[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr14:103,161,201-105,211,221

Best TWAS P=1.47e-18 · Best GWAS P=1.07e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	-8.7	-8.8	1.5e-18	0.98	0.02	0.95	TRUE
12	GTEx	Breast Mammary Tissue	MARK3	0.12	0.11	lasso	2	0.08	3.9e-05	-8.7	-8.7	2.7e-18	0.98	0.01	0.98	FALSE
29	GTEx	Stomach	TRMT61A	0.12	0.11	lasso	5	0.08	1.2e-04	-8.7	-8.7	2.7e-18	0.98	0.02	0.97	FALSE
32	GTEx	Thyroid	MARK3	0.38	0.48	lasso	4	0.48	2.8e-41	-8.7	-8.7	2.7e-18	0.98	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BAG5	0.08	0.09	lasso	2	0.08	3.7e-04	-8.7	-8.7	4.1e-18	0.98	0.00	0.97	FALSE
22	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	-8.7	-8.6	9.0e-18	0.98	0.02	0.97	FALSE
17	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	-8.7	-8.6	1.2e-17	0.96	0.02	0.97	FALSE
10	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	-8.7	-8.5	1.4e-17	0.96	0.02	0.98	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	MARK3	0.16	0.10	lasso	3	0.10	6.7e-06	-8.7	-8.5	1.4e-17	0.95	0.02	0.98	FALSE
23	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	-8.7	-8.5	1.5e-17	0.97	0.02	0.97	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	-8.7	-8.5	2.5e-17	0.93	0.01	0.63	FALSE
26	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	-8.8	-8.4	3.0e-17	0.93	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	MARK3	0.12	0.05	lasso	3	0.06	2.5e-05	-8.8	-8.4	3.8e-17	0.93	0.01	0.99	FALSE
18	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	-5.7	-7.9	4.0e-15	0.91	0.02	0.94	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARK3	0.07	0.06	enet	7	0.08	1.0e-08	-6.2	-7.8	7.5e-15	0.86	0.04	0.96	FALSE
13	GTEx	Breast Mammary Tissue (Male)	MARK3	0.08	0.00	enet	9	-0.01	7.2e-01	-8.7	-7.7	1.1e-14	0.85	0.02	0.46	FALSE
7	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	-8.7	-7.7	1.7e-14	0.84	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	-8.7	-7.5	7.5e-14	0.85	0.00	0.68	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	-6.1	-7.1	1.2e-12	0.83	0.05	0.95	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	3.5	-6.9	4.3e-12	0.78	0.02	0.66	FALSE
36	YFS	Blood	KLC1	0.01	0.01	blup	389	0.01	1.0e-03	-6.1	6.9	4.4e-12	-0.77	0.13	0.65	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MARK3	0.07	0.03	blup	64	0.06	5.5e-07	-6.3	-6.9	6.7e-12	0.79	0.03	0.96	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	2.8	-6.8	9.4e-12	0.81	0.01	0.73	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	-5.8	-6.8	1.2e-11	0.84	0.01	0.52	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CKB	0.43	0.32	enet	16	0.34	5.9e-29	-6.3	-6.6	5.1e-11	0.74	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf153	0.05	0.05	blup	40	0.04	8.6e-06	-6.1	-6.5	8.3e-11	0.79	0.36	0.56	FALSE
21	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	-5.8	6.5	9.9e-11	-0.77	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TRMT61A	0.06	0.03	lasso	3	0.04	6.6e-06	3.6	-6.5	1.0e-10	0.79	0.04	0.96	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	CKB	0.28	0.26	lasso	4	0.25	6.4e-14	-6.3	-6.4	1.6e-10	0.69	0.98	0.02	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-5.8	-6.4	1.8e-10	0.75	0.05	0.82	FALSE
55	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	3.6	-6.2	4.0e-10	0.78	0.01	0.46	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	-5.8	-6.2	4.5e-10	0.77	0.11	0.84	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	-6.1	-6.2	7.8e-10	0.74	0.06	0.72	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKB	0.06	0.03	lasso	3	0.03	2.5e-06	-6.2	-6.1	9.5e-10	0.70	0.37	0.55	FALSE
19	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	-5.8	6.1	9.9e-10	-0.69	0.58	0.11	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	MARK3	0.10	0.03	blup	61	0.03	4.0e-04	-6.3	-6.0	1.9e-09	0.68	0.01	0.61	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	3.7	-6.0	2.2e-09	0.69	0.10	0.14	FALSE
35	NTR	Blood	BAG5	0.02	0.00	lasso	5	0.01	6.3e-03	-5.8	6.0	2.5e-09	-0.76	0.20	0.58	FALSE
16	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	-5.7	6.0	2.7e-09	-0.57	0.14	0.36	FALSE
9	GTEx	Artery Tibial	KLC1	0.11	0.08	lasso	3	0.08	1.1e-06	-5.7	5.9	3.9e-09	-0.72	0.87	0.02	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf153	0.07	0.05	lasso	4	0.04	1.5e-03	-6.1	-5.8	5.1e-09	0.73	0.04	0.46	FALSE
3	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	3.7	5.8	6.1e-09	-0.66	0.24	0.20	FALSE
30	GTEx	Testis	ZFYVE21	0.11	0.14	lasso	2	0.11	1.4e-05	-5.8	5.8	7.8e-09	-0.71	0.42	0.33	FALSE
4	GTEx	Adipose Visceral Omentum	KLC1	0.06	0.02	lasso	2	0.00	2.2e-01	-5.7	5.7	1.0e-08	-0.68	0.14	0.17	FALSE
8	GTEx	Artery Tibial	ZFYVE21	0.11	0.09	lasso	1	0.08	8.0e-07	-5.7	5.7	1.3e-08	-0.71	0.96	0.03	FALSE
5	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	2.9	5.7	1.4e-08	-0.65	0.05	0.67	FALSE
15	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	3.8	5.7	1.4e-08	-0.62	0.06	0.60	FALSE
6	GTEx	Artery Aorta	KLC1	0.10	0.14	lasso	3	0.14	6.1e-08	-5.8	5.7	1.5e-08	-0.69	0.93	0.06	FALSE
33	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	3.5	-5.6	1.9e-08	0.62	0.77	0.19	FALSE
20	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-5.8	5.6	2.6e-08	-0.67	0.98	0.02	FALSE
14	GTEx	Cells Transformed fibroblasts	APOPT1	0.14	0.12	lasso	3	0.10	6.4e-08	-5.8	-5.5	3.1e-08	0.68	0.97	0.02	FALSE
11	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	4.1	-5.5	4.5e-08	0.68	0.11	0.43	FALSE
31	GTEx	Testis	APOPT1	0.13	0.07	enet	21	0.12	8.4e-06	3.0	5.4	7.1e-08	-0.70	0.20	0.69	FALSE
34	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	3.8	-5.4	7.6e-08	0.44	0.56	0.44	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	4.1	-5.3	8.7e-08	0.63	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG5	0.06	0.02	blup	30	0.03	1.4e-04	1.8	-5.3	9.1e-08	0.70	0.03	0.93	FALSE