	-1.2	-1.9	-0.8	-1.0	1.5	1.2
Nervous feelings	0.3	0.5	3.6	0.3	0.1	-0.1	0.3	-1.9	-0.1
Mouth/teeth dental problems	0.3	0.4	2.2	0.2	0.7	1.5	-0.2	-0.0	0.6
Allergy	0.3	0.7	2.7	0.1	-0.6	-1.6	0.0	-1.3	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-1.1	-1.0	-0.9	-0.3	0.3	0.2
Lung cancer (father)	0.3	0.4	1.5	0.5	0.4	0.3	-0.5	0.5	1.2
Arm fat mass (right)	0.3	1.3	3.4	-1.0	-1.1	-0.0	-1.2	1.8	1.4
Standing height	0.3	2.5	8.5	1.6	2.3	2.9	-0.4	0.4	1.1
Breastfed as a baby	0.3	0.4	1.0	-0.8	-0.1	-0.2	-0.9	-1.0	0.3
Tense / ‘highly strung’	0.3	0.4	1.2	0.6	0.1	-0.3	1.1	-1.0	-0.6
Hair/balding pattern: Pattern 4	0.3	0.6	1.7	-0.4	-1.2	-1.3	-0.3	-0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.0	0.0	0.3	-0.4	-0.5	-1.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.2	0.2	-1.2	-1.5	-0.7	0.4	-0.5
Leg fat mass (right)	0.3	1.2	2.2	-1.0	-1.5	-1.1	-1.0	1.4	1.1
Alcohol intake frequency.	0.3	0.7	3.3	-0.4	-1.8	-0.8	0.3	0.8	0.1
Chest pain or discomfort	0.3	0.5	1.5	0.2	-0.1	-1.2	0.8	-0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	-0.9	-0.2	0.5	-0.7	-1.1	-0.1
Average weekly red wine intake	0.3	0.5	1.6	0.2	0.6	0.3	1.1	1.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.6	-0.0	0.7	0.7	0.8	0.9
Osteoporosis (self-reported)	0.3	0.3	1.0	0.4	-0.5	-0.4	0.1	0.8	-1.0
Arm fat mass (left)	0.3	1.2	2.3	-1.0	-1.4	-0.3	-1.3	1.5	1.3
Hearing aid user	0.3	0.4	0.8	0.5	0.8	0.9	0.7	-0.7	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	2.2	0.4	-0.1	0.0	0.8	-0.3	-1.5
Leg fat mass (left)	0.3	1.3	2.9	-1.2	-1.3	-0.9	-0.9	1.7	1.2
Bipolar Disorder (2018)	0.2	0.3	0.8	0.9	-0.4	-0.5	-0.1	-0.6	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.0	0.8	0.1	-0.6	0.8	-0.3
Mean Putamen Volume	0.2	0.2	0.3	-0.5	-0.6	0.6	-0.3	-0.2	-0.5
HDL Cholesterol	0.2	0.3	0.7	-0.1	0.1	0.6	-0.5	0.7	-0.8
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.4	-0.3	0.5	-0.8	0.4	-1.0
Hypothyroidism (self reported)	0.2	0.5	1.7	0.4	-1.1	-0.8	-1.3	0.4	0.2
Hair Pigment	0.2	5.1	16.1	1.2	3.1	4.0	2.6	0.9	0.7
Average weekly spirits intake	0.2	0.2	0.5	0.7	0.3	0.0	0.7	-0.5	-0.5
Diabetes (mother)	0.2	0.2	0.8	0.9	-0.6	0.6	-0.1	0.3	0.1
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.6	-0.6	0.5	-0.2	-0.8	0.0
Fed-up feelings	0.2	0.3	0.9	0.9	0.7	-0.1	0.7	-0.6	0.3
Relative age voice broke	0.2	0.3	0.8	0.6	0.9	0.5	0.0	0.2	0.5
Medication: Levothyroxine sodium	0.2	0.3	1.3	0.1	-0.3	-0.5	0.4	-0.3	-1.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.7	-0.1	0.0	-0.6	-0.8	0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.5	-0.1	-0.4	0.5	-0.9	1.0
Weight	0.2	1.2	4.4	-0.1	-0.1	1.2	-1.0	2.1	1.2
Hip circumference	0.2	0.6	3.2	-0.1	0.2	0.7	-0.1	1.8	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.9	0.3	-0.2	0.6	-1.4	-1.0	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.8	-0.0	0.5	-0.4	-0.5	-0.7
Number of children fathered	0.2	0.2	0.5	-0.6	0.0	-0.6	-0.7	0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.8	0.0	0.2	0.2	0.2	-0.8
Suffer from ‘nerves’	0.2	0.3	1.0	0.8	1.0	0.2	0.2	-0.3	-0.5
Family relationship satisfaction	0.2	0.3	0.8	0.5	-0.2	-0.8	0.1	-0.9	0.2
Ever taken oral contraceptive pill	0.2	0.2	1.0	1.0	0.7	0.3	-0.2	0.0	0.2
Mother’s age at death	0.2	0.3	1.0	-0.4	-0.1	0.4	-1.0	0.7	0.0
Alcohol drinker status: Never	0.2	0.2	1.1	0.3	0.0	0.6	0.1	1.0	-0.3
Number of operations (self-reported)	0.2	0.3	0.7	0.6	-0.4	0.7	-0.2	0.1	-0.8
Risk taking	0.2	0.3	1.4	-0.7	0.2	0.3	0.4	-1.2	0.3
Myopia	0.2	0.3	0.7	-0.7	0.7	0.9	0.3	-0.7	0.3
Worry (Nagel 2018)	0.1	0.2	1.1	0.5	0.2	-0.2	0.3	-1.0	-0.3
Triglycerides	0.1	0.1	0.6	0.0	0.1	0.4	-0.1	-0.1	0.8
BMI	0.1	0.4	1.3	-0.2	-0.4	0.6	-0.9	1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.5	-0.3	-0.4	-0.2	-0.4
Alcohol usually taken with meals	0.1	0.2	0.9	-0.0	0.5	0.1	-0.5	1.0	0.2
Medication: Lansoprazole	0.1	0.2	0.6	-0.8	-0.4	-0.4	-0.1	0.2	0.4
Medication: Paracetamol	0.1	0.2	0.7	0.6	0.4	-0.1	0.9	0.2	0.1
Headache pain in last month	0.1	0.2	0.8	0.7	0.1	-0.9	0.0	0.2	0.6
Pulse rate, automated reading	0.1	0.4	1.3	1.1	0.8	0.3	0.7	-0.4	-0.1
Comparative height size at age 10	0.1	0.4	1.6	0.8	-0.5	0.3	-1.3	0.5	0.1
Friendships satisfaction	0.1	0.1	0.6	0.8	-0.0	-0.0	0.1	-0.5	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.3	-0.6	-0.5	0.6	-0.2	-0.1

Hub : Genes

TMEM133

Models

Trait associations