Hub : Genes

CDC23

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.105 0.0440 0.00052 0.068 NA 0.068 NA 0.063 5.9e-04 NA 6.1e-04 NA 8.8e-04
2 YFS Blood 0.008 0.0045 0.00970 0.008 0.004 0.002 0.004 0.006 6.3e-04 0.01800 4.5e-02 0.018 3.1e-03
3 TCGA Breast Invasive Carcinoma 0.112 0.0429 0.00077 0.024 0.000 0.009 NA 0.020 6.9e-06 0.37000 4.1e-03 NA 5.4e-05
4 TCGA Ovarian Serous Cystadenocarcinoma 0.214 0.0930 0.00950 0.006 -0.004 0.021 NA 0.040 1.1e-01 0.86000 1.4e-02 NA 9.6e-04
5 TCGA Pancreatic Adenocarcinoma 0.103 0.0720 0.00990 0.001 0.020 0.032 NA 0.002 2.9e-01 0.04700 1.7e-02 NA 2.7e-01
6 TCGA Prostate Adenocarcinoma 0.141 0.0561 0.00014 0.003 0.037 0.045 NA 0.018 1.3e-01 0.00009 1.8e-05 NA 4.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.7 1.1 4.1 -2.0 1.5 0.0 0.0 0.3 0.0
Bipolar Disorder or Schizophrenia 0.7 1.7 7.7 -2.8 1.6 0.0 0.0 -0.0 -0.0
Depressed Affect (Nagel 2018) 0.5 1.1 3.2 1.8 -1.1 -0.1 -0.6 -0.7 -1.1
Depression (Nagel 2018) 1.6 2.4 4.7 1.3 -2.2 -1.1 -1.4 -1.9 -1.2
Intelligence (Savage-Jansen 2018) 2.6 7.9 12.7 -2.8 3.5 2.0 2.3 3.6 2.3
Neuroticism (Nagel 2018) 0.5 1.2 3.1 1.8 -1.7 0.8 0.3 -0.1 0.4
Schizophrenia (2018) 0.4 0.8 3.6 -1.9 0.9 0.0 0.0 -0.3 -0.0
Schizophrenia vs Biploar Disorder 1.1 1.4 4.8 1.6 -2.2 0.0 0.0 -0.7 0.6
Worry (Nagel 2018) 1.2 2.5 5.6 1.9 -2.0 0.9 0.4 0.8 2.4
Alzheimer’s Disease (in mother) 0.7 0.8 1.6 -0.6 0.3 0.9 1.3 1.2 0.6
Alzheimer’s Disease (in father) 1.1 1.1 1.9 1.4 -0.8 -1.2 -1.2 -1.0 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.4 0.1 -0.0 0.3 0.4 -0.0
Crohns Disease (2017) 0.4 0.9 2.1 1.0 0.2 1.4 1.4 0.3 -0.2
Irritable Bowel Disease (IBD) 0.4 0.8 2.0 0.7 0.4 1.2 1.4 -0.2 -1.0
Ulcerative Colitis (UC) 0.2 0.4 1.0 0.4 0.0 0.6 1.0 -0.3 -0.9
Major Depression (MDD) 1.9 2.3 4.7 2.0 -2.2 1.2 0.8 -1.3 -1.0
Reaction Time 1.4 2.6 7.1 0.8 -1.9 -0.8 0.8 -1.8 -2.7
Verbal and Numeric Reasoning (VNR) 2.1 5.1 9.0 -1.8 2.7 2.2 1.9 3.0 1.6
Breast Cancer 0.6 1.4 2.3 -1.0 1.0 1.5 1.4 1.2 0.8
Ovarian Cancer 0.4 0.5 1.7 -0.6 1.3 0.5 0.6 0.5 -0.1
Prostate Cancer 0.4 0.6 1.0 0.6 0.3 1.0 0.9 0.9 -0.6
Age at First Birth 1.5 2.2 4.4 -2.1 2.0 0.0 0.0 2.0 0.8
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.5 -0.0 0.0 0.0 0.0 0.4
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 0.3 -0.2 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 2.8 3.4 8.2 1.1 -1.9 0.0 0.0 -2.7 -2.9
Crohns Disease (2012) 0.3 0.4 1.3 0.3 1.1 0.0 0.0 -0.3 -1.1
Mean Putamen Volume 0.6 0.7 1.8 0.3 -0.7 0.9 1.4 -0.4 -1.1
Fasting Glucose 1.6 1.9 8.1 -1.3 0.3 0.0 0.0 1.2 2.9
HbA1C 1.9 2.1 8.5 -1.5 1.4 0.0 0.0 0.4 -2.9
HDL Cholesterol 0.6 1.0 3.2 -1.7 1.8 0.0 0.0 0.0 0.0
LDL Cholesterol 0.1 0.2 1.0 0.5 -1.0 0.0 0.0 0.0 0.0
Lupus 1.8 2.7 8.2 0.9 -0.4 -1.3 -1.3 -2.0 -2.9
Neuroticism (2016) 1.0 1.4 3.4 1.9 -1.7 0.0 0.0 0.3 1.4
Primary Biliary Cirrhosis 0.5 0.7 2.5 -1.6 0.8 0.6 0.5 -0.1 0.4
Rheumatoid Arthritis 0.6 0.8 1.6 1.3 -0.6 1.2 0.8 -0.0 -0.9
Schizophrenia (2014) 0.3 0.7 3.8 -1.9 0.5 0.0 0.0 -0.3 0.6
Triglycerides 0.8 1.4 5.3 1.7 -2.3 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.3 -0.5 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.7 2.5 9.1 0.7 -0.6 0.0 0.0 -2.3 -3.0
Blood Eosinophil Count 1.0 7.6 15.9 2.7 -3.3 -1.5 -2.2 -4.0 -2.3
Blood Platelet Count 0.3 3.7 10.4 -2.4 0.8 1.3 0.4 2.0 3.2
Blood Red Count 1.6 15.2 36.1 6.0 -5.4 -0.9 -1.3 -4.4 -2.1
Blood White Count 0.1 0.5 0.9 0.8 -0.9 0.4 0.3 0.9 -0.3
Heel T-Score 0.2 1.9 5.4 0.5 0.4 -2.2 -2.3 -0.8 -0.5
BMI 1.0 5.9 15.7 0.8 0.3 -2.5 -4.0 -2.6 -2.5
Height 0.5 9.5 22.0 -4.2 4.7 1.1 2.2 3.3 -0.2
Waist Hip Ratio (WHR) 0.7 3.2 8.2 -2.9 2.0 0.3 1.0 1.8 1.7
Systolic Blood Pressure 0.8 4.0 11.7 -3.4 2.7 -1.6 -1.4 0.5 -0.2
Smoking Status 3.3 7.9 11.8 3.2 -3.4 -1.6 -0.6 -3.4 -3.3
Allergy or Eczema 2.4 6.4 16.4 4.0 -3.9 -1.4 -1.7 -1.5 0.2
Cardiovascular Disease 0.4 1.2 2.8 -1.7 1.4 -1.3 -0.8 -0.4 -0.5
Hypothyroidism (self reported) 0.5 1.2 2.6 1.4 -1.6 -1.0 -0.6 -1.1 -0.6
Respiratory disease 1.4 3.2 7.5 2.5 -2.7 -0.4 -1.4 -1.5 -1.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.3 -0.2 -0.5 -0.7 -0.0 0.5 -1.8
Lung FEV1/FVC ratio 0.8 4.2 8.5 -2.9 1.8 0.4 0.6 2.6 2.4
Lung FVC 0.3 1.4 2.0 -0.9 1.2 1.4 1.3 1.0 1.2
Neuroticism 0.9 2.3 4.7 2.2 -2.1 -0.9 -1.3 -1.2 -0.6
Chronotype (morning person) 1.1 2.6 8.4 -2.5 2.9 -0.6 -0.0 0.5 -0.7
Hair Pigment 0.1 1.6 5.0 -2.2 1.1 -0.5 0.6 -0.5 -1.6
Tanning 0.1 0.6 1.7 0.6 0.9 -0.9 -1.3 -0.1 0.3
Hand grip strength (left) 0.1 0.2 0.7 0.3 0.1 0.5 0.5 -0.0 -0.8
Number of treatments/medications taken 3.4 6.1 9.5 2.2 -1.3 -2.4 -2.8 -2.7 -3.1
Average weekly spirits intake 0.8 1.0 2.6 -1.6 1.6 -0.5 -0.1 0.9 0.1
Sensitivity / hurt feelings 1.2 2.0 4.7 1.4 -1.9 0.0 0.1 -1.3 -2.2
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.1 1.1 -1.7 -0.7 -1.5 -1.2 -0.0
Hearing difficulty/problems: Yes 0.2 0.4 0.9 0.1 -0.1 1.0 0.3 0.9 0.6
Relative age of first facial hair 0.6 1.3 2.4 1.6 -1.4 1.1 0.8 -1.1 -0.3
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 4.3 -1.3 1.3 -1.3 0.2 -0.2 -2.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 0.6 -1.1 0.2 0.7 0.2 -0.4
Ever had hysterectomy (womb removed) 0.4 0.5 1.2 -1.1 0.9 -0.5 0.1 0.3 -0.8
Systolic blood pressure, automated reading 0.6 1.8 7.8 -2.8 1.3 -0.6 -0.6 0.8 0.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.9 -0.9 0.3 -0.7 -0.9 0.7 0.7
Angina 2.0 2.6 4.9 2.2 -1.9 -0.4 -1.3 -2.2 -0.6
Medication for hormone replacement therapy 0.3 0.3 0.9 -0.6 0.1 -0.5 -0.9 -0.4 -0.2
Vitamin and mineral supplements 0.7 1.0 2.7 1.6 -1.0 0.4 0.8 -0.2 -1.2
Supplements: Zinc 0.9 1.0 3.5 -1.9 1.5 -0.0 0.0 0.4 0.2
Medication: Co-codamol 0.7 0.8 2.7 0.6 -0.6 1.1 1.6 0.4 0.1
Medication: Metformin 0.5 0.7 1.9 -0.3 0.3 0.8 0.8 1.4 -0.8
Diabetes (father) 0.3 0.4 1.1 -0.1 0.3 -0.3 -1.0 -0.4 -1.1
Diabetes (mother) 0.3 0.3 1.3 0.2 -0.0 0.4 0.4 1.1 0.6
Severe depression (siblings) 0.6 0.7 2.1 -1.1 0.5 -0.7 -1.5 0.1 0.0
Pack years adult smoking proportion 2.3 3.6 6.3 1.5 -1.7 -1.8 -2.4 -2.5 -0.8
Impedance of leg (right) 0.8 3.8 9.9 1.2 -2.6 1.1 1.6 1.2 3.1
Leg fat-free mass (left) 0.9 4.9 12.1 -1.4 2.7 -1.6 -2.1 -1.2 -3.5
Trunk fat percentage 0.6 2.2 8.0 -0.1 -0.2 -0.6 -1.0 -2.0 -2.8
Hand grip strength (right) 0.1 0.3 1.4 -0.2 0.1 -0.3 -0.1 -0.1 -1.2
Townsend deprivation index at recruitment 0.9 1.2 2.7 0.6 -1.6 1.2 1.2 0.8 0.8
Current tobacco smoking 1.8 2.9 9.9 0.0 -1.1 -1.6 -0.3 -1.9 -3.2
Average weekly fortified wine intake 0.4 0.5 1.2 0.5 -0.3 0.8 1.1 0.8 0.4
Maternal smoking around birth 1.6 2.3 5.4 1.5 -1.9 0.1 0.5 -1.5 -2.3
Fed-up feelings 1.2 2.2 2.7 1.5 -1.4 -1.4 -1.3 -1.6 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 4.7 1.8 -2.1 -1.0 -1.5 -2.2 -1.8
Relative age voice broke 0.3 0.4 1.3 0.3 -1.1 0.2 0.7 -0.1 0.7
Taking other prescription medications 1.4 2.1 4.6 0.7 -0.2 -1.6 -1.6 -1.6 -2.1
Age when periods started (menarche) 0.9 2.3 3.4 -1.5 0.8 1.8 1.7 1.3 1.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.8 0.3 -0.1 0.1 1.0 0.4 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.7 -0.4 1.1 -1.3 -1.0 -0.2 -1.1
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.9 0.8 -0.6 -0.6 -1.5 -1.7 -1.0
Qualifications: CSEs or equivalent 2.8 3.7 7.5 2.7 -2.6 -0.7 -1.3 -2.1 -1.2
Serious illness, injury or assault to yourself 1.1 1.4 2.3 -1.4 1.0 1.1 1.5 1.4 -0.4
High blood pressure 0.8 2.3 4.5 -0.5 0.6 -2.1 -1.4 -1.9 -1.8
Hayfever, allergic rhinitis or eczema 2.7 5.8 15.5 3.9 -3.9 -0.9 -0.9 -1.4 0.3
Multivitamins +/- minerals 0.6 0.8 3.1 -1.8 1.0 -0.4 0.2 0.7 0.1
Stomach or abdominal pain in last month 0.6 0.7 2.0 -1.0 0.4 -0.5 -0.6 -0.9 -1.4
Supplements: Glucosamine 1.6 2.1 4.2 1.7 -1.4 -0.8 -1.4 -2.0 -1.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 0.7 -1.1 0.7 1.3 0.2 -0.5
Medication: Atenolol 0.5 0.6 1.3 -1.1 1.1 -0.0 0.6 0.8 0.4
Medication: Levothyroxine sodium 0.2 0.4 1.1 0.7 -0.3 0.5 0.6 1.0 -0.3
Sitting height 0.5 3.7 10.7 -2.0 3.3 1.0 0.7 2.5 0.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 0.2 -0.2 0.7 0.9 0.5 0.4
High blood pressure (mother) 0.9 1.3 4.2 -0.8 0.9 -1.3 -2.0 -0.5 0.0
Body mass index (BMI) 1.3 5.6 13.7 0.8 0.1 -1.9 -2.8 -2.8 -3.7
Impedance of leg (left) 0.9 4.6 12.8 0.8 -2.3 1.8 2.0 1.4 3.6
Leg predicted mass (left) 0.9 4.9 12.4 -1.4 2.7 -1.5 -2.1 -1.2 -3.5
Trunk fat mass 0.7 2.9 9.9 -0.4 0.7 -1.1 -1.6 -1.8 -3.1
Waist circumference 0.8 2.9 9.5 -0.1 0.9 -1.2 -1.5 -1.7 -3.1
Number of incorrect matches in round 2.6 4.3 11.4 3.3 -3.4 -0.5 -0.6 -1.6 -0.0
Past tobacco smoking 2.0 3.8 8.3 -2.9 2.5 0.6 0.5 2.1 1.6
Alcohol usually taken with meals 0.5 0.7 3.1 -0.1 0.7 0.7 0.1 0.5 1.8
Nervous feelings 1.3 2.4 8.0 1.9 -2.8 0.8 0.8 0.4 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 2.9 1.6 -1.7 0.4 -0.2 -0.5 -0.3
Hearing difficulty/problems with background noise 1.9 3.0 10.8 2.5 -3.3 -0.4 -0.5 -0.7 0.3
Hair/balding pattern: Pattern 2 0.7 0.8 1.8 0.4 -0.7 1.1 -0.1 1.4 1.1
Had menopause 0.2 0.2 0.6 -0.7 0.2 0.1 0.4 0.5 0.5
Had other major operations 1.1 1.4 2.8 -1.7 1.3 0.9 1.4 1.0 0.1
Forced vital capacity (FVC) 1.2 4.7 9.2 -3.0 3.0 1.1 1.6 2.3 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 1.2 -0.1 1.0 -0.9 -1.1 -0.1 -0.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.1 0.6 -1.7 0.1 -1.1 -0.9 0.7
Qualifications: None of the above 2.5 5.4 13.1 2.8 -3.6 -0.6 -0.5 -2.3 -2.3
Financial difficulties in last 2 years 0.1 0.1 0.3 -0.3 0.3 -0.4 -0.4 0.1 -0.5
Mouth/teeth dental problems 0.6 1.0 2.1 -1.0 1.4 -1.4 -0.8 0.3 0.0
Heart attack 1.2 1.5 2.6 1.6 -1.3 1.4 0.7 -1.4 -0.6
Allergy 2.1 4.9 12.2 -3.5 3.3 0.9 1.6 1.6 0.6
Pain all over the body in last month 0.4 0.4 1.0 -0.1 -0.4 -1.0 -0.6 -0.6 -0.8
Diabetes (self-reported) 0.4 0.7 1.6 -0.8 0.6 0.2 0.7 1.0 -1.2
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.5 1.6 -0.6 -0.6 -0.1 -0.8 -1.3
Medication: Ramipril 3.1 4.0 5.0 1.7 -2.0 -2.2 -2.2 -2.2 -1.5
Medication: Simvastatin 0.4 0.6 1.5 0.9 -1.2 0.4 0.1 -0.4 -1.2
Fluid intelligence score 2.3 4.9 15.9 -2.7 4.0 0.5 0.9 2.2 0.6
Illnesses of siblings 0.5 0.7 2.2 0.5 0.3 -1.5 -1.0 -0.9 0.2
Neuroticism score 0.8 1.6 4.1 2.0 -2.0 -0.1 -0.8 -0.8 -0.6
Weight 0.9 4.3 12.7 -0.7 1.8 -1.6 -2.2 -1.5 -3.6
Impedance of arm (right) 0.9 4.3 9.6 -1.4 -0.5 2.1 3.1 2.1 2.3
Arm fat percentage (right) 0.6 2.5 7.5 0.4 -0.2 -0.8 -1.5 -2.2 -2.7
Trunk fat-free mass 0.6 3.6 8.1 -0.9 2.9 -1.7 -1.9 -0.3 -2.5
Hip circumference 1.1 4.5 15.5 0.5 0.6 -1.3 -1.9 -2.4 -3.9
Time employed in main current job 0.6 0.7 1.7 -1.1 1.3 0.3 0.5 1.0 -0.2
Alcohol intake versus 10 years previously 0.8 1.1 2.0 0.6 -1.4 -0.6 -1.0 -1.4 -1.1
Father’s age at death 1.0 1.4 3.1 -1.3 1.7 0.2 0.5 1.6 0.8
Worrier / anxious feelings 0.7 1.3 2.9 1.7 -1.7 0.0 -0.8 -0.4 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.7 -0.2 -0.0 -0.5 -0.7 -0.7 -1.3
Falls in the last year 0.3 0.4 0.6 0.8 -0.8 0.5 -0.2 0.6 0.7
Hair/balding pattern: Pattern 3 0.5 0.7 3.4 0.4 0.1 -0.3 0.1 -0.6 -1.8
Number of live births 2.3 3.3 8.9 2.1 -3.0 -0.3 -0.5 -2.4 0.7
Forced expiratory volume in 1-second (FEV1) 1.9 6.4 11.8 -3.4 3.2 1.1 1.5 3.1 1.9
Pulse rate 6.5 11.0 36.7 -6.1 4.4 -1.9 -1.0 2.3 -0.3
Happiness 3.5 4.3 11.7 3.4 -3.4 0.7 0.3 -1.0 1.0
Noisy workplace 0.4 0.5 1.2 0.3 -0.6 -0.3 -1.0 -0.6 -1.1
Qualifications: A levels/AS levels or equivalent 5.9 13.1 26.4 -4.0 5.0 1.4 1.6 5.1 2.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.8 -1.3 1.2 -0.6 -0.8 1.3 0.8
Mouth/teeth dental problems: Dentures 3.2 5.4 13.8 3.7 -3.7 1.3 1.2 -1.1 -0.8
Asthma 1.1 2.1 4.7 2.0 -2.2 -0.0 -1.0 -1.4 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 0.3 0.1 -1.0 -1.2 -1.5 -0.4
Medication: Cholesterol lowering 0.3 0.5 2.3 -0.1 0.0 -0.6 0.1 -0.7 -1.5
Depression (self-reported) 0.0 0.0 0.2 0.1 0.4 0.2 -0.1 0.0 0.2
Medication: Lansoprazole 1.2 1.4 2.7 1.4 -1.2 -0.7 -0.3 -1.6 -1.2
Prospective memory result 0.7 0.9 2.1 -1.5 0.2 0.9 0.5 0.9 1.0
Lung cancer (father) 0.3 0.4 0.7 0.6 -0.1 -0.5 -0.7 -0.6 -0.8
Illnesses of mother 1.4 1.7 3.7 -1.0 0.8 1.4 1.1 1.4 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 8.6 -2.0 2.7 1.3 1.4 2.9 1.6
Pulse wave Arterial Stiffness index 0.9 1.0 2.6 -1.2 0.7 -1.2 -0.2 -0.4 -1.6
Impedance of arm (left) 0.9 4.0 8.3 -1.3 -0.7 2.1 2.9 1.8 2.4
Arm fat mass (right) 0.9 3.6 10.6 0.3 0.2 -1.2 -1.9 -2.4 -3.3
Trunk predicted mass 0.7 3.7 8.7 -1.1 3.0 -1.7 -1.9 -0.3 -2.4
Standing height 0.6 5.5 13.3 -3.3 3.6 0.8 1.3 2.5 0.2
Length of working week for main job 2.6 2.9 7.7 -1.6 2.8 -1.4 -0.9 -0.9 -1.9
Exposure to tobacco smoke at home 0.6 0.6 1.4 -1.2 1.1 -0.8 -0.4 0.3 -0.6
Breastfed as a baby 1.6 1.9 3.3 1.0 -1.1 -1.5 -1.8 -1.6 -1.1
Tense / ‘highly strung’ 1.0 1.7 2.9 1.7 -1.6 1.6 1.5 0.1 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.0 0.8 -2.0 1.7 0.9 0.3 0.6
Hair/balding pattern: Pattern 4 0.1 0.1 0.3 0.2 0.6 -0.4 0.1 0.5 -0.2
Birth weight of first child 0.1 0.2 0.9 -0.2 0.5 0.9 0.4 -0.2 0.2
Peak expiratory flow (PEF) 1.8 4.1 8.0 -2.0 2.1 1.9 1.4 2.8 1.5
Pulse wave reflection index 1.8 2.2 5.5 2.3 -1.8 -0.5 -0.2 -1.7 -1.1
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.6 -1.2 0.5 -0.4 0.6 -0.4 -1.2
Loud music exposure frequency 1.0 1.1 2.4 0.5 -1.4 0.5 -1.2 -0.5 1.5
Qualifications: O levels/GCSEs or equivalent 1.9 3.1 8.2 -2.9 2.6 -0.6 0.7 1.6 0.6
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 3.3 0.0 0.1 1.8 0.7 0.5 0.7
Blood clot in the leg (DVT) 0.2 0.2 0.7 0.3 0.2 0.1 -0.8 -0.3 -0.8
Medication: Paracetamol 1.6 2.7 4.2 2.0 -1.3 -1.6 -0.9 -1.7 -2.0
Headache pain in last month 0.7 1.2 2.4 -1.5 1.5 -0.7 -0.0 0.2 -1.4
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 4.3 1.3 -1.5 1.9 0.9 0.6 2.1
Glaucoma (self-reported) 1.6 1.8 3.5 1.7 -1.2 1.9 1.6 0.7 0.4
Gout (self-reported) 1.1 1.5 4.0 -0.2 1.1 1.7 0.6 0.5 2.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 1.2 -1.0 -0.3 -0.3 -0.3 -0.8
Medication: Amlodipine 0.8 1.1 2.4 -0.4 0.9 -1.6 -1.5 -0.9 -0.1
Medication: Ventolin 100micrograms inhaler 2.4 3.1 9.9 2.1 -3.1 -0.6 -0.4 -1.8 -0.4
Birth weight 0.3 0.6 1.2 0.3 -0.7 1.1 0.6 -0.8 1.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.4 -0.4 0.2 -0.3 0.1 -0.6 -1.5
High blood pressure (siblings) 0.3 0.5 1.2 -0.9 -0.5 1.1 -0.1 -0.4 0.7
Forced vital capacity (FVC), Best measure 0.9 3.3 5.8 -1.5 2.4 1.4 2.0 2.4 0.7
Body fat percentage 0.7 2.6 6.7 0.7 -0.8 -0.7 -1.6 -2.2 -2.6
Leg fat percentage (right) 1.7 6.2 10.0 1.9 -1.6 -2.3 -3.2 -3.0 -2.7
Arm fat-free mass (right) 0.8 4.2 9.2 -0.5 2.1 -1.9 -2.5 -1.3 -3.0
Exposure to tobacco smoke outside home 1.2 1.5 5.9 -2.4 1.6 0.4 -0.2 0.7 -0.4
Comparative body size at age 10 0.4 1.2 3.7 -1.2 1.2 -0.5 -0.2 -0.6 -1.9
Number of full brothers 0.8 1.0 3.1 1.8 -1.3 0.7 0.4 -0.8 0.5
Worry too long after embarrassment 0.4 0.7 1.4 1.1 -1.1 1.2 0.5 0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.2 0.2 -0.5 0.9 1.1 0.5 -0.8
Wheeze or whistling in the chest in last year 1.3 2.3 5.2 1.0 -1.5 -0.5 -1.3 -1.9 -2.3
Number of children fathered 2.6 3.0 7.9 1.9 -0.9 -1.5 -2.8 -1.8 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 0.9 -1.3 0.7 0.6 -0.3 0.7
Age at first live birth 1.1 1.9 6.8 -1.6 2.6 -0.9 -0.8 0.6 0.7
Pulse wave peak to peak time 1.0 1.1 2.9 1.0 -0.5 1.4 0.6 0.7 1.7
Health satisfaction 0.6 0.7 1.2 1.0 -1.0 -0.4 -0.5 -0.9 -1.1
Shortness of breath walking on level ground 1.3 1.5 3.4 -1.6 1.8 0.5 0.9 1.4 0.5
Qualifications: College or University degree 2.6 8.1 15.9 -2.5 4.0 1.9 2.3 3.3 2.7
Eye problems/disorders: None of the above 2.3 2.6 5.0 -2.1 2.2 -1.9 -0.5 0.8 -1.3
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 0.7 -0.5 0.5 1.0 -0.2 -0.6
Emphysema/chronic bronchitis 2.5 2.9 7.8 1.4 -2.8 -0.5 -0.9 -2.5 -0.1
Medication for pain relief, constipation, heartburn 2.4 4.0 6.0 -1.7 1.3 2.2 2.3 2.4 1.8
Neck or shoulder pain in last month 0.5 0.7 3.0 -0.5 0.7 -0.4 -0.1 -0.4 -1.7
Medication: Blood pressure 1.5 2.6 6.0 -0.5 0.8 -2.5 -1.4 -1.1 -2.3
Angina (self-reported) 2.1 2.7 5.6 2.0 -1.9 -0.6 -1.5 -2.4 -0.8
Migraine (self-reported) 0.9 1.2 4.2 -2.0 1.6 -0.1 0.0 -0.1 -0.4
Medication: Ibuprofen 0.9 1.1 3.1 0.3 0.3 -1.4 -1.8 -1.1 -0.0
Medication: Allopurinol 0.6 0.7 3.1 0.3 0.2 1.1 -0.2 -0.3 1.8
Medication: Omeprazole 1.2 1.4 3.3 0.8 -1.0 -0.7 -1.0 -1.8 -1.5
Medication: Seretide 50 evohaler 1.2 1.4 3.1 0.6 -1.8 -1.0 -0.1 -1.7 -1.1
Mean time to correctly identify matches 1.1 2.1 4.7 1.0 -1.8 -0.8 0.6 -1.6 -2.2
Heart disease (mother) 2.4 2.9 4.9 2.2 -2.1 -0.2 0.1 -2.2 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 4.8 0.7 -0.8 -2.0 -2.2 -2.2 -0.7
Whole body fat mass 0.8 3.2 9.5 0.4 -0.0 -1.1 -1.8 -2.3 -3.1
Leg fat mass (right) 1.4 5.5 10.5 0.8 -0.2 -2.1 -3.1 -2.8 -3.2
Arm predicted mass (right) 0.7 3.7 9.0 -0.4 2.1 -1.6 -2.2 -1.3 -3.0
Pulse rate, automated reading 9.2 29.8 99.9 -10.0 7.0 -1.5 -0.3 5.1 1.1
Alcohol intake frequency. 0.5 1.3 2.1 -0.1 -1.2 1.4 1.0 -1.3 -1.3
Comparative height size at age 10 0.5 2.7 6.1 -1.7 2.5 -0.0 0.8 2.5 -0.5
Number of full sisters 0.3 0.4 1.4 -0.6 -0.3 0.6 -0.2 0.1 1.2
Suffer from ‘nerves’ 1.7 2.6 8.9 1.8 -3.0 0.5 -0.4 0.1 1.8
Overall health rating 2.2 4.7 14.3 1.4 -1.3 -1.4 -1.7 -2.3 -3.8
Chest pain or discomfort 0.3 0.5 2.6 0.1 -0.1 -0.3 0.0 -0.1 -1.6
Had major operations 2.1 2.4 6.5 0.4 -0.3 2.4 2.6 1.4 -0.0
Age at last live birth 1.0 1.5 4.1 0.4 -0.0 -1.4 -2.0 -1.5 0.6
Family relationship satisfaction 1.5 1.9 6.1 1.6 -2.5 0.0 0.3 -1.6 -0.0
Leg pain on walking 0.9 1.2 4.2 0.4 0.0 -1.4 -0.5 -0.7 -2.0
Qualifications: NVQ or HND or HNC or equivalent 2.8 3.3 6.7 1.6 -1.8 -0.8 -2.5 -2.6 -0.9
Commuting to job workplace: Car/motor vehicle 2.4 2.8 8.7 0.1 0.7 -1.6 -1.5 -1.7 -3.0
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 3.7 1.7 -1.9 1.4 0.7 -1.0 1.1
Medication: Aspirin 0.2 0.3 0.7 -0.2 -0.4 -0.2 -0.6 -0.8 -0.8
Supplements: Vitamin C 1.2 1.5 4.0 -1.8 2.0 0.9 0.2 -0.1 0.8
Knee pain experienced in last month 0.8 1.2 2.9 0.5 -0.2 -1.6 -1.7 -0.5 -1.0
Hypertension (Self-reported) 0.6 1.5 3.6 -0.7 0.8 -1.6 -0.5 -1.2 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.2 3.7 7.3 1.9 -2.0 -1.6 -1.9 -2.7 -1.2
Illnesses of father: Heart disease 0.2 0.3 0.7 0.6 -0.8 0.5 0.8 -0.1 -0.2
Illnesses of siblings: Diabetes 1.1 1.3 3.3 -1.3 0.7 0.6 1.3 1.8 -0.4
Smoking status: Previous 1.1 1.7 5.7 2.4 -1.5 0.1 -0.1 -1.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.5 -1.1 0.6 -0.2 0.8 0.4 -1.2
Whole body fat-free mass 0.8 4.6 9.1 -1.3 3.0 -1.7 -2.1 -0.7 -3.0
Leg fat-free mass (right) 0.9 4.6 10.0 -1.9 3.2 -1.1 -1.7 -0.8 -3.0
Arm fat percentage (left) 0.8 3.0 8.7 0.6 -0.4 -0.9 -1.7 -2.3 -2.9
Average weekly red wine intake 1.2 1.7 6.4 0.1 0.6 1.0 0.8 1.4 2.5
Handedness (chirality/laterality): Left-handed 2.7 3.2 8.9 -2.7 3.0 -0.3 0.9 0.5 -1.4
Mood swings 0.5 0.9 3.0 0.3 -0.5 -0.7 -0.6 -1.1 -1.7
Loneliness, isolation 1.1 1.5 4.1 1.9 -2.0 0.6 0.2 -0.4 0.7
Long-standing illness, disability or infirmity 1.2 1.9 8.1 0.8 -0.9 -0.8 0.6 -0.9 -2.8
Ever had bowel cancer screening 1.2 1.3 4.3 1.6 -2.1 0.2 -0.6 -0.9 0.1
Diabetes diagnosed by doctor 0.3 0.5 1.1 -0.7 0.5 -0.3 0.3 1.0 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.8 1.3 -1.3 -0.5 -1.2 -0.0 1.3
Friendships satisfaction 4.8 5.9 18.1 3.3 -4.3 1.5 1.9 -0.9 -0.1
Qualifications: nursing, teaching 3.1 4.8 8.8 -1.8 1.9 2.4 2.0 3.0 1.7
Commuting to job workplace: Walk 2.7 2.9 8.3 -1.4 1.4 -0.0 -0.5 2.2 2.9
Eye problems/disorders: Cataract 4.4 5.1 11.9 3.4 -3.0 0.5 -1.4 -2.5 1.0
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.2 -0.2 -0.2 0.1 -0.3 -0.4 0.3
Medication for cholesterol 2.8 4.3 7.1 -1.8 2.1 1.9 2.7 2.5 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 -0.2 0.4 -0.0 0.8 0.0 -0.8
Back pain experienced in last month 0.3 0.4 0.8 0.0 -0.8 0.7 0.2 0.6 0.9
Mineral and other dietary supplements 2.1 2.8 5.0 -2.1 2.2 0.4 0.9 2.1 1.3
Breast cancer (self-reported) 0.3 0.3 0.7 0.1 -0.7 0.2 0.5 0.6 0.8
Asthma (self-reported) 1.2 2.5 5.9 2.2 -2.4 0.2 -0.9 -1.5 -0.9
Osteoporosis (self-reported) 0.6 0.7 1.6 0.9 -1.3 0.0 0.6 -1.0 -0.7
Osteoarthritis (self-reported) 0.2 0.3 0.9 0.8 0.5 -0.1 0.1 0.1 -0.9
Medication: Aspirin 0.7 0.9 2.0 -0.0 -0.3 -0.8 -1.0 -1.4 -1.4
Medication: Gliclazide 1.1 1.2 2.4 -1.4 1.6 0.0 0.2 1.6 0.6
Illnesses of father: None of the above (group 1) 0.6 0.7 1.8 -0.8 0.2 -0.2 -1.2 0.4 1.4
Smoking status: Current 1.4 2.2 7.9 0.1 -1.0 -1.3 0.1 -1.6 -2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 8.8 -0.9 1.1 1.2 1.7 3.0 1.3
Whole body water mass 0.8 4.5 9.2 -1.1 2.9 -1.7 -2.1 -0.8 -3.0
Leg predicted mass (right) 0.9 4.8 10.2 -1.9 3.2 -1.1 -1.8 -0.8 -3.1
Arm fat mass (left) 1.0 4.0 11.6 0.2 0.3 -1.4 -2.2 -2.4 -3.4
Number of self-reported non-cancer illnesses 1.2 2.1 4.2 1.8 -1.1 -0.9 -1.2 -1.3 -2.0
Average weekly champagne plus white wine intake 0.3 0.4 1.0 0.2 1.0 0.3 0.4 0.6 1.0
Miserableness 2.4 4.2 10.4 2.9 -3.2 -0.3 -1.2 -1.5 -1.5
Guilty feelings 0.8 1.2 3.1 -1.0 0.9 1.8 1.3 0.8 -0.5
Wears glasses or contact lenses 1.7 2.0 4.1 1.6 -1.5 -0.7 -0.3 -1.6 -2.0
Ever taken oral contraceptive pill 1.3 1.5 3.0 -0.4 0.7 1.4 1.1 1.7 1.4
Hearing aid user 0.5 0.5 1.1 -0.5 0.5 0.4 0.5 1.1 1.1
Mother’s age at death 2.3 2.9 5.2 -2.2 1.7 -0.1 -0.3 2.0 2.3
Financial situation satisfaction 0.4 0.4 1.2 0.4 -0.2 -0.7 -0.8 -0.4 -1.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.3 -0.4 -0.6 -1.4 -1.5 -0.4 -0.4
Commuting to job workplace: Public transport 2.1 2.5 4.8 -1.6 1.7 0.8 0.8 2.2 1.9
Eye problems/disorders: Glaucoma 2.8 3.3 7.7 1.4 -1.1 2.8 2.4 1.6 1.0
Medication: Blood pressure 1.0 1.9 3.3 1.8 -1.5 -1.0 -1.5 -1.6 -0.1
Pain type(s) experienced in last month: Hip pain 3.7 4.6 10.9 2.2 -1.1 -1.5 -1.2 -2.7 -3.3
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.3 0.2 -0.6 -0.3 -0.8 -1.1 -0.6
High cholesterol (Self-reported) 0.3 0.5 1.6 0.2 -0.8 0.6 1.3 0.3 -0.3
Medication: Bendroflumethiazide 1.1 1.7 3.2 0.9 -0.9 -1.8 -1.2 -1.6 -1.3
Medication: Paracetamol 1.4 2.2 3.5 1.9 -1.3 -1.4 -0.9 -1.4 -1.8
Medication: Lisinopril 0.7 0.9 2.4 -0.5 0.5 -1.5 -1.0 -0.1 -1.3
Medication: Atorvastatin 1.1 1.4 3.0 -0.3 0.7 -1.7 -1.4 -1.2 -1.0
Illnesses of father: High blood pressure 0.2 0.3 0.6 -0.5 0.7 0.8 0.5 0.2 -0.1
Alcohol drinker status: Never 0.2 0.3 0.7 -0.7 0.7 -0.3 -0.8 0.2 0.2
Ever smoked 1.6 2.8 4.2 1.6 -2.1 -1.4 -0.8 -1.8 -2.0
Basal metabolic rate 0.8 4.3 10.1 -1.0 2.6 -1.6 -2.1 -1.0 -3.2
Leg fat percentage (left) 1.4 5.2 8.7 1.6 -1.4 -1.9 -3.0 -2.8 -2.5
Arm fat-free mass (left) 0.8 4.0 9.6 -0.8 2.3 -1.7 -2.1 -1.0 -3.1
Number of operations (self-reported) 0.6 0.8 2.1 0.4 -0.8 1.1 1.5 0.6 -0.8
Average weekly beer plus cider intake 0.2 0.3 1.0 -0.4 0.4 0.2 -0.3 1.0 0.0
Irritability 0.2 0.4 0.9 0.6 -0.4 0.2 0.8 -0.6 -0.9
Risk taking 0.3 0.5 1.3 -0.7 1.1 0.5 0.2 0.8 -0.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.5 -0.1 0.8 -0.2 0.4 0.1 -1.9
Fractured/broken bones in last 5 years 0.9 1.1 2.8 -1.7 0.6 1.0 1.4 0.1 -0.8
Age started oral contraceptive pill 1.6 2.0 5.0 2.1 -2.2 1.1 0.1 -0.8 0.8
Diastolic blood pressure, automated reading 1.1 3.5 12.8 -3.6 1.8 -1.5 -1.5 -0.2 0.1
Ever depressed for a whole week 1.7 2.1 5.6 1.2 -1.6 -1.1 -2.4 -1.5 0.2
Unable to work because of sickness or disability 0.5 0.7 2.8 0.4 -0.3 0.4 0.9 -0.1 -1.7
Commuting to job workplace: Cycle 0.5 0.7 1.7 -1.2 1.3 -0.3 0.0 0.4 -0.8
Myopia 0.1 0.1 0.3 -0.1 0.3 -0.1 -0.5 -0.5 -0.0
Vascular/heart problems diagnosed by doctor 0.9 2.6 6.1 -0.3 0.4 1.9 1.7 2.5 1.6
Cholesterol lowering medication 0.7 1.0 1.5 0.9 -1.2 -0.6 -0.7 -1.2 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.2 0.9 -0.9 -0.9 -1.4 -1.5 -0.7
Pain experienced in last month 0.9 1.4 3.7 1.1 -1.1 0.9 0.9 0.9 1.9
Supplements: Calcium 1.2 1.3 3.8 -0.9 0.4 1.9 1.0 0.7 1.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 0.1 -0.4 -0.4 -0.2 -0.7 -0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.1 1.5 -1.2 1.4 0.6 -1.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.6 0.1 0.4 -0.6 -0.3 -0.8
Heart disease (siblings) 0.5 0.6 2.2 -0.4 0.8 -0.2 0.5 0.3 -1.5
Alcohol drinker status: Previous 0.6 0.7 2.7 0.4 -0.5 1.6 0.9 -0.0 0.3
Pack years of smoking 2.3 3.4 6.0 1.6 -1.8 -1.7 -2.5 -2.3 -0.4
Impedance of whole body 0.9 4.8 10.3 -0.5 -1.6 2.2 2.8 1.7 3.2
Leg fat mass (left) 1.3 5.1 10.4 0.7 -0.1 -2.0 -3.0 -2.6 -3.2
Arm predicted mass (left) 0.8 3.9 9.1 -0.8 2.2 -1.6 -2.1 -1.2 -3.0