TWAS hub - RGS11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1480	0.0510	1.9e-04	0.007	NA	0.004	NA	0.009	7.9e-02	NA	1.3e-01	NA	5.9e-02
2	GTEx	Adipose Visceral Omentum	0.1860	0.0610	4.3e-04	0.019	NA	0.115	NA	0.071	3.3e-02	NA	1.5e-06	NA	1.6e-04
3	GTEx	Artery Aorta	0.2510	0.0570	5.7e-06	0.052	NA	0.137	NA	0.132	7.5e-04	NA	5.5e-08	NA	9.5e-08
4	GTEx	Artery Tibial	0.1963	0.0500	5.0e-06	0.057	NA	0.106	NA	0.074	3.0e-05	NA	1.2e-08	NA	2.0e-06
5	GTEx	Cells Transformed fibroblasts	0.1110	0.0410	1.2e-03	0.012	NA	0.052	NA	0.024	4.0e-02	NA	9.2e-05	NA	6.0e-03
6	GTEx	Colon Sigmoid	0.2330	0.0770	5.7e-04	0.000	NA	0.052	NA	0.017	3.3e-01	NA	6.5e-03	NA	8.3e-02
7	GTEx	Esophagus Mucosa	0.1390	0.0490	1.2e-03	0.023	NA	0.014	NA	0.022	1.1e-02	NA	3.7e-02	NA	1.1e-02
8	GTEx	Esophagus Muscularis	0.1650	0.0520	1.8e-04	0.052	NA	0.059	NA	0.066	4.0e-04	NA	1.7e-04	NA	7.6e-05
9	GTEx	Muscle Skeletal	0.2612	0.0640	4.4e-06	0.001	NA	-0.003	NA	-0.003	2.3e-01	NA	8.1e-01	NA	9.9e-01
10	GTEx	Skin Sun Exposed Lower leg	0.2150	0.0590	2.5e-05	0.079	NA	0.036	NA	0.060	4.5e-07	NA	5.7e-04	NA	1.1e-05
11	GTEx	Testis	0.3260	0.0730	3.4e-06	0.036	NA	0.074	NA	0.076	9.7e-03	NA	3.6e-04	NA	2.8e-04
12	ROSMAP	Brain Pre-frontal Cortex	0.1198	0.0328	1.7e-06	0.072	0.057	0.069	0.059	0.065	1.6e-09	7.0e-08	3.3e-09	4.5e-08	9.3e-09
13	TCGA	Breast Invasive Carcinoma	0.0381	0.0174	2.7e-04	-0.001	0.015	0.001	NA	0.002	4.6e-01	3.8e-04	2.2e-01	NA	9.8e-02
14	TCGA	Cervical Squamous Cell Carcinoma	0.0880	0.0450	8.2e-03	0.049	0.040	0.051	NA	0.045	1.9e-03	4.6e-03	1.5e-03	NA	3.0e-03
15	TCGA	Head and Neck Squamous Cell Carcinoma	0.0713	0.0303	5.3e-05	0.018	0.039	0.036	NA	0.033	3.2e-03	2.8e-05	5.6e-05	NA	1.3e-04
16	TCGA	Kidney Renal Clear Cell Carcinoma	0.1081	0.0410	1.7e-05	0.035	0.043	0.053	NA	0.046	7.4e-05	1.3e-05	1.3e-06	NA	5.5e-06
17	TCGA	Lung Adenocarcinoma	0.0545	0.0226	9.8e-05	0.014	0.029	0.011	NA	0.008	7.3e-03	2.4e-04	1.5e-02	NA	3.6e-02
18	TCGA	Lung Squamous Cell Carcinoma	0.0788	0.0299	6.2e-05	0.027	0.045	0.038	NA	0.041	4.6e-04	6.5e-06	3.3e-05	NA	1.8e-05
19	TCGA	Prostate Adenocarcinoma	0.1320	0.0456	1.3e-07	0.012	0.054	0.053	NA	0.054	1.6e-02	2.4e-06	3.1e-06	NA	2.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Stomach or abdominal pain in last month	8.5	10.6	17.3	-3.6	-2.8	-3.0	-3.6	-4.2	-3.2	-3.0	-3.8	-1.1	-2.9	-3.3	-4.0	-3.4	-3.1	-4.1	-2.8	-3.2	-2.8	-2.8
Diabetes (father)	7.7	9.5	15.4	-2.8	-2.8	-3.2	-3.6	-3.5	-3.1	-3.9	-3.1	-2.9	-3.5	-3.1	-2.4	-2.9	-1.4	-2.5	-2.5	-3.9	-2.5	-3.7
Illnesses of siblings	6.1	8.5	25.5	3.1	1.7	3.4	2.9	3.5	2.0	1.7	3.1	4.3	2.4	5.0	3.4	2.1	3.2	2.2	2.9	1.8	2.1	1.9
Number of treatments/medications taken	5.7	10.2	16.6	-3.9	-2.1	-3.7	-3.8	-4.1	-2.6	-2.1	-2.8	-2.3	-3.2	-3.9	-3.4	-2.8	-3.0	-3.7	-3.4	-2.6	-3.5	-2.5
Medication: Metformin	5.4	7.6	14.6	-2.8	-1.8	-3.8	-2.8	-3.3	-1.2	-2.3	-3.1	-1.4	-2.0	-3.3	-2.1	-3.2	-2.9	-2.8	-2.4	-3.5	-2.2	-3.5
Unable to work because of sickness or disability	5.2	6.7	11.1	-2.3	-2.1	-3.2	-3.2	-3.1	-1.8	-1.7	-2.6	-1.3	-2.0	-2.4	-2.6	-2.9	-2.4	-2.9	-3.3	-2.3	-3.0	-2.9
Heel T-Score	5.0	39.4	216.1	7.9	5.1	6.3	1.0	6.8	0.7	-2.7	5.0	2.8	0.2	5.4	4.8	6.8	14.7	10.1	6.0	5.0	5.8	4.7
Diabetes diagnosed by doctor	5.0	8.2	18.8	-2.7	-0.4	-4.3	-2.4	-3.6	-1.4	-3.2	-2.9	-1.9	-2.5	-3.6	-1.5	-3.6	-2.3	-2.7	-2.8	-3.9	-2.3	-3.6
Serious illness, injury or assault to yourself	4.8	5.8	12.2	-1.9	-1.3	-3.0	-3.5	-2.3	-2.8	-2.1	-2.8	-1.8	-2.2	-3.0	-3.5	-2.1	-1.2	-2.2	-2.7	-1.7	-1.9	-1.9
Heart disease (siblings)	4.7	5.7	14.2	-3.6	-0.7	-2.8	-2.6	-2.7	-2.3	-2.2	-2.3	-2.7	-3.1	-3.8	-1.8	-1.8	-1.6	-1.2	-2.3	-1.8	-2.4	-1.8
Number of full brothers	4.4	5.6	17.7	-3.2	-1.1	-3.0	-2.8	-2.9	-1.8	-1.2	-2.5	-1.5	-1.5	-4.2	-2.7	-1.8	-3.0	-2.7	-1.7	-1.7	-1.6	-0.7
Current tobacco smoking	4.1	6.7	11.1	-2.7	-3.2	-2.3	-3.2	-2.9	-3.1	-1.8	-2.8	-0.6	-2.2	-3.3	-2.7	-2.4	-2.7	-2.8	-2.1	-2.6	-2.0	-2.4
Leg pain on walking	4.1	5.1	13.8	-1.8	-1.4	-2.9	-3.0	-2.5	-0.5	-1.3	-3.3	-3.0	-1.4	-2.9	-3.7	-1.6	-2.9	-2.0	-1.8	-1.5	-1.0	-1.1
Illnesses of siblings: Diabetes	4.0	4.9	11.2	-1.6	-1.6	-1.6	-3.1	-2.5	-2.0	-2.4	-2.9	-2.8	-1.9	-3.4	-3.3	-1.5	-1.3	-2.2	-1.5	-1.9	-0.9	-1.4
Qualifications: O levels/GCSEs or equivalent	3.7	6.0	12.0	2.2	2.2	2.2	1.7	2.6	2.4	3.2	3.5	1.9	2.7	3.5	2.6	2.1	2.7	2.5	0.8	3.0	1.4	1.3
Illnesses of father: None of the above (group 1)	3.7	4.5	15.8	3.5	0.4	1.7	2.7	2.1	2.2	3.5	1.2	1.4	4.0	2.3	0.6	1.2	0.4	1.2	1.0	2.4	1.8	1.9
Health satisfaction	3.5	4.6	6.7	-2.6	-2.6	-2.5	-2.6	-2.4	-2.0	-1.5	-2.4	-1.9	-2.3	-1.5	-2.3	-1.7	-2.3	-2.4	-1.7	-1.7	-2.1	-1.4
Smoking status: Current	3.5	5.5	8.8	-2.6	-3.0	-1.9	-2.9	-2.7	-2.8	-1.9	-2.6	-0.4	-2.2	-2.8	-2.4	-2.2	-2.6	-2.4	-1.6	-2.4	-1.8	-2.2
Pain experienced in last month	3.5	5.8	20.6	2.8	3.0	1.8	3.1	2.3	2.4	2.6	2.3	1.7	2.2	4.5	2.5	1.6	2.7	2.3	0.9	2.0	1.1	1.1
Neck or shoulder pain in last month	3.4	4.8	7.6	-1.8	-2.6	-1.7	-2.7	-2.0	-1.8	-2.8	-2.4	-1.7	-2.5	-2.3	-2.5	-2.3	-1.0	-2.4	-1.9	-2.6	-1.9	-2.1
Medication: Co-codamol	3.2	3.7	7.6	-1.9	-2.0	-1.9	-2.3	-2.2	-1.3	-2.2	-2.4	-1.4	-2.2	-2.8	-1.9	-1.8	-1.6	-1.8	-1.3	-2.1	-1.0	-1.7
Gout (self-reported)	3.2	4.3	11.3	1.8	2.0	2.3	0.6	2.4	1.1	0.5	1.6	-0.1	0.3	1.1	1.0	2.9	2.5	3.1	2.8	2.9	2.3	3.4
Smoking status: Previous	3.2	4.9	15.9	2.9	1.5	1.9	1.4	2.0	1.8	3.0	2.2	0.5	4.0	0.7	2.2	2.4	1.4	2.0	1.9	2.6	2.3	2.4
Medication: Paracetamol	3.2	4.9	11.5	-2.3	-1.7	-3.0	-2.7	-2.8	-0.2	-0.9	-0.9	-0.7	-1.3	-1.7	-0.9	-3.1	-1.6	-2.7	-3.4	-2.3	-3.3	-2.6
Time employed in main current job	3.1	3.6	10.3	-2.2	-1.0	-2.7	-1.3	-2.3	-1.4	0.2	-1.8	-0.7	-0.8	-1.3	-1.7	-2.1	-2.3	-2.1	-2.9	-1.2	-3.2	-1.7
Medication for pain relief, constipation, heartburn	3.1	5.4	13.8	3.2	1.0	2.2	3.1	2.8	0.7	1.0	1.5	2.5	2.0	3.7	2.3	1.6	2.5	2.9	2.6	1.5	2.9	1.1
Overall health rating	3.1	6.6	17.8	-3.1	-2.1	-3.0	-3.7	-3.1	-2.1	-1.5	-2.6	-1.5	-2.0	-4.2	-2.9	-1.5	-2.4	-2.6	-2.9	-1.4	-3.0	-0.9
Medication for cholesterol	3.1	4.7	8.4	2.2	1.1	2.3	1.8	2.1	1.0	2.3	2.0	1.6	2.4	2.6	1.7	2.6	1.6	2.7	2.6	2.9	2.0	2.6
Diabetes (self-reported)	3.0	4.6	11.1	-1.7	-0.2	-3.3	-1.9	-2.7	-0.8	-2.6	-2.4	-0.9	-1.9	-2.8	-1.3	-2.6	-1.3	-1.9	-2.0	-2.9	-1.4	-2.8
Age at first live birth	3.0	5.4	11.3	0.9	2.6	2.1	3.1	2.4	3.2	2.5	3.4	1.5	1.7	2.3	2.5	2.6	2.0	1.8	1.8	2.6	1.5	1.8
Medication: Aspirin	3.0	3.9	7.2	-2.3	-1.5	-1.6	-2.2	-2.1	-2.0	-1.9	-1.6	-2.0	-2.7	-2.3	-1.7	-1.7	-0.9	-2.3	-2.1	-2.1	-2.4	-1.3
Supplements: Zinc	2.8	3.0	7.5	-2.2	-0.1	-2.0	-2.7	-2.7	-0.6	-1.2	-1.7	-1.2	-2.4	-1.9	-2.2	-1.4	-1.2	-1.1	-1.5	-1.3	-1.6	-1.5
Medication: Gliclazide	2.8	3.2	7.4	-1.4	0.4	-1.9	-1.0	-2.1	-0.5	-2.3	-2.1	-2.7	-1.3	-2.7	-1.4	-1.7	-1.8	-1.7	-0.6	-2.4	-0.3	-2.4
Number of self-reported non-cancer illnesses	2.8	4.8	11.1	-3.0	-1.0	-3.2	-3.3	-3.0	-1.9	-1.5	-1.7	-1.4	-2.5	-3.2	-2.4	-1.3	-1.0	-1.4	-2.3	-1.2	-2.3	-1.2
Medication: Lisinopril	2.8	3.6	7.8	-2.2	-0.3	-1.8	-1.3	-2.5	-1.1	-2.7	-1.9	-2.1	-2.8	-1.6	-1.0	-2.1	-1.0	-1.6	-1.1	-2.5	-2.0	-2.2
Type 2 Diabetes (T2D) (2018)	2.7	5.1	14.8	-1.7	-0.5	-2.7	-2.1	-2.1	-0.8	-3.3	-2.6	-0.7	-2.0	-3.9	-1.3	-2.7	-1.5	-2.2	-1.3	-3.3	-1.3	-3.0
Diabetes (mother)	2.7	3.5	7.5	-2.1	-0.5	-2.0	-1.4	-2.4	-1.0	-1.9	-1.7	-0.9	-1.8	-1.9	-1.1	-2.4	-1.3	-1.8	-2.1	-2.7	-2.1	-2.5
Medication: Aspirin	2.7	3.6	5.9	-2.1	-1.4	-1.5	-2.1	-2.0	-2.1	-1.6	-1.7	-2.1	-2.2	-2.4	-1.8	-1.7	-1.1	-2.4	-2.1	-1.8	-2.0	-1.2
Medication: Atenolol	2.6	3.3	6.6	-2.6	-1.7	-1.6	-0.7	-2.2	-1.6	-0.8	-1.4	-1.1	-1.0	-2.5	-1.6	-2.0	-1.9	-2.5	-2.2	-1.4	-2.4	-1.3
High blood pressure (siblings)	2.6	3.8	16.3	-1.9	-1.5	-2.3	-2.4	-1.7	-1.4	-0.5	-1.9	-3.4	-1.0	-4.0	-2.5	-0.9	-2.1	-0.8	-1.9	-0.5	-0.9	-0.8
Exposure to tobacco smoke outside home	2.6	3.4	6.9	-2.1	-1.5	-2.6	-2.5	-2.4	-1.4	-1.2	-1.2	-0.9	-1.4	-1.8	-0.4	-2.4	-1.7	-1.6	-2.1	-2.0	-2.0	-2.1
Medication: Paracetamol	2.5	4.2	11.1	-2.1	-1.3	-3.0	-2.8	-2.5	0.1	-0.5	-0.7	-1.4	-0.9	-1.8	-1.0	-2.7	-1.6	-2.2	-3.3	-1.6	-3.0	-2.1
Commuting to job workplace: Walk	2.5	2.7	7.4	0.5	0.3	2.2	1.3	1.7	0.5	-0.5	1.4	1.7	-0.1	2.3	1.4	2.0	2.3	2.2	2.7	0.9	2.1	1.0
Respiratory disease	2.4	5.2	16.0	-2.4	-0.5	-3.1	-2.5	-3.0	-4.0	-2.0	-2.0	-0.4	-2.1	-2.3	-1.4	-2.6	-1.7	-2.0	-1.8	-2.4	-2.3	-2.4
Headache pain in last month	2.4	4.1	7.5	-2.2	-1.9	-2.7	-2.1	-2.7	-2.0	-1.5	-0.7	-0.8	-1.4	-1.1	-0.9	-2.6	-1.3	-2.1	-2.7	-2.1	-2.7	-2.4
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	6.8	-1.7	-2.6	-1.3	-1.8	-2.0	-1.4	0.1	-2.2	-0.8	-0.4	-2.1	-2.1	-1.3	-2.6	-2.2	-1.3	-1.3	-1.6	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	31.3	1.2	0.5	2.5	-1.1	1.8	-1.7	-2.4	0.5	-0.7	-2.2	0.0	-0.3	3.5	5.6	3.3	1.8	2.0	2.1	2.4
Wears glasses or contact lenses	2.3	2.7	7.2	-1.6	-1.7	-1.9	-1.2	-2.7	-0.2	-0.8	-2.2	-1.4	-1.2	-1.1	-1.8	-1.8	-2.0	-1.9	-1.7	-1.6	-1.4	-1.3
Pack years of smoking	2.3	3.4	6.5	-1.5	-1.6	-2.0	-2.1	-2.4	-1.1	-0.8	-2.5	-1.1	-1.3	-2.5	-2.2	-1.9	-2.4	-2.1	-2.0	-1.3	-1.9	-1.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	9.9	-1.6	-1.7	-1.8	-3.1	-1.5	-2.2	-1.6	-1.9	-1.1	-2.1	-2.1	-2.8	-0.7	-0.8	-0.8	-1.2	-0.3	-1.0	0.1
Qualifications: CSEs or equivalent	2.2	2.9	6.0	-1.4	-1.3	-1.7	-2.5	-2.2	-0.4	-1.5	-1.8	-1.4	-1.2	-2.4	-1.5	-1.9	-0.9	-1.4	-2.0	-1.9	-1.6	-1.8
Ever highly irritable/argumentative for 2 days	2.1	2.6	9.4	-2.7	-0.9	-2.2	-1.3	-1.9	-1.9	0.1	-0.9	-1.2	-0.9	-1.9	-0.7	-1.1	-3.1	-1.4	-1.3	-0.8	-2.2	-0.5
Medication: Omeprazole	2.1	2.5	5.9	-1.5	-2.4	-1.3	-1.9	-2.0	-0.7	-0.2	-1.8	-0.6	-0.4	-1.7	-1.7	-1.4	-2.1	-2.2	-1.4	-1.5	-1.5	-1.5
Illnesses of father: High blood pressure	2.1	2.6	8.5	-2.6	1.0	-1.4	-1.6	-1.9	-1.9	-2.4	-0.2	-0.7	-2.9	-1.7	0.2	-0.6	-0.0	-1.1	-1.1	-1.9	-1.8	-1.7
Vascular/heart problems diagnosed by doctor	2.1	5.6	24.1	2.7	0.6	2.7	2.7	2.5	-0.6	1.5	2.7	2.0	2.5	4.9	3.1	1.0	2.6	2.7	2.1	1.4	1.6	0.9
Pack years adult smoking proportion	2.0	3.0	5.9	-1.4	-1.4	-1.8	-2.2	-2.2	-1.0	-1.0	-2.4	-1.1	-1.2	-2.4	-2.0	-1.8	-2.0	-2.0	-1.8	-1.3	-1.8	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	29.1	1.3	0.1	2.3	-1.2	1.7	-1.6	-2.1	0.6	-0.3	-1.7	0.4	0.3	2.9	5.4	3.5	1.8	1.8	2.0	1.9
Back pain experienced in last month	2.0	3.0	10.1	-1.9	-1.6	-0.9	-2.7	-1.1	-2.3	-2.5	-1.5	0.5	-2.0	-3.2	-2.0	-1.0	-0.9	-1.8	-0.8	-1.7	-0.4	-0.6
Pain type(s) experienced in last month: Hip pain	2.0	2.5	12.4	-2.1	-0.2	-0.6	-1.3	-1.0	-3.5	-1.2	-1.6	-2.5	-1.4	-2.8	-1.3	0.7	-1.9	-0.5	1.0	-0.2	0.1	0.8
Mean Putamen Volume	1.9	2.2	8.0	-1.4	-0.2	-1.6	-0.7	-1.3	-1.5	-0.6	0.0	-0.1	-0.7	-0.1	0.6	-2.4	-1.3	-1.6	-1.8	-2.2	-2.8	-2.4
Waist Hip Ratio (WHR)	1.9	8.5	14.9	-3.6	-2.4	-3.0	-2.0	-3.9	-2.2	-1.8	-2.4	-1.8	-2.1	-2.9	-1.3	-3.6	-3.4	-3.3	-3.3	-3.5	-3.4	-3.7
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.0	-2.1	-2.1	-2.3	-1.1	-2.0	-2.4	-1.3	-1.9	-1.1	-1.6	-1.0	-1.5	-0.6	-1.7	-0.6	-1.0	-1.0	-1.1	-0.5
Systolic blood pressure, automated reading	1.9	5.5	15.5	-3.0	-2.2	-2.4	-3.0	-2.2	-2.3	-1.3	-3.2	-2.8	-2.1	-3.9	-3.3	-0.7	-2.7	-1.8	-1.4	-0.8	-1.0	-0.1
Townsend deprivation index at recruitment	1.9	2.6	7.0	-1.5	-1.4	-1.0	-1.8	-1.9	-2.6	-2.1	-1.4	-1.6	-2.3	-2.1	-1.4	-0.9	-0.6	-1.1	-1.4	-1.6	-1.3	-1.1
Chronic bronchitis/emphysema (father)	1.9	2.2	4.3	-1.5	-1.6	-0.9	-2.1	-1.6	-1.1	-1.5	-1.4	-1.7	-1.8	-0.7	-1.6	-1.5	-1.1	-1.7	-1.7	-1.1	-1.9	-0.6
Father’s age at death	1.9	2.5	9.2	2.2	0.9	0.4	1.6	1.9	1.9	1.2	2.2	2.8	1.4	3.0	1.6	0.6	1.5	0.3	0.8	0.5	0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.2	-0.7	-0.6	-1.9	-1.9	-2.0	-0.3	-1.6	-0.7	-0.5	-2.0	-1.0	-1.3	-1.9	0.7	-0.6	-2.5	-1.7	-1.7	-2.0
Hypertension (Self-reported)	1.9	5.3	19.3	-2.5	-0.2	-2.8	-2.7	-2.5	0.7	-1.7	-2.7	-2.2	-2.4	-4.4	-2.9	-1.2	-2.4	-2.5	-2.1	-1.7	-1.5	-1.1
Qualifications: nursing, teaching	1.9	2.9	5.1	1.2	1.1	2.2	2.3	1.9	0.9	1.0	1.8	1.2	0.9	2.1	1.2	2.2	1.7	1.7	2.3	2.2	1.7	1.9
Medication: Blood pressure	1.9	3.6	7.2	-1.6	-0.5	-1.5	-2.0	-1.7	0.2	-2.3	-1.5	-1.5	-2.3	-2.4	-1.2	-2.1	-0.7	-2.4	-2.6	-2.4	-2.7	-2.2
Cholesterol lowering medication	1.9	2.7	6.6	-2.1	-0.7	-1.5	-1.0	-1.2	-1.9	-1.8	-1.4	-1.8	-2.1	-2.6	-1.6	-1.1	-1.2	-2.2	-1.8	-1.8	-1.5	-1.0
Blood Red Count	1.8	17.0	82.3	-2.2	-2.7	-1.4	0.8	-1.2	-1.7	-1.7	-6.5	-3.2	1.3	-8.9	-3.0	-1.5	-9.1	-6.5	2.2	-3.6	3.4	-1.6
Cardiovascular Disease	1.8	5.9	23.9	-2.4	-0.4	-3.2	-3.5	-2.6	0.7	-1.6	-2.3	-1.8	-2.2	-4.9	-2.9	-1.3	-1.2	-2.3	-2.9	-1.5	-2.7	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	6.9	-1.5	-0.9	-1.6	-2.6	-1.0	-1.1	-2.2	-1.1	-1.0	-2.4	-2.3	-1.1	-0.7	0.6	0.3	-1.2	-1.3	-1.2	-1.0
Diastolic blood pressure, automated reading	1.8	5.5	17.6	-3.0	-0.9	-2.2	-3.5	-2.3	-1.8	-1.8	-2.3	-2.3	-2.3	-4.2	-3.2	-1.1	-2.1	-2.2	-2.2	-1.6	-1.6	-1.1
Worry (Nagel 2018)	1.7	3.7	9.3	-3.0	-1.3	-2.9	-1.8	-2.4	0.3	-0.5	-0.5	-0.0	-1.3	-2.5	-0.2	-1.9	-1.8	-1.7	-2.9	-1.8	-2.8	-1.9
High blood pressure	1.7	4.8	21.1	-2.3	0.0	-2.4	-2.5	-2.2	1.1	-1.5	-2.6	-2.2	-2.3	-4.6	-2.7	-0.9	-2.6	-2.4	-1.7	-1.4	-1.2	-0.9
Hayfever, allergic rhinitis or eczema	1.7	3.8	9.4	-1.7	0.3	-2.3	-1.6	-1.9	-0.9	-0.5	-1.1	-1.4	-0.5	-1.2	-0.2	-3.0	-2.3	-2.5	-2.6	-2.8	-2.6	-3.1
Qualifications: None of the above	1.7	3.7	7.3	-1.3	-2.6	-1.8	-1.8	-1.9	-2.5	-1.1	-2.6	-1.5	-0.7	-2.4	-1.6	-2.2	-2.7	-2.2	-1.7	-1.9	-1.4	-0.7
Medication: Allopurinol	1.7	2.2	6.9	1.1	1.2	1.8	1.1	1.3	0.8	-0.2	1.3	0.1	-0.3	1.2	1.3	1.5	2.2	2.6	2.5	1.3	1.6	1.9
Age at last live birth	1.7	2.5	11.4	-0.4	1.6	0.9	1.8	1.5	1.5	2.3	3.4	0.9	0.9	0.3	1.6	2.4	0.0	0.2	1.2	2.0	0.9	1.7
Knee pain experienced in last month	1.7	2.7	9.9	-2.0	-1.6	-1.4	-2.3	-1.8	-2.3	-1.2	-1.4	-1.8	-1.5	-3.1	-1.8	-0.4	-1.9	-1.3	-1.0	-0.4	-0.9	-0.0
Ever had prostate specific antigen (PSA) test	1.7	1.9	6.1	-1.5	-1.5	-0.9	-1.1	-1.4	-0.7	-0.7	0.1	-0.2	-1.0	-0.8	-0.1	-1.9	-1.7	-2.5	-1.2	-2.2	-2.2	-1.3
HDL Cholesterol	1.6	2.7	8.1	-1.0	-1.8	-2.6	-1.6	-1.8	-1.1	-0.1	-1.5	-0.6	-0.5	0.2	-1.3	-2.8	-1.2	-1.1	-2.5	-1.8	-2.1	-2.2
Waist circumference	1.6	5.7	29.2	-1.8	-0.1	-1.5	-3.0	-1.9	-1.5	-2.2	-3.0	-3.1	-1.4	-5.4	-3.7	-0.9	-1.8	-3.1	-1.6	-0.9	-1.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	7.2	-2.7	-1.1	-2.5	-1.1	-1.9	-0.5	-0.0	-1.0	-2.0	-1.0	-2.0	-0.6	-1.0	-2.5	-1.7	-1.7	-1.0	-1.8	-1.1
Standing height	1.6	15.7	33.5	5.7	4.9	4.8	4.1	4.5	5.0	-1.4	0.2	1.5	1.8	4.4	0.6	3.5	5.7	3.7	5.2	2.6	5.8	2.3
Birth weight	1.6	3.5	12.5	3.0	2.0	1.8	1.8	1.8	2.3	1.0	2.0	2.1	1.5	3.5	1.8	0.5	2.4	1.4	1.0	0.6	1.3	0.4
Wheeze or whistling in the chest in last year	1.6	2.8	8.0	-2.3	-0.1	-2.1	-2.6	-2.1	-2.8	-0.8	-0.2	-1.4	-1.4	-2.1	-0.7	-0.9	-0.5	-0.9	-2.1	-1.2	-2.4	-1.4
Migraine (self-reported)	1.6	2.0	4.4	-1.3	-0.8	-1.5	-0.8	-1.7	-0.8	-1.4	-1.2	-1.5	-1.1	-1.1	-1.1	-2.0	-1.0	-1.8	-0.9	-1.9	-1.5	-2.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	6.9	-0.6	-1.8	-0.4	-2.0	-0.9	-0.7	-0.7	-0.7	-0.5	-0.4	-2.6	-1.1	-1.6	-1.6	-2.3	-1.3	-1.5	-1.3	-1.2
Allergy	1.5	3.4	6.0	1.8	-0.8	2.4	1.8	2.0	2.3	1.1	1.3	1.1	1.0	1.5	0.6	2.4	2.0	2.2	2.0	2.3	2.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.9	-2.2	0.1	-2.3	-2.2	-1.8	-1.0	-1.1	-0.8	-1.3	-1.5	-2.6	-1.2	-0.9	-1.9	-1.1	-1.0	-1.4	-1.4	-1.6
Loud music exposure frequency	1.5	1.7	5.6	0.7	0.8	1.5	-0.9	1.2	-1.5	-0.1	0.9	-1.0	-0.5	0.2	0.7	2.4	1.6	1.8	1.8	1.3	1.2	2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	8.0	1.5	0.9	1.0	1.8	1.8	0.3	1.3	1.2	2.8	1.6	0.9	0.8	1.3	0.5	0.3	1.6	1.0	1.5	1.2
Medication: Atorvastatin	1.5	1.8	6.1	-1.7	-0.1	-1.4	-2.5	-1.6	-0.5	-1.6	-0.6	-0.7	-2.0	-1.7	0.2	-1.1	-0.4	-0.7	-1.1	-1.8	-1.4	-1.3
Age started oral contraceptive pill	1.5	1.9	8.0	1.5	-0.7	1.5	2.8	2.0	-0.4	0.7	0.2	1.0	0.8	1.4	0.4	1.5	0.6	1.1	1.7	1.3	1.9	1.3
Ulcerative Colitis	1.4	2.0	8.7	2.0	0.7	-0.1	1.3	1.1	1.7	3.0	1.2	1.2	2.7	1.2	1.4	0.6	-0.1	0.6	-0.1	1.5	0.5	1.3
Financial difficulties in last 2 years	1.4	1.9	8.8	-1.4	0.0	-0.8	-2.1	-1.5	-0.5	-0.1	-1.6	-0.6	-0.4	-3.0	-2.7	0.2	-2.0	-1.3	-0.3	0.3	-0.5	0.4
Falls in the last year	1.4	1.9	5.3	-2.3	-1.3	-1.5	-1.0	-1.8	-0.4	-0.3	-1.6	-0.3	-0.5	-1.8	-2.1	-0.7	-2.3	-1.8	-1.0	-0.3	-0.9	-0.3
Exposure to tobacco smoke at home	1.4	1.6	4.4	-1.3	-0.9	-1.4	-2.0	-1.4	-0.8	-0.8	-0.9	-2.0	-1.3	-1.0	-1.1	-1.2	-0.3	-0.9	-1.7	-0.7	-2.1	-0.6
Chest pain or discomfort	1.4	2.0	5.6	-2.0	-0.6	-1.0	-1.8	-2.4	-1.9	-1.7	-1.1	-2.2	-2.1	-1.4	-1.7	0.0	-0.2	-0.9	-0.3	-0.5	-0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	6.2	0.5	-0.5	1.6	2.5	1.6	-0.2	0.1	0.1	-0.6	0.6	2.0	1.3	1.3	0.1	0.9	2.3	0.8	1.7	1.5
Osteoporosis (self-reported)	1.4	1.8	11.1	-1.8	-1.1	-1.7	-0.8	-1.3	-0.4	0.7	-1.4	-0.2	-0.5	-0.7	-1.1	-1.4	-3.3	-1.7	-0.6	-1.2	-0.7	-1.1
Intelligence (Savage-Jansen 2018)	1.3	4.0	11.0	2.2	1.9	2.0	1.0	2.4	2.2	0.6	2.2	-0.1	0.6	2.9	1.6	2.3	3.3	2.7	1.8	1.6	2.2	1.3
Sitting height	1.3	9.3	26.0	5.1	3.0	3.6	2.2	3.2	3.2	-1.8	-1.0	0.4	1.4	3.7	-1.2	2.2	5.1	2.8	3.9	2.0	4.7	1.6
Past tobacco smoking	1.3	2.4	9.8	-1.8	-0.8	-1.5	-0.7	-0.8	-0.5	-2.6	-1.4	0.1	-3.1	-0.1	-1.3	-1.8	-0.4	-1.3	-1.3	-2.1	-1.6	-2.0
Qualifications: A levels/AS levels or equivalent	1.3	3.0	7.5	0.9	2.7	0.8	1.7	1.5	1.8	1.3	2.1	0.9	0.8	2.5	1.5	1.9	1.4	2.2	1.8	2.0	2.0	1.1
Mouth/teeth dental problems: Dentures	1.3	2.1	7.9	-1.2	-1.9	-0.7	-1.1	-1.7	-0.2	-0.5	-2.1	0.6	-0.8	-2.8	-2.3	-0.6	-2.4	-2.0	-0.9	-0.7	-0.3	0.1
Leg fat percentage (right)	1.3	4.6	22.3	-1.6	-0.3	-1.7	-3.0	-1.7	-2.8	-1.2	-1.3	-2.6	-1.0	-4.7	-2.4	-0.9	-1.3	-2.8	-2.5	-0.8	-2.5	-0.3
Pulse wave peak to peak time	1.3	1.6	3.8	0.5	1.2	1.7	1.5	1.4	-0.8	0.4	1.1	-1.4	0.4	1.6	1.2	1.4	2.0	1.5	1.1	1.3	0.9	1.0
Qualifications: College or University degree	1.3	4.1	14.8	0.8	3.2	1.5	3.5	1.9	1.8	0.5	2.0	1.4	0.1	3.9	1.7	1.8	2.1	2.2	1.8	1.4	1.7	0.9
Long-standing illness, disability or infirmity	1.3	2.0	7.7	-1.3	-0.8	-2.3	-2.8	-1.0	-2.1	-0.4	-1.0	-1.1	-1.2	-1.9	-1.8	-0.5	-1.2	-1.2	-1.4	-0.3	-0.6	-0.3
Mineral and other dietary supplements	1.3	1.7	4.5	1.8	1.8	1.1	1.4	1.3	1.9	1.9	0.9	0.8	2.1	1.4	1.7	0.3	0.7	1.0	0.4	0.8	-0.2	0.3
Alzheimer’s Disease (in father)	1.2	1.3	6.2	-1.2	0.1	-1.1	-0.8	-0.9	-2.5	-2.0	-0.7	-1.1	-2.5	-1.3	-0.1	0.3	0.7	0.5	-0.1	-0.7	-0.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.9	-1.5	0.2	-1.7	-1.8	-1.8	-0.9	-1.3	-0.7	-2.0	-1.4	-1.4	-1.0	-0.8	-0.7	-0.8	-1.1	-1.2	-1.2	-1.1
Number of incorrect matches in round	1.2	2.0	5.6	-2.3	-0.4	-1.2	0.4	-1.8	-0.3	-0.7	-0.5	-1.8	-1.0	-0.9	0.0	-1.6	-2.4	-1.9	-0.8	-1.6	-2.3	-1.3
Fluid intelligence score	1.2	2.4	6.8	0.9	1.4	1.6	1.1	1.8	1.3	0.8	2.6	0.2	0.7	2.2	2.0	1.6	2.3	2.1	1.0	1.5	1.2	0.8
Noisy workplace	1.2	1.5	4.9	-0.9	0.1	-1.5	-2.0	-1.4	-0.1	0.4	-1.2	-1.8	0.3	-2.2	-2.2	-0.5	-2.1	-0.9	-0.7	0.1	-0.6	0.1
Medication: Lansoprazole	1.2	1.3	3.3	-1.6	-1.5	-1.8	-1.3	-1.1	-0.2	-0.5	-1.3	0.2	-0.6	-1.3	-1.3	-1.1	-1.2	-1.4	-1.3	-0.6	-1.2	-0.3
Prospective memory result	1.2	1.5	8.7	-0.0	0.7	1.2	1.6	0.8	2.3	1.2	2.2	-0.7	0.6	1.1	3.0	0.2	-0.2	0.4	0.9	0.2	0.1	0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.8	0.4	-0.1	1.3	0.3	1.9	-1.4	-0.4	0.6	-1.0	-0.4	1.0	0.7	1.5	2.0	1.7	1.7	1.0	1.8	1.7
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.1	-1.8	-0.8	-1.6	-1.5	-1.3	-1.6	-0.6	-0.9	-1.5	-1.0	-1.7	-1.4	-0.2	-1.5	-0.8	-1.1	-0.6	-1.0	0.1
Myopia	1.2	1.8	6.5	1.2	1.1	1.2	1.7	1.2	1.7	0.7	0.7	2.6	0.8	0.6	1.6	1.5	0.6	1.6	1.8	0.7	1.5	0.6
Taking other prescription medications	1.1	1.7	6.9	-1.3	0.1	-2.1	-0.9	-1.4	-0.7	1.2	-0.8	0.2	0.5	-1.8	-1.1	-0.8	-2.6	-1.9	-1.4	0.0	-1.5	-0.4
Supplements: Glucosamine	1.1	1.5	4.7	-0.9	-1.7	-0.7	-1.9	-0.7	-1.9	-2.2	-1.1	-1.1	-1.9	-1.1	-1.8	-0.0	0.5	-0.4	-0.1	-0.7	-0.1	-0.0
Body mass index (BMI)	1.1	4.8	26.5	-1.2	-0.4	-1.1	-3.3	-1.2	-1.9	-1.1	-2.3	-3.1	-0.7	-5.2	-3.8	0.1	-0.9	-2.4	-1.6	0.4	-1.9	1.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.7	-1.7	-0.7	-1.9	-1.1	-1.4	-1.2	-0.3	-1.7	-1.1	-0.8	-1.4	-1.1	-0.5	-1.6	-0.7	0.0	-0.4	-1.3	-0.1
Pulse wave Arterial Stiffness index	1.1	1.2	3.6	-0.1	-1.0	-1.5	-1.3	-1.1	1.2	-0.4	-1.3	1.2	-0.2	-1.4	-1.4	-1.1	-1.9	-1.2	-0.7	-1.0	-0.4	-0.7
Tense / ‘highly strung’	1.1	1.8	5.1	-2.3	-1.2	-1.8	-0.8	-1.9	0.3	0.2	-0.8	-0.4	-0.8	-1.4	-0.7	-0.9	-2.1	-1.1	-1.9	-0.5	-2.2	-0.6
Worry too long after embarrassment	1.1	1.9	5.0	1.3	0.7	0.8	1.8	1.9	2.2	0.8	1.6	0.3	1.2	1.2	1.4	1.7	1.5	1.3	1.4	1.4	0.8	1.6
Alcohol intake frequency.	1.1	2.6	7.3	0.4	-2.2	-1.8	-2.7	-1.0	-1.0	-0.6	-1.0	2.1	-0.5	-0.4	-1.3	-2.3	-0.1	-1.0	-2.6	-1.7	-1.8	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.4	-1.7	-1.3	-1.1	-1.0	-1.4	-1.5	0.2	-0.9	-0.2	0.1	-1.8	-0.8	-1.0	-1.9	-1.1	-1.0	-0.5	-0.9	-1.0
Arm fat percentage (left)	1.1	4.6	24.3	-1.8	0.4	-1.6	-3.1	-1.3	-2.1	-1.2	-1.6	-3.0	-1.1	-4.9	-2.9	-0.0	-0.7	-2.4	-2.2	0.1	-2.5	0.7
Breast cancer (self-reported)	1.1	1.3	5.2	1.5	2.3	1.1	1.2	1.4	0.2	-0.3	0.4	-0.6	0.1	0.9	0.3	1.4	1.6	1.2	1.2	0.9	1.6	1.1
Alzheimer’s Disease (including proxy)	1.0	1.4	4.9	0.7	1.1	1.6	0.2	1.4	-0.5	-0.7	1.4	0.2	-1.0	0.2	1.2	1.7	2.2	1.1	1.3	0.8	1.2	1.4
Hypothyroidism (self reported)	1.0	2.3	11.3	-1.3	-1.6	-2.3	-3.4	-1.8	-0.2	-0.3	-0.7	0.3	-1.2	-1.2	-0.6	-1.7	-0.5	-0.2	-2.0	-1.2	-2.0	-1.5
Neuroticism	1.0	2.4	6.2	-2.1	-1.8	-2.5	-1.6	-1.7	-0.1	-1.0	-1.3	-1.5	-1.1	-2.2	-1.7	-1.2	-0.9	-1.4	-1.3	-1.0	-2.1	-1.2
Hand grip strength (right)	1.0	2.8	11.3	3.1	1.3	2.7	0.7	1.8	1.7	-0.8	0.4	1.0	0.7	1.4	0.4	0.8	3.4	1.9	2.0	0.2	2.1	0.1
Medication: Levothyroxine sodium	1.0	1.7	5.6	-1.1	-1.2	-2.0	-2.4	-1.6	-1.1	-0.6	-0.9	-0.7	-1.2	-1.3	-1.1	-1.3	-0.5	-0.3	-1.9	-1.0	-1.5	-1.2
Arm fat percentage (right)	1.0	3.9	21.3	-1.5	0.5	-1.6	-2.9	-1.1	-2.0	-0.9	-1.5	-2.7	-0.8	-4.6	-2.8	-0.1	-0.9	-2.4	-2.1	0.2	-2.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.3	-1.6	-0.5	-2.1	-1.1	-1.7	-1.3	-0.0	-0.8	-0.9	-0.9	-0.9	-0.9	-0.6	-1.6	-0.7	-0.9	-0.7	-1.7	-0.7
Asthma (self-reported)	1.0	2.1	8.1	-1.4	0.3	-2.0	-1.4	-1.8	-2.9	-0.6	-0.8	-0.5	-0.7	-1.6	-0.5	-1.6	-1.5	-1.4	-1.3	-1.4	-1.4	-1.6
Leg fat percentage (left)	1.0	3.6	19.7	-1.3	-0.2	-1.5	-2.6	-1.3	-2.4	-0.8	-1.0	-2.3	-0.7	-4.4	-2.2	-0.5	-1.2	-2.5	-2.3	-0.3	-2.5	0.2
Ever depressed for a whole week	1.0	1.3	2.9	-1.2	-1.0	-1.7	-1.2	-1.6	-1.3	0.0	-1.7	-1.6	-0.4	-1.6	-1.7	-0.1	-1.4	0.2	-0.0	0.2	-0.6	0.1
Commuting to job workplace: Cycle	1.0	1.2	6.2	0.2	0.4	1.1	1.4	0.9	0.3	-0.9	1.5	-0.2	-1.4	2.5	1.0	1.0	2.0	1.0	0.8	0.1	0.1	0.1
Primary Biliary Cirrhosis	0.9	1.3	3.0	-0.6	0.4	-1.0	-0.8	-1.2	-1.6	-1.0	-1.0	-1.1	-1.1	-0.8	-0.9	-1.6	-0.3	-1.1	-1.3	-1.7	-1.1	-1.7
Height	0.9	17.5	43.6	6.6	4.0	4.7	4.6	5.1	6.2	-1.6	-0.3	0.9	2.2	3.3	-0.5	3.9	6.0	3.5	5.3	2.7	6.2	2.7
Allergy or Eczema	0.9	2.3	6.9	-0.9	0.7	-2.0	-0.8	-1.3	-0.7	0.6	-1.0	-1.0	0.8	-0.3	0.2	-2.6	-2.4	-1.7	-2.1	-1.8	-1.8	-2.4
Sensitivity / hurt feelings	0.9	1.6	12.3	0.9	0.9	0.4	2.2	0.8	3.5	1.5	0.8	0.7	1.6	0.5	1.0	0.5	-0.8	0.3	1.1	0.6	0.5	0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	5.8	-0.5	-0.6	-1.3	-2.4	-1.3	-0.6	-0.6	-1.2	-1.9	-0.5	-0.4	-0.9	-0.5	-0.4	-0.1	-0.8	-0.0	0.1	-0.5
High blood pressure (mother)	0.9	1.3	3.5	-0.8	1.1	-1.3	0.9	-1.2	0.7	-0.7	-0.3	-1.4	-0.5	-1.1	0.9	-1.1	-1.0	-1.5	-1.0	-1.4	-1.5	-1.9
Alcohol usually taken with meals	0.9	1.4	6.4	0.8	1.5	1.0	2.2	0.9	1.4	-0.3	1.0	2.5	0.5	0.8	1.3	-0.7	-0.2	-0.9	0.3	-1.2	0.6	-1.4
Birth weight of first child	0.9	1.7	4.4	1.9	0.3	1.1	2.1	1.2	1.2	0.8	0.4	0.7	1.5	1.4	0.9	1.0	1.5	0.9	1.5	1.2	2.1	1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	4.1	0.1	0.7	-1.2	-1.7	-1.3	-0.8	-0.2	-0.4	0.6	0.4	-0.1	-0.1	-2.0	-0.2	-1.3	-1.5	-1.3	-1.4	-1.4
Emphysema/chronic bronchitis	0.9	1.0	1.9	0.1	0.8	1.2	-0.0	0.3	-1.2	-1.4	0.1	-1.1	-1.1	0.2	-0.1	1.2	1.3	1.3	1.1	0.7	1.3	1.4
Comparative height size at age 10	0.9	4.7	14.8	3.9	2.1	2.3	2.2	2.7	3.6	0.3	-0.2	0.6	2.1	1.8	0.0	1.6	3.0	1.8	2.3	1.9	2.4	1.6
Supplements: Vitamin C	0.9	1.1	4.3	-2.1	-0.4	-1.1	-1.4	-1.1	-0.6	-1.1	-0.6	-2.0	-1.5	-1.5	-0.7	-0.1	-0.7	-0.3	-0.5	-0.2	-0.3	-0.2
Average weekly red wine intake	0.9	1.4	3.5	1.7	1.1	1.3	1.6	1.2	1.5	0.9	-0.1	0.4	1.7	-0.2	-0.8	1.1	-0.6	-0.5	1.7	0.5	1.9	0.8
Alzheimer’s Disease (in mother)	0.8	0.9	3.3	0.5	0.3	1.8	-0.2	1.1	0.4	0.1	1.0	0.1	-0.3	0.3	0.5	1.5	1.6	0.8	1.1	1.0	0.9	1.5
Ulcerative Colitis (UC)	0.8	1.5	6.3	1.2	0.9	-0.1	0.9	1.1	1.3	2.5	1.5	1.1	1.8	1.3	1.5	0.9	0.1	1.0	0.6	1.3	0.2	0.9
Fasting Glucose	0.8	1.0	4.4	-0.1	0.6	-0.1	-1.9	-0.9	-0.4	-2.0	0.4	-0.4	-2.1	0.3	0.1	-0.5	1.6	0.4	-0.2	-1.1	-0.1	-0.9
Rheumatoid Arthritis	0.8	1.1	3.0	0.2	-0.2	0.8	-1.4	0.6	-0.9	-1.2	-1.3	-0.3	-0.7	-1.4	-1.1	0.9	1.2	1.0	1.3	0.7	1.7	1.1
Leg fat-free mass (left)	0.8	4.0	8.6	2.1	2.9	2.2	-0.2	1.6	2.2	-1.5	-1.8	-1.4	0.4	-1.2	-2.5	2.5	2.9	1.0	2.1	2.4	2.0	2.4
Maternal smoking around birth	0.8	1.1	4.8	1.4	0.1	-0.6	-0.8	-0.4	0.2	0.9	-0.8	-1.0	2.2	-2.2	-1.1	-0.7	-0.5	-1.2	-1.1	0.5	-0.7	-0.0
Multivitamins +/- minerals	0.8	1.0	2.4	-1.4	-0.2	-1.5	-1.5	-1.1	-1.3	-0.9	-0.5	-1.0	-1.2	-1.5	-1.1	-0.5	-0.8	-0.5	-0.8	-0.4	-0.9	-0.6
Forced vital capacity (FVC)	0.8	3.1	15.1	2.5	2.6	2.0	1.3	1.9	2.2	-1.0	0.7	-0.3	0.6	2.4	0.3	0.9	3.9	1.5	1.5	0.7	1.7	0.3
Mouth/teeth dental problems	0.8	1.2	3.3	1.5	1.3	0.4	0.8	0.2	1.5	0.8	1.1	-0.1	1.8	1.8	1.6	-0.7	1.4	0.2	-0.1	0.1	-0.8	-0.9
Trunk fat-free mass	0.8	4.7	10.9	3.3	2.2	3.1	0.6	2.2	2.6	-1.5	-1.8	-0.7	0.9	-0.1	-2.4	2.0	3.0	1.0	2.8	1.8	3.2	2.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	15.3	2.0	2.4	1.7	1.1	1.8	2.0	-1.4	0.7	-0.5	0.3	1.7	0.3	0.8	3.9	1.3	1.5	0.3	1.1	-0.1
Pulse rate	0.8	1.3	3.9	-0.7	-1.3	-1.5	-1.6	-0.7	-2.0	-0.2	-1.6	-0.9	-0.5	-0.8	-1.6	-0.6	-1.2	-0.6	-1.3	-0.2	-1.4	-0.7
Trunk predicted mass	0.8	4.7	10.2	3.2	2.2	3.1	0.6	2.2	2.6	-1.6	-1.8	-0.7	0.9	-0.2	-2.4	2.1	2.9	1.0	2.8	1.8	3.2	2.0
Medication: Amlodipine	0.8	1.1	5.2	-0.5	-0.9	-1.4	-1.4	-0.9	1.2	-0.4	-1.2	0.7	-0.7	-1.8	-2.3	-0.2	-0.9	-1.4	-0.8	0.0	-0.3	-0.3
Body fat percentage	0.8	3.0	18.3	-1.0	0.8	-1.2	-2.5	-0.8	-1.8	-1.2	-1.1	-2.1	-0.8	-4.3	-2.3	0.3	-0.2	-2.0	-1.8	0.3	-1.9	0.9
Arm fat-free mass (right)	0.8	3.9	8.5	2.9	1.9	2.6	0.3	1.9	2.1	-1.7	-1.8	-1.2	0.8	-1.0	-2.6	2.0	2.9	0.5	2.2	1.8	2.2	2.2
Shortness of breath walking on level ground	0.8	1.0	4.9	-0.8	-0.1	-0.4	-0.8	-1.5	-1.0	-1.1	-1.2	-2.2	-0.8	-1.2	-1.1	-0.5	-0.6	-1.3	0.3	-0.7	-0.1	-0.1
Whole body fat-free mass	0.8	4.5	8.8	3.0	2.5	2.8	0.3	2.0	2.5	-1.5	-2.0	-1.1	0.8	-0.6	-2.6	2.2	3.0	0.9	2.5	2.1	2.7	2.3
Leg fat-free mass (right)	0.8	4.3	8.5	2.3	2.9	2.3	-0.0	1.8	2.5	-1.1	-1.7	-1.3	0.6	-0.9	-2.5	2.6	2.9	1.2	2.2	2.6	2.0	2.6
Eye problems/disorders: Cataract	0.8	1.0	7.5	2.7	1.0	0.3	0.5	0.8	1.1	-0.8	-0.7	1.3	0.8	0.6	-0.8	-0.4	1.2	0.1	0.2	-0.1	1.3	-0.2
Osteoarthritis (self-reported)	0.8	1.0	3.5	-0.8	-1.1	-0.8	-1.9	-0.5	-1.6	-0.3	-1.5	-0.2	-0.9	-1.0	-1.6	-0.6	-0.9	-0.6	-0.8	-0.3	-1.0	-0.6
Whole body water mass	0.8	4.6	9.0	2.9	2.5	2.8	0.2	2.0	2.5	-1.6	-2.0	-1.1	0.7	-0.7	-2.7	2.3	3.0	0.9	2.6	2.1	2.7	2.3
Leg predicted mass (right)	0.8	4.2	8.7	2.3	3.0	2.2	-0.1	1.8	2.5	-1.1	-1.7	-1.2	0.6	-0.9	-2.5	2.5	2.9	1.2	2.2	2.6	2.0	2.5
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.7	-1.0	-0.9	-0.7	-1.2	-0.9	-1.3	-1.6	-0.9	-0.6	-1.2	-1.5	-1.9	-0.3	-0.1	-1.2	-0.8	-0.6	0.7	-0.4
High cholesterol (Self-reported)	0.8	1.4	7.6	-2.0	-1.2	-1.1	-1.4	-0.3	-0.6	-0.7	0.1	-1.5	-1.4	-2.8	-0.0	-0.1	-0.4	-1.0	-1.2	-0.5	-1.2	-0.3
Arm predicted mass (left)	0.8	3.8	8.7	3.0	2.0	2.7	0.1	1.8	2.1	-1.6	-2.0	-1.1	0.9	-1.1	-2.8	1.8	2.6	0.4	2.1	1.8	2.5	2.2
Depression (Nagel 2018)	0.7	1.0	2.6	-1.2	-1.1	-1.6	-1.3	-1.0	-0.6	-0.7	-0.8	-0.5	-1.2	-1.0	-0.8	-0.9	-0.6	-0.5	-1.1	-0.9	-1.3	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.9	0.6	1.0	1.6	0.9	1.5	1.1	-0.1	1.6	0.7	-0.1	1.9	1.3	1.6	2.0	1.9	1.5	0.7	1.5	0.9
Prostate Cancer	0.7	1.0	6.8	-0.2	-0.1	-0.4	1.3	-0.7	-0.5	0.1	0.9	1.0	0.2	2.6	1.9	-0.4	0.9	1.5	-0.1	0.4	-0.0	-0.4
Age at First Birth	0.7	1.1	4.1	1.0	0.2	0.5	0.6	1.0	2.0	1.0	0.8	1.1	1.0	1.4	0.3	0.7	1.1	1.1	0.5	1.1	1.3	1.1
HbA1C	0.7	0.8	3.1	0.2	-0.4	-0.5	-1.0	-0.1	-0.8	-0.9	-1.3	1.6	0.1	-1.8	-0.2	-1.0	-0.8	-0.4	0.2	-1.0	1.2	-0.6
Triglycerides	0.7	1.1	4.2	0.3	0.8	1.4	0.7	0.7	0.0	-0.8	1.0	0.5	-0.5	-0.4	1.0	2.0	1.4	1.2	1.7	0.7	1.1	1.7
Smoking Status	0.7	1.7	6.8	-0.9	-2.6	-0.7	-1.9	-1.4	-2.3	-0.2	-1.4	-1.1	0.0	-2.5	-0.9	-0.0	-1.5	-0.9	-0.1	-0.4	-0.4	-0.1
Hand grip strength (left)	0.7	1.8	7.7	2.3	0.7	2.4	0.3	1.7	1.4	-0.2	0.8	0.7	0.7	0.9	-0.2	1.0	2.8	1.3	1.8	0.7	1.3	0.7
Average weekly fortified wine intake	0.7	0.8	2.6	-1.1	0.0	-0.4	0.1	-0.9	0.2	-0.8	-0.9	-1.6	-1.0	-0.6	-0.9	-1.1	-1.0	-1.2	-0.4	-1.1	-0.7	-0.8
Leg predicted mass (left)	0.7	4.0	8.8	2.1	2.8	2.2	-0.3	1.6	2.1	-1.6	-1.9	-1.5	0.4	-1.1	-2.6	2.4	3.0	0.9	2.1	2.3	1.9	2.4
Pain all over the body in last month	0.7	0.8	2.8	0.7	0.6	-0.2	1.0	0.9	0.6	1.1	0.4	-0.5	1.7	-0.9	0.3	0.7	-1.2	-0.6	0.3	0.7	1.6	0.7
Hip circumference	0.7	2.9	13.9	0.2	0.9	-0.0	-2.2	0.0	-0.3	-1.6	-2.3	-2.9	-0.5	-3.7	-3.5	0.8	0.4	-1.4	-0.1	0.7	-0.2	1.5
Medication: Cholesterol lowering	0.7	1.0	4.7	-1.6	-1.8	-1.3	-1.4	-0.8	-0.1	-0.5	-0.9	-0.5	-1.1	-2.2	-1.0	-0.2	-0.4	-0.6	-0.8	0.2	-0.4	0.1
Lung cancer (father)	0.7	0.8	3.0	-0.3	-0.4	-0.5	0.9	-0.9	0.5	-0.0	-0.9	-1.7	0.2	-1.1	-0.6	-0.9	-1.6	-1.4	-0.4	-0.8	0.0	-0.9
Arm fat mass (right)	0.7	2.8	17.3	-0.3	1.0	-0.5	-2.2	-0.4	-0.9	-1.2	-1.8	-2.6	-0.4	-4.2	-3.1	0.4	0.1	-1.8	-1.1	0.6	-1.2	1.0
Chronic bronchitis/emphysema (mother)	0.7	0.9	3.8	0.3	1.1	0.2	1.3	0.4	-0.3	1.9	1.2	0.7	1.3	-0.1	0.8	0.9	0.2	0.4	0.0	1.5	-0.4	1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	11.9	2.6	2.1	2.2	1.0	1.5	2.0	-1.3	-0.2	-0.6	0.5	2.3	-0.7	0.6	3.5	0.9	1.7	0.4	1.8	0.3
Medication: Ibuprofen	0.7	0.8	4.2	-1.3	0.7	-0.5	0.4	-1.0	-0.2	-0.5	-0.7	-1.3	-0.7	-1.5	-0.5	0.3	-2.1	-1.3	0.3	-0.4	-0.5	-0.4
Mean time to correctly identify matches	0.7	1.3	6.3	-1.4	-0.3	-0.0	-1.2	-0.4	-2.0	-2.5	-0.2	-0.4	-2.4	-0.6	-0.8	0.9	0.7	-0.2	1.0	-0.3	1.1	0.7
Arm predicted mass (right)	0.7	3.8	8.4	2.8	1.9	2.7	0.1	1.7	2.2	-1.8	-1.9	-1.1	0.7	-1.0	-2.6	1.9	2.9	0.6	2.2	1.7	2.1	2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	11.1	1.6	1.5	0.6	-0.6	0.6	1.2	-2.4	-0.8	-0.9	-0.5	0.4	-0.8	-0.2	3.3	0.8	0.2	-0.5	0.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.5	-1.2	1.5	0.8	1.0	-0.0	-0.0	1.1	1.6	-0.4	-0.1	-0.4	1.3	1.1	-0.7	-0.6	0.1	0.5	-1.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.3	-1.5	-0.9	-1.4	-0.9	-1.0	-1.2	-0.4	-0.9	-0.6	-1.3	-1.0	-1.4	-0.5	-1.8	-0.3	-1.0	-0.4	-0.4	-0.8
Arm fat mass (left)	0.7	2.9	18.0	-0.3	1.1	-0.3	-2.2	-0.3	-0.8	-1.3	-1.8	-2.5	-0.5	-4.2	-3.1	0.6	0.2	-1.8	-0.9	0.7	-1.2	1.3
Average weekly champagne plus white wine intake	0.7	0.9	3.2	-0.4	1.6	1.0	1.8	0.7	1.3	-0.6	0.8	0.7	-0.6	1.0	1.5	0.6	0.4	0.5	1.7	-0.1	0.4	0.3
Commuting to job workplace: Public transport	0.7	0.8	3.0	1.5	1.4	0.4	0.5	0.8	1.6	0.2	-0.2	0.4	0.1	1.5	-0.0	0.3	0.8	0.8	0.6	0.3	1.7	0.5
Basal metabolic rate	0.7	4.0	7.8	2.6	2.6	2.4	-0.1	1.8	2.1	-1.6	-1.9	-1.4	0.7	-1.3	-2.8	2.2	2.7	0.6	2.1	2.0	2.2	2.3
Arm fat-free mass (left)	0.7	3.5	8.0	2.8	1.9	2.4	0.0	1.7	2.2	-1.5	-2.1	-1.2	0.9	-1.1	-2.8	1.8	2.4	0.3	1.9	1.7	2.2	2.0
Alcohol drinker status: Previous	0.7	0.7	3.7	0.1	-1.3	-1.3	-1.4	-0.5	-0.6	-0.0	-0.8	0.9	-0.1	0.1	-1.9	-0.9	0.3	-0.2	-1.2	-0.1	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.6	0.8	5.4	0.4	-0.2	-0.0	-1.4	0.1	0.5	-0.7	-1.4	0.6	-0.3	-2.3	-1.8	-0.1	0.1	-1.1	-0.4	0.0	-0.5	0.2
Schizophrenia (2014)	0.6	1.3	3.7	-1.0	1.6	-0.5	1.3	-1.7	0.5	0.9	0.3	0.2	0.2	-0.2	1.3	-1.4	-1.9	-1.1	0.0	-1.0	-1.9	-1.4
BMI	0.6	3.3	23.7	-0.2	-0.0	-0.3	-2.9	-0.7	-1.3	-0.8	-1.9	-1.3	0.2	-4.9	-3.4	0.4	-0.5	-1.9	-0.7	0.8	-1.9	1.3
Average weekly spirits intake	0.6	0.8	2.5	-1.3	0.1	-1.5	-1.1	-1.3	0.3	-0.2	-0.8	-1.2	-0.6	-1.6	-0.5	-0.0	-1.0	-0.0	-0.5	-0.2	-1.1	0.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	-1.0	0.0	-0.9	-0.3	-1.3	0.7	-0.7	-1.2	-0.3	-1.1	-0.7	-0.9	-0.4	-1.2	-0.6	-0.8	-0.9	-0.4	-0.8
Trunk fat percentage	0.6	2.3	14.4	-0.8	1.3	-1.0	-1.9	-0.4	-1.2	-1.1	-1.0	-1.9	-0.7	-3.8	-2.0	0.6	0.1	-1.6	-1.4	0.7	-1.6	1.1
Had other major operations	0.6	0.8	4.0	-0.1	-0.1	-1.2	-1.1	-0.9	-2.0	-0.9	-1.0	-0.1	-1.1	0.1	-1.3	-0.4	0.7	-0.1	-1.1	-0.3	-0.4	-0.7
Weight	0.6	2.9	10.6	1.4	1.8	0.9	-1.5	0.9	0.4	-1.7	-2.0	-2.4	0.1	-3.0	-3.3	1.6	1.7	-0.6	0.7	1.5	0.8	2.1
Hair/balding pattern: Pattern 3	0.6	0.9	3.7	0.3	0.9	1.9	0.9	0.3	1.4	0.1	0.3	1.6	0.3	-0.3	0.5	0.8	0.3	1.1	1.4	0.6	1.3	1.0
Number of live births	0.6	0.9	5.3	-1.3	-0.8	-0.9	-0.6	-1.1	-0.7	-0.2	-1.0	-0.5	-0.5	-2.3	-0.7	0.4	-1.9	-0.6	0.5	-0.4	0.2	-0.2
Asthma	0.6	1.3	6.8	-1.0	0.5	-1.6	-0.8	-1.3	-2.6	-0.3	-0.6	-0.2	-0.3	-1.0	-0.5	-1.3	-1.1	-1.1	-1.0	-0.9	-1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.8	-1.1	1.1	0.1	0.3	-0.5	0.2	-0.1	-0.5	-1.7	-0.4	-1.5	-0.7	1.2	-1.4	-0.5	0.8	0.6	-0.1	0.7
Illnesses of mother	0.6	0.7	1.7	0.6	-0.9	0.7	-0.9	0.9	-0.1	0.6	0.0	1.3	0.8	0.4	-0.6	1.0	0.2	0.7	1.0	1.0	1.3	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	11.7	1.7	1.6	1.9	0.5	1.3	1.5	-1.7	0.0	-0.9	-0.1	1.3	-0.7	0.8	3.4	0.8	1.7	0.2	1.3	0.2
Breastfed as a baby	0.6	0.8	3.3	-0.2	0.5	-0.4	-0.2	-0.5	0.2	-0.7	-1.0	-1.2	-0.5	-0.9	0.1	-1.2	-1.8	-0.8	-0.3	-1.4	0.9	-1.3
Hair/balding pattern: Pattern 4	0.6	1.4	6.8	-1.1	-0.4	-1.8	-2.6	-0.7	0.2	0.5	1.2	0.1	-1.0	-0.7	1.7	-0.8	-0.3	0.8	-1.4	-0.9	-2.0	-0.7
Peak expiratory flow (PEF)	0.6	1.4	7.7	1.9	2.8	1.0	1.1	1.4	1.2	-1.0	0.2	-0.1	0.8	0.3	0.0	0.6	2.6	0.2	1.0	0.3	0.7	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	4.3	-0.2	0.5	0.1	-0.4	0.3	0.2	2.1	0.7	0.4	1.2	-0.3	0.2	1.1	-0.8	0.3	0.2	1.2	0.5	1.6
Whole body fat mass	0.6	2.3	14.7	0.1	1.5	-0.2	-1.8	-0.0	-0.5	-1.5	-1.6	-2.1	-0.4	-3.8	-2.6	0.7	0.6	-1.6	-0.7	0.7	-0.9	1.2
Leg fat mass (right)	0.6	2.5	15.7	-0.2	1.0	-0.3	-2.1	-0.6	-1.2	-1.3	-1.6	-2.3	-0.3	-4.0	-2.7	0.3	0.2	-1.9	-1.0	0.4	-1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.6	2.0	-0.6	-1.1	-1.4	-0.9	-1.1	-1.3	0.1	-0.8	-0.8	0.1	-0.5	-0.4	-0.3	-1.4	0.1	-0.7	0.2	-0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.2	0.6	1.1	1.4	0.4	0.8	-0.1	0.1	1.2	0.8	-0.0	1.4	0.4	0.9	1.5	1.0	0.3	0.7	0.2	1.0
Risk taking	0.6	0.8	4.0	-1.3	-0.4	-0.4	0.3	-0.8	-2.0	-0.5	-1.2	-1.1	-0.8	-0.1	-1.2	0.3	-1.7	-0.7	0.7	-0.1	0.2	0.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	0.4	0.8	0.7	0.9	0.5	0.1	1.0	0.1	1.2	1.2	0.4	0.3	0.9	-1.2	0.3	0.9	1.1	0.9	1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.2	-0.8	-0.5	-0.9	-1.4	-0.7	-0.8	0.1	0.2	0.6	-0.7	-0.7	-0.7	-0.8	-0.7	-1.0	-1.2	-0.5	-1.5	-1.1
Schizophrenia (2018)	0.5	1.0	2.8	-0.8	0.9	-0.5	1.1	-1.7	1.0	1.0	0.2	-0.7	0.6	-0.6	0.6	-1.2	-1.6	-1.3	0.0	-1.0	-1.4	-1.1
Reaction Time	0.5	0.9	5.4	-1.1	0.4	0.5	-0.8	-0.5	-1.2	-2.3	-0.1	-0.3	-2.0	-0.4	-0.4	0.6	0.9	-0.3	0.9	-0.5	0.9	0.2
Lupus	0.5	0.8	2.1	0.3	-1.2	-0.9	-0.2	-0.9	-0.1	-1.4	-0.6	-0.6	-0.1	1.3	-0.8	-1.3	0.7	-0.7	-0.8	-0.9	-1.1	-1.2
Blood White Count	0.5	3.4	12.0	-3.5	-1.1	-1.3	-2.2	-2.0	-2.1	-0.8	-1.0	-1.7	-1.7	-2.7	-1.3	-1.0	-2.4	-2.2	-1.6	-1.0	-2.3	-0.7
Vitamin and mineral supplements	0.5	0.7	3.1	1.0	-0.3	1.4	1.2	0.7	1.1	0.5	0.2	1.8	0.9	1.0	1.0	-0.2	0.1	-0.4	0.5	-0.4	0.2	0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.7	0.3	0.9	0.4	0.6	0.8	1.6	0.9	0.9	1.0	0.3	1.2	0.9	0.7	0.0	0.2	0.1	0.5	0.2	0.5
Trunk fat mass	0.5	2.0	11.0	0.3	1.9	0.1	-1.5	0.4	-0.3	-1.4	-1.2	-1.8	-0.3	-3.3	-2.3	1.2	1.0	-1.1	-0.3	1.1	-0.5	1.6
Hearing difficulty/problems with background noise	0.5	0.7	2.4	-0.3	0.6	-0.1	0.8	0.6	-0.6	-0.2	0.8	1.3	0.0	-0.5	0.8	1.5	0.1	0.8	1.6	1.1	0.7	1.5
Had menopause	0.5	0.7	2.2	0.1	-0.6	0.2	0.4	0.5	-0.8	-0.6	-1.0	-0.4	-0.5	-0.6	-0.8	1.1	-0.6	0.9	1.1	1.1	1.5	1.2
Heart attack	0.5	0.7	3.2	0.2	-0.4	-1.3	-1.8	-0.5	0.2	0.7	-0.4	1.1	0.4	-0.7	-1.2	-0.8	0.2	-0.4	-1.3	0.1	-1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.0	-1.4	0.3	-1.4	-0.7	-1.2	-0.8	-0.0	-0.4	-0.6	-0.6	-0.5	0.1	-0.6	-1.1	-0.0	-0.7	-0.6	-1.2	-0.7
Medication: Simvastatin	0.5	0.7	2.2	-1.1	-1.0	0.1	0.2	0.1	-1.0	-1.1	-0.5	-0.9	-1.5	-1.4	-1.1	0.7	0.3	-0.5	-0.1	0.5	-0.4	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	5.4	-0.4	-0.5	-1.7	-2.3	-0.8	-0.4	0.1	-0.2	0.6	-0.4	-0.5	0.4	-1.2	0.3	0.3	-1.8	-0.7	-1.1	-1.3
Had major operations	0.5	0.6	2.3	-1.3	-1.5	-0.2	-0.5	-0.1	-1.4	-0.7	-1.3	0.4	-1.1	-0.7	-0.4	0.3	-0.7	-0.1	0.5	0.2	-0.2	0.2
Mood swings	0.5	0.8	2.0	-0.2	-0.8	-1.2	-1.1	-0.8	1.0	-0.4	-0.7	-0.3	0.1	-1.0	-1.4	-1.4	0.1	-0.9	-1.3	-0.5	-1.1	-1.0
Mother’s age at death	0.5	0.6	3.3	0.3	0.8	0.2	0.8	-0.3	-0.2	-0.7	0.7	1.1	-0.6	1.8	1.5	-0.4	0.1	0.5	0.6	-1.0	0.3	-0.7
Fractured/broken bones in last 5 years	0.5	0.7	2.9	-1.7	-0.4	-0.0	-0.1	-0.3	-1.1	-0.2	-0.4	0.9	-0.9	-1.1	-0.2	-0.4	-1.4	-1.2	-0.4	-0.6	-1.0	-0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.9	-0.2	-0.7	-1.2	-1.7	-0.7	-0.1	0.4	-0.7	0.9	0.1	-0.9	-1.6	-0.8	-0.1	-0.6	-1.2	-0.0	-1.0	0.1
Leg fat mass (left)	0.5	2.1	14.2	-0.0	1.1	-0.1	-1.8	-0.4	-1.1	-1.1	-1.3	-2.2	-0.2	-3.8	-2.5	0.6	0.3	-1.6	-0.8	0.7	-1.1	1.2
Ovarian Cancer	0.4	0.5	2.0	0.2	-1.4	-0.6	-0.2	-0.6	-0.4	0.3	-0.6	-0.1	0.2	-0.4	-0.5	-1.1	-0.7	-0.7	-1.2	-0.6	-0.6	-1.0
Neuroticism (2016)	0.4	0.6	3.3	-0.9	-1.8	-1.3	-0.8	-0.6	0.3	-0.4	-0.1	0.5	-0.3	-0.1	-1.0	-0.3	-0.0	-0.6	-1.2	-0.5	-0.6	-0.4
Blood Platelet Count	0.4	4.8	12.1	-0.8	-0.8	-1.4	-2.4	-2.3	-1.6	-1.6	-3.1	-1.7	-1.0	-3.5	-3.0	-1.9	-3.5	-3.4	-0.8	-2.5	0.4	-1.8
Systolic Blood Pressure	0.4	2.2	8.3	-2.6	-0.4	-1.4	-1.6	-1.6	-1.0	-1.1	-2.1	-1.8	-1.9	-2.9	-1.8	0.7	-1.4	-0.3	-0.1	0.1	-0.1	0.4
Hearing difficulty/problems: Yes	0.4	0.6	3.5	0.1	-0.1	0.4	0.2	0.6	-0.9	-1.2	-0.4	-0.1	-0.2	-1.0	-0.3	1.0	0.3	0.8	1.9	0.6	1.0	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.9	0.5	-0.1	-0.3	-0.3	-0.7	-0.2	-1.1	-1.1	-0.7	-1.0	-1.2	0.1	-0.9	-0.5	-0.1	-0.2	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.3	0.1	-1.0	0.1	0.6	-0.1	-1.1	1.0	0.9	0.6	0.9	0.3	0.0	0.3	-0.6	-1.1	-0.1	0.3	0.5	0.4
Impedance of leg (left)	0.4	1.7	9.2	0.3	0.0	-0.3	2.0	0.1	-0.4	0.5	2.2	2.0	0.4	1.9	3.0	-1.1	-0.2	0.2	-0.6	-1.5	-0.0	-1.6
Nervous feelings	0.4	0.7	3.6	-1.9	-0.6	-1.0	-0.3	-0.4	0.4	0.1	1.1	0.5	-1.2	-0.6	1.0	-0.1	0.1	0.2	-0.5	-0.5	-1.5	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	-0.6	1.5	-0.2	1.3	-0.7	0.9	-1.0	-1.0	-0.1	-0.6	-0.2	-0.7	0.1	-0.0	-0.7	0.0	-0.3	-0.2	0.0
Worrier / anxious feelings	0.4	0.7	2.5	-1.5	-0.6	-0.8	-0.5	-0.5	0.8	-1.2	0.6	-0.8	-1.6	-0.7	0.3	-0.8	0.1	-0.1	-0.2	-1.2	-1.0	-0.9
Length of working week for main job	0.4	0.4	1.5	-0.4	0.3	0.8	1.2	0.3	-0.7	-0.7	0.6	-0.0	-0.8	-0.4	0.7	0.8	-0.1	-0.5	1.0	0.0	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	3.6	-0.8	0.3	-1.9	-0.8	-0.9	-0.3	1.4	0.6	0.4	0.6	-0.8	0.1	-0.2	-0.5	0.1	-1.2	0.3	-1.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.1	1.2	0.4	0.5	0.7	0.8	-0.1	0.2	0.9	1.1	1.0	1.8	0.8	-0.5	0.5	0.1	-0.0	-0.7	-0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.8	-0.9	-0.4	-0.4	-0.8	-0.2	-1.4	0.1	-0.5	-0.9	0.0	-1.1	-1.0	0.1	-0.8	-0.4	-0.6	0.4	-0.5	0.9
Family relationship satisfaction	0.4	0.5	2.1	0.2	-0.6	0.0	0.9	0.3	0.8	1.2	1.4	1.2	0.9	-0.0	0.8	0.4	-0.5	-0.6	-0.0	0.4	-0.2	0.4
Ever had bowel cancer screening	0.4	0.4	1.9	-0.5	-0.2	0.7	0.7	0.3	-1.4	-0.3	0.2	-0.4	-0.2	0.6	-0.0	0.8	-0.2	0.5	1.1	0.7	1.0	0.9
Friendships satisfaction	0.4	0.5	1.7	-0.6	-1.3	-0.7	-0.7	-0.5	0.1	-0.9	-0.2	-0.9	-0.5	-0.9	-0.2	-0.7	-0.5	-1.3	-0.2	-0.9	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	2.9	0.6	-1.1	0.7	-0.7	1.1	-0.2	-0.1	-0.1	-0.5	0.4	0.9	-0.3	0.6	1.7	1.4	1.0	1.0	1.2	0.6
Hearing aid user	0.4	0.5	3.0	0.9	-0.0	0.1	0.5	0.6	-1.7	0.8	-0.1	-0.7	1.2	0.2	-0.1	0.3	-0.4	0.0	0.2	0.8	0.2	1.0
Alcohol drinker status: Never	0.4	0.5	3.9	0.6	-0.1	0.6	0.8	0.4	0.7	0.3	0.6	2.0	0.6	1.4	0.1	-0.4	0.3	-0.1	0.0	-0.2	-0.4	0.0
Irritability	0.4	0.7	4.4	0.4	0.2	-0.1	0.4	0.3	-0.0	0.0	0.3	-0.8	-0.0	0.9	0.2	1.1	2.1	1.9	0.2	1.2	0.4	1.1
Neuroticism (Nagel 2018)	0.3	0.7	2.6	-1.4	-1.4	-1.6	-0.8	-0.7	0.3	-0.7	-0.7	0.1	-0.7	-0.7	-0.3	-0.8	0.0	-0.1	-1.2	-0.6	-1.0	-0.8
Breast Cancer	0.3	0.7	3.5	-1.0	-0.8	-0.6	-0.9	-1.0	-1.2	-1.1	0.1	-1.9	-1.1	0.4	-0.8	-0.3	0.6	-0.3	-0.2	-0.5	-0.9	-0.8
LDL Cholesterol	0.3	0.5	2.0	0.8	0.0	-0.7	-1.0	-0.2	0.3	0.6	-0.7	0.2	0.3	-1.4	-1.4	0.4	-0.8	-0.7	-0.6	0.3	-0.3	0.4
Blood Eosinophil Count	0.3	2.0	5.9	-1.4	-0.2	-1.5	0.4	-1.6	1.0	0.9	-0.7	0.6	0.7	-1.0	0.1	-2.2	-2.4	-2.3	-1.7	-1.6	-1.6	-1.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.9	-0.8	0.5	-0.6	-0.4	-0.2	0.5	1.0	0.4	-1.7	0.1	-0.9	-0.2	0.4	-1.1	0.1	-0.1	0.5	-0.8	0.1
Angina	0.3	0.3	1.8	-0.2	-0.4	-0.0	0.3	0.0	-0.2	0.9	-0.3	0.5	0.4	-0.5	-0.8	0.5	0.3	0.3	-0.3	1.3	-0.1	1.2
Impedance of leg (right)	0.3	1.7	8.5	-0.1	-0.2	-0.6	1.6	-0.2	-0.8	-0.0	1.8	1.6	0.0	1.6	2.9	-1.5	-0.3	-0.1	-0.7	-2.0	-0.0	-2.1
Age when periods started (menarche)	0.3	0.7	2.8	-1.3	-0.3	-0.3	0.3	-0.5	-0.1	0.1	0.2	-0.6	-0.8	-0.3	1.4	-0.9	-1.7	-1.0	-0.1	-1.5	-0.5	-1.3
Impedance of arm (right)	0.3	1.6	7.4	-0.0	1.3	-0.7	1.9	0.4	0.5	0.7	1.8	1.9	0.1	2.5	2.7	-0.2	0.2	0.8	-0.1	-0.6	0.6	-1.1
Alcohol intake versus 10 years previously	0.3	0.5	3.0	-0.3	-1.7	-0.6	-0.5	-0.3	-1.5	0.2	0.4	-0.4	-0.3	1.0	0.2	-0.1	0.4	0.6	-0.8	0.1	-0.3	-0.0
Depression (self-reported)	0.3	0.4	2.5	-0.0	1.6	-0.4	-0.8	-0.4	0.5	0.6	-0.2	-0.0	0.1	-1.1	-0.2	-0.1	-0.3	0.7	-0.2	0.6	-0.6	0.1
Pulse wave reflection index	0.3	0.4	1.2	0.4	0.1	-0.5	-0.7	-0.3	1.0	-0.7	-0.6	1.1	-0.3	-1.0	-0.4	-0.6	-0.3	-0.5	-0.1	-0.8	0.3	-0.3
Glaucoma (self-reported)	0.3	0.3	1.1	-0.2	-0.6	-0.6	-0.5	-0.7	1.1	0.1	-0.2	0.2	-0.3	0.1	-0.1	-0.9	-0.1	-0.4	-0.8	-0.6	-0.9	-0.7
Comparative body size at age 10	0.3	0.8	6.0	0.6	0.0	-0.3	-1.4	0.5	-0.2	-0.3	-0.0	-0.6	0.4	-2.5	-1.3	0.1	0.7	-1.1	-0.9	-0.1	-1.0	0.1
Eye problems/disorders: None of the above	0.3	0.3	2.7	-1.6	-0.4	-0.1	-0.2	-0.3	-0.1	0.5	0.5	0.3	-0.1	-0.7	0.5	0.5	-0.9	-0.4	0.1	0.2	-0.5	0.3
Medication: Blood pressure	0.3	0.5	2.2	-0.6	0.6	-0.7	-0.5	-0.7	0.5	-0.1	-1.1	-0.7	-0.7	-1.5	-1.1	0.5	-0.6	0.0	-0.1	0.8	0.3	0.8
Angina (self-reported)	0.3	0.3	1.7	-0.3	-0.3	-0.0	0.4	-0.0	0.2	1.0	-0.2	0.5	0.4	-0.5	-0.8	0.5	0.3	0.3	-0.4	1.3	-0.3	1.1
Heart disease (mother)	0.3	0.4	1.3	-0.4	0.4	0.3	1.2	-0.2	-0.6	-0.4	-0.3	-0.9	-0.7	-0.2	-0.3	1.0	-0.3	0.8	0.5	0.8	0.6	0.5
Suffer from ‘nerves’	0.3	0.5	2.9	-0.7	-0.1	-0.3	0.2	0.2	0.6	0.7	1.7	-0.8	0.5	-0.2	1.7	0.0	0.5	0.3	-0.6	0.2	-1.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.1	0.2	-0.4	-0.2	-1.5	-0.4	-1.1	0.2	0.1	-1.2	0.2	-1.4	-0.3	0.3	-0.3	0.1	0.1	0.2	0.4	0.5
Illnesses of father: Heart disease	0.3	0.5	1.4	-0.8	0.8	-0.6	-0.5	0.4	1.2	-0.9	-0.1	0.3	-0.8	-1.1	0.0	-0.0	0.9	1.1	0.5	0.0	0.8	-0.1
Miserableness	0.3	0.5	2.4	0.2	0.8	0.1	-0.4	0.9	0.0	0.4	1.2	0.5	0.6	-0.5	0.1	0.9	1.6	1.0	0.4	1.1	-0.1	0.7
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.9	0.7	1.1	0.1	0.2	-0.1	-0.1	0.5	-0.8	-0.2	0.4	0.1	0.4	1.0	0.6	0.6	0.2	0.7	0.5
Financial situation satisfaction	0.3	0.4	1.3	-0.1	-0.2	-0.6	-0.5	-0.2	-0.5	1.1	0.0	0.0	0.9	-0.7	-0.2	-0.1	-1.1	-0.7	-0.9	0.5	-1.0	-0.0
Eye problems/disorders: Glaucoma	0.3	0.4	2.8	0.6	-0.5	-0.3	-0.3	0.1	1.7	0.9	0.3	0.3	0.3	1.0	0.0	-0.5	0.5	0.5	-0.8	0.1	-0.5	-0.4
Ever smoked	0.3	0.6	1.8	0.7	0.1	0.5	-0.0	-0.2	-1.1	0.9	0.2	-0.8	1.4	0.0	0.2	0.9	0.4	0.7	1.0	1.0	1.1	1.0
Average weekly beer plus cider intake	0.3	0.4	1.8	-0.1	-0.1	0.1	-0.2	0.9	-0.9	1.0	0.4	-0.2	0.8	-0.2	-0.5	1.0	0.2	-0.1	0.3	1.0	0.5	1.3
Supplements: Calcium	0.3	0.3	1.0	0.9	-0.5	0.2	0.2	-0.1	0.7	0.7	0.1	0.4	0.8	0.7	0.5	-0.0	-1.0	-0.4	0.2	0.3	0.8	0.4
Impedance of whole body	0.3	1.8	9.0	-0.1	0.8	-0.8	1.8	-0.0	0.3	0.2	2.0	2.0	-0.1	2.4	3.0	-0.9	0.1	0.4	-0.8	-1.4	-0.2	-1.7
Bipolar Disorder (2018)	0.2	0.3	1.5	-0.7	-0.2	0.3	0.6	0.0	-1.2	-0.5	0.5	0.6	-0.6	0.4	0.1	0.8	0.1	0.4	0.0	0.6	-0.5	0.9
Bipolar Disorder or Schizophrenia	0.2	0.5	1.8	-1.1	0.8	-0.2	1.3	-1.3	0.0	0.5	0.5	-0.1	0.2	-0.2	0.6	-0.4	-1.2	-0.8	0.0	-0.3	-1.3	-0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.5	-0.6	-0.7	-0.5	-0.9	-0.1	-0.7	-0.8	-1.2	0.2	-0.4	-0.5	-1.2	-0.7	0.4	-0.1	-0.6	-0.3	-0.6	-0.6
Irritable Bowel Disease (IBD)	0.2	0.6	2.0	0.7	1.2	-0.4	-0.0	0.2	1.3	1.4	0.8	0.1	0.6	0.2	0.9	0.9	0.6	0.8	0.3	0.8	0.1	0.8
Chronotype (morning person)	0.2	0.5	3.4	-0.3	0.8	-0.4	0.8	-0.9	0.4	0.1	-0.0	-0.9	-0.0	-0.4	-0.1	-0.8	-0.3	-1.0	-0.8	-0.8	-1.8	-0.7
Relative age of first facial hair	0.2	0.4	1.4	-0.5	-0.9	-0.4	0.3	-0.9	-0.9	-0.3	-0.8	-1.2	-0.0	0.6	-0.6	-0.7	0.1	-1.2	-0.3	-0.5	0.0	-0.5
Medication for hormone replacement therapy	0.2	0.2	1.1	-0.9	-0.0	-0.6	0.4	-0.2	-1.1	-0.1	0.3	0.7	-0.1	-0.1	0.3	0.0	-0.7	-0.6	0.1	-0.0	-0.3	0.2
Severe depression (siblings)	0.2	0.2	1.2	-0.2	-0.0	-0.2	-1.1	-0.1	-0.6	-0.0	-0.6	-0.2	0.2	-0.4	-0.1	0.2	0.1	0.5	0.5	0.2	0.9	0.1
Relative age voice broke	0.2	0.3	1.0	-0.4	-0.3	-0.1	0.4	-1.0	-0.4	-0.8	-0.3	0.4	-0.4	0.3	0.5	-0.6	0.5	-0.7	-0.4	-0.9	-0.5	-0.9
Medication: Ramipril	0.2	0.3	2.0	-0.7	-0.1	0.0	0.1	0.0	0.1	-0.6	0.4	-0.2	-0.9	-0.1	1.4	0.2	1.0	0.6	-0.1	0.0	-0.4	-0.5
Happiness	0.2	0.2	1.4	-1.2	-0.5	-0.5	-0.3	-0.6	-0.1	-0.9	0.3	0.3	-0.8	-0.7	-0.0	0.0	-0.1	-0.4	0.3	-0.0	-0.1	-0.0
Impedance of arm (left)	0.2	1.1	4.8	-0.7	0.9	-1.3	1.1	-0.3	0.3	-0.1	1.3	1.4	-0.6	1.8	2.2	-0.6	0.0	0.2	-0.7	-1.1	-0.3	-1.3
Blood clot in the leg (DVT)	0.2	0.2	1.0	-0.3	-0.0	-0.3	-1.0	-0.2	-0.2	0.4	0.4	0.7	-0.3	-0.3	-0.5	-0.2	-0.6	-0.6	-0.6	-0.0	-0.8	-0.5
Number of children fathered	0.2	0.2	1.4	0.8	-0.3	0.3	-0.1	0.0	-0.5	0.5	-0.0	-1.0	1.2	0.4	0.1	-0.3	-0.1	-0.6	-0.1	-0.1	-0.3	0.2
Pulse rate, automated reading	0.2	0.6	2.0	0.6	-0.5	-0.9	-0.8	0.2	-0.8	1.4	-0.5	0.1	1.3	-0.0	-1.4	0.4	-0.6	0.4	-0.4	1.4	-0.5	0.7
Loneliness, isolation	0.2	0.2	1.4	-0.2	-0.1	-0.3	-0.3	0.1	-0.4	-0.2	-0.3	0.2	-0.3	0.5	-0.4	-0.6	0.0	-0.4	-0.5	-0.5	-1.2	-0.8
Guilty feelings	0.2	0.3	1.3	-0.5	0.3	-0.7	0.2	0.2	0.8	0.0	-0.1	-0.4	-0.1	-1.0	-0.2	1.2	-0.2	0.4	0.7	1.0	0.1	0.9
Medication: Bendroflumethiazide	0.2	0.3	1.5	-0.5	1.2	0.9	0.4	-0.0	0.5	-0.7	-0.0	-0.2	-1.0	0.2	0.3	0.6	0.7	-0.5	-0.4	0.1	-0.0	0.2
Number of operations (self-reported)	0.2	0.4	1.5	-0.4	-0.3	-0.1	-0.7	0.3	-0.7	-0.2	-0.2	-0.6	-0.6	-1.2	-0.3	1.2	0.2	0.0	0.6	0.8	0.6	0.8
Crohns Disease (2017)	0.1	0.3	1.2	-0.3	0.6	-0.7	-0.9	-0.6	0.0	-0.5	-0.3	-0.5	-1.0	-0.8	-0.1	0.4	1.1	0.5	0.2	-0.2	-0.0	0.1
Crohns Disease (2012)	0.1	0.1	0.5	-0.4	0.2	-0.5	-0.1	-0.6	-0.2	0.1	-0.1	-0.6	-0.1	-0.7	-0.0	0.1	-0.1	-0.4	0.2	-0.3	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.8	0.4	-0.3	0.0	-0.7	-0.1	-0.5
Lung FVC	0.1	0.6	2.4	0.6	-1.0	-0.1	-1.6	-0.1	-0.6	0.5	-0.0	-1.4	0.2	0.4	-1.1	0.2	1.0	0.8	-0.4	0.8	0.6	0.5
Hair Pigment	0.1	2.1	8.4	-0.9	-0.3	-0.3	0.6	-0.7	0.4	-1.8	-1.9	-0.9	-0.7	-2.9	-1.9	-1.1	-1.9	-2.9	-0.5	-1.3	-1.4	-0.7
Fed-up feelings	0.1	0.1	0.7	-0.0	-0.4	0.1	-0.3	0.1	-0.5	0.1	-0.0	0.2	0.3	-0.1	-0.2	-0.4	-0.0	-0.5	-0.6	-0.2	-0.8	-0.5
Neuroticism score	0.1	0.3	1.0	-0.9	-0.1	-0.9	-0.3	-0.1	1.0	0.3	0.6	0.0	-0.1	-0.9	0.0	0.2	0.3	0.2	-0.3	0.3	-1.0	0.1
Number of full sisters	0.1	0.2	1.6	-0.2	0.1	-0.3	0.1	-0.3	-0.1	-0.2	-0.1	1.3	-0.4	0.5	-0.7	0.1	0.3	-0.1	-0.4	0.2	-0.2	-0.0
Schizophrenia vs Biploar Disorder	0.0	0.1	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.1	0.8	-0.1	0.4	0.4	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.2	1.1	-0.3	-1.1	0.6	-0.5	0.5	-0.2	-0.6	0.0	0.4	0.1	-0.4	0.1	0.0	0.6	-0.3	0.4	-0.4	-0.4	-0.3
Tanning	0.0	0.5	2.0	-0.7	-0.7	0.4	1.4	-0.3	-1.2	0.8	-1.0	0.2	0.7	0.7	0.3	-0.2	-1.4	-0.0	0.5	0.2	0.2	0.1

Hub : Genes

RGS11

Models

Trait associations