[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr17:41,393,295-43,332,365

Best TWAS P=5.92e-17 · Best GWAS P=2.43e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Esophagus Mucosa	HDAC5	0.06	0.05	lasso	3	0.02	9.2e-03	8.47	-8.4	5.9e-17	-0.99	0.01	0.97	TRUE
22	GTEx	Pituitary	ASB16-AS1	0.19	0.17	lasso	4	0.22	3.8e-06	7.59	-8.3	8.1e-17	-0.91	0.06	0.86	FALSE
2	GTEx	Adipose Subcutaneous	ASB16-AS1	0.12	0.05	enet	16	0.05	3.7e-05	7.27	-7.8	5.8e-15	-0.64	0.21	0.47	FALSE
3	GTEx	Adipose Visceral Omentum	ASB16-AS1	0.14	0.12	lasso	5	0.10	9.8e-06	7.28	-7.4	1.1e-13	-0.78	0.07	0.92	FALSE
25	GTEx	Skin Sun Exposed Lower leg	ASB16-AS1	0.13	0.09	lasso	5	0.07	2.7e-06	7.29	-7.4	1.2e-13	-0.82	0.56	0.44	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	ASB16	0.05	0.06	blup	40	0.05	4.6e-04	6.95	-7.4	1.3e-13	-0.80	0.02	0.94	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C17orf65	0.04	0.03	blup	39	0.03	2.7e-03	7.19	-7.4	1.8e-13	-0.78	0.02	0.84	FALSE
48	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C17orf65	0.09	0.09	enet	8	0.08	2.9e-04	7.07	-7.3	2.3e-13	-0.79	0.02	0.95	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf65	0.03	0.03	lasso	7	0.03	3.8e-04	7.23	-7.3	2.6e-13	-0.79	0.02	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C17orf65	0.07	0.06	enet	15	0.07	4.5e-09	7.21	-7.3	2.7e-13	-0.74	0.84	0.16	FALSE
20	GTEx	Nerve Tibial	ASB16	0.12	0.07	lasso	5	0.07	7.5e-06	7.21	-7.3	2.7e-13	-0.79	0.86	0.13	FALSE
28	GTEx	Thyroid	ASB16-AS1	0.14	0.06	lasso	2	0.04	5.4e-04	7.22	-7.3	2.8e-13	-0.79	0.12	0.80	FALSE
14	GTEx	Esophagus Mucosa	ASB16	0.10	0.10	lasso	4	0.08	8.2e-06	7.27	-7.3	2.9e-13	-0.80	0.08	0.91	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB16	0.02	0.03	blup	40	0.03	1.3e-04	7.29	-7.3	3.2e-13	-0.78	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	C17orf65	0.05	0.06	blup	38	0.05	4.2e-04	6.59	-7.3	3.3e-13	-0.78	0.02	0.95	FALSE
9	GTEx	Cells Transformed fibroblasts	ASB16	0.14	0.14	lasso	3	0.12	2.0e-09	7.26	-7.3	3.4e-13	-0.79	0.76	0.24	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf65	0.04	0.04	blup	37	0.03	1.4e-04	7.23	-7.3	3.5e-13	-0.77	0.02	0.98	FALSE
30	GTEx	Whole Blood	ASB16-AS1	0.14	0.05	lasso	6	0.04	3.1e-04	7.22	-7.3	3.6e-13	-0.81	0.12	0.88	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ASB16-AS1	0.08	0.04	lasso	2	0.06	7.9e-03	7.28	-7.3	3.8e-13	-0.77	0.06	0.50	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB16	0.03	0.03	lasso	3	0.03	3.2e-04	7.25	-7.2	4.4e-13	-0.76	0.02	0.96	FALSE
26	GTEx	Testis	ASB16-AS1	0.35	0.25	lasso	5	0.23	1.0e-10	7.22	-7.2	6.2e-13	-0.79	0.85	0.15	FALSE
49	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C17orf65	0.15	0.05	blup	37	0.09	1.7e-03	7.23	-7.2	7.3e-13	-0.74	0.02	0.70	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	ASB16	0.02	0.02	lasso	4	0.01	6.3e-03	7.26	-7.2	8.3e-13	-0.77	0.02	0.82	FALSE
15	GTEx	Esophagus Mucosa	ASB16-AS1	0.11	0.08	enet	16	0.07	3.7e-05	8.00	-7.1	1.1e-12	-0.89	0.03	0.97	FALSE
19	GTEx	Muscle Skeletal	ASB16	0.07	0.06	lasso	3	0.06	2.9e-06	6.59	7.1	1.1e-12	0.74	0.50	0.48	FALSE
21	GTEx	Nerve Tibial	ASB16-AS1	0.17	0.15	lasso	5	0.16	1.4e-11	7.22	-7.1	1.5e-12	-0.79	0.96	0.04	FALSE
27	GTEx	Thyroid	RP5-882C2.2	0.10	0.07	lasso	3	0.07	2.9e-06	7.23	-7.1	1.6e-12	-0.72	0.58	0.29	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ASB16	0.04	0.04	lasso	4	0.03	1.8e-04	6.91	-7.0	1.8e-12	-0.75	0.02	0.96	FALSE
11	GTEx	Cells Transformed fibroblasts	ASB16-AS1	0.17	0.17	lasso	4	0.16	2.3e-12	7.26	-7.0	3.1e-12	-0.78	0.97	0.03	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf65	0.09	0.02	blup	38	0.04	8.0e-03	7.23	-6.9	5.7e-12	-0.77	0.01	0.52	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C17orf65	0.03	0.00	blup	37	0.01	2.3e-02	7.23	-6.8	9.3e-12	-0.74	0.02	0.84	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C17orf65	0.05	0.05	lasso	2	0.05	2.5e-06	6.59	-6.8	9.5e-12	-0.72	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf65	0.02	0.01	blup	38	0.02	2.6e-04	6.95	-6.7	2.3e-11	-0.75	0.02	0.94	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf65	0.07	0.02	blup	38	0.04	1.1e-02	7.25	-6.7	2.4e-11	-0.73	0.01	0.55	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ASB16	0.03	0.01	enet	4	0.02	1.2e-02	7.29	-6.6	3.6e-11	-0.74	0.02	0.67	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C17orf65	0.07	0.05	lasso	6	0.05	3.1e-06	7.18	-6.6	4.0e-11	-0.77	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	ASB16	0.07	0.01	blup	39	0.02	1.6e-03	7.18	-6.5	7.7e-11	-0.63	0.02	0.79	FALSE
31	YFS	Blood	G6PC3	0.02	0.01	bslmm	350	0.02	3.0e-06	2.83	6.4	1.4e-10	0.59	0.80	0.09	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ASB16	0.02	0.02	blup	39	0.02	3.8e-03	7.19	-6.4	1.5e-10	-0.74	0.02	0.46	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	ASB16-AS1	0.17	0.13	lasso	7	0.11	8.6e-05	5.84	-6.2	4.3e-10	-0.64	0.06	0.78	FALSE
8	GTEx	Cells Transformed fibroblasts	NAGS	0.07	0.00	enet	13	0.00	3.2e-01	7.65	6.1	1.1e-09	0.66	0.08	0.29	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf65	0.03	0.01	lasso	10	0.02	3.6e-03	4.04	-5.9	4.0e-09	-0.64	0.05	0.78	FALSE
16	GTEx	Esophagus Muscularis	NAGS	0.11	0.03	enet	10	0.05	5.1e-04	-2.53	5.9	4.7e-09	0.58	0.13	0.22	FALSE
29	GTEx	Whole Blood	ASB16	0.11	0.03	enet	24	0.03	6.3e-04	7.29	-5.8	5.8e-09	-0.65	0.08	0.74	FALSE
23	GTEx	Prostate	RP5-882C2.2	0.17	-0.01	lasso	7	-0.01	5.9e-01	6.59	-5.8	8.9e-09	-0.55	0.04	0.13	FALSE
18	GTEx	Lung	ASB16	0.09	0.09	enet	15	0.07	3.4e-06	7.27	-5.7	1.4e-08	-0.74	0.34	0.66	FALSE
10	GTEx	Cells Transformed fibroblasts	FZD2	0.11	0.00	enet	21	0.04	1.0e-03	0.16	5.6	2.8e-08	0.45	0.08	0.36	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	ASB16-AS1	0.19	0.15	enet	16	0.13	2.0e-04	7.59	-5.5	3.1e-08	-0.62	0.04	0.67	FALSE
24	GTEx	Skin Sun Exposed Lower leg	ASB16	0.11	0.03	enet	9	0.02	4.3e-03	7.29	-5.5	3.3e-08	-0.73	0.18	0.57	FALSE
17	GTEx	Heart Left Ventricle	RP5-882C2.2	0.14	0.08	lasso	5	0.10	8.1e-06	3.93	-5.4	7.8e-08	-0.66	0.33	0.58	FALSE
6	GTEx	Breast Mammary Tissue	FZD2	0.35	0.01	enet	16	0.02	2.2e-02	-1.33	5.3	1.4e-07	0.53	0.04	0.37	FALSE
4	GTEx	Brain Cerebellum	ASB16-AS1	0.37	0.06	enet	32	0.19	3.1e-06	8.04	-5.2	1.6e-07	-0.68	0.03	0.86	FALSE