Best TWAS P=8.89e-11 · Best GWAS P=1.84e-13 conditioned to 8.34e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | LRRC29 | 0.53 | 0.02 | enet | 20 | 0.12 | 3.2e-04 | -7.2 | -6.5 | 8.9e-11 | 0.70 | 0.05 | 0.51 | TRUE |
| 2 | GTEx | Pancreas | TPPP3 | 0.24 | 0.01 | lasso | 4 | 0.00 | 2.0e-01 | -6.5 | -6.4 | 2.1e-10 | 0.92 | 0.07 | 0.17 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | E2F4 | 0.11 | 0.01 | blup | 34 | 0.02 | 3.2e-03 | -7.2 | 6.0 | 2.3e-09 | -0.83 | 0.00 | 0.92 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FBXL8 | 0.04 | 0.01 | enet | 8 | 0.02 | 6.7e-03 | -6.6 | 5.7 | 1.3e-08 | -0.87 | 0.00 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC9A5 | 0.01 | 0.00 | blup | 30 | 0.01 | 1.1e-02 | -3.3 | -5.5 | 4.0e-08 | 0.83 | 0.02 | 0.43 | FALSE |
| 4 | YFS | Blood | NAE1 | 0.04 | 0.03 | bslmm | 343 | 0.04 | 1.2e-11 | 3.3 | -5.4 | 6.3e-08 | 0.29 | 1.00 | 0.00 | FALSE |
| 3 | YFS | Blood | DYNC1LI2 | 0.03 | 0.02 | blup | 352 | 0.02 | 4.5e-07 | 3.8 | -5.4 | 6.7e-08 | 0.25 | 1.00 | 0.00 | FALSE |