Best TWAS P=1.4e-17 · Best GWAS P=3.34e-19 conditioned to 0.0492
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DOCK9-AS2 | 0.20 | 0.16 | lasso | 9 | 0.20 | 1.4e-16 | -6.1 | -5.3 | 1.5e-07 | -0.45 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | DOCK9-AS2 | 0.16 | 0.11 | lasso | 6 | 0.17 | 2.1e-09 | -6.4 | -6.9 | 4.1e-12 | -0.48 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | DOCK9 | 0.09 | 0.02 | lasso | 3 | 0.03 | 1.2e-03 | 6.8 | -8.0 | 1.8e-15 | -0.68 | 0.05 | 0.85 | FALSE |
| 4 | GTEx | Artery Tibial | DOCK9-AS2 | 0.16 | 0.14 | lasso | 14 | 0.17 | 1.5e-13 | 5.2 | -6.4 | 1.9e-10 | -0.47 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | DOCK9-AS2 | 0.20 | 0.01 | lasso | 5 | -0.01 | 7.4e-01 | 5.0 | -6.1 | 1.1e-09 | -0.44 | 0.08 | 0.07 | FALSE |
| 6 | GTEx | Brain Cortex | DOCK9-AS2 | 0.25 | 0.08 | lasso | 6 | 0.05 | 2.2e-02 | 5.2 | -5.5 | 4.4e-08 | -0.40 | 0.14 | 0.07 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | DOCK9-AS2 | 0.14 | 0.08 | lasso | 9 | 0.08 | 7.7e-05 | 5.5 | -7.0 | 1.9e-12 | -0.58 | 0.78 | 0.19 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | DOCK9-AS2 | 0.14 | 0.07 | lasso | 9 | 0.04 | 2.0e-02 | 7.2 | -8.0 | 9.5e-16 | -0.68 | 0.09 | 0.70 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | DOCK9-AS2 | 0.11 | 0.02 | lasso | 6 | 0.05 | 4.9e-03 | -6.3 | -7.1 | 1.4e-12 | -0.49 | 0.25 | 0.31 | TRUE |
| 10 | GTEx | Esophagus Mucosa | DOCK9 | 0.18 | 0.09 | lasso | 5 | 0.13 | 6.9e-09 | -6.4 | -8.0 | 1.5e-15 | -0.65 | 0.94 | 0.03 | FALSE |
| 11 | GTEx | Lung | DOCK9-AS2 | 0.14 | 0.05 | enet | 6 | 0.04 | 3.1e-04 | -5.8 | -6.3 | 3.7e-10 | -0.39 | 0.94 | 0.00 | FALSE |
| 12 | GTEx | Muscle Skeletal | DOCK9-AS2 | 0.22 | 0.24 | lasso | 8 | 0.21 | 7.8e-20 | -6.3 | -6.3 | 2.9e-10 | -0.42 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Nerve Tibial | DOCK9 | 0.17 | 0.17 | lasso | 1 | 0.16 | 4.1e-11 | 8.5 | -8.5 | 1.4e-17 | -0.89 | 0.08 | 0.92 | TRUE |
| 14 | GTEx | Pancreas | DOCK9-AS2 | 0.09 | 0.08 | lasso | 6 | 0.08 | 3.0e-04 | -6.3 | -7.3 | 3.8e-13 | -0.55 | 0.27 | 0.23 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | DOCK9-AS2 | 0.20 | 0.25 | enet | 17 | 0.22 | 3.1e-12 | -5.8 | -6.3 | 3.8e-10 | -0.39 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | DOCK9-AS2 | 0.15 | 0.14 | lasso | 9 | 0.19 | 2.1e-15 | 5.5 | -6.1 | 1.2e-09 | -0.44 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Spleen | DOCK9 | 0.34 | 0.11 | enet | 35 | 0.12 | 5.3e-04 | 7.1 | 7.3 | 2.9e-13 | 0.54 | 0.21 | 0.41 | TRUE |
| 18 | GTEx | Stomach | DOCK9-AS2 | 0.07 | 0.08 | lasso | 1 | 0.05 | 2.0e-03 | 5.5 | -5.5 | 3.3e-08 | -0.51 | 0.29 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | DOCK9 | 0.06 | 0.02 | blup | 212 | 0.02 | 1.9e-03 | 5.5 | -5.7 | 9.0e-09 | -0.56 | 0.26 | 0.21 | FALSE |