Best TWAS P=1.5e-16 · Best GWAS P=9.19e-21 conditioned to 0.00159
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MTL5 | 0.05 | 0.02 | bslmm | 426 | 0.05 | 2.6e-06 | -3.2 | 5.6 | 2.1e-08 | -0.42 | 0.92 | 0.01 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TPCN2 | 0.17 | 0.10 | lasso | 6 | 0.10 | 9.3e-12 | -6.5 | -6.8 | 1.4e-11 | 0.13 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | TPCN2 | 0.21 | 0.17 | lasso | 2 | 0.16 | 5.5e-09 | 7.1 | 7.0 | 2.9e-12 | -0.07 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | TPCN2 | 0.37 | 0.12 | enet | 25 | 0.22 | 2.3e-17 | 5.8 | 6.8 | 1.4e-11 | -0.10 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Esophagus Mucosa | TPCN2 | 0.20 | 0.07 | lasso | 8 | 0.06 | 5.6e-05 | 6.1 | 7.4 | 1.0e-13 | -0.08 | 0.68 | 0.03 | TRUE |
| 6 | GTEx | Esophagus Muscularis | IGHMBP2 | 0.12 | 0.06 | enet | 17 | 0.06 | 9.4e-05 | 3.4 | 5.5 | 4.1e-08 | -0.34 | 0.66 | 0.24 | FALSE |
| 7 | GTEx | Esophagus Muscularis | TPCN2 | 0.23 | 0.01 | lasso | 5 | 0.01 | 6.0e-02 | -5.5 | 5.3 | 9.8e-08 | -0.60 | 0.09 | 0.27 | FALSE |
| 8 | GTEx | Esophagus Muscularis | MRGPRF | 0.09 | 0.01 | lasso | 3 | 0.01 | 1.3e-01 | -6.2 | 6.8 | 8.5e-12 | -0.55 | 0.12 | 0.15 | FALSE |
| 9 | GTEx | Muscle Skeletal | TPCN2 | 0.19 | 0.11 | enet | 6 | 0.13 | 6.8e-13 | 5.5 | 6.3 | 3.5e-10 | -0.08 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | TPCN2 | 0.28 | 0.13 | enet | 25 | 0.17 | 4.9e-12 | 6.1 | 5.4 | 6.4e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | TPCN2 | 0.19 | 0.10 | lasso | 4 | 0.10 | 3.0e-06 | 7.1 | 7.3 | 2.5e-13 | -0.10 | 0.91 | 0.00 | FALSE |
| 12 | GTEx | Testis | TPCN2 | 0.26 | 0.05 | lasso | 3 | 0.07 | 5.9e-04 | 7.1 | 5.4 | 7.6e-08 | -0.11 | 0.14 | 0.05 | FALSE |
| 13 | GTEx | Testis | RP11-554A11.9 | 0.25 | 0.13 | enet | 11 | 0.18 | 2.8e-08 | 5.5 | -6.1 | 1.1e-09 | 0.04 | 0.02 | 0.98 | FALSE |
| 14 | GTEx | Thyroid | TPCN2 | 0.15 | 0.08 | enet | 17 | 0.06 | 1.9e-05 | 5.8 | 6.0 | 2.1e-09 | -0.07 | 0.97 | 0.00 | FALSE |
| 15 | NTR | Blood | TPCN2 | 0.08 | 0.06 | enet | 30 | 0.05 | 9.1e-17 | 5.5 | -6.0 | 2.7e-09 | 0.11 | 1.00 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | GAL | 0.21 | 0.17 | bslmm | 393 | 0.17 | 1.5e-21 | -6.7 | -7.7 | 1.9e-14 | 0.49 | 1.00 | 0.00 | TRUE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | PPP6R3 | 0.04 | 0.01 | blup | 421 | 0.02 | 3.2e-04 | -9.0 | 6.9 | 6.3e-12 | -0.85 | 0.04 | 0.96 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAPS3 | 0.04 | 0.02 | blup | 84 | 0.04 | 2.5e-05 | -8.1 | 8.3 | 1.5e-16 | -0.86 | 0.11 | 0.89 | TRUE |