Best TWAS P=8.55e-09 · Best GWAS P=3.5e-11 conditioned to 0.000165
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM8A | 0.07 | 0.00 | blup | 51 | 0.03 | 2.3e-04 | 6.5 | 5.8 | 8.6e-09 | 0.66 | 0.01 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RGS11 | 0.09 | 0.05 | enet | 8 | 0.05 | 1.5e-03 | -5.0 | 5.6 | 2.2e-08 | 0.63 | 0.03 | 0.36 | FALSE |
| 1 | GTEx | Cells EBV-transformed lymphocytes | MRPL28 | 0.48 | 0.22 | enet | 30 | 0.31 | 8.5e-11 | 4.5 | 5.6 | 2.5e-08 | 0.79 | 0.15 | 0.85 | FALSE |
| 2 | NTR | Blood | TMEM8A | 0.02 | 0.02 | enet | 8 | 0.02 | 1.7e-06 | -4.9 | 5.6 | 2.7e-08 | 0.66 | 0.79 | 0.19 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMEM8A | 0.03 | 0.01 | blup | 52 | 0.02 | 3.4e-03 | 4.3 | 5.4 | 6.4e-08 | 0.71 | 0.02 | 0.39 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MRPL28 | 0.05 | 0.03 | enet | 7 | 0.03 | 2.2e-04 | 4.4 | 5.4 | 8.6e-08 | 0.60 | 0.08 | 0.87 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | MRPL28 | 0.17 | 0.10 | lasso | 5 | 0.12 | 1.1e-15 | 4.5 | 5.3 | 1.3e-07 | 0.76 | 0.19 | 0.81 | FALSE |