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chr11:60,839,578-62,346,131

Best TWAS P=1.04e-13 · Best GWAS P=1.14e-13 conditioned to 0.0339

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	7.1	-7.1	1.3e-12	-0.98	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	7.1	7.1	1.3e-12	0.98	0.02	0.98	FALSE
3	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	6.6	6.1	8.9e-10	0.80	0.02	0.96	FALSE
4	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	7.0	7.0	3.4e-12	0.97	0.02	0.97	FALSE
5	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	6.7	-7.0	3.2e-12	-0.92	0.01	0.99	FALSE
6	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	6.7	-6.9	5.2e-12	-0.93	0.03	0.82	FALSE
7	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	7.1	-6.1	9.0e-10	-0.77	0.02	0.93	FALSE
8	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	4.2	5.4	5.6e-08	0.78	0.04	0.45	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	6.6	5.2	2.0e-07	0.78	0.02	0.98	FALSE
10	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	7.3	-7.1	9.4e-13	-0.87	0.01	0.96	FALSE
11	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	6.7	5.8	5.2e-09	0.90	0.05	0.94	FALSE
12	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	6.7	-6.8	1.1e-11	-0.92	0.02	0.98	FALSE
13	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	6.6	6.8	7.5e-12	0.92	0.08	0.92	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	6.6	6.9	5.1e-12	0.94	0.03	0.97	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	7.1	-7.3	2.2e-13	-0.97	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	6.7	-5.6	1.9e-08	-0.83	0.02	0.71	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	6.0	-6.0	2.2e-09	-0.87	0.04	0.96	FALSE
18	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	7.0	-7.4	1.0e-13	-0.85	0.02	0.92	TRUE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	6.7	6.3	2.2e-10	0.91	0.03	0.73	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	6.7	-5.2	2.4e-07	-0.71	0.05	0.65	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	5.9	6.8	1.1e-11	0.95	0.02	0.70	FALSE