Hub : Genes

CDC23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.105	0.0440	0.00052	0.068	NA	0.068	NA	0.063	5.9e-04	NA	6.1e-04	NA	8.8e-04
2	YFS	Blood	0.008	0.0045	0.00970	0.008	0.004	0.002	0.004	0.006	6.3e-04	0.01800	4.5e-02	0.018	3.1e-03
3	TCGA	Breast Invasive Carcinoma	0.112	0.0429	0.00077	0.024	0.000	0.009	NA	0.020	6.9e-06	0.37000	4.1e-03	NA	5.4e-05
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.214	0.0930	0.00950	0.006	-0.004	0.021	NA	0.040	1.1e-01	0.86000	1.4e-02	NA	9.6e-04
5	TCGA	Pancreatic Adenocarcinoma	0.103	0.0720	0.00990	0.001	0.020	0.032	NA	0.002	2.9e-01	0.04700	1.7e-02	NA	2.7e-01
6	TCGA	Prostate Adenocarcinoma	0.141	0.0561	0.00014	0.003	0.037	0.045	NA	0.018	1.3e-01	0.00009	1.8e-05	NA	4.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.1	4.1	-2.0	1.5	0.0	0.0	0.3	0.0
Bipolar Disorder or Schizophrenia	0.7	1.7	7.7	-2.8	1.6	0.0	0.0	-0.0	-0.0
Depressed Affect (Nagel 2018)	0.5	1.1	3.2	1.8	-1.1	-0.1	-0.6	-0.7	-1.1
Depression (Nagel 2018)	1.6	2.4	4.7	1.3	-2.2	-1.1	-1.4	-1.9	-1.2
Intelligence (Savage-Jansen 2018)	2.6	7.9	12.7	-2.8	3.5	2.0	2.3	3.6	2.3
Neuroticism (Nagel 2018)	0.5	1.2	3.1	1.8	-1.7	0.8	0.3	-0.1	0.4
Schizophrenia (2018)	0.4	0.8	3.6	-1.9	0.9	0.0	0.0	-0.3	-0.0
Schizophrenia vs Biploar Disorder	1.1	1.4	4.8	1.6	-2.2	0.0	0.0	-0.7	0.6
Worry (Nagel 2018)	1.2	2.5	5.6	1.9	-2.0	0.9	0.4	0.8	2.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	-0.6	0.3	0.9	1.3	1.2	0.6
Alzheimer’s Disease (in father)	1.1	1.1	1.9	1.4	-0.8	-1.2	-1.2	-1.0	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.4	0.1	-0.0	0.3	0.4	-0.0
Crohns Disease (2017)	0.4	0.9	2.1	1.0	0.2	1.4	1.4	0.3	-0.2
Irritable Bowel Disease (IBD)	0.4	0.8	2.0	0.7	0.4	1.2	1.4	-0.2	-1.0
Ulcerative Colitis (UC)	0.2	0.4	1.0	0.4	0.0	0.6	1.0	-0.3	-0.9
Major Depression (MDD)	1.9	2.3	4.7	2.0	-2.2	1.2	0.8	-1.3	-1.0
Reaction Time	1.4	2.6	7.1	0.8	-1.9	-0.8	0.8	-1.8	-2.7
Verbal and Numeric Reasoning (VNR)	2.1	5.1	9.0	-1.8	2.7	2.2	1.9	3.0	1.6
Breast Cancer	0.6	1.4	2.3	-1.0	1.0	1.5	1.4	1.2	0.8
Ovarian Cancer	0.4	0.5	1.7	-0.6	1.3	0.5	0.6	0.5	-0.1
Prostate Cancer	0.4	0.6	1.0	0.6	0.3	1.0	0.9	0.9	-0.6
Age at First Birth	1.5	2.2	4.4	-2.1	2.0	0.0	0.0	2.0	0.8
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.5	-0.0	0.0	0.0	0.0	0.4
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.3	-0.2	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	2.8	3.4	8.2	1.1	-1.9	0.0	0.0	-2.7	-2.9
Crohns Disease (2012)	0.3	0.4	1.3	0.3	1.1	0.0	0.0	-0.3	-1.1
Mean Putamen Volume	0.6	0.7	1.8	0.3	-0.7	0.9	1.4	-0.4	-1.1
Fasting Glucose	1.6	1.9	8.1	-1.3	0.3	0.0	0.0	1.2	2.9
HbA1C	1.9	2.1	8.5	-1.5	1.4	0.0	0.0	0.4	-2.9
HDL Cholesterol	0.6	1.0	3.2	-1.7	1.8	0.0	0.0	0.0	0.0
LDL Cholesterol	0.1	0.2	1.0	0.5	-1.0	0.0	0.0	0.0	0.0
Lupus	1.8	2.7	8.2	0.9	-0.4	-1.3	-1.3	-2.0	-2.9
Neuroticism (2016)	1.0	1.4	3.4	1.9	-1.7	0.0	0.0	0.3	1.4
Primary Biliary Cirrhosis	0.5	0.7	2.5	-1.6	0.8	0.6	0.5	-0.1	0.4
Rheumatoid Arthritis	0.6	0.8	1.6	1.3	-0.6	1.2	0.8	-0.0	-0.9
Schizophrenia (2014)	0.3	0.7	3.8	-1.9	0.5	0.0	0.0	-0.3	0.6
Triglycerides	0.8	1.4	5.3	1.7	-2.3	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.3	-0.5	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.7	2.5	9.1	0.7	-0.6	0.0	0.0	-2.3	-3.0
Blood Eosinophil Count	1.0	7.6	15.9	2.7	-3.3	-1.5	-2.2	-4.0	-2.3
Blood Platelet Count	0.3	3.7	10.4	-2.4	0.8	1.3	0.4	2.0	3.2
Blood Red Count	1.6	15.2	36.1	6.0	-5.4	-0.9	-1.3	-4.4	-2.1
Blood White Count	0.1	0.5	0.9	0.8	-0.9	0.4	0.3	0.9	-0.3
Heel T-Score	0.2	1.9	5.4	0.5	0.4	-2.2	-2.3	-0.8	-0.5
BMI	1.0	5.9	15.7	0.8	0.3	-2.5	-4.0	-2.6	-2.5
Height	0.5	9.5	22.0	-4.2	4.7	1.1	2.2	3.3	-0.2
Waist Hip Ratio (WHR)	0.7	3.2	8.2	-2.9	2.0	0.3	1.0	1.8	1.7
Systolic Blood Pressure	0.8	4.0	11.7	-3.4	2.7	-1.6	-1.4	0.5	-0.2
Smoking Status	3.3	7.9	11.8	3.2	-3.4	-1.6	-0.6	-3.4	-3.3
Allergy or Eczema	2.4	6.4	16.4	4.0	-3.9	-1.4	-1.7	-1.5	0.2
Cardiovascular Disease	0.4	1.2	2.8	-1.7	1.4	-1.3	-0.8	-0.4	-0.5
Hypothyroidism (self reported)	0.5	1.2	2.6	1.4	-1.6	-1.0	-0.6	-1.1	-0.6
Respiratory disease	1.4	3.2	7.5	2.5	-2.7	-0.4	-1.4	-1.5	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.3	-0.2	-0.5	-0.7	-0.0	0.5	-1.8
Lung FEV1/FVC ratio	0.8	4.2	8.5	-2.9	1.8	0.4	0.6	2.6	2.4
Lung FVC	0.3	1.4	2.0	-0.9	1.2	1.4	1.3	1.0	1.2
Neuroticism	0.9	2.3	4.7	2.2	-2.1	-0.9	-1.3	-1.2	-0.6
Chronotype (morning person)	1.1	2.6	8.4	-2.5	2.9	-0.6	-0.0	0.5	-0.7
Hair Pigment	0.1	1.6	5.0	-2.2	1.1	-0.5	0.6	-0.5	-1.6
Tanning	0.1	0.6	1.7	0.6	0.9	-0.9	-1.3	-0.1	0.3
Hand grip strength (left)	0.1	0.2	0.7	0.3	0.1	0.5	0.5	-0.0	-0.8
Number of treatments/medications taken	3.4	6.1	9.5	2.2	-1.3	-2.4	-2.8	-2.7	-3.1
Average weekly spirits intake	0.8	1.0	2.6	-1.6	1.6	-0.5	-0.1	0.9	0.1
Sensitivity / hurt feelings	1.2	2.0	4.7	1.4	-1.9	0.0	0.1	-1.3	-2.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.1	1.1	-1.7	-0.7	-1.5	-1.2	-0.0
Hearing difficulty/problems: Yes	0.2	0.4	0.9	0.1	-0.1	1.0	0.3	0.9	0.6
Relative age of first facial hair	0.6	1.3	2.4	1.6	-1.4	1.1	0.8	-1.1	-0.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.3	-1.3	1.3	-1.3	0.2	-0.2	-2.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	0.6	-1.1	0.2	0.7	0.2	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.2	-1.1	0.9	-0.5	0.1	0.3	-0.8
Systolic blood pressure, automated reading	0.6	1.8	7.8	-2.8	1.3	-0.6	-0.6	0.8	0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.9	0.3	-0.7	-0.9	0.7	0.7
Angina	2.0	2.6	4.9	2.2	-1.9	-0.4	-1.3	-2.2	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.6	0.1	-0.5	-0.9	-0.4	-0.2
Vitamin and mineral supplements	0.7	1.0	2.7	1.6	-1.0	0.4	0.8	-0.2	-1.2
Supplements: Zinc	0.9	1.0	3.5	-1.9	1.5	-0.0	0.0	0.4	0.2
Medication: Co-codamol	0.7	0.8	2.7	0.6	-0.6	1.1	1.6	0.4	0.1
Medication: Metformin	0.5	0.7	1.9	-0.3	0.3	0.8	0.8	1.4	-0.8
Diabetes (father)	0.3	0.4	1.1	-0.1	0.3	-0.3	-1.0	-0.4	-1.1
Diabetes (mother)	0.3	0.3	1.3	0.2	-0.0	0.4	0.4	1.1	0.6
Severe depression (siblings)	0.6	0.7	2.1	-1.1	0.5	-0.7	-1.5	0.1	0.0
Pack years adult smoking proportion	2.3	3.6	6.3	1.5	-1.7	-1.8	-2.4	-2.5	-0.8
Impedance of leg (right)	0.8	3.8	9.9	1.2	-2.6	1.1	1.6	1.2	3.1
Leg fat-free mass (left)	0.9	4.9	12.1	-1.4	2.7	-1.6	-2.1	-1.2	-3.5
Trunk fat percentage	0.6	2.2	8.0	-0.1	-0.2	-0.6	-1.0	-2.0	-2.8
Hand grip strength (right)	0.1	0.3	1.4	-0.2	0.1	-0.3	-0.1	-0.1	-1.2
Townsend deprivation index at recruitment	0.9	1.2	2.7	0.6	-1.6	1.2	1.2	0.8	0.8
Current tobacco smoking	1.8	2.9	9.9	0.0	-1.1	-1.6	-0.3	-1.9	-3.2
Average weekly fortified wine intake	0.4	0.5	1.2	0.5	-0.3	0.8	1.1	0.8	0.4
Maternal smoking around birth	1.6	2.3	5.4	1.5	-1.9	0.1	0.5	-1.5	-2.3
Fed-up feelings	1.2	2.2	2.7	1.5	-1.4	-1.4	-1.3	-1.6	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	4.7	1.8	-2.1	-1.0	-1.5	-2.2	-1.8
Relative age voice broke	0.3	0.4	1.3	0.3	-1.1	0.2	0.7	-0.1	0.7
Taking other prescription medications	1.4	2.1	4.6	0.7	-0.2	-1.6	-1.6	-1.6	-2.1
Age when periods started (menarche)	0.9	2.3	3.4	-1.5	0.8	1.8	1.7	1.3	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.8	0.3	-0.1	0.1	1.0	0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.7	-0.4	1.1	-1.3	-1.0	-0.2	-1.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	0.8	-0.6	-0.6	-1.5	-1.7	-1.0
Qualifications: CSEs or equivalent	2.8	3.7	7.5	2.7	-2.6	-0.7	-1.3	-2.1	-1.2
Serious illness, injury or assault to yourself	1.1	1.4	2.3	-1.4	1.0	1.1	1.5	1.4	-0.4
High blood pressure	0.8	2.3	4.5	-0.5	0.6	-2.1	-1.4	-1.9	-1.8
Hayfever, allergic rhinitis or eczema	2.7	5.8	15.5	3.9	-3.9	-0.9	-0.9	-1.4	0.3
Multivitamins +/- minerals	0.6	0.8	3.1	-1.8	1.0	-0.4	0.2	0.7	0.1
Stomach or abdominal pain in last month	0.6	0.7	2.0	-1.0	0.4	-0.5	-0.6	-0.9	-1.4
Supplements: Glucosamine	1.6	2.1	4.2	1.7	-1.4	-0.8	-1.4	-2.0	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	0.7	-1.1	0.7	1.3	0.2	-0.5
Medication: Atenolol	0.5	0.6	1.3	-1.1	1.1	-0.0	0.6	0.8	0.4
Medication: Levothyroxine sodium	0.2	0.4	1.1	0.7	-0.3	0.5	0.6	1.0	-0.3
Sitting height	0.5	3.7	10.7	-2.0	3.3	1.0	0.7	2.5	0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.2	-0.2	0.7	0.9	0.5	0.4
High blood pressure (mother)	0.9	1.3	4.2	-0.8	0.9	-1.3	-2.0	-0.5	0.0
Body mass index (BMI)	1.3	5.6	13.7	0.8	0.1	-1.9	-2.8	-2.8	-3.7
Impedance of leg (left)	0.9	4.6	12.8	0.8	-2.3	1.8	2.0	1.4	3.6
Leg predicted mass (left)	0.9	4.9	12.4	-1.4	2.7	-1.5	-2.1	-1.2	-3.5
Trunk fat mass	0.7	2.9	9.9	-0.4	0.7	-1.1	-1.6	-1.8	-3.1
Waist circumference	0.8	2.9	9.5	-0.1	0.9	-1.2	-1.5	-1.7	-3.1
Number of incorrect matches in round	2.6	4.3	11.4	3.3	-3.4	-0.5	-0.6	-1.6	-0.0
Past tobacco smoking	2.0	3.8	8.3	-2.9	2.5	0.6	0.5	2.1	1.6
Alcohol usually taken with meals	0.5	0.7	3.1	-0.1	0.7	0.7	0.1	0.5	1.8
Nervous feelings	1.3	2.4	8.0	1.9	-2.8	0.8	0.8	0.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.9	1.6	-1.7	0.4	-0.2	-0.5	-0.3
Hearing difficulty/problems with background noise	1.9	3.0	10.8	2.5	-3.3	-0.4	-0.5	-0.7	0.3
Hair/balding pattern: Pattern 2	0.7	0.8	1.8	0.4	-0.7	1.1	-0.1	1.4	1.1
Had menopause	0.2	0.2	0.6	-0.7	0.2	0.1	0.4	0.5	0.5
Had other major operations	1.1	1.4	2.8	-1.7	1.3	0.9	1.4	1.0	0.1
Forced vital capacity (FVC)	1.2	4.7	9.2	-3.0	3.0	1.1	1.6	2.3	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.2	-0.1	1.0	-0.9	-1.1	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.1	0.6	-1.7	0.1	-1.1	-0.9	0.7
Qualifications: None of the above	2.5	5.4	13.1	2.8	-3.6	-0.6	-0.5	-2.3	-2.3
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.3	0.3	-0.4	-0.4	0.1	-0.5
Mouth/teeth dental problems	0.6	1.0	2.1	-1.0	1.4	-1.4	-0.8	0.3	0.0
Heart attack	1.2	1.5	2.6	1.6	-1.3	1.4	0.7	-1.4	-0.6
Allergy	2.1	4.9	12.2	-3.5	3.3	0.9	1.6	1.6	0.6
Pain all over the body in last month	0.4	0.4	1.0	-0.1	-0.4	-1.0	-0.6	-0.6	-0.8
Diabetes (self-reported)	0.4	0.7	1.6	-0.8	0.6	0.2	0.7	1.0	-1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	1.6	-0.6	-0.6	-0.1	-0.8	-1.3
Medication: Ramipril	3.1	4.0	5.0	1.7	-2.0	-2.2	-2.2	-2.2	-1.5
Medication: Simvastatin	0.4	0.6	1.5	0.9	-1.2	0.4	0.1	-0.4	-1.2
Fluid intelligence score	2.3	4.9	15.9	-2.7	4.0	0.5	0.9	2.2	0.6
Illnesses of siblings	0.5	0.7	2.2	0.5	0.3	-1.5	-1.0	-0.9	0.2
Neuroticism score	0.8	1.6	4.1	2.0	-2.0	-0.1	-0.8	-0.8	-0.6
Weight	0.9	4.3	12.7	-0.7	1.8	-1.6	-2.2	-1.5	-3.6
Impedance of arm (right)	0.9	4.3	9.6	-1.4	-0.5	2.1	3.1	2.1	2.3
Arm fat percentage (right)	0.6	2.5	7.5	0.4	-0.2	-0.8	-1.5	-2.2	-2.7
Trunk fat-free mass	0.6	3.6	8.1	-0.9	2.9	-1.7	-1.9	-0.3	-2.5
Hip circumference	1.1	4.5	15.5	0.5	0.6	-1.3	-1.9	-2.4	-3.9
Time employed in main current job	0.6	0.7	1.7	-1.1	1.3	0.3	0.5	1.0	-0.2
Alcohol intake versus 10 years previously	0.8	1.1	2.0	0.6	-1.4	-0.6	-1.0	-1.4	-1.1
Father’s age at death	1.0	1.4	3.1	-1.3	1.7	0.2	0.5	1.6	0.8
Worrier / anxious feelings	0.7	1.3	2.9	1.7	-1.7	0.0	-0.8	-0.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	-0.2	-0.0	-0.5	-0.7	-0.7	-1.3
Falls in the last year	0.3	0.4	0.6	0.8	-0.8	0.5	-0.2	0.6	0.7
Hair/balding pattern: Pattern 3	0.5	0.7	3.4	0.4	0.1	-0.3	0.1	-0.6	-1.8
Number of live births	2.3	3.3	8.9	2.1	-3.0	-0.3	-0.5	-2.4	0.7
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	11.8	-3.4	3.2	1.1	1.5	3.1	1.9
Pulse rate	6.5	11.0	36.7	-6.1	4.4	-1.9	-1.0	2.3	-0.3
Happiness	3.5	4.3	11.7	3.4	-3.4	0.7	0.3	-1.0	1.0
Noisy workplace	0.4	0.5	1.2	0.3	-0.6	-0.3	-1.0	-0.6	-1.1
Qualifications: A levels/AS levels or equivalent	5.9	13.1	26.4	-4.0	5.0	1.4	1.6	5.1	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.8	-1.3	1.2	-0.6	-0.8	1.3	0.8
Mouth/teeth dental problems: Dentures	3.2	5.4	13.8	3.7	-3.7	1.3	1.2	-1.1	-0.8
Asthma	1.1	2.1	4.7	2.0	-2.2	-0.0	-1.0	-1.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.3	0.3	0.1	-1.0	-1.2	-1.5	-0.4
Medication: Cholesterol lowering	0.3	0.5	2.3	-0.1	0.0	-0.6	0.1	-0.7	-1.5
Depression (self-reported)	0.0	0.0	0.2	0.1	0.4	0.2	-0.1	0.0	0.2
Medication: Lansoprazole	1.2	1.4	2.7	1.4	-1.2	-0.7	-0.3	-1.6	-1.2
Prospective memory result	0.7	0.9	2.1	-1.5	0.2	0.9	0.5	0.9	1.0
Lung cancer (father)	0.3	0.4	0.7	0.6	-0.1	-0.5	-0.7	-0.6	-0.8
Illnesses of mother	1.4	1.7	3.7	-1.0	0.8	1.4	1.1	1.4	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	8.6	-2.0	2.7	1.3	1.4	2.9	1.6
Pulse wave Arterial Stiffness index	0.9	1.0	2.6	-1.2	0.7	-1.2	-0.2	-0.4	-1.6
Impedance of arm (left)	0.9	4.0	8.3	-1.3	-0.7	2.1	2.9	1.8	2.4
Arm fat mass (right)	0.9	3.6	10.6	0.3	0.2	-1.2	-1.9	-2.4	-3.3
Trunk predicted mass	0.7	3.7	8.7	-1.1	3.0	-1.7	-1.9	-0.3	-2.4
Standing height	0.6	5.5	13.3	-3.3	3.6	0.8	1.3	2.5	0.2
Length of working week for main job	2.6	2.9	7.7	-1.6	2.8	-1.4	-0.9	-0.9	-1.9
Exposure to tobacco smoke at home	0.6	0.6	1.4	-1.2	1.1	-0.8	-0.4	0.3	-0.6
Breastfed as a baby	1.6	1.9	3.3	1.0	-1.1	-1.5	-1.8	-1.6	-1.1
Tense / ‘highly strung’	1.0	1.7	2.9	1.7	-1.6	1.6	1.5	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.0	0.8	-2.0	1.7	0.9	0.3	0.6
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	0.2	0.6	-0.4	0.1	0.5	-0.2
Birth weight of first child	0.1	0.2	0.9	-0.2	0.5	0.9	0.4	-0.2	0.2
Peak expiratory flow (PEF)	1.8	4.1	8.0	-2.0	2.1	1.9	1.4	2.8	1.5
Pulse wave reflection index	1.8	2.2	5.5	2.3	-1.8	-0.5	-0.2	-1.7	-1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-1.2	0.5	-0.4	0.6	-0.4	-1.2
Loud music exposure frequency	1.0	1.1	2.4	0.5	-1.4	0.5	-1.2	-0.5	1.5
Qualifications: O levels/GCSEs or equivalent	1.9	3.1	8.2	-2.9	2.6	-0.6	0.7	1.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.3	0.0	0.1	1.8	0.7	0.5	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.7	0.3	0.2	0.1	-0.8	-0.3	-0.8
Medication: Paracetamol	1.6	2.7	4.2	2.0	-1.3	-1.6	-0.9	-1.7	-2.0
Headache pain in last month	0.7	1.2	2.4	-1.5	1.5	-0.7	-0.0	0.2	-1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.3	1.3	-1.5	1.9	0.9	0.6	2.1
Glaucoma (self-reported)	1.6	1.8	3.5	1.7	-1.2	1.9	1.6	0.7	0.4
Gout (self-reported)	1.1	1.5	4.0	-0.2	1.1	1.7	0.6	0.5	2.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	1.2	-1.0	-0.3	-0.3	-0.3	-0.8
Medication: Amlodipine	0.8	1.1	2.4	-0.4	0.9	-1.6	-1.5	-0.9	-0.1
Medication: Ventolin 100micrograms inhaler	2.4	3.1	9.9	2.1	-3.1	-0.6	-0.4	-1.8	-0.4
Birth weight	0.3	0.6	1.2	0.3	-0.7	1.1	0.6	-0.8	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.4	-0.4	0.2	-0.3	0.1	-0.6	-1.5
High blood pressure (siblings)	0.3	0.5	1.2	-0.9	-0.5	1.1	-0.1	-0.4	0.7
Forced vital capacity (FVC), Best measure	0.9	3.3	5.8	-1.5	2.4	1.4	2.0	2.4	0.7
Body fat percentage	0.7	2.6	6.7	0.7	-0.8	-0.7	-1.6	-2.2	-2.6
Leg fat percentage (right)	1.7	6.2	10.0	1.9	-1.6	-2.3	-3.2	-3.0	-2.7
Arm fat-free mass (right)	0.8	4.2	9.2	-0.5	2.1	-1.9	-2.5	-1.3	-3.0
Exposure to tobacco smoke outside home	1.2	1.5	5.9	-2.4	1.6	0.4	-0.2	0.7	-0.4
Comparative body size at age 10	0.4	1.2	3.7	-1.2	1.2	-0.5	-0.2	-0.6	-1.9
Number of full brothers	0.8	1.0	3.1	1.8	-1.3	0.7	0.4	-0.8	0.5
Worry too long after embarrassment	0.4	0.7	1.4	1.1	-1.1	1.2	0.5	0.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.2	-0.5	0.9	1.1	0.5	-0.8
Wheeze or whistling in the chest in last year	1.3	2.3	5.2	1.0	-1.5	-0.5	-1.3	-1.9	-2.3
Number of children fathered	2.6	3.0	7.9	1.9	-0.9	-1.5	-2.8	-1.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	0.9	-1.3	0.7	0.6	-0.3	0.7
Age at first live birth	1.1	1.9	6.8	-1.6	2.6	-0.9	-0.8	0.6	0.7
Pulse wave peak to peak time	1.0	1.1	2.9	1.0	-0.5	1.4	0.6	0.7	1.7
Health satisfaction	0.6	0.7	1.2	1.0	-1.0	-0.4	-0.5	-0.9	-1.1
Shortness of breath walking on level ground	1.3	1.5	3.4	-1.6	1.8	0.5	0.9	1.4	0.5
Qualifications: College or University degree	2.6	8.1	15.9	-2.5	4.0	1.9	2.3	3.3	2.7
Eye problems/disorders: None of the above	2.3	2.6	5.0	-2.1	2.2	-1.9	-0.5	0.8	-1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	0.7	-0.5	0.5	1.0	-0.2	-0.6
Emphysema/chronic bronchitis	2.5	2.9	7.8	1.4	-2.8	-0.5	-0.9	-2.5	-0.1
Medication for pain relief, constipation, heartburn	2.4	4.0	6.0	-1.7	1.3	2.2	2.3	2.4	1.8
Neck or shoulder pain in last month	0.5	0.7	3.0	-0.5	0.7	-0.4	-0.1	-0.4	-1.7
Medication: Blood pressure	1.5	2.6	6.0	-0.5	0.8	-2.5	-1.4	-1.1	-2.3
Angina (self-reported)	2.1	2.7	5.6	2.0	-1.9	-0.6	-1.5	-2.4	-0.8
Migraine (self-reported)	0.9	1.2	4.2	-2.0	1.6	-0.1	0.0	-0.1	-0.4
Medication: Ibuprofen	0.9	1.1	3.1	0.3	0.3	-1.4	-1.8	-1.1	-0.0
Medication: Allopurinol	0.6	0.7	3.1	0.3	0.2	1.1	-0.2	-0.3	1.8
Medication: Omeprazole	1.2	1.4	3.3	0.8	-1.0	-0.7	-1.0	-1.8	-1.5
Medication: Seretide 50 evohaler	1.2	1.4	3.1	0.6	-1.8	-1.0	-0.1	-1.7	-1.1
Mean time to correctly identify matches	1.1	2.1	4.7	1.0	-1.8	-0.8	0.6	-1.6	-2.2
Heart disease (mother)	2.4	2.9	4.9	2.2	-2.1	-0.2	0.1	-2.2	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.8	0.7	-0.8	-2.0	-2.2	-2.2	-0.7
Whole body fat mass	0.8	3.2	9.5	0.4	-0.0	-1.1	-1.8	-2.3	-3.1
Leg fat mass (right)	1.4	5.5	10.5	0.8	-0.2	-2.1	-3.1	-2.8	-3.2
Arm predicted mass (right)	0.7	3.7	9.0	-0.4	2.1	-1.6	-2.2	-1.3	-3.0
Pulse rate, automated reading	9.2	29.8	99.9	-10.0	7.0	-1.5	-0.3	5.1	1.1
Alcohol intake frequency.	0.5	1.3	2.1	-0.1	-1.2	1.4	1.0	-1.3	-1.3
Comparative height size at age 10	0.5	2.7	6.1	-1.7	2.5	-0.0	0.8	2.5	-0.5
Number of full sisters	0.3	0.4	1.4	-0.6	-0.3	0.6	-0.2	0.1	1.2
Suffer from ‘nerves’	1.7	2.6	8.9	1.8	-3.0	0.5	-0.4	0.1	1.8
Overall health rating	2.2	4.7	14.3	1.4	-1.3	-1.4	-1.7	-2.3	-3.8
Chest pain or discomfort	0.3	0.5	2.6	0.1	-0.1	-0.3	0.0	-0.1	-1.6
Had major operations	2.1	2.4	6.5	0.4	-0.3	2.4	2.6	1.4	-0.0
Age at last live birth	1.0	1.5	4.1	0.4	-0.0	-1.4	-2.0	-1.5	0.6
Family relationship satisfaction	1.5	1.9	6.1	1.6	-2.5	0.0	0.3	-1.6	-0.0
Leg pain on walking	0.9	1.2	4.2	0.4	0.0	-1.4	-0.5	-0.7	-2.0
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	6.7	1.6	-1.8	-0.8	-2.5	-2.6	-0.9
Commuting to job workplace: Car/motor vehicle	2.4	2.8	8.7	0.1	0.7	-1.6	-1.5	-1.7	-3.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.7	1.7	-1.9	1.4	0.7	-1.0	1.1
Medication: Aspirin	0.2	0.3	0.7	-0.2	-0.4	-0.2	-0.6	-0.8	-0.8
Supplements: Vitamin C	1.2	1.5	4.0	-1.8	2.0	0.9	0.2	-0.1	0.8
Knee pain experienced in last month	0.8	1.2	2.9	0.5	-0.2	-1.6	-1.7	-0.5	-1.0
Hypertension (Self-reported)	0.6	1.5	3.6	-0.7	0.8	-1.6	-0.5	-1.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	7.3	1.9	-2.0	-1.6	-1.9	-2.7	-1.2
Illnesses of father: Heart disease	0.2	0.3	0.7	0.6	-0.8	0.5	0.8	-0.1	-0.2
Illnesses of siblings: Diabetes	1.1	1.3	3.3	-1.3	0.7	0.6	1.3	1.8	-0.4
Smoking status: Previous	1.1	1.7	5.7	2.4	-1.5	0.1	-0.1	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.5	-1.1	0.6	-0.2	0.8	0.4	-1.2
Whole body fat-free mass	0.8	4.6	9.1	-1.3	3.0	-1.7	-2.1	-0.7	-3.0
Leg fat-free mass (right)	0.9	4.6	10.0	-1.9	3.2	-1.1	-1.7	-0.8	-3.0
Arm fat percentage (left)	0.8	3.0	8.7	0.6	-0.4	-0.9	-1.7	-2.3	-2.9
Average weekly red wine intake	1.2	1.7	6.4	0.1	0.6	1.0	0.8	1.4	2.5
Handedness (chirality/laterality): Left-handed	2.7	3.2	8.9	-2.7	3.0	-0.3	0.9	0.5	-1.4
Mood swings	0.5	0.9	3.0	0.3	-0.5	-0.7	-0.6	-1.1	-1.7
Loneliness, isolation	1.1	1.5	4.1	1.9	-2.0	0.6	0.2	-0.4	0.7
Long-standing illness, disability or infirmity	1.2	1.9	8.1	0.8	-0.9	-0.8	0.6	-0.9	-2.8
Ever had bowel cancer screening	1.2	1.3	4.3	1.6	-2.1	0.2	-0.6	-0.9	0.1
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.7	0.5	-0.3	0.3	1.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.8	1.3	-1.3	-0.5	-1.2	-0.0	1.3
Friendships satisfaction	4.8	5.9	18.1	3.3	-4.3	1.5	1.9	-0.9	-0.1
Qualifications: nursing, teaching	3.1	4.8	8.8	-1.8	1.9	2.4	2.0	3.0	1.7
Commuting to job workplace: Walk	2.7	2.9	8.3	-1.4	1.4	-0.0	-0.5	2.2	2.9
Eye problems/disorders: Cataract	4.4	5.1	11.9	3.4	-3.0	0.5	-1.4	-2.5	1.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.2	-0.2	0.1	-0.3	-0.4	0.3
Medication for cholesterol	2.8	4.3	7.1	-1.8	2.1	1.9	2.7	2.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	-0.2	0.4	-0.0	0.8	0.0	-0.8
Back pain experienced in last month	0.3	0.4	0.8	0.0	-0.8	0.7	0.2	0.6	0.9
Mineral and other dietary supplements	2.1	2.8	5.0	-2.1	2.2	0.4	0.9	2.1	1.3
Breast cancer (self-reported)	0.3	0.3	0.7	0.1	-0.7	0.2	0.5	0.6	0.8
Asthma (self-reported)	1.2	2.5	5.9	2.2	-2.4	0.2	-0.9	-1.5	-0.9
Osteoporosis (self-reported)	0.6	0.7	1.6	0.9	-1.3	0.0	0.6	-1.0	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.8	0.5	-0.1	0.1	0.1	-0.9
Medication: Aspirin	0.7	0.9	2.0	-0.0	-0.3	-0.8	-1.0	-1.4	-1.4
Medication: Gliclazide	1.1	1.2	2.4	-1.4	1.6	0.0	0.2	1.6	0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	-0.8	0.2	-0.2	-1.2	0.4	1.4
Smoking status: Current	1.4	2.2	7.9	0.1	-1.0	-1.3	0.1	-1.6	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	8.8	-0.9	1.1	1.2	1.7	3.0	1.3
Whole body water mass	0.8	4.5	9.2	-1.1	2.9	-1.7	-2.1	-0.8	-3.0
Leg predicted mass (right)	0.9	4.8	10.2	-1.9	3.2	-1.1	-1.8	-0.8	-3.1
Arm fat mass (left)	1.0	4.0	11.6	0.2	0.3	-1.4	-2.2	-2.4	-3.4
Number of self-reported non-cancer illnesses	1.2	2.1	4.2	1.8	-1.1	-0.9	-1.2	-1.3	-2.0
Average weekly champagne plus white wine intake	0.3	0.4	1.0	0.2	1.0	0.3	0.4	0.6	1.0
Miserableness	2.4	4.2	10.4	2.9	-3.2	-0.3	-1.2	-1.5	-1.5
Guilty feelings	0.8	1.2	3.1	-1.0	0.9	1.8	1.3	0.8	-0.5
Wears glasses or contact lenses	1.7	2.0	4.1	1.6	-1.5	-0.7	-0.3	-1.6	-2.0
Ever taken oral contraceptive pill	1.3	1.5	3.0	-0.4	0.7	1.4	1.1	1.7	1.4
Hearing aid user	0.5	0.5	1.1	-0.5	0.5	0.4	0.5	1.1	1.1
Mother’s age at death	2.3	2.9	5.2	-2.2	1.7	-0.1	-0.3	2.0	2.3
Financial situation satisfaction	0.4	0.4	1.2	0.4	-0.2	-0.7	-0.8	-0.4	-1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	-0.4	-0.6	-1.4	-1.5	-0.4	-0.4
Commuting to job workplace: Public transport	2.1	2.5	4.8	-1.6	1.7	0.8	0.8	2.2	1.9
Eye problems/disorders: Glaucoma	2.8	3.3	7.7	1.4	-1.1	2.8	2.4	1.6	1.0
Medication: Blood pressure	1.0	1.9	3.3	1.8	-1.5	-1.0	-1.5	-1.6	-0.1
Pain type(s) experienced in last month: Hip pain	3.7	4.6	10.9	2.2	-1.1	-1.5	-1.2	-2.7	-3.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.2	-0.6	-0.3	-0.8	-1.1	-0.6
High cholesterol (Self-reported)	0.3	0.5	1.6	0.2	-0.8	0.6	1.3	0.3	-0.3
Medication: Bendroflumethiazide	1.1	1.7	3.2	0.9	-0.9	-1.8	-1.2	-1.6	-1.3
Medication: Paracetamol	1.4	2.2	3.5	1.9	-1.3	-1.4	-0.9	-1.4	-1.8
Medication: Lisinopril	0.7	0.9	2.4	-0.5	0.5	-1.5	-1.0	-0.1	-1.3
Medication: Atorvastatin	1.1	1.4	3.0	-0.3	0.7	-1.7	-1.4	-1.2	-1.0
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.5	0.7	0.8	0.5	0.2	-0.1
Alcohol drinker status: Never	0.2	0.3	0.7	-0.7	0.7	-0.3	-0.8	0.2	0.2
Ever smoked	1.6	2.8	4.2	1.6	-2.1	-1.4	-0.8	-1.8	-2.0
Basal metabolic rate	0.8	4.3	10.1	-1.0	2.6	-1.6	-2.1	-1.0	-3.2
Leg fat percentage (left)	1.4	5.2	8.7	1.6	-1.4	-1.9	-3.0	-2.8	-2.5
Arm fat-free mass (left)	0.8	4.0	9.6	-0.8	2.3	-1.7	-2.1	-1.0	-3.1
Number of operations (self-reported)	0.6	0.8	2.1	0.4	-0.8	1.1	1.5	0.6	-0.8
Average weekly beer plus cider intake	0.2	0.3	1.0	-0.4	0.4	0.2	-0.3	1.0	0.0
Irritability	0.2	0.4	0.9	0.6	-0.4	0.2	0.8	-0.6	-0.9
Risk taking	0.3	0.5	1.3	-0.7	1.1	0.5	0.2	0.8	-0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.5	-0.1	0.8	-0.2	0.4	0.1	-1.9
Fractured/broken bones in last 5 years	0.9	1.1	2.8	-1.7	0.6	1.0	1.4	0.1	-0.8
Age started oral contraceptive pill	1.6	2.0	5.0	2.1	-2.2	1.1	0.1	-0.8	0.8
Diastolic blood pressure, automated reading	1.1	3.5	12.8	-3.6	1.8	-1.5	-1.5	-0.2	0.1
Ever depressed for a whole week	1.7	2.1	5.6	1.2	-1.6	-1.1	-2.4	-1.5	0.2
Unable to work because of sickness or disability	0.5	0.7	2.8	0.4	-0.3	0.4	0.9	-0.1	-1.7
Commuting to job workplace: Cycle	0.5	0.7	1.7	-1.2	1.3	-0.3	0.0	0.4	-0.8
Myopia	0.1	0.1	0.3	-0.1	0.3	-0.1	-0.5	-0.5	-0.0
Vascular/heart problems diagnosed by doctor	0.9	2.6	6.1	-0.3	0.4	1.9	1.7	2.5	1.6
Cholesterol lowering medication	0.7	1.0	1.5	0.9	-1.2	-0.6	-0.7	-1.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.2	0.9	-0.9	-0.9	-1.4	-1.5	-0.7
Pain experienced in last month	0.9	1.4	3.7	1.1	-1.1	0.9	0.9	0.9	1.9
Supplements: Calcium	1.2	1.3	3.8	-0.9	0.4	1.9	1.0	0.7	1.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.1	-0.4	-0.4	-0.2	-0.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	1.5	-1.2	1.4	0.6	-1.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.6	0.1	0.4	-0.6	-0.3	-0.8
Heart disease (siblings)	0.5	0.6	2.2	-0.4	0.8	-0.2	0.5	0.3	-1.5
Alcohol drinker status: Previous	0.6	0.7	2.7	0.4	-0.5	1.6	0.9	-0.0	0.3
Pack years of smoking	2.3	3.4	6.0	1.6	-1.8	-1.7	-2.5	-2.3	-0.4
Impedance of whole body	0.9	4.8	10.3	-0.5	-1.6	2.2	2.8	1.7	3.2
Leg fat mass (left)	1.3	5.1	10.4	0.7	-0.1	-2.0	-3.0	-2.6	-3.2
Arm predicted mass (left)	0.8	3.9	9.1	-0.8	2.2	-1.6	-2.1	-1.2	-3.0