[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr11:60,869,481-62,346,131

Best TWAS P=2.42e-10 · Best GWAS P=3.41e-08 conditioned to 0.434

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	5.2	5.5	4.7e-08	0.72	0.01	0.98	FALSE
2	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	5.5	-5.3	1.2e-07	-0.99	0.01	0.95	FALSE
3	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	5.2	5.2	2.5e-07	0.64	0.02	0.98	FALSE
4	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	5.2	6.3	2.4e-10	0.80	0.01	0.99	TRUE
5	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	5.2	5.2	2.3e-07	0.63	0.02	0.98	FALSE
6	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	5.2	5.2	2.1e-07	0.73	0.02	0.98	FALSE
7	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	5.2	5.2	2.1e-07	0.64	0.02	0.95	FALSE
8	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	5.2	5.2	1.8e-07	0.65	0.02	0.98	FALSE
9	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	5.5	-5.4	5.4e-08	-0.99	0.01	0.99	FALSE
10	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	5.2	5.5	5.1e-08	0.74	0.02	0.98	FALSE
11	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	5.2	5.2	1.8e-07	0.66	0.02	0.98	FALSE
12	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	5.2	5.2	2.3e-07	0.68	0.02	0.98	FALSE
13	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	5.2	6.1	8.8e-10	0.82	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	5.5	-5.3	8.6e-08	-0.92	0.01	0.81	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	5.2	5.4	5.5e-08	0.76	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	5.2	5.2	2.0e-07	0.72	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	5.2	5.3	8.9e-08	0.80	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	5.2	5.5	3.4e-08	0.72	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	5.2	5.3	1.1e-07	0.92	0.01	0.79	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	5.2	5.2	2.2e-07	0.73	0.02	0.98	FALSE