Best TWAS P=4.99e-10 · Best GWAS P=1.05e-09 conditioned to 0.324
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZNF774 | 0.22 | 0.24 | enet | 16 | 0.23 | 7.6e-13 | -5.9 | -5.8 | 8.4e-09 | 0.87 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ZNF774 | 0.16 | 0.16 | lasso | 2 | 0.11 | 7.8e-05 | -6.1 | -6.1 | 1.1e-09 | 0.96 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Esophagus Mucosa | CRTC3 | 0.08 | 0.07 | enet | 7 | 0.04 | 6.1e-04 | -5.5 | 5.5 | 3.2e-08 | -0.93 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ZNF774 | 0.18 | 0.19 | lasso | 5 | 0.18 | 4.1e-11 | -5.8 | 5.7 | 9.2e-09 | -0.88 | 0.06 | 0.94 | FALSE |
| 5 | GTEx | Lung | ZNF774 | 0.06 | 0.09 | enet | 6 | 0.03 | 1.5e-03 | -6.1 | -5.4 | 6.2e-08 | 0.89 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | CRTC3 | 0.10 | 0.08 | lasso | 3 | 0.05 | 7.5e-05 | -5.9 | 5.8 | 5.0e-09 | -0.96 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Stomach | IQGAP1 | 0.21 | 0.14 | enet | 17 | 0.18 | 8.3e-09 | -5.0 | -5.3 | 9.6e-08 | 0.85 | 0.08 | 0.92 | FALSE |
| 8 | GTEx | Testis | ZNF774 | 0.13 | 0.09 | lasso | 4 | 0.08 | 1.5e-04 | -5.0 | 5.2 | 2.6e-07 | -0.77 | 0.24 | 0.46 | FALSE |
| 9 | METSIM | Adipose | IQGAP1 | 0.11 | 0.08 | enet | 32 | 0.12 | 3.9e-17 | -6.0 | -5.8 | 5.4e-09 | 0.89 | 0.02 | 0.98 | FALSE |
| 10 | NTR | Blood | IQGAP1 | 0.03 | 0.04 | enet | 10 | 0.04 | 1.5e-12 | -6.0 | -5.6 | 1.8e-08 | 0.93 | 0.02 | 0.98 | FALSE |
| 11 | YFS | Blood | IQGAP1 | 0.18 | 0.17 | enet | 46 | 0.20 | 5.8e-65 | -4.8 | -5.6 | 2.1e-08 | 0.84 | 0.90 | 0.10 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQGAP1 | 0.04 | 0.03 | lasso | 4 | 0.02 | 6.5e-03 | -6.0 | -5.8 | 8.4e-09 | 0.95 | 0.02 | 0.88 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQGAP1 | 0.03 | 0.02 | blup | 94 | 0.02 | 6.5e-05 | -4.9 | -5.2 | 1.7e-07 | 0.80 | 0.10 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IQGAP1 | 0.15 | 0.09 | lasso | 4 | 0.12 | 1.9e-06 | -5.9 | -6.2 | 5.0e-10 | 0.92 | 0.02 | 0.98 | TRUE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF774 | 0.04 | 0.02 | blup | 57 | 0.02 | 1.2e-03 | -4.4 | 5.4 | 8.5e-08 | -0.76 | 0.02 | 0.86 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IQGAP1 | 0.07 | 0.06 | blup | 94 | 0.07 | 9.5e-09 | -6.1 | -5.2 | 2.1e-07 | 0.85 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF774 | 0.04 | 0.00 | enet | 7 | 0.01 | 5.1e-02 | -6.1 | -5.9 | 3.0e-09 | 0.79 | 0.01 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF774 | 0.06 | 0.06 | lasso | 3 | 0.04 | 1.2e-05 | -6.1 | 6.0 | 1.6e-09 | -0.93 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | IQGAP1 | 0.06 | 0.04 | blup | 94 | 0.03 | 5.8e-05 | -5.7 | -5.3 | 1.4e-07 | 0.90 | 0.04 | 0.96 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IQGAP1 | 0.11 | 0.03 | enet | 8 | 0.06 | 1.4e-06 | -5.3 | -5.6 | 1.8e-08 | 0.78 | 0.05 | 0.95 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IQGAP1 | 0.12 | 0.07 | lasso | 4 | 0.07 | 1.4e-05 | -6.0 | -5.9 | 3.8e-09 | 0.96 | 0.02 | 0.98 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | IQGAP1 | 0.06 | 0.04 | blup | 95 | 0.08 | 3.0e-08 | -5.0 | -5.4 | 5.3e-08 | 0.83 | 0.03 | 0.97 | FALSE |