Best TWAS P=7.77e-11 · Best GWAS P=7.77e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-381K20.5 | 0.09 | 0.09 | lasso | 1 | 0.06 | 8.4e-06 | -6.5 | 6.5 | 7.8e-11 | -1.00 | 0.00 | 1.00 | TRUE |
| 7 | METSIM | Adipose | REEP2 | 0.36 | 0.15 | enet | 32 | 0.15 | 4.2e-22 | 3.4 | 5.5 | 4.0e-08 | -0.16 | 1.00 | 0.00 | TRUE |
| 8 | METSIM | Adipose | RP11-381K20.5 | 0.05 | 0.06 | lasso | 4 | 0.05 | 3.1e-08 | -6.4 | 6.4 | 1.7e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Heart Left Ventricle | REEP2 | 0.14 | 0.05 | lasso | 2 | 0.04 | 2.9e-03 | -6.5 | 6.1 | 9.3e-10 | -0.87 | 0.01 | 0.92 | FALSE |
| 5 | GTEx | Testis | CDC23 | 0.10 | 0.07 | enet | 10 | 0.07 | 6.1e-04 | -5.6 | -6.1 | 1.4e-09 | 0.56 | 0.24 | 0.61 | FALSE |
| 3 | GTEx | Nerve Tibial | RP11-381K20.5 | 0.10 | 0.08 | lasso | 3 | 0.09 | 1.1e-06 | -6.4 | 5.8 | 5.7e-09 | -0.97 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Testis | RP11-381K20.5 | 0.16 | 0.05 | lasso | 5 | 0.03 | 1.5e-02 | 4.1 | 5.7 | 1.6e-08 | -0.56 | 0.06 | 0.67 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | KDM3B | 0.07 | 0.01 | blup | 307 | 0.03 | 1.0e-04 | 3.2 | -5.5 | 3.3e-08 | 0.64 | 0.06 | 0.91 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | RP11-381K20.5 | 0.07 | 0.04 | lasso | 2 | 0.03 | 9.7e-04 | -5.5 | 5.5 | 4.2e-08 | -0.90 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIF20A | 0.01 | 0.00 | blup | 27 | 0.01 | 1.4e-02 | -5.7 | 5.5 | 4.5e-08 | -0.46 | 0.01 | 0.58 | FALSE |