Best TWAS P=3.31e-10 · Best GWAS P=1.31e-10 conditioned to 0.00163
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Whole Blood | MS4A6A | 0.05 | 0.03 | lasso | 5 | 0.03 | 6.1e-04 | -5.1 | 5.2 | 2.2e-07 | -0.62 | 0.58 | 0.28 | FALSE |
| 2 | YFS | Blood | MS4A6A | 0.13 | 0.10 | enet | 33 | 0.11 | 2.5e-35 | -5.1 | 5.8 | 5.8e-09 | -0.78 | 0.80 | 0.20 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MS4A4A | 0.04 | 0.03 | blup | 79 | 0.04 | 7.2e-08 | 5.5 | 6.3 | 3.3e-10 | -0.64 | 0.56 | 0.44 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MS4A7 | 0.02 | 0.00 | blup | 77 | 0.00 | 1.2e-01 | -3.7 | 5.3 | 9.1e-08 | -0.22 | 0.03 | 0.59 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MS4A6A | 0.05 | 0.01 | enet | 10 | 0.03 | 6.6e-03 | 5.6 | 5.7 | 1.1e-08 | -0.36 | 0.01 | 0.78 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MS4A4A | 0.07 | 0.03 | blup | 79 | 0.04 | 2.8e-05 | 5.5 | 5.2 | 2.1e-07 | -0.47 | 0.45 | 0.54 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MS4A2 | 0.04 | 0.04 | blup | 55 | 0.04 | 8.2e-04 | -4.9 | -5.4 | 7.9e-08 | 0.58 | 0.13 | 0.64 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MS4A4A | 0.16 | 0.02 | blup | 78 | 0.03 | 2.7e-02 | 5.5 | 5.5 | 3.4e-08 | -0.45 | 0.02 | 0.10 | FALSE |