[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) :

chr15:90,208,219-91,886,448

Best TWAS P=4.99e-10 · Best GWAS P=1.05e-09 conditioned to 0.324

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta ZNF774 0.22 0.24 enet 16 0.23 7.6e-13 -5.9 -5.8 8.4e-09 0.87 0.05 0.95 FALSE
2 GTEx Esophagus Gastroesophageal Junction ZNF774 0.16 0.16 lasso 2 0.11 7.8e-05 -6.1 -6.1 1.1e-09 0.96 0.02 0.96 FALSE
3 GTEx Esophagus Mucosa CRTC3 0.08 0.07 enet 7 0.04 6.1e-04 -5.5 5.5 3.2e-08 -0.93 0.05 0.95 FALSE
4 GTEx Esophagus Muscularis ZNF774 0.18 0.19 lasso 5 0.18 4.1e-11 -5.8 5.7 9.2e-09 -0.88 0.06 0.94 FALSE
5 GTEx Lung ZNF774 0.06 0.09 enet 6 0.03 1.5e-03 -6.1 -5.4 6.2e-08 0.89 0.01 0.99 FALSE
6 GTEx Skin Sun Exposed Lower leg CRTC3 0.10 0.08 lasso 3 0.05 7.5e-05 -5.9 5.8 5.0e-09 -0.96 0.02 0.98 FALSE
7 GTEx Stomach IQGAP1 0.21 0.14 enet 17 0.18 8.3e-09 -5.0 -5.3 9.6e-08 0.85 0.08 0.92 FALSE
8 GTEx Testis ZNF774 0.13 0.09 lasso 4 0.08 1.5e-04 -5.0 5.2 2.6e-07 -0.77 0.24 0.46 FALSE
9 METSIM Adipose IQGAP1 0.11 0.08 enet 32 0.12 3.9e-17 -6.0 -5.8 5.4e-09 0.89 0.02 0.98 FALSE
10 NTR Blood IQGAP1 0.03 0.04 enet 10 0.04 1.5e-12 -6.0 -5.6 1.8e-08 0.93 0.02 0.98 FALSE
11 YFS Blood IQGAP1 0.18 0.17 enet 46 0.20 5.8e-65 -4.8 -5.6 2.1e-08 0.84 0.90 0.10 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma IQGAP1 0.04 0.03 lasso 4 0.02 6.5e-03 -6.0 -5.8 8.4e-09 0.95 0.02 0.88 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma IQGAP1 0.03 0.02 blup 94 0.02 6.5e-05 -4.9 -5.2 1.7e-07 0.80 0.10 0.88 FALSE
14 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma IQGAP1 0.15 0.09 lasso 4 0.12 1.9e-06 -5.9 -6.2 5.0e-10 0.92 0.02 0.98 TRUE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNF774 0.04 0.02 blup 57 0.02 1.2e-03 -4.4 5.4 8.5e-08 -0.76 0.02 0.86 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IQGAP1 0.07 0.06 blup 94 0.07 9.5e-09 -6.1 -5.2 2.1e-07 0.85 0.01 0.99 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF774 0.04 0.00 enet 7 0.01 5.1e-02 -6.1 -5.9 3.0e-09 0.79 0.01 0.90 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF774 0.06 0.06 lasso 3 0.04 1.2e-05 -6.1 6.0 1.6e-09 -0.93 0.00 1.00 FALSE
19 The Cancer Genome Atlas Lung Adenocarcinoma IQGAP1 0.06 0.04 blup 94 0.03 5.8e-05 -5.7 -5.3 1.4e-07 0.90 0.04 0.96 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma IQGAP1 0.11 0.03 enet 8 0.06 1.4e-06 -5.3 -5.6 1.8e-08 0.78 0.05 0.95 FALSE
21 The Cancer Genome Atlas Stomach Adenocarcinoma IQGAP1 0.12 0.07 lasso 4 0.07 1.4e-05 -6.0 -5.9 3.8e-09 0.96 0.02 0.98 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma IQGAP1 0.06 0.04 blup 95 0.08 3.0e-08 -5.0 -5.4 5.3e-08 0.83 0.03 0.97 FALSE