TWAS hub - KDM3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.208	0.083	2.1e-03	0.015	NA	-0.012	NA	-0.006	0.140	NA	0.9200	NA	0.4900
2	ROSMAP	Brain Pre-frontal Cortex	0.069	0.030	7.9e-05	0.013	0.029	0.017	0.027	0.019	0.007	0.0001	0.0023	0.00017	0.0013
3	TCGA	Thyroid Carcinoma	0.050	0.029	6.2e-03	-0.001	0.014	0.021	NA	0.007	0.400	0.0150	0.0037	NA	0.0670

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	12.7	41.1	90.3	-2.9	-9.5	-5.0
Pulse rate	9.9	16.8	30.5	-1.6	-5.5	-4.1
Friendships satisfaction	6.1	7.5	16.5	1.6	4.1	1.9
Happiness	6.0	7.2	12.8	1.6	3.6	2.5
Handedness (chirality/laterality): Left-handed	5.5	6.7	16.4	-1.2	-1.5	-4.1
Migraine (self-reported)	4.8	5.9	8.9	-0.4	-3.0	-3.0
Number of live births	4.7	6.6	8.0	2.8	2.1	2.7
Mouth/teeth dental problems: Dentures	4.5	7.6	11.4	2.3	3.4	2.4
Qualifications: A levels/AS levels or equivalent	4.1	9.1	11.1	-3.3	-2.9	-2.8
Qualifications: CSEs or equivalent	4.0	5.2	8.7	1.6	2.1	2.9
Peak expiratory flow (PEF)	4.0	9.3	13.2	-3.6	-3.6	-1.3
Emphysema/chronic bronchitis	4.0	4.5	12.9	3.6	0.3	0.7
Leg predicted mass (right)	4.0	21.2	39.1	-2.8	-6.2	-4.1
Body Mass Index (BMI) (2010)	3.9	5.3	8.4	-2.4	-2.9	-1.4
Leg fat-free mass (right)	3.9	21.0	38.6	-2.8	-6.2	-4.1
Leg fat-free mass (left)	3.6	18.9	37.1	-2.7	-6.1	-3.5
Leg predicted mass (left)	3.6	18.8	37.3	-2.6	-6.1	-3.5
Eye problems/disorders: Cataract	3.6	4.2	6.1	2.5	2.1	1.5
Whole body fat-free mass	3.3	18.8	36.0	-3.1	-6.0	-3.2
Maternal smoking around birth	3.2	4.7	11.2	1.2	3.4	1.2
Commuting to job workplace: Cycle	3.2	3.9	6.2	-2.2	-0.7	-2.5
Impedance of leg (right)	3.1	14.9	23.3	2.5	3.9	4.8
Forced expiratory volume in 1-second (FEV1)	3.1	10.4	14.0	-3.1	-3.7	-2.7
Whole body water mass	3.1	17.9	34.7	-3.0	-5.9	-3.2
Bipolar Disorder or Schizophrenia	3.0	7.4	21.5	-0.6	-0.7	-4.6
Impedance of leg (left)	3.0	14.5	19.0	2.9	4.0	4.4
Comparative body size at age 10	3.0	8.2	20.9	-0.6	-4.6	-1.8
Basal metabolic rate	3.0	16.6	34.1	-2.7	-5.8	-2.9
Arm fat-free mass (left)	3.0	15.2	30.0	-3.0	-5.5	-2.5
Bipolar Disorder (2018)	2.9	4.5	11.9	-0.8	-1.0	-3.5
Trunk predicted mass	2.9	16.7	31.2	-3.4	-5.6	-2.7
Commuting to job workplace: Public transport	2.9	3.4	6.3	-1.3	-2.5	-1.5
Hearing difficulty/problems with background noise	2.8	4.5	8.0	1.6	1.7	2.8
Trunk fat-free mass	2.8	16.1	30.5	-3.3	-5.5	-2.6
Arm predicted mass (left)	2.8	14.3	27.8	-2.7	-5.3	-2.8
Age at First Birth	2.7	3.9	10.0	-1.3	0.1	-3.2
Arm fat-free mass (right)	2.7	13.8	30.2	-2.4	-5.5	-2.3
Number of incorrect matches in round	2.6	4.3	8.2	-0.2	2.9	2.1
Diabetes (self-reported)	2.6	3.9	8.6	-2.9	-1.2	-1.4
Length of working week for main job	2.6	2.9	4.8	0.7	-2.2	-1.8
Forced vital capacity (FVC)	2.5	9.8	14.8	-2.4	-3.8	-2.9
Fluid intelligence score	2.5	5.2	5.4	-2.2	-2.3	-2.3
Comparative height size at age 10	2.5	13.5	25.1	-3.6	-5.0	-1.5
Major Depression (MDD)	2.4	2.9	4.3	0.6	2.1	2.0
Arm predicted mass (right)	2.4	12.5	26.0	-2.5	-5.1	-2.3
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	8.6	0.2	2.9	-0.0
Osteoporosis (self-reported)	2.4	3.0	6.4	2.5	0.3	1.6
Qualifications: None of the above	2.3	4.9	8.5	2.2	2.9	1.2
Ever highly irritable/argumentative for 2 days	2.3	2.7	8.1	0.3	0.0	-2.8
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	8.6	-0.1	-2.9	-1.5
Age at first live birth	2.3	4.1	6.6	-0.1	-2.6	-2.4
Ever had bowel cancer screening	2.3	2.7	3.3	1.4	1.8	1.7
Diabetes diagnosed by doctor	2.3	3.7	8.7	-2.9	-0.8	-1.4
Smoking Status	2.2	5.4	11.2	3.4	2.2	0.4
Nervous feelings	2.2	4.1	10.9	0.3	3.3	1.1
Weight	2.2	10.8	25.4	-1.3	-5.0	-2.3
Mother’s age at death	2.2	2.8	4.9	-1.2	-2.2	-1.4
Fractured/broken bones in last 5 years	2.2	2.8	3.9	-1.6	-1.4	-2.0
Chronotype (morning person)	2.0	4.5	8.6	-1.7	-1.5	-2.9
Ever used hormone-replacement therapy (HRT)	2.0	2.5	6.3	0.2	2.5	1.1
Relative age voice broke	2.0	3.0	7.8	1.0	2.8	0.4
Family relationship satisfaction	2.0	2.5	7.3	0.2	2.7	-0.2
Illnesses of father: Heart disease	2.0	2.8	4.7	-1.6	2.2	-1.0
Alzheimer’s Disease (in father)	1.9	2.0	4.4	0.7	2.1	1.1
Pulse wave reflection index	1.9	2.3	6.7	-0.1	2.6	0.5
Myopia	1.9	2.8	3.8	2.0	-1.9	-0.9
Impedance of whole body	1.9	9.7	12.1	2.7	3.1	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.4	1.8	1.0	1.4
Diastolic blood pressure, automated reading	1.8	5.7	12.1	1.1	-3.5	-1.9
Ever had hysterectomy (womb removed)	1.7	1.9	2.7	-1.1	-1.3	-1.7
Mouth/teeth dental problems	1.7	2.6	6.0	-1.3	-2.4	-0.4
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	5.7	2.4	0.4	1.5
Number of children fathered	1.7	2.0	3.4	1.3	0.9	1.9
Eye problems/disorders: None of the above	1.7	2.0	3.3	-1.8	-1.1	-1.2
Illnesses of father: None of the above (group 1)	1.7	2.0	5.7	0.6	-2.4	-0.3
Schizophrenia (2018)	1.6	3.3	10.0	-0.1	-0.0	-3.2
Hip circumference	1.6	7.0	18.1	0.2	-4.3	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	5.8	-2.4	-2.3	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.1	1.8	-0.7	1.4
Supplements: Vitamin C	1.6	1.9	4.9	0.8	-2.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.6	-1.7	-2.4	-1.1
Schizophrenia vs Biploar Disorder	1.5	2.0	4.9	0.9	2.2	0.5
Triglycerides	1.5	2.5	4.9	1.3	0.8	2.2
Type 2 Diabetes (T2D) (2018)	1.5	2.8	8.5	-2.9	-0.0	-0.0
Average weekly spirits intake	1.5	1.8	3.9	-0.3	-1.2	-2.0
Relative age of first facial hair	1.5	3.0	4.9	2.2	1.8	1.0
Fed-up feelings	1.5	2.7	5.8	-0.5	2.4	1.4
Hayfever, allergic rhinitis or eczema	1.5	3.3	7.6	2.8	-0.2	1.5
Standing height	1.5	14.8	32.7	-3.1	-5.7	-1.4
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.8	1.9	-0.9	1.2
Stomach or abdominal pain in last month	1.4	1.7	2.8	1.0	-1.1	-1.7
Past tobacco smoking	1.4	2.6	5.4	-1.5	-2.3	0.5
Worrier / anxious feelings	1.4	2.7	5.9	0.0	2.4	1.5
Medication: Cholesterol lowering	1.4	2.1	3.0	-1.7	1.3	-1.3
Birth weight	1.4	3.1	7.2	2.7	-1.5	0.2
Worry too long after embarrassment	1.4	2.4	5.8	-0.1	2.4	1.2
Mineral and other dietary supplements	1.4	1.9	3.9	-2.0	0.5	-1.3
Miserableness	1.4	2.4	4.9	1.3	0.7	2.2
Medication: Paracetamol	1.4	2.1	3.3	1.5	1.8	0.9
Pack years of smoking	1.4	2.0	2.7	1.1	1.6	1.4
Worry (Nagel 2018)	1.3	2.8	6.7	0.7	2.6	1.1
Angina	1.3	1.7	2.8	1.2	1.7	0.9
Sitting height	1.3	9.5	14.8	-3.7	-3.9	-0.5
Chronic bronchitis/emphysema (father)	1.3	1.5	2.0	1.1	1.4	1.1
Medication: Lansoprazole	1.3	1.5	3.1	1.1	0.4	1.8
Pulse wave Arterial Stiffness index	1.3	1.5	2.4	-1.2	-0.8	-1.6
Tense / ‘highly strung’	1.3	2.1	4.6	0.7	2.1	1.1
Medication: Paracetamol	1.3	2.1	3.2	1.1	1.8	1.4
Headache pain in last month	1.3	2.3	6.1	-0.5	-0.8	-2.5
Wheeze or whistling in the chest in last year	1.3	2.3	3.9	2.0	-1.7	0.2
Qualifications: nursing, teaching	1.3	2.0	5.3	-0.2	-2.3	-0.7
Eye problems/disorders: Glaucoma	1.3	1.5	2.6	0.4	1.3	1.6
Age started oral contraceptive pill	1.3	1.7	2.4	0.5	1.6	1.5
Supplements: Calcium	1.3	1.5	3.1	1.1	-1.8	0.2
Neuroticism (2016)	1.2	1.8	2.1	1.0	1.4	1.4
Schizophrenia (2014)	1.2	2.6	7.7	-0.2	0.2	-2.8
BMI	1.2	6.9	16.1	-0.3	-4.0	-2.1
Allergy or Eczema	1.2	3.1	6.7	2.6	0.1	1.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.3	-1.0	-1.8	-0.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.4	-1.9	-0.5	-0.5
Vitamin and mineral supplements	1.2	1.7	4.8	-0.4	2.2	-0.2
Severe depression (siblings)	1.2	1.3	2.4	-0.7	-0.9	-1.6
Pack years adult smoking proportion	1.2	1.8	2.4	1.2	1.5	1.3
Trunk fat mass	1.2	5.0	13.8	0.3	-3.7	-1.1
Hair/balding pattern: Pattern 2	1.2	1.5	2.7	-1.6	1.4	0.1
Allergy	1.2	2.8	4.9	-2.2	0.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.4	0.8	-1.8	-0.2
Angina (self-reported)	1.2	1.6	3.1	1.1	1.8	0.8
Mean time to correctly identify matches	1.2	2.2	3.6	0.5	1.7	-1.9
Illnesses of siblings: Diabetes	1.2	1.5	3.5	-1.9	-0.5	-0.8
Arm fat mass (left)	1.2	5.0	12.9	0.1	-3.6	-1.4
Guilty feelings	1.2	1.8	3.4	-1.2	0.7	-1.9
Alcohol drinker status: Never	1.2	1.4	2.2	-0.7	-1.5	-1.2
Irritability	1.2	2.0	4.9	0.3	2.2	-1.0
Depression (Nagel 2018)	1.1	1.7	1.7	1.3	1.3	1.3
Neuroticism (Nagel 2018)	1.1	2.7	7.2	0.3	2.7	0.8
Ovarian Cancer	1.1	1.5	3.0	-0.8	-1.7	-0.9
Fasting Glucose	1.1	1.3	2.4	-0.8	-1.5	-0.9
Primary Biliary Cirrhosis	1.1	1.5	1.8	-1.0	-1.3	-1.3
Blood Red Count	1.1	10.5	27.7	5.3	1.0	1.6
Height	1.1	22.1	49.8	-3.5	-7.1	-2.1
Neuroticism	1.1	2.5	5.8	0.4	2.4	1.3
Sensitivity / hurt feelings	1.1	2.0	4.8	-0.7	2.2	0.8
Multivitamins +/- minerals	1.1	1.3	3.6	-0.6	-1.9	0.2
High blood pressure (mother)	1.1	1.5	2.7	-0.9	-1.6	-1.0
Had other major operations	1.1	1.4	3.1	0.3	-1.8	-0.9
Medication: Simvastatin	1.1	1.6	4.2	-0.0	0.9	-2.0
Father’s age at death	1.1	1.4	2.6	0.9	-1.6	-0.9
Pulse wave peak to peak time	1.1	1.3	2.5	1.1	0.6	1.6
Heart disease (mother)	1.1	1.4	4.0	0.1	2.0	-0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.9	1.7	1.0	0.2
Heart disease (siblings)	1.1	1.3	2.1	-1.4	0.8	-1.2
Reaction Time	1.0	1.9	5.2	0.1	0.7	-2.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.4	-1.2	-2.1	-1.2
Number of treatments/medications taken	1.0	1.8	4.5	2.1	0.9	-0.1
Medication: Co-codamol	1.0	1.1	2.1	1.0	1.4	-0.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.6	1.6	-0.6	0.6
Pain all over the body in last month	1.0	1.0	1.7	-1.0	0.6	1.3
Arm fat mass (right)	1.0	4.1	10.7	0.1	-3.3	-1.3
Exposure to tobacco smoke at home	1.0	1.1	3.1	0.3	0.4	-1.8
Forced vital capacity (FVC), Best measure	1.0	3.7	4.5	-1.5	-2.1	-2.1
Medication: Blood pressure	1.0	1.7	2.7	-1.4	-1.6	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.5	-0.3	1.2	1.2
Smoking status: Current	1.0	1.5	4.0	2.0	0.4	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.4	-1.6	-0.7	-0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.5	-1.1	-0.6	1.2
Financial difficulties in last 2 years	0.9	1.2	3.0	-0.6	-1.7	0.6
Medication: Ramipril	0.9	1.2	1.8	-1.4	0.7	1.1
Neuroticism score	0.9	1.8	4.8	-0.1	2.2	0.8
Glaucoma (self-reported)	0.9	1.0	1.8	0.9	0.7	1.4
Medication: Allopurinol	0.9	1.2	3.1	1.8	-0.6	0.2
Whole body fat mass	0.9	3.7	10.5	0.5	-3.2	-0.7
Overall health rating	0.9	1.9	2.9	1.0	1.3	-1.7
Commuting to job workplace: Walk	0.9	0.9	2.3	-0.0	-1.5	-0.7
Back pain experienced in last month	0.9	1.3	2.7	1.1	0.3	1.6
Alcohol drinker status: Previous	0.9	1.0	1.8	0.6	1.4	-0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	-0.1	1.9	-0.2
Coronary Artery Disease (CAD)	0.8	0.9	2.2	1.5	0.6	0.5
HbA1C	0.8	0.9	2.4	-0.5	-1.5	-0.1
Hand grip strength (right)	0.8	2.3	6.6	-0.5	-2.6	0.2
Body mass index (BMI)	0.8	3.4	7.4	-0.0	-2.7	-1.7
Prospective memory result	0.8	1.0	2.3	-1.5	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.6	-0.6	0.9	1.3
Medication: Seretide 50 evohaler	0.8	1.0	2.5	-0.6	1.6	0.1
Suffer from ‘nerves’	0.8	1.3	2.1	0.9	1.5	1.1
Had major operations	0.8	0.9	1.9	1.4	-0.8	0.4
Smoking status: Previous	0.8	1.2	3.4	0.2	1.8	0.2
Long-standing illness, disability or infirmity	0.8	1.2	3.3	0.3	-0.1	-1.8
Medication for cholesterol	0.8	1.2	1.5	-1.2	-1.2	-0.7
Medication: Gliclazide	0.8	0.9	2.5	-0.3	-1.6	0.1
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	1.5	-0.1	0.7
Leg fat mass (left)	0.8	3.0	7.8	0.6	-2.8	-0.9
Intelligence (Savage-Jansen 2018)	0.7	2.3	3.1	-1.5	-1.3	-1.7
Rheumatoid Arthritis	0.7	1.0	3.0	-0.1	1.7	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-0.5	-0.2	1.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.1	1.4	0.4	0.9
Medication: Metformin	0.7	1.0	1.7	-1.3	-0.9	-0.6
Heart attack	0.7	0.9	2.2	0.7	1.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.2	1.5	-0.9	-0.0
Impedance of arm (right)	0.7	3.2	3.4	1.8	1.9	1.7
Alcohol intake versus 10 years previously	0.7	1.0	2.2	1.5	-0.5	0.7
Impedance of arm (left)	0.7	3.4	3.8	1.9	1.7	1.9
Exposure to tobacco smoke outside home	0.7	0.9	1.7	-0.5	-0.8	-1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	1.8	-1.2	-1.3	-0.7
Leg fat mass (right)	0.7	2.9	7.8	0.6	-2.8	-0.7
Loneliness, isolation	0.7	1.0	2.4	0.7	0.4	1.5
High cholesterol (Self-reported)	0.7	1.2	3.0	0.5	1.7	-0.7
Ever smoked	0.7	1.3	1.5	1.2	1.0	-1.1
Unable to work because of sickness or disability	0.7	0.9	1.7	1.0	-0.3	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	0.7	1.4	0.5
Depressed Affect (Nagel 2018)	0.6	1.2	2.6	0.2	1.0	1.6
Mean Putamen Volume	0.6	0.7	1.8	1.3	0.0	0.6
Waist Hip Ratio (WHR)	0.6	2.8	6.6	-0.6	1.2	-2.6
Respiratory disease	0.6	1.4	2.2	1.5	-1.1	0.9
Supplements: Zinc	0.6	0.7	1.0	-0.9	-1.0	-0.3
Trunk fat percentage	0.6	2.4	5.6	1.2	-2.4	-0.3
Current tobacco smoking	0.6	1.0	2.9	1.7	0.5	-0.2
Taking other prescription medications	0.6	0.9	1.7	0.6	-0.7	-1.3
Age when periods started (menarche)	0.6	1.5	3.1	1.8	0.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.0	-1.1	-0.1	-1.7
Supplements: Glucosamine	0.6	0.8	1.9	1.4	-0.5	0.5
Waist circumference	0.6	2.4	3.7	0.2	-1.8	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.4	-0.9	1.2	0.9
Arm fat percentage (right)	0.6	2.3	4.8	1.0	-2.2	-0.9
Time employed in main current job	0.6	0.7	1.0	-0.7	-0.8	-1.0
Illnesses of mother	0.6	0.7	1.0	-0.3	-1.0	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	1.2	-1.0	0.5	-1.1
Medication: Amlodipine	0.6	0.8	0.9	-0.8	0.9	-0.9
Qualifications: College or University degree	0.6	1.9	2.3	-1.2	-1.5	-1.4
Leg pain on walking	0.6	0.7	1.1	1.1	0.9	-0.5
Asthma (self-reported)	0.6	1.3	1.9	1.4	-1.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.5	-1.9	0.2	-0.7
Ever taken oral contraceptive pill	0.6	0.6	1.2	-0.9	0.1	1.1
Medication: Blood pressure	0.6	1.2	1.5	1.2	0.8	1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.1	0.6	-1.1	0.8
Medication: Lisinopril	0.6	0.7	1.4	-1.2	-0.8	-0.4
Illnesses of father: High blood pressure	0.6	0.8	1.4	-0.8	-1.2	-0.6
Leg fat percentage (left)	0.6	2.0	4.9	2.2	-1.0	0.5
Breast Cancer	0.5	1.3	1.9	1.4	-1.3	-0.3
Prostate Cancer	0.5	0.7	1.5	-1.2	0.3	0.6
Bipolar Disorder (2011)	0.5	0.5	1.1	-0.4	0.4	-1.1
LDL Cholesterol	0.5	0.8	1.7	-0.1	1.3	0.8
Blood Eosinophil Count	0.5	4.0	9.2	3.0	-1.1	1.2
Hypothyroidism (self reported)	0.5	1.1	1.5	0.9	1.2	1.1
Hand grip strength (left)	0.5	1.3	3.0	-0.3	-1.7	1.0
Serious illness, injury or assault to yourself	0.5	0.6	0.8	-0.9	-0.8	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	0.8	0.9	-0.6
Illnesses of siblings	0.5	0.8	1.7	1.3	-0.7	0.3
Asthma	0.5	1.1	1.7	1.3	-1.0	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	0.2	-0.9
Blood clot in the leg (DVT)	0.5	0.6	1.3	-1.1	-0.7	0.4
Body fat percentage	0.5	2.0	3.4	1.6	-1.9	0.2
Leg fat percentage (right)	0.5	1.9	3.8	1.9	-1.0	0.9
Number of full brothers	0.5	0.6	1.7	1.3	0.3	0.2
Health satisfaction	0.5	0.7	1.2	0.6	1.1	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	-0.2	1.0	0.8
Medication: Ibuprofen	0.5	0.6	1.0	1.0	0.1	-0.9
Medication: Omeprazole	0.5	0.6	1.3	1.1	-0.1	-0.7
Age at last live birth	0.5	0.7	1.2	1.1	-0.5	-0.9
Knee pain experienced in last month	0.5	0.7	2.0	1.4	0.2	0.5
Arm fat percentage (left)	0.5	2.2	4.5	1.2	-2.1	-0.8
Osteoarthritis (self-reported)	0.5	0.6	1.1	0.4	-0.8	-1.0
Cholesterol lowering medication	0.5	0.7	0.9	0.9	0.7	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	1.4	-0.2	-0.1
Systolic Blood Pressure	0.4	1.9	4.2	0.2	-2.0	-1.2
Hearing difficulty/problems: Yes	0.4	0.6	0.8	0.9	0.6	0.9
Systolic blood pressure, automated reading	0.4	1.3	3.7	0.1	-1.9	-0.3
Diabetes (father)	0.4	0.5	0.9	-0.9	-0.4	-0.7
Medication: Atenolol	0.4	0.5	1.0	-1.0	-0.5	-0.4
Alcohol usually taken with meals	0.4	0.7	1.3	-1.1	-1.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	-1.3	-0.5	-1.1
Falls in the last year	0.4	0.6	1.7	1.3	-0.1	-0.3
Lung cancer (father)	0.4	0.4	1.2	1.1	0.0	-0.3
Breastfed as a baby	0.4	0.4	0.7	0.9	0.1	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	3.0	-1.7	0.1	0.1
Loud music exposure frequency	0.4	0.5	1.1	0.5	1.0	0.3
Alcohol intake frequency.	0.4	0.9	1.8	0.6	-1.3	-0.9
Number of full sisters	0.4	0.4	0.5	0.7	0.6	-0.7
Average weekly red wine intake	0.4	0.7	2.0	-1.4	-0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.6	1.3	0.1	-0.3
Medication: Atorvastatin	0.4	0.5	1.6	-1.3	0.1	0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	-0.6	0.4	-1.2
Ulcerative Colitis (UC)	0.3	0.6	0.9	-0.8	0.4	-1.0
HDL Cholesterol	0.3	0.5	1.5	-0.1	-0.2	-1.2
Cardiovascular Disease	0.3	0.9	1.1	-0.9	-0.8	-1.1
Diabetes (mother)	0.3	0.3	0.7	0.3	-0.5	-0.8
Depression (self-reported)	0.3	0.4	0.7	0.9	0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.3	0.8	-0.6
Neck or shoulder pain in last month	0.3	0.5	0.9	0.6	0.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.9	-0.1	-0.5
Chest pain or discomfort	0.3	0.5	1.0	0.3	-0.5	-1.0
Hypertension (Self-reported)	0.3	0.8	2.0	-0.5	-1.4	-0.3
Breast cancer (self-reported)	0.3	0.4	0.6	-0.6	0.4	0.8
Wears glasses or contact lenses	0.3	0.4	1.0	0.1	0.3	1.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.9	-0.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	-0.4	0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.5	0.4	-0.6
Crohns Disease (2012)	0.2	0.4	0.6	-0.1	0.7	0.7
Hair Pigment	0.2	4.4	8.9	0.4	-2.0	-3.0
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.3	-0.5	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.9	0.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.6	0.1	0.7
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.8	-0.7	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	0.8	0.3
Noisy workplace	0.2	0.3	0.5	0.5	0.2	-0.7
Gout (self-reported)	0.2	0.3	0.8	0.9	-0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.4	1.0	0.2
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.8	-0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.2	0.3	-0.9
Shortness of breath walking on level ground	0.2	0.3	0.5	0.2	-0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.8	0.1	-0.4
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.4	0.2
Mood swings	0.2	0.4	1.0	-0.2	1.0	-0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	0.6	-0.8	-0.3
Number of operations (self-reported)	0.2	0.2	0.4	0.7	-0.5	0.1
Ever depressed for a whole week	0.2	0.3	0.5	0.7	0.2	0.5
Crohns Disease (2017)	0.1	0.2	0.5	-0.1	0.7	-0.2
Lupus	0.1	0.1	0.2	0.3	0.0	-0.5
Blood Platelet Count	0.1	1.0	1.2	1.1	-0.9	-1.0
Blood White Count	0.1	0.8	1.2	1.0	0.2	1.1
Heel T-Score	0.1	0.8	1.7	1.3	-0.5	-0.7
Lung FVC	0.1	0.7	2.0	-0.2	0.4	-1.4
Tanning	0.1	1.0	1.4	-0.8	-1.2	0.9
High blood pressure	0.1	0.4	1.1	-0.1	-1.1	0.1
Had menopause	0.1	0.1	0.3	0.1	0.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	-0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.4	-0.1	0.3
Birth weight of first child	0.1	0.2	0.4	0.3	-0.6	0.3
High blood pressure (siblings)	0.1	0.1	0.3	0.2	0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.7	-0.0	-0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.4	0.5	-0.1
Hearing aid user	0.1	0.1	0.2	-0.4	0.0	-0.3
Financial situation satisfaction	0.1	0.1	0.3	0.0	-0.1	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	0.5	0.3
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	0.2	0.2
Risk taking	0.1	0.2	0.4	-0.6	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.7	0.2	-0.2
Pain experienced in last month	0.1	0.2	0.7	0.0	0.3	0.8
Ulcerative Colitis	0.0	0.1	0.1	-0.2	0.2	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.5	-0.4	0.4
Average weekly fortified wine intake	0.0	0.0	0.1	-0.3	-0.1	0.2
Medication: Aspirin	0.0	0.0	0.0	-0.2	-0.0	-0.0

Hub : Genes

KDM3B

Models

Trait associations