[Hub]/) : Traits : Pulse rate :

chr11:60,839,578-62,346,131

Best TWAS P=1.04e-13 · Best GWAS P=1.14e-13 conditioned to 0.0339

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 7.1 -7.1 1.3e-12 -0.98 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 7.1 7.1 1.3e-12 0.98 0.02 0.98 FALSE
3 GTEx Artery Tibial FADS2 0.08 0.02 lasso 4 0.02 6.9e-03 6.6 6.1 8.9e-10 0.80 0.02 0.96 FALSE
4 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 7.0 7.0 3.4e-12 0.97 0.02 0.97 FALSE
5 GTEx Brain Cerebellum FADS1 0.35 0.24 enet 16 0.30 2.1e-09 6.7 -7.0 3.2e-12 -0.92 0.01 0.99 FALSE
6 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 6.7 -6.9 5.2e-12 -0.93 0.03 0.82 FALSE
7 GTEx Brain Putamen basal ganglia FADS1 0.29 0.21 enet 30 0.16 1.4e-04 7.1 -6.1 9.0e-10 -0.77 0.02 0.93 FALSE
8 GTEx Breast Mammary Tissue (Female) TMEM258 0.20 0.02 lasso 7 0.00 2.3e-01 4.2 5.4 5.6e-08 0.78 0.04 0.45 FALSE
9 GTEx Cells Transformed fibroblasts TMEM258 0.15 0.05 enet 15 0.07 1.1e-05 6.6 5.2 2.0e-07 0.78 0.02 0.98 FALSE
10 GTEx Esophagus Mucosa FADS1 0.11 0.00 lasso 4 0.02 1.9e-02 7.3 -7.1 9.4e-13 -0.87 0.01 0.96 FALSE
11 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 6.7 5.8 5.2e-09 0.90 0.05 0.94 FALSE
12 GTEx Pancreas FADS1 0.17 0.13 lasso 6 0.12 1.2e-05 6.7 -6.8 1.1e-11 -0.92 0.02 0.98 FALSE
13 NTR Blood C11orf10 0.06 0.08 bslmm 399 0.08 1.3e-24 6.6 6.8 7.5e-12 0.92 0.08 0.92 FALSE
14 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 6.6 6.9 5.1e-12 0.94 0.03 0.97 FALSE
15 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 7.1 -7.3 2.2e-13 -0.97 0.01 0.99 FALSE
16 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FADS1 0.06 0.03 lasso 4 0.04 7.4e-03 6.7 -5.6 1.9e-08 -0.83 0.02 0.71 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma FADS1 0.05 0.05 blup 53 0.04 6.8e-05 6.0 -6.0 2.2e-09 -0.87 0.04 0.96 FALSE
18 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FADS1 0.20 0.01 blup 51 0.07 3.2e-04 7.0 -7.4 1.0e-13 -0.85 0.02 0.92 TRUE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FADS2 0.02 0.01 blup 71 0.02 1.9e-03 6.7 6.3 2.2e-10 0.91 0.03 0.73 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma FADS1 0.06 0.04 blup 53 0.03 2.0e-04 6.7 -5.2 2.4e-07 -0.71 0.05 0.65 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 5.9 6.8 1.1e-11 0.95 0.02 0.70 FALSE