TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Heel bone mineral density (BMD) T-score, automated (left)
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chr17:1,263,564-2,899,908
Best TWAS P=9.35e-20 · Best GWAS P=3.03e-25 conditioned to 0.007
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
2.8M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
SMG6
0.03
0.01
blup
144
0.01
4.8e-03
6.6
9.1
9.3e-20
-0.67
0.10
0.58
TRUE
1
GTEx
Brain Cerebellum
SMG6
0.24
0.03
enet
16
0.05
1.3e-02
1.2
5.5
3.0e-08
-0.51
0.04
0.63
TRUE
3
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
SMG6
0.08
0.05
blup
144
0.07
1.3e-04
7.0
8.3
9.5e-17
-0.71
0.35
0.45
FALSE
4
The Cancer Genome Atlas
Testicular Germ Cell Tumors
SRR
0.35
0.07
enet
11
0.14
1.1e-05
1.5
-5.5
5.0e-08
0.65
0.02
0.93
FALSE