[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr15:90,208,219-91,886,448

Best TWAS P=4.99e-10 · Best GWAS P=1.05e-09 conditioned to 0.324

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IQGAP1	0.15	0.09	lasso	4	0.12	1.9e-06	-5.9	-6.2	5.0e-10	0.92	0.02	0.98	TRUE
2	GTEx	Esophagus Gastroesophageal Junction	ZNF774	0.16	0.16	lasso	2	0.11	7.8e-05	-6.1	-6.1	1.1e-09	0.96	0.02	0.96	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF774	0.06	0.06	lasso	3	0.04	1.2e-05	-6.1	6.0	1.6e-09	-0.93	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF774	0.04	0.00	enet	7	0.01	5.1e-02	-6.1	-5.9	3.0e-09	0.79	0.01	0.90	FALSE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQGAP1	0.12	0.07	lasso	4	0.07	1.4e-05	-6.0	-5.9	3.8e-09	0.96	0.02	0.98	FALSE
6	GTEx	Skin Sun Exposed Lower leg	CRTC3	0.10	0.08	lasso	3	0.05	7.5e-05	-5.9	5.8	5.0e-09	-0.96	0.02	0.98	FALSE
9	METSIM	Adipose	IQGAP1	0.11	0.08	enet	32	0.12	3.9e-17	-6.0	-5.8	5.4e-09	0.89	0.02	0.98	FALSE
1	GTEx	Artery Aorta	ZNF774	0.22	0.24	enet	16	0.23	7.6e-13	-5.9	-5.8	8.4e-09	0.87	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQGAP1	0.04	0.03	lasso	4	0.02	6.5e-03	-6.0	-5.8	8.4e-09	0.95	0.02	0.88	FALSE
4	GTEx	Esophagus Muscularis	ZNF774	0.18	0.19	lasso	5	0.18	4.1e-11	-5.8	5.7	9.2e-09	-0.88	0.06	0.94	FALSE
10	NTR	Blood	IQGAP1	0.03	0.04	enet	10	0.04	1.5e-12	-6.0	-5.6	1.8e-08	0.93	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQGAP1	0.11	0.03	enet	8	0.06	1.4e-06	-5.3	-5.6	1.8e-08	0.78	0.05	0.95	FALSE
11	YFS	Blood	IQGAP1	0.18	0.17	enet	46	0.20	5.8e-65	-4.8	-5.6	2.1e-08	0.84	0.90	0.10	FALSE
3	GTEx	Esophagus Mucosa	CRTC3	0.08	0.07	enet	7	0.04	6.1e-04	-5.5	5.5	3.2e-08	-0.93	0.05	0.95	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	IQGAP1	0.06	0.04	blup	95	0.08	3.0e-08	-5.0	-5.4	5.3e-08	0.83	0.03	0.97	FALSE
5	GTEx	Lung	ZNF774	0.06	0.09	enet	6	0.03	1.5e-03	-6.1	-5.4	6.2e-08	0.89	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF774	0.04	0.02	blup	57	0.02	1.2e-03	-4.4	5.4	8.5e-08	-0.76	0.02	0.86	FALSE
7	GTEx	Stomach	IQGAP1	0.21	0.14	enet	17	0.18	8.3e-09	-5.0	-5.3	9.6e-08	0.85	0.08	0.92	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	IQGAP1	0.06	0.04	blup	94	0.03	5.8e-05	-5.7	-5.3	1.4e-07	0.90	0.04	0.96	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQGAP1	0.03	0.02	blup	94	0.02	6.5e-05	-4.9	-5.2	1.7e-07	0.80	0.10	0.88	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQGAP1	0.07	0.06	blup	94	0.07	9.5e-09	-6.1	-5.2	2.1e-07	0.85	0.01	0.99	FALSE
8	GTEx	Testis	ZNF774	0.13	0.09	lasso	4	0.08	1.5e-04	-5.0	5.2	2.6e-07	-0.77	0.24	0.46	FALSE