[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr8:70,788,124-72,399,360

Best TWAS P=1.11e-09 · Best GWAS P=4.78e-10 conditioned to 1.79e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LACTB2	0.07	0.09	lasso	5	0.08	3.7e-10	5.9	-5.9	4.3e-09	0.11	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC286190	0.04	0.01	bslmm	317	0.03	2.3e-04	5.7	-5.1	2.8e-07	0.10	0.05	0.91	FALSE
3	CommonMind	Brain Pre-frontal Cortex	XKR9	0.26	0.52	lasso	13	0.51	1.6e-72	5.8	5.9	3.1e-09	-0.08	0.04	0.96	FALSE
4	GTEx	Heart Atrial Appendage	LACTB2	0.19	0.13	enet	43	0.16	1.6e-07	5.8	-5.6	1.6e-08	0.09	0.05	0.95	FALSE
5	GTEx	Nerve Tibial	LACTB2	0.07	0.06	lasso	2	0.04	1.5e-03	5.7	-5.5	2.9e-08	0.07	0.05	0.94	FALSE
6	GTEx	Pancreas	LACTB2	0.13	0.11	enet	19	0.05	3.3e-03	5.7	-5.7	1.5e-08	0.07	0.04	0.94	FALSE
7	GTEx	Pituitary	LACTB2	0.25	0.08	lasso	8	0.13	4.3e-04	4.9	-5.4	5.7e-08	0.13	0.12	0.43	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	LACTB2	0.07	0.07	lasso	2	0.07	7.5e-05	5.9	-5.8	7.0e-09	0.09	0.07	0.92	FALSE
9	GTEx	Skin Sun Exposed Lower leg	LACTB2	0.05	0.03	lasso	3	0.04	4.6e-04	5.8	-5.4	5.1e-08	0.09	0.08	0.91	FALSE
10	METSIM	Adipose	XKR9	0.17	0.37	enet	33	0.38	8.6e-60	5.9	-5.8	8.7e-09	0.10	0.06	0.94	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	XKR9	0.22	0.38	bslmm	366	0.40	1.0e-54	5.8	-6.1	1.1e-09	0.10	0.06	0.94	TRUE
12	YFS	Blood	TRAM1	0.02	0.01	enet	22	0.02	8.1e-07	5.8	-5.4	8.4e-08	-0.02	0.04	0.94	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XKR9	0.31	0.44	enet	13	0.44	1.4e-40	5.8	-5.5	4.2e-08	0.06	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	XKR9	0.25	0.51	lasso	8	0.51	2.4e-123	5.7	-5.7	1.1e-08	0.08	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XKR9	0.35	0.42	enet	12	0.42	3.5e-22	5.8	-5.9	2.7e-09	0.08	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	XKR9	0.32	0.44	lasso	12	0.45	7.9e-29	5.7	-5.7	1.1e-08	0.07	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Esophageal Carcinoma	XKR9	0.12	0.16	blup	44	0.13	6.4e-05	5.7	-5.3	1.4e-07	0.08	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Glioblastoma Multiforme	XKR9	0.18	0.15	enet	19	0.20	1.1e-06	5.8	-5.8	6.4e-09	0.11	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XKR9	0.21	0.38	lasso	6	0.38	4.6e-45	5.9	-5.7	1.1e-08	0.08	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XKR9	0.34	0.51	enet	16	0.51	9.7e-66	5.7	-5.8	8.9e-09	0.06	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XKR9	0.45	0.55	lasso	3	0.57	1.2e-38	5.7	-5.7	1.2e-08	0.07	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	XKR9	0.18	0.35	enet	13	0.34	7.7e-40	5.9	-5.7	9.6e-09	0.08	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	XKR9	0.40	0.46	lasso	5	0.46	5.5e-24	5.9	-5.8	6.7e-09	0.07	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	XKR9	0.31	0.43	enet	14	0.43	1.9e-54	5.8	-5.6	1.7e-08	0.06	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	XKR9	0.28	0.46	lasso	9	0.46	1.7e-57	5.8	-5.7	9.0e-09	0.08	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XKR9	0.32	0.53	lasso	7	0.52	6.5e-40	5.9	-5.9	4.9e-09	0.08	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XKR9	0.23	0.32	lasso	7	0.34	3.7e-15	5.7	-5.3	1.5e-07	0.06	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	XKR9	0.47	0.58	enet	13	0.59	1.5e-28	5.7	-5.8	6.5e-09	0.08	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	XKR9	0.51	0.62	lasso	7	0.64	4.7e-86	5.8	-5.7	1.3e-08	0.08	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Rectum Adenocarcinoma	XKR9	0.40	0.50	enet	18	0.52	2.6e-14	5.7	-5.6	1.9e-08	0.09	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Soft Tissue Sarcoma	XKR9	0.30	0.36	blup	44	0.37	3.8e-23	5.8	-5.8	7.6e-09	0.07	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	XKR9	0.22	0.26	enet	13	0.24	1.8e-17	5.9	-5.9	4.4e-09	0.06	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	XKR9	0.33	0.33	enet	21	0.34	9.6e-13	5.8	-5.8	8.3e-09	0.10	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	LACTB2	0.03	0.01	enet	5	0.01	6.1e-02	5.8	-5.8	6.7e-09	0.06	0.01	0.80	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	XKR9	0.38	0.55	lasso	9	0.56	2.5e-65	5.8	-5.8	7.1e-09	0.08	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	XKR9	0.24	0.24	lasso	4	0.25	1.3e-07	5.9	-6.1	1.4e-09	0.09	0.01	0.99	FALSE