Best TWAS P=1.97e-12 · Best GWAS P=5.24e-08 conditioned to 0.909
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | MAP3K11 | 0.15 | 0.15 | lasso | 4 | 0.13 | 1.8e-07 | 5.4 | 5.2 | 2.5e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | KAT5 | 0.15 | 0.06 | lasso | 10 | 0.02 | 2.1e-02 | -4.9 | -5.3 | 9.7e-08 | -0.27 | 0.07 | 0.33 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | KAT5 | 0.05 | -0.01 | lasso | 4 | -0.01 | 7.4e-01 | -4.8 | -5.3 | 1.2e-07 | -0.27 | 0.03 | 0.10 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | MAP3K11 | 0.18 | 0.11 | enet | 29 | 0.08 | 2.6e-03 | 5.2 | 5.8 | 4.8e-09 | 0.75 | 0.02 | 0.82 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | SIPA1 | 0.19 | 0.00 | enet | 30 | 0.05 | 2.5e-04 | 5.3 | 6.3 | 3.3e-10 | 0.60 | 0.01 | 0.94 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-867G23.1 | 0.15 | 0.05 | lasso | 3 | 0.04 | 1.2e-03 | -5.1 | 5.2 | 1.6e-07 | 0.23 | 0.00 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | -5.0 | 6.7 | 2.8e-11 | 0.56 | 0.04 | 0.89 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP3K11 | 0.06 | 0.03 | lasso | 4 | 0.03 | 2.1e-04 | -5.0 | 5.8 | 6.3e-09 | 0.57 | 0.01 | 0.82 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | -5.2 | 7.0 | 2.0e-12 | 0.61 | 0.01 | 0.35 | TRUE |